ライフサイエンスコーパス: ubiquitin-conjugating enzyme

1 ventional genes such as Argonaute2 and an E2-ubiquitin conjugating enzyme.

2 f Mdm2 facilitates the recruitment of the E2 ubiquitin-conjugating enzyme.

3 53 localization and activity by Ubc13, an E2 ubiquitin-conjugating enzyme.

4 plexes by providing a recognition site for a ubiquitin-conjugating enzyme.

5 iquitin chains with Ubc13-Mms2 acting as the ubiquitin-conjugating enzyme.

6 ith a SUMO-conjugating enzyme but not with a ubiquitin-conjugating enzyme.

7 bstrates for polyubiquitination by the Cdc34 ubiquitin-conjugating enzyme.

8 (RBX1) subunit and preventing binding to the ubiquitin-conjugating enzyme.

9 Nedd4-2 cooperation with UBE2D and UBE2L3 E2 ubiquitin-conjugating enzymes.

10 and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes.

11 s insights into the structural plasticity of ubiquitin-conjugating enzymes.

12 ct subsets of E2 (ubiquitin carrier protein) ubiquitin-conjugating enzymes.

13 Human Ubc9 is homologous to ubiquitin-conjugating enzymes.

14 identified a P. falciparum homolog of the E2 ubiquitin-conjugating enzyme 13 (UBC13) as an endogenous

15 at-shock protein 90 (13%); osteopontin (4%); ubiquitin-conjugating enzyme (15%); translation-initiati

16 iquitin proteasome system, and inhibition of ubiquitin-conjugating enzyme 2 N (UBE2N) with a specific

17 ies showed that miR-934 binds to a 3'-UTR of ubiquitin-conjugating enzyme 2N (ube2n) mRNA, down-regul

18 Here, we report that the plant ubiquitin-conjugating enzyme 32 (UBC32), an ER-bound E2

19 we identify an E2 enzyme, Triticum aestivum Ubiquitin conjugating enzyme 4 (TaU4) that functions in

20 Use of a temperature-sensitive mutant of ubiquitin-conjugating enzyme 4 (Ubc4') as a model substr

21 stability) were Prdm4 (PR domain 4) > Ube4a (Ubiquitin-Conjugating Enzyme 4a) > Enox2 (Ecto-NOX Disul

22 except for modest declines in parkin, human ubiquitin-conjugating enzyme 5 (UbcH5), and beta-TRCP (t

23 munofluorescence staining; HDAC4, Rad51, and ubiquitin-conjugating enzyme 9 (Ubc9) in HCC cell nuclei

24 Ubiquitin-conjugating enzyme 9 (Ubc9) is required for su

25 Ubiquitin-conjugating enzyme 9 (UBC9) is the only known

26 ying Apobec2-interacting proteins, including ubiquitin-conjugating enzyme 9 (Ubc9); topoisomerase I-b

27 arcomeric M-line region.MURF-1 also binds to ubiquitin-conjugating enzyme-9 and isopeptidase T-3, enz

28 Using UbcH5c as ubiquitin-conjugating enzyme, a ubiquitin ligase activit

29 erved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in

30 OspG has been reported to bind host E2 ubiquitin-conjugating enzymes activated with ubiquitin (

31 fore pVHL can serve as an adaptor for both a ubiquitin conjugating enzyme and a kinase.

32 Mechanistically, we find that the E2 ubiquitin-conjugating enzyme and IPO11 cargo, UBE2E1, is

33 L is stabilized when a peroxisome-associated ubiquitin-conjugating enzyme and its membrane anchor are

34 hich is defective in a peroxisome-associated ubiquitin-conjugating enzyme and its membrane tether.

35 licational repair mediated by the Mms2-Ubc13 ubiquitin-conjugating enzyme and Rad5.

