ライフサイエンスコーパス: ubiquitin-protein ligase

1 ase due to a loss of function mutation in an ubiquitin protein ligase.

2 ecognizing component of the SCF(HOS)-Roc1 E3 ubiquitin protein ligase.

3 , the anaphase promoting complex (APC), is a ubiquitin protein ligase.

4 bsentia homologue-1 (Siah-1), a RING-type E3 ubiquitin-protein ligase.

5 me, and, frequently, a substrate-specific E3 ubiquitin-protein ligase.

6 anaphase-promoting complex/cyclosome (APC/C) ubiquitin-protein ligase.

7 ne encoding the E6-associated protein (E6AP) ubiquitin-protein ligase.

8 utations of the parkin gene, which encodes a ubiquitin-protein ligase.

9 , presumably through its ability to act as a ubiquitin-protein ligase.

10 isiae RSP5 gene encodes an essential HECT E3 ubiquitin-protein ligase.

11 gnaling, has recently been shown to act as a ubiquitin-protein ligase.

12 nd degradation of p53, dependent on the E6AP ubiquitin-protein ligase.

13 ns and functionally classifies Rsp5 as an E3 ubiquitin-protein ligase.

14 uitination of active RTKs by acting as an E3 ubiquitin-protein ligase.

15 tions in the UBE3A locus which encodes E6-AP ubiquitin-protein ligase.

16 ndent functions, as both a coactivator and a ubiquitin-protein ligase.

17 allelic to RSP5, which encodes an essential ubiquitin-protein ligase.

18 1 maps to RSP5, a gene encoding an essential ubiquitin-protein ligase.

19 romyces cerevisiae, encodes a hect domain E3 ubiquitin-protein ligase.

20 Rad17 oscillation is mediated by Cdh1/APC, a ubiquitin-protein ligase.

21 ermeabilized cells, likely by membrane-bound ubiquitin protein ligases.

22 region of Gag with cellular Nedd4-family E3 ubiquitin protein ligases.

23 it of the SCF (SKP1, Cullin, F-box) class of ubiquitin protein ligases.

24 omponents of SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligases.

25 n Cul-3, a member of the cullin family of E3 ubiquitin-protein ligases.

26 main of Rsp5p that is highly conserved among ubiquitin-protein ligases.

27 xy-terminal HECT domain characteristic of E3 ubiquitin-protein ligases.

28 xy-terminal HECT domain characteristic of E3 ubiquitin-protein ligases.

29 downstream increase of target-HECT domain E3 ubiquitin protein ligase 1 (HECTD1) expression, an incre

30 Here, we identify mindbomb E3 ubiquitin protein ligase 1 (MIB1) as a novel E3 ubiquiti

31 pathway analysis identified SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) as a key miR-140-5p

32 SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) belongs to the Nedd4

33 The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is a homologous to the

34 Overexpression of E3 ubiquitin protein ligase 1 containing HECT, C2, and WW d

35 ion also depends on SMURF1 (SMAD specific E3 ubiquitin protein ligase 1), which promotes RhoA degrada

36 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1), which targets the Rac1 prot

37 Siah-1 [seven in absentia homolog 1 (Siah E3 ubiquitin protein ligase 1)] interacting protein] is a m

38 ting ducts in mice deficient for mindbomb E3 ubiquitin protein ligase 1, a key regulator of the Notch

39 HECT domain and ankyrin repeat-containing E3 ubiquitin protein ligase 1-null mouse hearts was associa

40 ECT) domain and Ankyrin repeat containing E3 ubiquitin-protein ligase 1 (HACE1) plays a protective ro

41 HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1) as an E3 ubiquitin ligase re

42 ) and ENHANCER OF GL3 (EGL3), is mediated by ubiquitin protein ligase 3 (UPL3).

