ライフサイエンスコーパス: ubiquitinated protein

1 ic number of ATPs is consumed in degrading a ubiquitinated protein.

2 mpairment and an accumulation of nondegraded ubiquitinated protein.

3 ion, KO of ubqln also caused accumulation of ubiquitinated proteins.

4 ability to bind, deubiquitinate, and degrade ubiquitinated proteins.

5 ed p62-independent autophagic degradation of ubiquitinated proteins.

6 autophagic substrates such as p62, LC3II and ubiquitinated proteins.

7 me is a large protease complex that degrades ubiquitinated proteins.

8 n family, which regulates the degradation of ubiquitinated proteins.

9 ased Bax by 140% (P<0.05) and also increased ubiquitinated proteins.

10 tions can affect proteasome interaction with ubiquitinated proteins.

11 perone proteins, proteasomal components, and ubiquitinated proteins.

12 100 nM) and causes accumulation of cellular ubiquitinated proteins.

13 nhibitor AUY922 promoted the accumulation of ubiquitinated proteins.

14 ning paralleled by accumulation of insoluble ubiquitinated proteins.

15 ivity upon interacting with ubiquitin and/or ubiquitinated proteins.

16 criteria necessary for the interpretation of ubiquitinated proteins.

17 damage sites in part through recognition of ubiquitinated proteins.

18 ivity, but significant affinity for cellular ubiquitinated proteins.

19 hat WRNIP1 plays a role in the metabolism of ubiquitinated proteins.

20 stability, function, and/or localization of ubiquitinated proteins.

21 nd occurrence of inclusion bodies containing ubiquitinated proteins.

22 disease, exhibit inclusion bodies containing ubiquitinated proteins.

23 a marked decrease in association of VCP with ubiquitinated proteins.

24 th dynein and induces marked accumulation of ubiquitinated proteins.

25 -mediated degradation and an accumulation of ubiquitinated proteins.

26 lexes that selectively degrade intracellular ubiquitinated proteins.

27 ding of RHBDL4 to p97/VCP and Lys(63)-linked ubiquitinated proteins.

28 ysis and enhance proteasomal specificity for ubiquitinated proteins.

29 basal ATP consumption and degradation of non-ubiquitinated proteins.

30 led to exert protection or blunt the rise in ubiquitinated proteins.

31 ransport (ESCRT) [10-12], small GTPases, and ubiquitinated proteins.

32 target oligomers assembled from N-terminally ubiquitinated proteins.

33 of high molecular weight TDP-43 species and ubiquitinated proteins.

34 , accompanied by an increase of oxidized and ubiquitinated proteins.

35 western blotting quantities of endogenously ubiquitinated proteins.

36 mployed unanchored ubiquitin chains and mono-ubiquitinated proteins.

37 ondrial impairment led to down-regulation of ubiquitinated-proteins, 26S proteasome disassembly, and

38 fication and quantification of more than 400 ubiquitinated proteins, a fraction of which were found t

39 Finally, ubiquitinated proteins accumulate in cilia of mammalian

40 Our data indicate that ubiquitinated proteins accumulate in DvSnf7 dsRNA-fed la

41 Significantly, ubiquitinated proteins accumulate in the TDP-43-depleted

42 n Clcc1-deficient granule cells in vivo, and ubiquitinated proteins accumulate in these neurons befor

43 the nervous system, pathologic aggregates of ubiquitinated proteins accumulate only in specific neuro

44 heat-shock or arsenite treatment, when poly-ubiquitinated proteins accumulate.

45 including potentially toxic aggregate-prone ubiquitinated proteins, accumulate in Pompe myofibers an

46 that they exhibit reduced ability to degrade ubiquitinated proteins, accumulate short-lived GFPu, and

47 Fewer ubiquitinated proteins accumulated in the swoF1 mutant c

48 lysis degradation pathway genes resulting in ubiquitinated protein accumulation in muscle.