36 nt yeast genetic studies have implicated the ubiquitin-conjugating enzyme and ubiquitin ligase functi

37 ion of reticulocyte proteins, which contains ubiquitin-conjugating enzymes and the proteasome, to det

38 In the ubiquitin-proteasome system, ubiquitin-conjugating enzymes and ubiquitin ligases appe

39 ymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligase

40 e UbcH5 subfamily (ubiquitin carrier protein/ubiquitin-conjugating enzymes), and in the case of caspa

41 ed degradation (ERAD) components Ubc7, an E2 ubiquitin conjugating enzyme, and Hrd1, an E3 ubiquitin

42 onds to HR6B, the yeast homologue of Rad6, a ubiquitin-conjugating enzyme, and a key player in postre

43 ing an E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and an E3 ubiquitin ligase

44 These host proteins, such as eEF1A, Cdc34 E2 ubiquitin-conjugating enzyme, and ESCRT proteins (Bro1p

45 CP0 (residues 20-241) bind the UbcH3 (cdc34) ubiquitin-conjugating enzyme, and its carboxy terminus e

46 ncentration in the vicinity of the Rbx-bound ubiquitin-conjugating enzyme, and thus the rate at which

47 es the E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and, frequently, a substra

48 tive inactivation, whereas activities of the ubiquitin-conjugating enzymes are more resistant to oxid

49 iquitin ligases, together with their cognate ubiquitin-conjugating enzymes, are responsible for the u

50 that SCF(Cdc4) acts together with the Cdc34 ubiquitin-conjugating enzyme at the level of the G prote

51 g indicated that XERICO interacts with an E2 ubiquitin-conjugating enzyme (AtUBC8) and ASK1-interacti

52 Tsg101 UEV resembles canonical E2 ubiquitin conjugating enzymes, but has an additional N-t

53 ic ablation of Ubc13, a Lys63 (K63)-specific ubiquitin-conjugating enzyme, caused aberrant T cell act

54 in ligase complex that functions with the E2 ubiquitin conjugating enzyme CDC34.

55 The ubiquitin-conjugating enzyme CDC34 (UBC3) is linked to c

56 The ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase

57 t chain assembly by ubiquitin ligase SCF and ubiquitin-conjugating enzyme Cdc34 is facilitated by the

58 We have found that the E2 ubiquitin-conjugating enzyme Cdc34 is required for degra

59 Furthermore, we demonstrate that the ubiquitin-conjugating enzyme Cdc34 mediates cell cycle-d

60 ally blocked in mutants defective for the E2 ubiquitin-conjugating enzyme Cdc34 or the cullin homolog

61 llin-RING ubiquitin ligase SCF(Cdc4) and the ubiquitin-conjugating enzyme Cdc34.

62 demonstrate that San1 can function with two ubiquitin-conjugating enzymes, Cdc34 and Ubc1.

63 protein ligase that, in conjunction with the ubiquitin-conjugating enzymes Cdc34p and Ubc1p, targets

64 tions and levels or/and activation levels of ubiquitin-conjugating enzymes change during development

65 lin-35 and ubc-18, a gene that encodes an E2 ubiquitin-conjugating enzyme closely related to human UB

66 TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13

67 ement of the Rad5 protein and the Mms2-Ubc13 ubiquitin-conjugating enzyme complex in this repair proc

68 The Rad6-Rad18 ubiquitin-conjugating enzyme complex of Saccharomyces ce

69 bc13, a member along with Uev1A of a dimeric ubiquitin-conjugating enzyme complex.

70 ribed previously for certain RING-associated ubiquitin-conjugating enzymes, constitutes a common prin

71 RAD6B, a ubiquitin-conjugating enzyme critical for translesion DN

72 Free ubiquitin and the ubiquitin-conjugating enzyme CrUbc13 are detected in fla

73 Finally, a giant ubiquitin-conjugating enzyme, dBruce, is required to pro

74 f the Not4-interacting protein Ubc4, a known ubiquitin-conjugating enzyme, decreases H3K4me3.