43 Absence of the maternal copy of ubiquitin protein ligase 3A (UBE3A) results in Angelman

44 ome (AS) result from loss or inactivation of ubiquitin protein ligase 3A (UBE3A), a gene displaying m

45 ersion and show that Itch encodes a novel E3 ubiquitin protein ligase, a protein involved in ubiquiti

46 In addition to the well-characterized E6AP ubiquitin-protein ligase, a second HECT domain protein (

47 Protein complexes and pathways involved in ubiquitin-protein ligase activities, sphingolipid metabo

48 efine a mechanism by which TNF-RII-regulated ubiquitin protein ligase activity can potentiate TNF-ind

49 E6AP and E6 together provide the E3-ubiquitin protein ligase activity in the transfer of ubi

50 The ubiquitin protein ligase activity of c-Cbl (abbreviated

51 Thus, the ubiquitin protein ligase activity of c-IAP1 is responsib

52 etic and functional analysis suggests the E3 ubiquitin protein ligase activity of parkin, and the ubi

53 g by regulating IRAK degradation through its ubiquitin protein ligase activity.

54 form of DRONC for degradation through its E3 ubiquitin protein ligase activity.

55 The ubiquitin-protein ligase activity associated with the E1

56 sed full-length XIAP, which is known to have ubiquitin-protein ligase activity for active caspase-3.

57 Parkin has ubiquitin-protein ligase activity in the presence of Ubc

58 e Parkinson's disease due to the loss of the ubiquitin-protein ligase activity of Parkin protein.

59 vivo function, strongly suggesting that the ubiquitin-protein ligase activity of Rsp5 is intrinsical

60 xport by E1B-55K and E4orf6 results from the ubiquitin-protein ligase activity of the adenovirus ubiq

61 viral late mRNA nuclear export requires the ubiquitin-protein ligase activity of this viral ubiquiti

62 tro experiments indicate that Rkr1 possesses ubiquitin-protein ligase activity.

63 mutant proteins to coactivate PR or provide ubiquitin-protein ligase activity.

64 teins, including Rsp5 and Nedd-4, which have ubiquitin-protein ligase activity.

65 (HECT, UBA, and WWE domain containing 1, E3 ubiquitin protein ligase), an E3 ligase implicated in ca

66 ue mutations in PEX2 and PEX10, which encode ubiquitin-protein ligases anchored in the peroxisomal me

67 associated protein, E6AP, acts both as an E3 ubiquitin-protein ligase and as a coactivator of steroid

68 RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and

69 The UBE3A gene encodes the E6-AP ubiquitin-protein ligase and has recently been shown to

70 n SH2-containing protein that functions as a ubiquitin-protein ligase and thus provide a distinct mec

71 NEDD8 acts predominantly as a regulator of ubiquitin-protein ligases and as a decoy for proteins ta

72 SCF complexes are the largest family of E3 ubiquitin-protein ligases and mediate the ubiquitination

73 (HECT, UBA, and WWE domain containing 1, E3 ubiquitin protein ligase) and NEDD4-1 (Neural precursor

74 zymes), E2 (ubiquitin-carrier proteins), E3 (ubiquitin-protein ligases), and E4 (ubiquitin chain asse

75 MDP1 is identical to RSP5, which encodes ubiquitin-protein ligase, and mdp1 mutations are suppres

76 Hsp70-type molecular chaperones, the Pib1 E3 ubiquitin-protein ligase, and the deubiquitylating enzym

77 utations of the parkin gene, which encodes a ubiquitin-protein ligase, are a common cause of autosoma

78 dentification of the Nedd4-like family of E3 ubiquitin protein ligases as proteins that specifically

79 en shown to physically associate with two E3 ubiquitin protein ligases as well as proteasomes, we inv

80 mone receptor-interacting protein 12), an E3 ubiquitin-protein ligase as a new partner of PTF1a.

81 ction but not the placement of the Rad6-Bre1 ubiquitin-protein ligase at the promoters of active gene

82 ription factors, and robust induction of the ubiquitin-protein ligase atrogin-1/MAFbx.

83 Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regu

84 vity of beta-transducin repeat containing E3 ubiquitin protein ligase, betaTrCP.

85 oxidation, and also RNF146, which encodes a ubiquitin protein ligase, both known pathways in breast

86 te Itch (a HECT domain-containing Nedd4-like ubiquitin protein ligase) bound to MKK4, ubiquitinated l

87 plex, indicating that it inhibited the viral ubiquitin-protein ligase but had no effect on viral earl

88 tly, evidence has started to emerge that the ubiquitin-protein ligase c-Cbl is involved in CSF-1 rece

89 Degradation required the ubiquitin protein ligase called the anaphase-promoting c

90 ox proteins [2] are components of modular E3 ubiquitin protein ligases called SCFs, which function in

91 box proteins are one of the four subunits of ubiquitin protein ligases called SCFs.