49 over, the overexpression of PARK2 diminished ubiquitinated proteins accumulation, improves its target

50 A proteomics strategy was used to identify ubiquitinated proteins after preconditioning ischemia.

51 Ubiquitinated proteins aggregate upon proteasome failure

52 ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skel

53 uction in AlaRS editing efficacy resulted in ubiquitinated protein aggregates and mitochondrial defec

54 autophagy defects including accumulation of ubiquitinated protein aggregates and p62/SQSTM1, deficie

55 n and proteolytic sequestration of insoluble ubiquitinated protein aggregates associated with p62 and

56 eriments revealed accumulations of insoluble ubiquitinated protein aggregates associated with the ada

57 teasome, reduces both the size and number of ubiquitinated protein aggregates in aged flies, and incr

58 t pressure overload promotes accumulation of ubiquitinated protein aggregates in the left ventricle,

59 sis in cerebellum as well as accumulation of ubiquitinated protein aggregates without any deficiency

60 changes, including gliosis, accumulation of ubiquitinated protein aggregates, lipofuscinosis, and en

61 Ubiquitinated protein aggregates, of which TDP-43 is a m

62 -weight alpha-synuclein, and the presence of ubiquitinated protein aggregates, recapitulating many of

63 R stress sensitivity and the accumulation of ubiquitinated protein aggregates, whose efficient degrad

64 rk, and Dark was observed to colocalize with ubiquitinated protein aggregates.

65 autophagosomal protein LC3 and clearance of ubiquitinated protein aggregates.

66 ssion level is closely linked to the rate of ubiquitinated protein aggregation, which are themselves

67 The absence of ubiquitinated proteins also argues against a model in wh

68 efoldin increased the level of SDS-insoluble ubiquitinated protein and reduced cell viability in lact

69 Here we report that MTA1 is an ubiquitinated protein and targeted by the RING-finger E3

70 Elevated levels of total ubiquitinated proteins and 19S and 20S proteasome subuni

71 hHR23A binds ubiquitinated proteins and acts as a shuttling factor to

72 nto a large centrosomal aggregate containing ubiquitinated proteins and alpha-synuclein.

73 The presence of increased ubiquitinated proteins and amyloid oligomers in failing

74 roteins and reduced the accumulation of both ubiquitinated proteins and APP/p-Tau proteins.

75 CHIP-S20E knock-in mice better clear ubiquitinated proteins and are cardio-protected.

76 120G) overexpression-induced accumulation of ubiquitinated proteins and cellular injury.

77 ved from L110R MM-1alpha mice, the levels of ubiquitinated proteins and cytotoxicity were higher in L

78 ration was accompanied by an accumulation of ubiquitinated proteins and decreased xeroderma pigmentos

79 resistant parasites exhibit lower levels of ubiquitinated proteins and delayed onset of cell death,

80 Firstly, we observed a reduction in ubiquitinated proteins and E1 activity.

81 receptor hRpn13, triggering accumulation of ubiquitinated proteins and endoplasmic reticulum stress-

82 correlate with an increased accumulation of ubiquitinated proteins and expression of CIN85/RukL in p

83 Our data suggest that recruitment of both ubiquitinated proteins and LC3-II by p62 directs ubiquit

84 es the selectivity of the 26S proteasome for ubiquitinated proteins and links their deubiquitination

85 ssue proteasome activity and accumulation of ubiquitinated proteins and natural proteasome substrates

86 ormal accumulations of amyloid-beta peptide, ubiquitinated proteins and other autophagic substrates w

87 and the 26S proteasomes' capacity to degrade ubiquitinated proteins and peptides.

88 f desmin filaments caused an accumulation of ubiquitinated proteins and rapid destruction of myofibri

89 easomal deubiquitinating enzyme that cleaves ubiquitinated proteins and releases ubiquitin chains.