75 scuss how these findings relate to how other ubiquitin-conjugating enzymes direct the lysine specific

76 mber of a small group of inactive variant E2 ubiquitin-conjugating enzyme domain-containing proteins

77 uentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3.

78 actosidase, peroxiredoxin 1, beta-actin, and ubiquitin-conjugating enzyme E2 among them.

79 The function of RBX1 is to bind the ubiquitin-conjugating enzyme E2 and bring it into close

80 Together with ubiquitin-conjugating enzyme E2 E1 (UBE2E1), TRIM21 acts

81 ses (CRLs) assist in ubiquitin transfer from ubiquitin-conjugating enzyme E2 to the substrate.

82 We identified Ube2v1 (ubiquitin-conjugating enzyme E2 variant 1) in a genome-w

83 changes in CBL stability and its binding to ubiquitin-conjugating enzyme E2, by performing blind CBL

84 -encoded proteins were identified, including ubiquitin-conjugating enzyme E2, casein kinase II (CKII)

85 trate that c-IAP1, in collaboration with the ubiquitin conjugating enzyme (E2) enzyme UbcH5a, mediate

86 Here we report that Miz1 interferes with the ubiquitin conjugating enzyme (E2) Ubc13 for binding to t

87 Using the ubiquitin conjugating enzyme (E2) UBE2T and ubiquitin li

88 ediated by ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ubiquitin ligase

89 tion of RIP1 in vitro in the presence of the ubiquitin conjugating enzymes (E2) UbcH13 or UbcH5a.

90 chain and requiring either a single pair of ubiquitin-conjugating enzyme (E2) and ubiquitin ligase (

91 l-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. r

92 RING domain is unable to bind and activate a ubiquitin-conjugating enzyme (E2) efficiently.

93 Here, we show that UBE2T is the ubiquitin-conjugating enzyme (E2) essential for this pat

94 inus of Ub and the active site cysteine of a ubiquitin-conjugating enzyme (E2) is formed.

95 To identify the ubiquitin-conjugating enzyme (E2) required for dislocati

96 tosol led to the identification of Ubc5 as a ubiquitin-conjugating enzyme (E2) required for IRF3 acti

97 Ubc7p is a ubiquitin-conjugating enzyme (E2) that functions with en

98 UBC13 (also known as UBE2N) is a ubiquitin-conjugating enzyme (E2) that heterodimerizes w

99 itination and proteasomal degradation of the ubiquitin-conjugating enzyme (E2) UbcH10.

100 istically, Ndfip1 facilitated recruitment of ubiquitin-conjugating enzyme (E2) UbcH7 to Itch.

101 ioester bond that links "donor" ubiquitin to ubiquitin-conjugating enzyme (E2) undergoes nucleophilic

102 port that COP10 encodes a protein similar to ubiquitin-conjugating enzyme (E2) variant proteins (UEV)

103 nzymes:a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), a ubiquitin protein l

104 a small RING domain protein Roc1/Rbx1 and a ubiquitin-conjugating enzyme (E2), and a substrate recru

105 It tethers the ERAD ubiquitin-conjugating enzyme (E2), Ubc7p, to the ER and

106 tion leads to a decrease in affinity for the ubiquitin-conjugating enzyme (E2), UbcH5b.

107 hemselves due to interactions with a charged ubiquitin-conjugating enzyme (E2).

108 inhibitor that blocks interactions with its ubiquitin-conjugating enzyme (E2).

109 intermediate and catalyzes its transfer to a ubiquitin-conjugating enzyme (E2).

110 oning between the attached substrate and the ubiquitin-conjugating enzyme (E2).

111 Together with ubiquitin ligases (E3), ubiquitin-conjugating enzymes (E2) are charged with the

112 ity to facilitate transfer of ubiquitin from ubiquitin-conjugating enzymes (E2) to substrates.

113 E1), the three-dimensional structures of the ubiquitin-conjugating enzymes (E2), and the chemistry of

114 1), which activate and transfer ubiquitin to ubiquitin-conjugating enzymes (E2).