92 Parkin, an E2-dependent ubiquitin protein ligase, carries pathogenic mutations i

93 Most function as E3 ubiquitin-protein ligases, catalyzing the terminal step

94 ondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism.

95 A1 also interacted with FBXW7, subunit of E3 ubiquitin protein ligase complex SCF, and the latter was

96 yeast Hs-CUL-2 homolog, Cdc53, is part of a ubiquitin protein ligase complex that targets cell cycle

97 mycin to downregulate Skp2, a subunit of the ubiquitin protein ligase complex, identifies tumors that

98 ndau tumor suppressor protein to form the E3 ubiquitin protein ligase complex, required for HIF-1alph

99 CCNF encodes cyclin F, a component of an E3 ubiquitin-protein ligase complex (SCF(Cyclin F)).

100 The S. cerevisiae SCFCdc4p ubiquitin-protein ligase complex promotes cell cycle tra

101 quitin-protein ligase activity of this viral ubiquitin-protein ligase complex, we designed and expres

102 in-protein ligase activity of the adenovirus ubiquitin-protein ligase complex.

103 tion of Bim through the Cullin2/ElonginB-CIS ubiquitin-protein ligase complex.

104 ty to components of cellular multisubunit E3 ubiquitin-protein ligase complexes, including 9 proteins

105 d protein and targeted by the RING-finger E3 ubiquitin-protein ligase constitutive photomorphogenesis

106 degradation by the SKP1-CULLIN1-F-BOX (SCF) ubiquitin-protein ligases containing TRANSPORT INHIBITOR

107 demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signalin

108 --conjugating enzymes Ubc6 and Ubc7, and the ubiquitin-protein ligase Doa10.

109 educes expression of RSP5/NPI1, a postulated ubiquitin-protein ligase, dramatically reduces the rate

110 ion followed by mass spectrometry identified ubiquitin protein ligase E3 component N-recognin 4 in co

111 und heterozygous deleterious variants in the Ubiquitin protein ligase E3 component N-recognin 5 (UBR5

112 ified a HECT domain-containing protein UBR5 (ubiquitin protein ligase E3 component n-recognin 5) as a

113 We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 Component N-Recognin7 (UBR7)

114 the 15q15.2 locus involved regulation of the ubiquitin protein ligase E3 component UBR1.

115 Addition of ubiquitin protein ligase E3 substantially enhanced the E

116 th RING-H2 and leucine zipper motifs showing ubiquitin protein ligase (E3) activity and is exposed on

117 bset of IAPs that contain a RING domain have ubiquitin protein ligase (E3) activity implied the prese

118 some pathway, at least partially through the ubiquitin protein ligase (E3) activity of SKP2.

119 main-containing IAPs, c-IAP1 and c-IAP2 have ubiquitin protein ligase (E3) activity.

120 -IAP2, which also have RING domain-dependent ubiquitin protein ligase (E3) activity.

121 ation by promoting the interaction between a ubiquitin protein ligase (E3) called SCF(TIR1) and the A

122 dation, Rad6 interacts with the UBR1-encoded ubiquitin protein ligase (E3) enzyme.

123 We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activ

124 E6-associated protein (E6AP) functions as a ubiquitin protein ligase (E3) in the E6-mediated ubiquit

125 tablish that gp78 is a RING finger-dependent ubiquitin protein ligase (E3) of the endoplasmic reticul

126 Mutations in components of SCF(TIR1), a ubiquitin protein ligase (E3) result in stabilization of

127 e containing the C2 domain of mouse Nedd4, a ubiquitin protein ligase (E3) that also contains a hect

128 (E1), a ubiquitin-conjugating enzyme (E2), a ubiquitin protein ligase (E3), and a de-ubiquitinating e

129 report that CARP-2, a RING domain-containing ubiquitin protein ligase (E3), is a negative regulator o

130 ves ubiquitin carrier protein (E2) E214k and ubiquitin-protein ligase (E3) E3alpha, have remained unc