90 tion was associated with the accumulation of ubiquitinated proteins and reversible opacification of t

91 nd SW480 cell lines leads to accumulation of ubiquitinated proteins and several proteasome target pro

92 which resulted in ER stress, accumulation of ubiquitinated proteins and subsequent ER dilation, contr

93 hows that IBMPFD mutant expression increases ubiquitinated proteins and susceptibility to proteasome

94 d histone deacetylase 6 recognize aggregated ubiquitinated proteins and target them for autophagy in

95 We show that RNF114 associates with ubiquitinated proteins and that it is a soluble cytosoli

96 tylase 6, which serves as an adaptor between ubiquitinated proteins and the dynein motor.

97 ytic activity of the 20S proteasome, because ubiquitinated proteins and the peptidase activities of 2

98 ccumulated abnormally, and co-localized with ubiquitinated proteins and the prelysosomal markers HRS

99 ncer cells, resulting in the accumulation of ubiquitinated proteins and the proteasome target protein

100 overexpression determines an accumulation of ubiquitinated proteins and this event requires the N-ter

101 sitive) cells results in the accumulation of ubiquitinated proteins and three natural proteasome subs

102 and in vivo by WA results in accumulation of ubiquitinated proteins and three proteasome target prote

103 c stress conditions allows cells to react to ubiquitinated proteins and to assemble nuclear, liquid c

104 R23B, were found to bind specifically to K48-ubiquitinated proteins and to stimulate proteasome bindi

105 n-binding domains, thereby bringing together ubiquitinated proteins and ubiquitin receptors to execut

106 y of brain 26S proteasomes, higher levels of ubiquitinated proteins and undegraded Ub-G76V-GFP.

107 Herp is in a complex with ubiquitinated proteins and with the 26S proteasome, sugg

108 DsRed marker protein, (2) a higher level of ubiquitinated proteins, and (3) coordinated induced expr

109 ance of glycoconjugates, alpha-synuclein and ubiquitinated proteins, and abrogation of inflammatory r

110 1 aggregates contained inactive proteasomes, ubiquitinated proteins, and autophagosomes.

111 e main non-lysosomal degradative pathway for ubiquitinated proteins, and autophagy, a lysosome-mediat

112 ia increased their connectivity, accumulated ubiquitinated proteins, and decreased their respiration.

113 gulation of iron metabolism, accumulation of ubiquitinated proteins, and incorporation of elements of

114 (DUBs) proteolytically cleave ubiquitin from ubiquitinated proteins, and inhibition of DUBs that resc

115 The 26S proteasome degrades ubiquitinated proteins, and proteasomal degradation cont

116 of cullins and noncullin proteins, increased ubiquitinated proteins, and stabilized a surrogate subst

117 ulated reactive oxygen species (ROS) damage, ubiquitinated proteins, and the multi-functional adapter

118 oteins, including amyloid-beta (Abeta), tau, ubiquitinated-proteins, apolipoprotein E, and alpha-synu

119 Enrichment analysis demonstrated that 35% of ubiquitinated proteins are cell-cycle regulated.

120 Ubiquitinated proteins are degraded by the 26 S proteaso

121 Ubiquitinated proteins are degraded by the proteasome, a

122 udies have shown that unfolded and misfolded ubiquitinated proteins are degraded not only by proteaso

123 Therefore, we investigated why K63-ubiquitinated proteins are not degraded by proteasomes.

124 Intrasarcoplasmic amyloidosis and increased ubiquitinated proteins are observed in human failing hea

125 Most poly-ubiquitinated proteins are recognized and degraded by th

126 Ubiquitinated proteins are sorted into distinct pathways

127 otein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and c

128 Large-scale analyses of ubiquitinated proteins are usually performed by combinin

129 Using ubiquitinated proteins as affinity ligands, we found tha

130 activity, which preceded the accumulation of ubiquitinated proteins as detergent/salt-insoluble aggre

131 s, a scaffold protein that co-localizes with ubiquitinated protein at the 30 days post irradiation ti

132 ation and aggregation of alpha-synuclein and ubiquitinated proteins at 20 months of age.