115 of the anaphase-promoting complex, including ubiquitin-conjugating enzyme E2C, resulting in degradati

116 tudy, including contactin 1, myozenin 2, and ubiquitin-conjugating enzymes E2C and E2S.

117 CH5a-ubiquitin thioester adduct (UBCH5a is a ubiquitin-conjugating enzyme E2D 1 UBC4/5 homolog yeast)

118 o-NOX Disulfide-Thiol Exchanger 2) > Ube2d2 (Ubiquitin-conjugating enzyme E2D 2) > Actb (Actin beta).

119 ndependent manner and cooperates with the E2 ubiquitin-conjugating enzyme E2D2 to promote ubiquitinat

120 or coexpression of the dominant-negative E2 ubiquitin-conjugating enzyme, E2D2, attenuates this modi

121 tide polymorphism in the gene coding for the ubiquitin-conjugating enzyme E2L6 (Ube2l6, also known as

122 bosomal protein L27a) and the ApE2N (Aplysia ubiquitin-conjugating enzyme E2N) mRNAs also increased a

123 ated the expression of the proapoptotic gene ubiquitin-conjugating enzyme E2N, and downregulated the

124 Here, we report that the stability of Ubiquitin-conjugating enzyme E2S (UBE2S) is regulated by

125 The class III ubiquitin conjugating enzymes (E2s) are distinguished fr

126 Ubiquitin-conjugating enzymes (E2s or Ubcs) are essentia

127 Although the functional interaction between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligase

128 gases (E3s) and function by interacting with ubiquitin-conjugating enzymes (E2s) charged with ubiquit

129 Ubiquitin-conjugating enzymes (E2s) collaborate with the

130 he heart of protein ubiquitination cascades, ubiquitin-conjugating enzymes (E2s) form reactive ubiqui

131 Protein ubiquitination is catalyzed by ubiquitin-conjugating enzymes (E2s) in collaboration wit

132 re, we demonstrate that COP10 interacts with ubiquitin-conjugating enzymes (E2s) in vivo, and can enh

133 bstrate for the E3 ligase Mdm2, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiq

134 Our work identified the ubiquitin-conjugating enzymes (E2s) UBC35/36 as the majo

135 by two distinct pathways, one involving the ubiquitin-conjugating enzymes (E2s) Ubc6 and Ubc7 and th

136 itin ligase (E3) that along with its cognate ubiquitin-conjugating enzymes (E2s), Ubc7 and the C-term

137 ation, suggesting a significant role for the ubiquitin-conjugating enzyme function of Cdc34p in TBSV

138 e P falciparum housekeeping gene (PF08_0085; ubiquitin-conjugating enzyme gene) in bone marrow (n = 1

139 on to cyanobacteria: six protease genes, one ubiquitin-conjugating enzyme gene, and two rRNA genes, a

140 e expression pattern of one protease and the ubiquitin-conjugating enzyme genes was positively correl

141 shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ub

142 In this way, we have uncovered a novel human ubiquitin-conjugating enzyme, have isolated a human cDNA

143 demonstrate that RFPL4 interacts with the E2 ubiquitin-conjugating enzyme HR6A, proteasome subunit be

144 UBR2 interacts with the ubiquitin conjugating enzyme HR6B and its substrate H2A

145 and could autoubquitylate with different E2 ubiquitin conjugating enzymes in vitro.