131 it was shown that E6-AP serves the role of a ubiquitin-protein ligase (E3) in the presence of the E6

132 The E6AP ubiquitin-protein ligase (E3) mediates the human papillo

133 cH5A, a 120-kDa protein(s) that behaves as a ubiquitin-protein ligase (E3), and ubiquitin-activating

134 The ubiquitin-protein ligase (E3), hRPF1/Nedd4, is a compone

135 y represent a core component of a CUL3-based ubiquitin-protein ligase (E3), we hypothesize that the p

136 , a ubiquitin-conjugating enzyme (E2), and a ubiquitin-protein ligase (E3).

137 e ubiquitin-conjugating enzyme (E2), and the ubiquitin-protein ligase (E3).

138 l nuclear ribonucleoprotein N (Snrpn (S)) to ubiquitin protein ligase E3A (Ube3a (U)) (mouse model re

139 esults from loss of function of the maternal ubiquitin protein ligase E3A (UBE3A) allele.

140 Disruptions in the ubiquitin protein ligase E3A (UBE3A) gene cause Angelman

141 AS results from loss of function of the ubiquitin protein ligase E3A (UBE3A) gene, whereas the g

142 mutation of the maternal allele encoding the ubiquitin protein ligase E3A (UBE3A), but it is unclear

143 al active maternal copy of the gene encoding ubiquitin protein ligase E3A (UBE3A).

144 on or mutation of the maternal allele of the ubiquitin protein ligase E3A (UBE3A).

145 Paramount among changing genes was ubiquitin protein ligase E3A (UBE3A; 15q11-q13), which w

146 ulating P16, accompanied by up-regulation of ubiquitin protein ligase E3A and human ubiquitin-related

147 maternally inherited UBE3A allele (encoding ubiquitin protein ligase E3A).

148 nal mRNA transcripts including sirtuin 1 and ubiquitin protein ligase E3a, two genes with established

149 caused by deficiency of maternally expressed ubiquitin-protein ligase E3A (UBE3A), an E3 ligase that

150 e both type III substrates for the mammalian ubiquitin-protein ligase E3alpha.

151 s to acute S1 removal include recruitment of ubiquitin protein ligase E3C (UBE3C) to the 26S proteaso

152 ense SNV, rs7739323, which is located in the ubiquitin protein ligase E3D (UBE3D) gene (Pmeta=1.46 x

153 Nedd4 family ubiquitin protein ligases (E3s) specifically associate w

154 of Apoptosis 1 and 2 (c-IAP1 and c-IAP2) are ubiquitin protein ligases (E3s) that constitutively ubiq

155 c-IAP1 and c-IAP2 are ubiquitin protein ligases (E3s) that repress noncanonica

156 The cullin CUL1 is a subunit in SCF-type ubiquitin protein ligases (E3s), including the SCF(TIR1)

157 arget proteins is catalyzed by the action of ubiquitin protein ligases (E3s).

158 d to be dictated by specific combinations of ubiquitin-protein ligases (E3s) and ubiquitin-conjugatin

159 Ubiquitin-protein ligases (E3s) of the HECT family share

160 Ubiquitin-protein ligases (E3s) regulate diverse cellula

161 mammalian homologue, Nedd4, are hect domain ubiquitin-protein ligases (E3s) required for the ubiquit

162 al step in this modification is performed by ubiquitin-protein ligases (E3s) that promote Ub transfer

163 Ubiquitin-protein ligases (E3s) that ubiquitinate substr

164 We have demonstrated that Nedd4 family ubiquitin-protein ligases (E3s), AIP4, WWP2/AIP2, and Ne

165 quitin-conjugating enzymes (Ubcs or E2s) and ubiquitin-protein ligases (E3s).

166 strates or with trans-acting factors such as ubiquitin-protein ligases (E3s).

167 eins Hrd1 and Doa10 are the predominant ERAD ubiquitin-protein ligases (E3s).

168 jugating enzymes (E2s) in collaboration with ubiquitin-protein ligases (E3s).

169 as BRG-1, and the less well-characterized E3 ubiquitin-protein ligases E6 papillomavirus protein-asso

170 man papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which cause

171 to E6-associated protein (E6AP), a cellular ubiquitin-protein ligase, enables E6AP to ubiquitinate p

172 was recently shown to interact with Nedd4, a ubiquitin-protein ligase expressed in epithelia.