133 ydr049 mutant cells accumulate Cdc48p-bound ubiquitinated proteins at the ER membrane.

134 Degradation of ubiquitinated proteins by 26 S proteasomes requires ATP

135 The degradation of ubiquitinated proteins by 26 S proteasomes requires ATP

136 proteasome activities and cellular levels of ubiquitinated proteins by activating protein kinase G (P

137 disorders associated with the aggregation of ubiquitinated proteins by impairing 26 S proteasome acti

138 the FIP200 CTR slows the phase separation of ubiquitinated proteins by p62 in a reconstituted system.

139 compared the turnover dynamics of endogenous ubiquitinated proteins by proteasomes and autophagy by a

140 has the capacity to delay the degradation of ubiquitinated proteins by the proteasome.

141 48 (K48) of ubiquitin mediate recognition of ubiquitinated proteins by the proteasome.

142 deubiquitination and allows for selection of ubiquitinated proteins capable of being unfolded and eff

143 We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and pr

144 normal storage of carbohydrates, lipids, and ubiquitinated proteins, combined with marked accumulatio

145 We observed that high molecular weight ubiquitinated proteins constitutively coimmunoprecipitat

146 ion is accompanied by a decrease of the poly-ubiquitinated protein content and co-immunoprecipitates

147 HDAC6 mutants, we show that HDAC6 binding to ubiquitinated proteins controls the duration of HSF1 act

148 revealed that this protein is essential for ubiquitinated protein degradation and for parasite survi

149 However, the regulation of ubiquitinated protein degradation in healthy, nonatrophy

150 tinated proteins in the knock-out cells, but ubiquitinated protein degradation was decreased during s

151 ome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recyc

152 a role for autophagy in clearance of diffuse ubiquitinated proteins delivered by p62/SQSTM1.

153 rison with normal tissues by accumulation of ubiquitinated proteins despite elevated proteasome level

154 Excess p62 inhibits the clearance of ubiquitinated proteins destined for proteasomal degradat

155 ing in accumulation of oxidative lesions and ubiquitinated proteins during heat stress in CWD clams.

156 Usp14 are much more active in degrading non-ubiquitinated proteins (e.g. Sic1) than WT particles.

157 on-gamma: (1) that immunoproteasomes degrade ubiquitinated proteins faster than the constitutive prot

158 tein catabolism could induce accumulation of ubiquitinated proteins followed by significant cell stre

159 nizing the Lys--Gly-Gly (diGly) remnant from ubiquitinated proteins following trypsinolysis have prov

160 an autophagy receptor involved in targeting ubiquitinated proteins for degradation.

161 plex is evolutionarily conserved and targets ubiquitinated proteins for degradation.

162 Our results suggest that ubiquitinated protein formation may be abnormal in both

163 A protocol to enrich K6-ubiquitinated proteins from cells identifies HUWE1 as a

164 entify 374 diglycine-modified lysines on 236 ubiquitinated proteins from HEK293 cells, including 80 p

165 acilitates the extraction and degradation of ubiquitinated proteins from larger structures.

166 which suggests a role for p97 in extracting ubiquitinated proteins from myofibrils.

167 p97/VCP aids in the extraction of ubiquitinated proteins from the endoplasmic reticulum (E

168 ubstrates, likely by facilitating release of ubiquitinated proteins from the OMM.

169 ged by the heterogeneity and sheer number of ubiquitinated proteins (>5,000).