146 (HLECs), the authors explored roles for this ubiquitin-conjugating enzyme in regulation of the HLEC c

147 n select biological pathways, exemplified by ubiquitin-conjugating enzymes in ubiquitination, carrier

148 -SMAD2/3 by binding to and inhibiting the E2 ubiquitin-conjugating enzymes independent of its catalyt

149 The second contains CDC34, encoding a ubiquitin conjugating enzyme, indicating a link between

150 on in the murine Ube2o gene, which encodes a ubiquitin-conjugating enzyme induced during erythropoies

151 analysis to determine that PEX4, an apparent ubiquitin-conjugating enzyme, interacts with a previousl

152 We show that Bendless (BEN), an E2 ubiquitin-conjugating enzyme, interacts with NOPO in a y

153 nkage-specific substrates, including Ubc6, a ubiquitin-conjugating enzyme involved in endoplasmic ret

154 ability of ICP0 to interact with cellular E2 ubiquitin-conjugating enzymes is fundamentally important

155 uitin conjugase BRUCE (BIR Repeat containing Ubiquitin-Conjugating Enzyme) is a guardian of chromosom

156 We have recently shown that Rad6B, an ubiquitin-conjugating enzyme, is a transcriptional targe

157 We show that RAD6, an ubiquitin-conjugating enzyme, is significantly overexpre

158 We show that UbcH7, an E2 ubiquitin-conjugating enzyme, is specifically involved i

159 A putative ubiquitin conjugating enzyme known as UBE2Q2 was previou

160 To determine whether hMms2, a ubiquitin-conjugating enzyme-like protein, plays a criti

161 ) receptor ubiquitination is mediated by the ubiquitin-conjugating enzyme, (mam)Ubc7, a component of

162 MfSTMIR interacted with the ERAD-associated ubiquitin-conjugating enzyme MtUBC32 and Sec61-transloco

163 -specific pattern was observed in the pex4-1 ubiquitin-conjugating enzyme mutant.

164 proteins in vitro in the presence of two E2 ubiquitin-conjugating enzymes, namely, UBE2D1 (UbcH5a) a

165 Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA r

166 Among these genes is cdc34, the ubiquitin-conjugating enzyme of the Skp1/cullin/F-box (S

167 ng complex (APC) E3 ligase functions with E2 ubiquitin-conjugating enzymes of the E2-C and Ubc4/5 fam

168 eukaryotic environment, utilize host cell E2 ubiquitin-conjugating enzymes of the Ube2D family, and t

169 3 ligase: ICP0 interacts with at least three ubiquitin-conjugating enzymes of which one, UbcH5a, is r

170 ducing function of the peroxisome-associated ubiquitin-conjugating enzyme PEX4 restored PEX10 levels

171 In yeast, the Rad6-Rad18 ubiquitin conjugating enzyme plays a critical role in pr

172 The Cdc34 ubiquitin-conjugating enzyme plays a central role in pro

173 expected to form the docking site of the E2 ubiquitin-conjugating enzyme, providing a structure-base

174 gase Bre1 (human RNF20/40) pairs with the E2 ubiquitin conjugating enzyme Rad6 to monoubiquitinate H2

175 Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2) mediates methyl

176 The E2 ubiquitin-conjugating enzyme RAD6 is essential for TLS.

177 biquitin ligase Bre1 and its partner, the E2 ubiquitin-conjugating enzyme Rad6, monoubiquitinate hist

178 The ubiquitin-conjugating enzyme Rad6, which directly intera

179 f phosphorylated Sml1 is dependent on the E2 ubiquitin-conjugating enzyme, Rad6, the E3 ubiquitin lig

180 in histone H2B ubiquitination along with the ubiquitin-conjugating enzyme Rad6p and the ubiquitin lig

181 ubiquitination requires the presence of the ubiquitin-conjugating enzyme Rad6p and the ubiquitin lig

182 te specificity and, in collaboration with E2 ubiquitin-conjugating enzymes, regulate the nature of po

183 Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonic

184 Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonica

185 een, revealing that mutation in ubcD1, an E2 ubiquitin-conjugating enzyme, resulted in retention of C

186 iochemical and genetic characterization of a ubiquitin-conjugating enzyme Rhp6 (a homolog of budding

187 By recruiting E2 ubiquitin-conjugating enzyme(s), Mdm2 acts as a molecula

188 t the ubiquitin proteasome system in which a ubiquitin-conjugating enzyme selectively inhibits and ma