173 es a member of the hect-domain-containing E3 ubiquitin-protein ligase family that is required for gro

174 by members of the hect-domain-containing E3 ubiquitin-protein ligase family.

175 c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and st

176 Cbl proteins function as ubiquitin protein ligases for the activated epidermal gr

177 Our results suggest that the ubiquitin protein ligase function of Cbl-b is regulated

178 The loss of Parkin's ubiquitin-protein ligase function in familial-linked mut

179 Our data show that the ubiquitin-protein ligase function of E6-AP is dispensabl

180 he majority of the AS patients examined, the ubiquitin-protein ligase function of E6-AP was defective

181 Familial-linked mutations disrupt the ubiquitin-protein ligase function of Parkin and impair P

182 Here, we report that PINK1 regulates the E3 ubiquitin-protein ligase function of parkin through dire

183 n induces apoptosis in part by disabling the ubiquitin-protein ligase function of XIAP and by stabili

184 correlate the E6-AP coactivator function and ubiquitin-protein ligase functions with the AS phenotype

185 KAI1, and report an interaction with the E3 ubiquitin-protein ligase gp78, a regulator of KAI1 degra

186 cells that express mutant ataxin-1 but not a ubiquitin-protein ligase have significantly fewer NIs.

187 e (NEDD4), HECT and RLD domain-containing E3 ubiquitin protein ligase (HERC), and "other." Most previ

188 DSmurf encodes a HECT domain ubiquitin-protein ligase, homologous to vertebrate Smurf

189 tally down-regulated 4 (Nedd4) was the first ubiquitin protein ligase identified to interact with con

190 sine kinase family as substrates of the E6AP ubiquitin-protein ligase implicates a role for the ubiqu

191 The cellular protein E6AP functions as an E3 ubiquitin protein ligase in the E6-dependent ubiquitinat

192 e c-IAPs represent a pair of TNFR-associated ubiquitin protein ligases in which one regulates the exp

193 Three peroxisome-associated ubiquitin-protein ligases in the Really Interesting New

194 /hHYD, encoding a progestin induced putative ubiquitin-protein ligase) in mammary ductal carcinoma.

195 Certain ubiquitin protein ligases, including the SCF complex and

196 fication of cellular targets for E6AP, an E3 ubiquitin protein ligase involved in ubquitin-mediated d

197 of RTF1 is lethal in the absence of Rkr1, a ubiquitin-protein ligase involved in the destruction of

198 d protein that binds to Nedd4 protein, an E3 ubiquitin-protein ligase involved in ubiquitin-dependent

199 Cbl-b, a ring-type E3 ubiquitin protein ligase, is implicated in setting the t

200 des a member of the cullin family subunit of ubiquitin-protein ligases, is expressed at abnormally hi

201 In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing co

202 with and is ubiquitylated on K1413 by the E3 ubiquitin-protein ligase Itchy homolog (Itch), a Nedd4 f

203 A key step in this process is catalyzed by a ubiquitin-protein ligase known as the anaphase-promoting

204 dentified a novel missense variant in the E3 ubiquitin-protein ligase LRSAM1 (p.Cys694Tyr).

205 utation in the gene encoding the putative E3 ubiquitin-protein ligase Mahogunin causes spongiform neu

206 lin-3, a small molecule antagonist of the E3 ubiquitin protein ligase MDM2, inhibited angiogenesis in

207 he 3'UTR of two oncoproteins: BRAF and an E3 ubiquitin protein ligase, MDM2.

208 ial transport through phosphorylation of the ubiquitin protein ligase Nedd4-2 (neuronal precursor cel

209 enhanced channel surface expression and the ubiquitin-protein ligase Nedd4-2 has emerged as a centra

210 Here, we investigated the role of ubiquitin-protein ligase NEDD4-2, which negatively regul

211 family comprises three subfamilies: NEDD4 E3 ubiquitin protein ligase (NEDD4), HECT and RLD domain-co

212 NEDD4-1 E3 ubiquitin protein ligase (NEDD4-1) and WW domain-contain

213 ing a significant upregulation of another E3 ubiquitin-protein ligase, NEDD4L, and of TNFRSF21, a key

214 on, ii) beta-transducin repeat containing E3 ubiquitin protein ligase nuclear accumulation, and iii)

215 Rsp5 is an E3 ubiquitin-protein ligase of Saccharomyces cerevisiae tha

216 s reflect the properties of enzymes known as ubiquitin-protein ligases or E3s.