170 tion of the proteasome's capacity to degrade ubiquitinated proteins has received little attention, al

171 Ubiquitin and ubiquitinated proteins have been shown to activate ExoU,

172 wn role in mediating the degradation of poly-ubiquitinated proteins, HDAC6 selectively interacted wit

173 Accumulation of ubiquitinated protein in spheroids was evident in some b

174 f TUNEL staining and lack of accumulation of ubiquitinated protein in vacuoles of motor and sensory n

175 ation scheme for the isolation of a specific ubiquitinated protein in which affinity moieties are fus

176 tophagy, an accumulation of p62/SQSTM-1, and ubiquitinated proteins in autophagosomes.

177 gradation through suppressing neddylation of ubiquitinated proteins in cardiomyocytes.

178 When degradation of ubiquitinated proteins in cells was inhibited, levels of

179 tetraubiquitin chains in vitro and binds to ubiquitinated proteins in cellular lysates.

180 evalence of receptors such as agglutinin and ubiquitinated proteins in ciliary ectosomes suggests tha

181 ce and promoted the degradation of insoluble ubiquitinated proteins in CryAB(R120G) cardiomyocytes bu

182 tergent-resistant CryAB oligomers, and total ubiquitinated proteins in CryAB(R120G) TG hearts.

183 strate accumulation of P56S VAPB protein and ubiquitinated proteins in cytoplasmic inclusions, select

184 oteasome inhibition and accumulation of poly-ubiquitinated proteins in diffuse large B-cell lymphoma

185 esistant' schizophrenia had higher levels of ubiquitinated proteins in erythrocytes compared to those

186 Furthermore, a proteomics screen comparing ubiquitinated proteins in hearts from Parkin(-/-) and Pa

187 enlargement, and cytoplasmic accumulation of ubiquitinated proteins in HeLa cells and wild-type mouse

188 veloped an approach for the visualization of ubiquitinated proteins in living cells designated ubiqui

189 with this view, NAC abolished an increase in ubiquitinated proteins in MG132-treated astrocytes.

190 f mutant desmin overexpression to accumulate ubiquitinated proteins in NRVMs.

191 utophagy inhibition (96 h) failed to elevate ubiquitinated proteins in rat cortical neurons, although

192 G treatment resulted in hyperaccumulation of ubiquitinated proteins in S. pombe cells.

193 formation of p62/SQTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-

194 The accumulation of ubiquitinated proteins in the autophagolysosome provides

195 ere we show that tau increased the levels of ubiquitinated proteins in the brain and triggered activa

196 e been described as transient aggregation of ubiquitinated proteins in the cytosol.

197 ditions there was no effect on the levels of ubiquitinated proteins in the knock-out cells, but ubiqu

198 e and protein level approaches to enrich for ubiquitinated proteins in the presence and absence of HR

199 om HCT116 cells to cause increased levels of ubiquitinated proteins in whole-cell extract and at prot

200 profiling both the entire yeast proteome and ubiquitinated proteins in wild-type and ubiquitin K11R m

201 e observed the corresponding accumulation of ubiquitinated-proteins in NSCLC cell lines and tissues a

202 uitinated proteins and LC3-II by p62 directs ubiquitinated proteins, including I-kappaBalpha, to the

203 abnormal ubiquitination and accumulation of ubiquitinated proteins, including TDP-43 and a SCF(Cycli

204 P-43) accumulation is the major component of ubiquitinated protein inclusions found in patients with

205 The well described accumulation of ubiquitinated protein inclusions in neurodegenerative di

206 in 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tiss

207 hibition, the cellular content of K48-linked ubiquitinated proteins increased without any change in p

208 ytes exhibit higher than wild-type levels of ubiquitinated proteins, increased levels of protein oxid

209 rtezomib and SP1017 augments accumulation of ubiquitinated proteins, increases markers of proteotoxic

210 monstrate reduced levels of proteasome-bound ubiquitinated proteins, indicating that the loss of hRpn

211 es growth retardation and an accumulation of ubiquitinated proteins, indicative of a cellular stress

212 However, the endosomal accumulation of ubiquitinated proteins induced by dysfunctional ESCRT-II

213 t that this early and persistent increase in ubiquitinated proteins induced by IBMPFD mutations in p9

214 penetrates cells, it causes accumulation of ubiquitinated proteins, inhibits human 20S proteasomes,

215 other potentially neighboring proteins, and ubiquitinated proteins into centrosomal aggregates.