189 Knockdown of MAGE-L2-TRIM27 or the Ube2O E2 ubiquitin-conjugating enzyme significantly impaired retr

190 UBE2L3 is an E2 ubiquitin-conjugating enzyme, specially adapted to funct

191 with Pi SLFs, S-RNases, Pi CUL1-G, and an E2 ubiquitin-conjugating enzyme, suggesting that Pi CUL1-G,

192 Rad6 is a yeast E2 ubiquitin conjugating enzyme that monoubiquitinates hist

193 nes, homologs of the yeast RAD6 gene, encode ubiquitin conjugating enzymes that are required for post

194 Fni3 encodes a homolog of the Ubc13-type ubiquitin-conjugating enzyme that catalyzes exclusively

195 s event is tightly regulated by UBE2C, an E2 ubiquitin-conjugating enzyme that donates ubiquitin to t

196 a pivotal negative regulator of Ubc13, an E2 ubiquitin-conjugating enzyme that facilitates TRAF6 K63-

197 UBC6e is a tail-anchored E2 ubiquitin-conjugating enzyme that is part of a dislocati

198 UbE2E1/UbcH6 is an E2 ubiquitin-conjugating enzyme that is regulated by USP7.

199 RAD6 is an E2 ubiquitin-conjugating enzyme that plays a pivotal role i

200 l that PHA-1, a novel protein, and UBC-18, a ubiquitin-conjugating enzyme that we have previously sho

201 s, homologues of the yeast Rad6 gene, encode ubiquitin-conjugating enzymes that are required for post

202 We profiled E2 ubiquitin-conjugating enzymes that pair with Roquins and

203 tion is the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate or a growing

204 which promote ubiquitin transfer from an E2 ubiquitin-conjugating enzyme to a substrate.

205 function is the selection of a particular E2 ubiquitin-conjugating enzyme to accomplish ubiquitinatio

206 mediate the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to specific substrate prote

207 d mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate.

208 tin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin

209 arkin functions with UbcH13/Uev1a, a dimeric ubiquitin-conjugating enzyme, to assemble ubiquitin lysi

210 IN-35 retinoblastoma protein homolog and the ubiquitin-conjugating enzyme UBC-18 function redundantly

211 d region (UTR) of a gene encoding a putative ubiquitin-conjugating enzyme (UBC) in Arabidopsis thalia

212 The ubiquitin-conjugating enzyme (UBC) involved in this impo

213 Here, we show that reduction in the E2 ubiquitin-conjugating enzyme (UBC) of the E2-C family th

214 Ubc3/Cdc34 is a ubiquitin-conjugating enzyme (Ubc) with well established

215 g the differentiation process, the levels of ubiquitin-conjugating enzyme (Ubc)-1 increased approxima

216 ogs, AtCHIP interacts with a unique class of ubiquitin-conjugating enzymes (UBC or E2) that belongs t

217 lutaryl-CoA reductase (HMGR) or deficient in ubiquitin-conjugating enzymes (Ubc; UBC), revealed that

218 Furthermore, we find that the E2 ubiquitin conjugating enzyme, UBC-18, is essential and s

219 a by XIAP is dependent on the activity of E2 ubiquitin conjugating enzyme Ubc13.

220 AP1 by antagonizing interactions with the E2 ubiquitin conjugating enzymes Ubc13 and UbcH5c.

221 SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes met

222 i deamidates a glutamine residue in the host ubiquitin-conjugating enzyme UBC13 and converts it to gl

223 We identified both the ubiquitin-conjugating enzyme Ubc13 and the ubiquitin lig

224 m-linked ubiquitin ligase RNF8 or associated ubiquitin-conjugating enzyme UBC13 in rodent cerebellar

225 The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-sp

226 The E2 ubiquitin-conjugating enzyme UBC13 plays pivotal roles i

227 E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically gener

228 ontaining adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor o

229 nuclein (PARK1), and in conjunction with the ubiquitin-conjugating enzyme Ubc13, stimulates K63-linke

230 es NF-kappaB in a manner that depends on the ubiquitin-conjugating enzyme Ubc13, TNF receptor-associa

231 vitro system to examine the activity of the ubiquitin-conjugating enzyme UBC13-UEV1A with TRAF6 in w

232 exhibited partial dependence on RNF8 and the ubiquitin-conjugating enzyme UBC13.