217 Ubiquitin-protein ligases (or E3s) are the components of

218 proteins is directed by diverse families of ubiquitin-protein ligases (or E3s) in plants.

219 ination of various intracellular proteins by ubiquitin-protein ligases (or E3s) plays an essential ro

220 ity of ubiquitination is often controlled by ubiquitin-protein ligases (or E3s), which facilitate the

221 itination is directed by diverse families of ubiquitin-protein ligases (or E3s).

222 Mutations in the ubiquitin-protein ligase Parkin are associated with auto

223 owed that the genetic invalidation of the E3 ubiquitin-protein ligase parkin PD gene leads to exagger

224 The Parkinson's disease-associated ubiquitin-protein ligase, Parkin, is important in the el

225 The E3 ubiquitin-protein ligases play an important role in cont

226 TRAF6, an E3 ubiquitin protein ligase, plays a critical role in T cel

227 We have identified that Cdh1/APC, a critical ubiquitin protein ligase, plays an important role in reg

228 Here we report that Cbl, a RING-type E3 ubiquitin-protein ligase, promotes ubiquitination of TCR

229 he exact feature of misfolding that each PQC ubiquitin-protein ligase recognizes in their substrates

230 ting complex/cyclosome (APC/C), an essential ubiquitin protein ligase, regulates mitotic progression

231 TIR1 is part of a ubiquitin protein ligase required for degradation of Aux

232 expression of the maternally inherited Ube3A ubiquitin protein ligase, required for the proteasomal d

233 ally localized serine/threonine kinase and a ubiquitin-protein ligase, respectively, result in recess

234 The subsequent recruitment of E3 ubiquitin-protein ligase RING finger protein 4 resulted

235 ge checkpoint protein 1 (phospho-MDC1) or E3 ubiquitin-protein ligase ring finger protein 8 (RNF8), t

236 d at recombination junctions derived from E3 ubiquitin-protein ligase RNF168-deficient, Fanconi anemi

237 s include the yAP180 proteins, clathrin, the ubiquitin-protein ligase Rsp5p, End3p, and synaptojanin.

238 nism, in which APP acts as a modulator of E3 ubiquitin-protein ligase(s), shared by distinct neuronal

239 revious studies of the budding yeast nuclear ubiquitin-protein ligase San1 indicated that it recogniz

240 uclear PQC degradation mediated by the yeast ubiquitin-protein ligase San1 often involves Ssa1/Ssa2,

241 Because AtCUL1 is a component of the ubiquitin protein ligase SCF(TIR1), a complex that also

242 ptional repressors through the action of the ubiquitin protein ligase SCF(TIR1).

243 response proteins through the action of the ubiquitin protein ligase SCF(TIR1).

244 Two different ubiquitin protein ligases, SCF(SKP2) and the RING protei

245 er, in females doubly mutant for bam and the ubiquitin protein ligase Smurf, the number of germ cells

246 responsiveness via up-regulation of SKI, E3 ubiquitin-protein ligase SMURF2, and SMAD7 (mothers agai

247 proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 ter

248 REM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which

249 Cullin-RING ubiquitin-protein ligases such as the Skp1, cullin, F-bo

250 The APC/C ubiquitin-protein ligase targets proteins by appending p

251 i's sarcoma-associated herpesvirus encodes a ubiquitin-protein ligase termed K3, which functions as a

252 ese domains bind Rhp18/Rad18, which is an E3 ubiquitin protein ligase that has crucial functions in p

253 Pellino 3b is the RING-like motif ubiquitin protein ligase that promotes the Lys-63-linked

254 This complex functions as a ubiquitin protein ligase that targets members of the aux

255 re the largest and best studied family of E3 ubiquitin protein ligases that facilitate the ubiquityla

256 The E6-AP gene (UBE3A) encodes an E3 ubiquitin-protein ligase that binds the human papillomav

257 se-promoting complex (APC) is a multisubunit ubiquitin-protein ligase that catalyzes the polyubiquiti

258 moting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiqu

259 Triad3A is an E3 ubiquitin-protein ligase that interacts with the Toll/in

260 arboxyl terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti

261 ble, and their degradation is triggered by a ubiquitin-protein ligase that is regulated by modificati

262 n is likely a recognition element for the E3 ubiquitin-protein ligase that modifies Gal4.