216 duces neuronal death and the accumulation of ubiquitinated proteins into distinct aggregates.

217 respect to endosomal movement and sorting of ubiquitinated proteins into lysosomes, its function in m

218 he defect resides apparently in the entry of ubiquitinated proteins into the 20S proteasome.

219 or K63-ubiquitin chains determine whether a ubiquitinated protein is targeted for proteasomal degrad

220 ubiquitin, indicating that incorporation of ubiquitinated proteins is a later event in the disease p

221 ng a clearer understanding of how sorting of ubiquitinated proteins is achieved.

222 re that the proteasome's capacity to degrade ubiquitinated proteins is also tightly regulated.

223 of trafficking machinery components to bind ubiquitinated proteins is known to have a function in ca

224 requency, demonstrating that accumulation of ubiquitinated proteins is not required.

225 Here, using shotgun proteomics, we map the ubiquitinated protein landscape during embryonic stem ce

226 atment with a proteasome inhibitor increases ubiquitinated protein levels and shortens the life span

227 The proteasome inhibitor epoxomicin raised ubiquitinated protein levels at least 3-fold higher than

228 Ubiquitinated protein levels were elevated in postmortem

229 ed production of reactive oxygen species and ubiquitinated protein levels, while the de-ubiquitinatio

230 ride, and 3-methyladenine failed to increase ubiquitinated protein levels.

231 we investigated the proteasome function and ubiquitinated protein levels.

232 ecreased proteasome activities and increased ubiquitinated protein levels.

233 overexpression had no impact on steady-state ubiquitinated protein levels.

234 Furthermore, many ubiquitinated proteins localize to the cytoskeleton and

235 protein inclusions and high-molecular-weight ubiquitinated proteins, markers of UPS dysfunction.

236 HC class I presentation, they do not degrade ubiquitinated proteins more efficiently than constitutiv

237 ions in Drosophila caused an accumulation of ubiquitinated proteins, neurodegeneration, larval-crawli

238 This accumulation of ubiquitinated proteins occurs primarily in the cell nucl

239 berrant membrane structures, accumulation of ubiquitinated proteins on membranes, and axon degenerati

240 If so, one would expect to find ubiquitinated proteins on vacuolar membranes.

241 e we describe UbiCRest, in which substrates (ubiquitinated proteins or polyubiquitin chains) are trea

242 tin to substrates, recognizing or processing ubiquitinated proteins, or constituting or regulating th

243 rected to the LDs via SQSTM1, which bound to ubiquitinated proteins, possibly including perilipin 1,

244 mplex components and have elevated levels of ubiquitinated proteins prior to manifestation of cardiom

245 Ubiquitin remnant profiling of the multi-ubiquitinated proteins proliferating cell nuclear antige

246 V), mutant profilin1 aggregation, abnormally ubiquitinated proteins, reduced choline acetyltransferas

247 inant protein species in the inclusions, and ubiquitinated proteins represent only a minor component;

248 e, suggesting that the increase in levels of ubiquitinated proteins resulting from avicin G treatment

249 s with CB-5083 leads to accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticul

250 nated substrate protein(s) possibly allowing ubiquitinated protein(s) to be degraded by the proteosom

251 with tau and were less active in hydrolyzing ubiquitinated proteins, small peptides and ATP.

252 control cells and treated with PKA degraded ubiquitinated proteins, small peptides, and ATP more rap

253 lation of both early endosome processing and ubiquitinated protein sorting.

254 Although the identity of the ubiquitinated protein specific to either disorder was un

255 ry, including Ub(G76V)-GFP, a representative ubiquitinated protein substrate that is accumulated in t

256 Through their multiple contacts with ubiquitinated protein substrates involved in these pathw

257 re to activate it and confer specificity for ubiquitinated protein substrates.

258 There was no overall increase in ubiquitinated proteins, suggesting the ubiquitin-proteas

259 e that is responsible for the degradation of ubiquitinated protein targets in all eukaryotic cells.

260 l signature of cytoplasmic inclusions of the ubiquitinated protein TDP-43.

261 F1;ssfA1 mutant accumulated higher levels of ubiquitinated proteins than wild-type.

262 or expanded ataxin-3 binds a broad range of ubiquitinated proteins that accumulate when the proteaso

263 Tom1 transports endosomal ubiquitinated proteins that are targeted for degradation

264 ss, which is characterized by the buildup of ubiquitinated proteins that cannot be degraded properly.

265 oquine (CQ) led to a massive accumulation of ubiquitinated proteins that correlated with increased ce

266 one resulted in an accumulation of puncta of ubiquitinated proteins that was further enhanced by the

267 Additionally, ubiquitinated proteins that were detected in proteasomes

268 he Rad23 family of proteins is known to bind ubiquitinated proteins through its two ubiquitin-associa

269 gnificant efforts have been made to identify ubiquitinated proteins through proteomics studies, but t

270 nactive ataxin-3 (normal or expanded) causes ubiquitinated proteins to accumulate in cells, even in t

271 adaptor protein p62, which normally targets ubiquitinated proteins to autophagosomes.

272 potentially allowing for the recruitment of ubiquitinated proteins to Cdc48.

273 Moreover, adding ubiquitinated proteins to cell extracts stimulated prote

274 a new strategy for the chemical synthesis of ubiquitinated proteins to generate a set of well-defined

275 quitin-like domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation.

276 id assay, we analyzed the initial binding of ubiquitinated proteins to purified 26S particles as an i

277 al protein and a signaling hub that shuttles ubiquitinated proteins to the lysosome during autophagy.

278 te ubiquitin recognition and the delivery of ubiquitinated proteins to the proteasome by autoinhibiti

279 a variety of cellular processes by targeting ubiquitinated proteins to the proteasome for degradation

280 The delivery of ubiquitinated proteins to the proteasome for degradation

281 e the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation

282 ains, and may participate in the delivery of ubiquitinated proteins to the proteasome through docking

283 face affects the ability of Rad23 to deliver ubiquitinated proteins to the proteasome.

284 ned Hspa1B (heat shock protein 1B hsp70) and ubiquitinated proteins, trapped other cytoskeletal prote

285 tant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-

286 tic inhibition of autophagy fails to elevate ubiquitinated proteins unless the proteasome is affected

287 th their associated components, also contain ubiquitinated proteins, vimentin, heat-shock protein 72,

288 Furthermore, VCP association with ubiquitinated proteins was demonstrated in vector-transf

289 The binding site for these ubiquitinated proteins was mapped to the UBA domain of C

290 In wild-type mice, an elevated level of ubiquitinated proteins was observed during muscle reload

291 in both ventilated groups, and the amount of ubiquitinated proteins was significantly and similarly e

292 actories that were regularly associated with ubiquitinated proteins, we conclude that reovirus factor

293 The increased levels of ubiquitinated protein were accompanied by increased leve

294 However, increased levels of ubiquitinated proteins were found associated with shuttl

295 Furthermore, levels of ubiquitinated proteins were higher in endosomal/lysosoma

296 Furthermore accumulating ubiquitinated proteins were observed primarily in insolu

297 y WT proteasomes is activated if they bind a ubiquitinated protein, which is loosely folded.

298 sulted in the dual accumulation of viral and ubiquitinated proteins, which led to enhanced ER stress,

299 The digestion of ubiquitinated proteins with trypsin yields a glycine-gly

300 reduced PSMD12 levels and an accumulation of ubiquitinated proteins without any impairment of proteas