233 ion of Tax is critically dependent on the E2 ubiquitin-conjugating enzyme Ubc13.

234 DNA damage repair by targeting ZEB1 and the ubiquitin-conjugating enzyme Ubc13.

235 ctivation of TAK1 and IKK requires the human ubiquitin-conjugating enzymes Ubc13 and UEV1a.

236 Paracaspase and a ubiquitin-conjugating enzyme (UBC13) were both required

237 Among all the E2 ubiquitin-conjugating enzymes, Ubc13, which heterodimeri

238 As in other organisms, the E2 ubiquitin-conjugating enzyme Ubc2 and the E3 ubiquitin l

239 es Rhp6, the S. pombe homologue of the human ubiquitin-conjugating enzyme Ubc2.

240 The ubiquitin-conjugating enzymes Ubc2 and Ubc4 assist the d

241 MicroRNA399-mediated regulation of the ubiquitin-conjugating enzyme UBC24/phosphate2 (PHO2) is

242 biquitin-proteasome pathway involving the E2 ubiquitin conjugating enzymes Ubc4/5 and the HECT (Homol

243 demonstrate that Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin liga

244 The ubiquitin-conjugating enzyme Ubc4 was found in the same

245 itin E3 ligase activity that requires the E2 ubiquitin-conjugating enzyme Ubc4.

246 in the proteasome, and in genes encoding the ubiquitin-conjugating enzymes Ubc4 and Ubc5, stabilized

247 te (ATP) and was stimulated by addition of a ubiquitin-conjugating enzyme, Ubc4.

248 r the gene coding for one of the major yeast ubiquitin-conjugating enzymes, Ubc4, or the gene coding

249 ubiquitylation of target proteins by the E2 ubiquitin-conjugating enzyme Ubc5.

250 gases that activate ubiquitylation by the E2 ubiquitin-conjugating enzyme Ubc5.

251 ng the ubiquitin-activating enzyme Uba1, the ubiquitin--conjugating enzymes Ubc6 and Ubc7, and the ub

252 e (RNAi) studies show that Aup1 recruits the ubiquitin-conjugating enzyme Ubc7 to lipid droplets and

253 Turnover of Mps3 requires the ubiquitin-conjugating enzyme Ubc7, but was independent o

254 Cue1p has been shown to recruit the soluble ubiquitin-conjugating enzyme, Ubc7p, to the cytoplasmic

255 ally important, we provide evidence that the ubiquitin-conjugating enzyme, Ubc9, is expressed at high

256 n of defects is also seen in a mutant in the ubiquitin-conjugating enzyme ubcD1 and a mutant in the 1

257 C) E3 ubiquitin ligase functions with the E2 ubiquitin-conjugating enzyme UbcH10 in the orderly progr

258 The human ubiquitin-conjugating enzyme, UbcH10, is an essential me

259 iquitylation is best supported by a specific ubiquitin-conjugating enzyme, UbcH3/CDC34, and requires

260 nteracts with MLK3 and, together with the E2 ubiquitin-conjugating enzyme UbcH5 (UbcH5a, -b, -c, or -

261 affect the protein levels of cIAP1 or its E2 ubiquitin-conjugating enzymes UbcH5 and Ubc13.

262 In addition, different IAPs require the same ubiquitin-conjugating enzymes UbcH5a and UbcH6 for their

263 omain is found to interact with the cellular ubiquitin-conjugating enzymes UbcH5A to -C and UbcH13, w

264 ubiquitin ligases that cooperate with the E2 ubiquitin-conjugating enzymes UbcH5a, -b, and -c to medi

265 iquitin ligase that acts in conjunction with ubiquitin-conjugating enzymes UbcH5a, UbcH5c, and UbcH6.

266 of interactions between CHIP and its cognate ubiquitin-conjugating enzyme, UbcH5a, which may in turn

267 ubiquitin ligase activity, BARD1 and the E2 ubiquitin-conjugating enzyme, UbcH5a.

268 that are important for interacting with the ubiquitin-conjugating enzyme UbcH5b.

269 that both PJA1 and PJA2 are able to bind the ubiquitin-conjugating enzyme UbcH5B.

270 Unlike most RINGs, AO7 (RNF25) binds the E2 ubiquitin-conjugating enzyme, UbcH5B (UBE2D2), with stri

271 bunits, Ring1B and Bmi1, together with an E2 ubiquitin-conjugating enzyme, UbcH5c.

272 TSSC5 that can function in concert with the ubiquitin-conjugating enzyme UbcH6.

273 Measurements of the E2 ubiquitin-conjugating enzyme UbcH7 binding to Parkin and

274 We investigated the role of the ubiquitin-conjugating enzyme UBCH7 in nuclear receptor t

275 Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjun

276 n contrast to promoting its degradation, the ubiquitin-conjugating enzyme UBCH7/UBE2L3 specifically p

277 Siah-1 binds the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 and facilitates mono-

278 We have discovered that the ubiquitin-conjugating enzyme UbcM2 is a novel regulator

279 ation is mediated by the concerted action of ubiquitin-conjugating enzymes (Ubcs or E2s) and ubiquiti

280 oss, which also require expression of the E2 ubiquitin-conjugating enzyme, UBE2C.

281 omotes the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D to its recruited subs

282 tein), elusive enzyme-substrate interaction (ubiquitin-conjugating enzyme UBE2D3 with substrate PCNA)

283 l TDP-43 is ubiquitinated, we focused on the ubiquitin-conjugating enzyme UBE2E3 and the ubiquitin is

284 as undertaken to determine whether the human ubiquitin-conjugating enzyme, UBE2E3, is essential for R

285 quality control is to recruit the soluble E2 ubiquitin-conjugating enzyme UBE2G2.

286 RAD) by the ubiquitin E3 ligase HRD1, and E2 ubiquitin conjugating enzyme UBE2J1, and represent one o

287 mal activity and also increases the level of ubiquitin-conjugating enzyme UBE2N (Ubc13) in synaptosom

288 fector MavC induces ubiquitination of the E2 ubiquitin-conjugating enzyme UBE2N by transglutamination

289 The E2 ubiquitin-conjugating enzyme UBE2N was a preferential bi

290 Here, we found that the conserved ubiquitin-conjugating enzyme UBE2O directly recognized j

291 The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite spec

292 al hit compound targeting the Fanconi anemia ubiquitin-conjugating enzyme Ube2T and describe its biop

293 quitin-activating enzyme UBA6 and the hybrid ubiquitin-conjugating enzyme/ubiquitin ligase BIRC6 as a

294 COP10 is a ubiquitin-conjugating enzyme variant (UEV), which is tho

295 ew member of the DLK-1 pathway, UEV-3, an E2 ubiquitin-conjugating enzyme variant.

296 s-63-linked ubiquitination, whereas Suv is a ubiquitin-conjugating enzyme variant.

297 ore, gene and protein expression of UbcH2, a ubiquitin conjugating enzyme, was also increased early i

298 d screening, the mitotic cyclin B1 and an E2 ubiquitin-conjugating enzyme were isolated as HEI10-inte

299 Further analysis of Cdc34p E2 ubiquitin-conjugating enzyme, which is one of the host p

300 UBE2L3 is an E2 ubiquitin-conjugating enzyme with specificity for RING-i