263 d additional cellular proteins to form an E3 ubiquitin-protein ligase that polyubiquitinates p53 and

264 +) absorption is regulated by Nedd4-2, an E3 ubiquitin-protein ligase that reduces expression of the

265 by disrupting its binding to Nedd4-2, an E3 ubiquitin-protein ligase that targets ENaC for degradati

266 by inhibiting the function of Nedd4-2, an E3 ubiquitin-protein ligase that targets ENaC for degradati

267 findings suggest that Staring is a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for deg

268 SGK phosphorylates Nedd4-2, an E3 ubiquitin-protein ligase that targets the epithelial Na+

269 complex (APC) or cyclosome is a multisubunit ubiquitin-protein ligase that ubiquitinates and thereby

270 Rsp5 is the sole yeast ubiquitin-protein ligase that ubiquitylates RNA pol II L

271 It is defined by San1p, a ubiquitin-protein ligase that, in conjunction with the u

272 degradation typically proceeds via multiple ubiquitin-protein ligases that act throughout the cell t

273 Two E3 ubiquitin-protein ligases that recognize the encephalomy

274 e chaperones that aid in protein folding and ubiquitin-protein ligases that ubiquitinate misfolded pr

275 As part of a ubiquitin-protein ligase, these viral proteins stimulate

276 C proteins can also interact with certain E3 ubiquitin protein ligases, they may provide a link betwe

277 sults suggest that Parkin functions as an E3 ubiquitin-protein ligase through its ring domains and th

278 Although p19Arf binds to the Mdm2 E3 ubiquitin protein ligase to activate p53, neither of the

279 ) family proteins themselves can function as ubiquitin protein ligases to ubiquitinate their target p

280 These results suggest that Triad3A is an E3 ubiquitin-protein ligase to RIP1 and that Hsp90 and Tria

281 s indicate that Siah proteins function as E3 ubiquitin-protein ligases to regulate the ubiquitination

282 somerase I-binding, arginine/serine-rich, E3 ubiquitin protein ligase (Toporsa); and POU class 6 home

283 s a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to bal

284 FOXM1 prevented the E3 ubiquitin-protein ligase transcriptional intermediary fa

285 The E3 ubiquitin-protein ligase TRIM21, of the RING-containing

286 with LPS increased the expression of the E3 ubiquitin-protein ligase tripartite motif -: containing

287 Loss of the E3 ubiquitin-protein ligase UBE3A causes Angelman syndrome.

288 st one other gene, the E6-associated protein ubiquitin-protein ligase (UBE3A) gene, has been implicat

289 Although the gene for E6-AP ubiquitin-protein ligase (UBE3A) was mapped to the criti

290 n mutations of E6-associated-protein (E6-AP) ubiquitin-protein ligase (UBE3A).

291 Both Rad23 and Cdc48 bind a ubiquitin protein ligase ubiquitin fusion degradation-2

292 Two multiprotein E3 (ubiquitin-protein ligase) ubiquitin ligases, the SCF (Sk

293 protein degradation via interaction with the ubiquitin-protein ligase Ubr1 and in DNA repair via inte

294 identified a family of seven HECT-containing ubiquitin-protein ligases (UPL1-UPL7) in Arabidopsis tha

295 city of the pathway is determined by E3s (or ubiquitin-protein ligases, UPLs), little is known about

296 two-hybrid screen, mouse Nedd4 (mNedd4-1), a ubiquitin protein ligase, was previously isolated as an

297 utations in the parkin gene, which encodes a ubiquitin-protein ligase, were found to underlie a famil

298 Cbl proteins are ubiquitin protein ligases, which ubiquitinate activated

299 is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a varie

300 d/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulate