ライフサイエンスコーパス: ubiquitination

1 below our detection limit (e.g. acetylation, ubiquitination).

2 regulated by C-terminal phosphorylation and ubiquitination.

3 of IQGAP1 (termed IQGAP1 GRD-2K) reduces its ubiquitination.

4 al and chromatin regulators and mediators of ubiquitination.

5 ein degradation mechanism by promoting their ubiquitination.

6 plant's response to ABA and is regulated by ubiquitination.

7 ed prior to and independent of HRD-dependent ubiquitination.

8 include enzymes involved in acetylation and ubiquitination.

9 and relevant cochaperones, for Ubr1-mediated ubiquitination.

10 ociated athanogene 1-M completely abolishing ubiquitination.

11 DNA binding domain of Zta in regulating Zta ubiquitination.

12 E3 domain, likely interfering with substrate ubiquitination.

13 l modifications, such as phosphorylation and ubiquitination.

14 RING domain and SIMs to facilitate substrate ubiquitination.

15 protein modification most closely related to ubiquitination.

16 S-associated LZTR1 mutations diminish CHMP1B ubiquitination.

17 including phosphorylation, SUMOylation, and ubiquitination.

18 through stabilization of VHL via K63-linked ubiquitination.

19 ification and deubiquitinases of this unique ubiquitination.

20 itination and diminished by a block of their ubiquitination.

21 ling pathway involves Nedd4-2-mediated Wnt3a ubiquitination.

22 th VASP and antagonizes TRIM9-dependent VASP ubiquitination.

23 e expression, RNA deadenylation, and protein ubiquitination.

24 Specifically, TRIM21-mediated p62 ubiquitination abrogates p62 oligomerization and sequest

25 h RNA polymerase II(2), the mechanism of H2B ubiquitination across genic nucleosomes remains unclear.

26 go ubiquitination, yet the mechanism whereby ubiquitination activates the adaptors and how this proce

27 We demonstrate that CERBERUS has auto-ubiquitination activity in vitro and is localized within

28 o promote AdV infection was dependent on its ubiquitination activity, suggesting that MIB1 may mediat

29 ons that induce a more extended shape reduce ubiquitination activity.

30 including phosphorylation, S-acylation, and ubiquitination, affect the stability, localization, and

31 Upon genotoxic stress, PCNA ubiquitination allows for replication of damaged DNA by

32 mmunity, endocytosis, cholesterol transport, ubiquitination, amyloid-beta and tau processing).

33 sp9X(-/Y) mice display increase of ankyrin-G ubiquitination and aggregation and hyperactivity.

34 nes from treatment studies are associated to ubiquitination and cellular response to stress.

35 tivation of Hedgehog signaling decreases Smo ubiquitination and ciliary removal, resulting in its acc

36 of USP7 or USP10 resulted in increased NHE3 ubiquitination and decreased NHE3 expression at the surf

37 ylation of RBOHD (T912D) results in enhanced ubiquitination and decreased protein abundance.

38 tial control in chromatin-associated protein ubiquitination and define a novel role for CUL1 in gene

39 ese data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia tela

40 on Proline residue 651 by EglN1 mediated its ubiquitination and degradation governed by pVHL.

41 lates TopBP1 protein level by preventing its ubiquitination and degradation mediated by the E3 ligase

42 3 ubiquitin ligase HUWE1, which promotes the ubiquitination and degradation of HIF-1alpha.

43 (KFB) proteins that are responsible for the ubiquitination and degradation of phenylalanine ammonia

44 Here, PJA1, an E3 ligase, promoted ubiquitination and degradation of phosphorylated SMAD3 a

45 t/beta-catenin signaling pathway through the ubiquitination and degradation of RACK1 at the lysine K1

46 is an E3 ubiquitin ligase that leads to the ubiquitination and degradation of several transcription

47 ubiquitin ligase complex that catalyzes the ubiquitination and degradation of the Hedgehog pathway t

48 igase to the POI and cause proximity-induced ubiquitination and degradation of the POI by the ubiquit

49 izes USP-46 protein levels by preventing the ubiquitination and degradation of USP-46 in the proteaso

50 ts with WRN in vitro and in vivo and induces ubiquitination and degradation of WRN in the ubiquitin-p

51 es cell survival by targeting substrates for ubiquitination and degradation through formation of sali

52 They are thought to require poly-ubiquitination and degradation through proteasome, endo-

53 nistic study suggests that NLK promotes mHTT ubiquitination and degradation via the proteasome pathwa

54 oss of EphB1 binding to Cav-1 promoted Cav-1 ubiquitination and degradation, and hence the loss of Ca

55 nd here that inhibiting USP7 increases NF-kB ubiquitination and degradation, prevents Toll-like recep

56 phosphorylates MYC at Thr58, leading to MYC ubiquitination and degradation, thereby regulating MYC t

57 L4(DCAF12) binds and targets Yki/Yap/Taz for ubiquitination and degradation, whereas CDK7 phosphoryla

58 Heat shock also induces LATS ubiquitination and degradation.

59 es C-MYC by antagonizing FBW7-mediated C-MYC ubiquitination and degradation.

60 n E3 ubiquitin ligase that targets SNAI2 for ubiquitination and degradation.

61 nistically, TRIM25 directly targets Keap1 by ubiquitination and degradation.

62 osphorylated KDM4C at Ser918, inducing KDM4C ubiquitination and degradation.

63 he AMPK activity via promoting the AMPKbeta1 ubiquitination and degradation.

64 hat PHGDH is a substrate for Parkin-mediated ubiquitination and degradation.

65 bstrate receptor and presenting cyclin K for ubiquitination and degradation.

66 s it to the SCF-TrCP E3-ubiquitin ligase for ubiquitination and destruction.

67 Appropriate VASP ubiquitination and deubiquitination are required for axo

68 subcellular compartment can be regulated by ubiquitination and deubiquitination by E3 ligase and DUB

69 to compete effectively was enhanced by their ubiquitination and diminished by a block of their ubiqui

70 ring CH (MARCH) E3 ubiquitin ligase-mediated ubiquitination and downregulation of cell surface CD98.

71 f SK2 in the C-terminal domain increases its ubiquitination and endocytosis.

72 t USP7 and USP10 are DUBs that regulate NHE3 ubiquitination and expression, and reveal a new mechanis

73 odel for the mechanisms of RING E3-dependent ubiquitination and for the diverse and complex interrela

74 tin ligase other than FBXO25 regulates ELK-1 ubiquitination and function.

75 ygen conditions may involve the VHL-impacted ubiquitination and nuclear localization of AR.

76 slational modification mechanisms, including ubiquitination and phosphorylation.

77 indicate that, although both Ube3a-mediated ubiquitination and PKA-induced phosphorylation reduce sy

78 -canonical phosphoribosyl-linked (PR) serine ubiquitination and promotes infectivity of Legionella pn

79 nslation initiation variants display reduced ubiquitination and proteasomal degradation as a result o

80 In HEK cells, LITAF increased ubiquitination and proteasomal degradation of co-express

81 alidomide binding to CRBN elicits subsequent ubiquitination and proteasomal degradation of CRBN neosu

82 of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host p

83 Akt-mediated phosphorylation, which promotes ubiquitination and proteasomal degradation of Tpl2, a p3

84 a-catenin, which attenuates its Lys48-linked ubiquitination and proteasomal degradation upon DNA dama

85 Y336, thereby augmenting NEDD4-mediated PTEN ubiquitination and proteasomal degradation.

86 egulated CIB1 levels by protecting CIB1 from ubiquitination and proteasomal degradation.

87 he P450 heme are necessary for NO to trigger ubiquitination and protein degradation.

88 d K77, upon UV stress and then promoted DDB2 ubiquitination and segregation from chromatin, thereby f

89 a deubiquitinase (DUB) that regulates SNAI2 ubiquitination and stability.

90 -promoting complex/cyclosome to initiate the ubiquitination and subsequent degradation of cell cycle

91 lowing erastin treatment, which leads to the ubiquitination and subsequent degradation of the channel

92 otein substrate to the E3 ligase complex for ubiquitination and subsequent degradation.

93 iates LMP1 signaling complex formation, NEMO ubiquitination and subsequent IKK2 activation.

94 der of the LDLR (IDOL) specifically promotes ubiquitination and subsequent lysosomal degradation of t

95 By targeting these transcription factors for ubiquitination and subsequent proteasomal degradation, B

96 ssion is reduced by MARCH1, 4, or 8-mediated ubiquitination and that emibetuzumab-induced MET ubiquit

97 Moreover, concomitant loss of PCNA-ubiquitination and the BRCA pathway results in increased

98 lar machinery, CSA and CSB contribute to the ubiquitination and the degradation of proteins such as P

99 le disassembly mechanism by which N-terminal ubiquitination and the proteasome may together impede ag

100 o oxidative stress via a mechanism involving ubiquitination and three antagonistic E3 ubiquitin ligas

101 ich interacts with OsNRPD1a and mediates its ubiquitination and UPS-dependent degradation in vitro an

102 c expression of P3 and RGSV infection induce ubiquitination and UPS-dependent degradation of rice NUC

103 1 (HECTD1) expression, an increase of HSP90 ubiquitination, and a consequent decrease of microglial

104 d resulted in cytoplasmic TDP-43, widespread ubiquitination, and cortical and hippocampal atrophy.

105 al degradation is often regulated by protein ubiquitination, and here we show that inhibition of ubiq

106 taining signaling complex (complex I), RIPK1 ubiquitination, and NF-kappaB activation.

107 , SUMOylation, methylation, O-GlcNAcylation, ubiquitination, and others, toward regulation of Hsp90 f

108 ex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiqui

109 lls, both HSP70 and HSP90 mediated substrate ubiquitination, and the canonical ATP cycle was required

110 changes in pathways associated with protein ubiquitination, antigen presentation, and mitochondrial

111 Recombinant ZIKV mutants that lack ubiquitination are attenuated in human cells and in wild

112 hrocyte membrane protein phosphorylation and ubiquitination are involved in SCD pathogenesis and prov

113 Our study identifies histone ubiquitination as essential for Schwann cell myelination

114 ic acidic residues abolishes RNF168-mediated ubiquitination as well as 53BP1 and BRCA1 ionizing radia

115 Here, using in vitro and in vivo ubiquitination assays, MS, and superresolution microscop

116 Using endocytic colocalization and ubiquitination assays, we have identified a correlation

117 latent peptidases DA1, DAR1 and DAR2 by mono-ubiquitination at multiple sites.

118 We find that, while ubiquitination at residue 6, 23, or 96 inhibits alpha-sy

119 fficiently used by the E6-E6AP complexes for ubiquitination but not by E6AP alone.

120 LTD increased ubiquitin/proteasome activity, ubiquitination but not proteasomal degradation was criti

121 t offer insight into a key step in substrate ubiquitination by a member of the largest ubiquitin liga

122 odel in which coordinated regulation of VASP ubiquitination by a pair of interfering ligases is a cri

123 ession and proteasomal degradation following ubiquitination by APC/C-CDH1 or SCF(FBXW7).

124 o their transmembrane domains for subsequent ubiquitination by Asi1/Asi3 and membrane extraction.

125 These data indicate that p50 mono-ubiquitination by BARD1/BRCA1 during the cell cycle regu

126 quitination without interference from direct ubiquitination by CHIP, as evidenced by Bcl-2 associated

127 inhibition of this transglutaminase-induced ubiquitination by MavC, but also sheds light on the futu

128 Our results revealed PHGDH ubiquitination by Parkin as a crucial mechanism for PHGD

129 sfolded proteins undergo chaperone-dependent ubiquitination by the action of the E3 ligases Ubr1 and

130 opterin (BH(4)) alteration and loss triggers ubiquitination by the Hsp70-associated E3 ligase c-termi

131 uced formation of BCL6 filaments facilitates ubiquitination by the SIAH1 E3 ubiquitin ligase.

132 This work provides a structural basis of ubiquitination by transglutamination and identifies this

133 te that the regulation of PrimPol K29-linked ubiquitination by USP36 plays a critical role in DNA rep

134 , but not ribosome association, requires 40S ubiquitination by ZNF598, but not GTP-dependent factors,

135 sa1/Ssa2, but San1 substrate recognition and ubiquitination can proceed without these Hsp70 chaperone

136 in-conjugating E2 enzymes are central to the ubiquitination cascade and have been implicated in cance

137 interrelationship between components of the ubiquitination cascade.

138 ighting the growing mechanistic diversity in ubiquitination cascades.

139 ted cell sorting assay based on fluorescence ubiquitination cell cycle indicator, which marks differe

140 ociated with neurogenesis, lipid metabolism, ubiquitination, chromatin regulation and translation.

141 uitination and that emibetuzumab-induced MET ubiquitination contributes to its capacity to downregula

142 the Cbl proto-oncogene (c-Cbl); promoted AXL ubiquitination; decreased AXL-mediated signaling, includ

143 ons, PX favored beta-arrestin1/Mdm2-mediated ubiquitination/degradation of IGF1R, a scenario usually

144 Ubiquitination-dependent adaptor activation required a u

145 tes it at three residues to promote its poly-ubiquitination-dependent degradation.

146 e finding that enhancing Hsp70:CHIP-mediated ubiquitination does not affect native proteins has impor

147 regate formation, partially by enhancing K63 ubiquitination during a proteotoxic stimulus.

148 comprise a family of proteases that regulate ubiquitination dynamics.

149 ter linked E2~Ub conjugate to monitor single ubiquitination events and demonstrate that ubiquitin is

150 is driven by eIF2B5-mediated translation of ubiquitination genes.

151 In this study, we have examined how MHC II ubiquitination impacts the composition and function of b

152 We found that Zta is subjected to ubiquitination in both EBV-infected and EBV-negative cel

153 hese findings expand our view of the role of ubiquitination in cell signaling and provide additional

154 light recently appreciated roles for histone ubiquitination in DNA methylation control, PTM crosstalk

155 tion, indicating the significance of protein ubiquitination in HL pathogenesis.

156 roles of K612 ubiquitination in mRIPK1/K627 ubiquitination in hRIPK1 in regulating its pro-death kin

157 Decreased TRAF3 ubiquitination in K48-linked chains and cIAP1-TRAF3 inte

158 tudy demonstrates the distinct roles of K612 ubiquitination in mRIPK1/K627 ubiquitination in hRIPK1 i

159 tion of IRAK1 was maintained by K63-mediated ubiquitination in preterm FM of humans with chorioamnion

160 Here, we report the role of ubiquitination in regulating Zta function.

161 n exhibited more protein phosphorylation and ubiquitination in SCD patients than in controls.

162 stone cross-talk and the dynamic role of H2B ubiquitination in stimulating histone methylation.

163 omatin-associated histone H2B to enhance H2B ubiquitination in the Myc promoter and promotes Myc tran

164 HOIP processing impeded substrate ubiquitination in the NF-kappaB pathway and resulted in

165 activation increases SK2 phosphorylation and ubiquitination in Ube3a-overexpressing mice.

166 P complexes by a combination of E3-selective ubiquitination in whole-cell extracts and high-resolutio

167 and promotes DDB2 stability by impairing its ubiquitination independent of methyltransferase activity

168 lysine residues in Zta largely abrogates its ubiquitination, indicating that these are primary ubiqui

169 rotein that regulates nonproteolytic protein ubiquitination, indicating the significance of protein u

170 bortezomib and carfilzomib in reversing the ubiquitination-induced downregulation of OAT1 expression

171 mmarize three agronomic traits influenced by ubiquitination: induction of flowering, seed size, and p

172 Ubiquitination influences trafficking and signaling of m

173 Ubiquitination is a fundamental posttranslational protei

174 Ubiquitination is a mechanism that dictates surface MHC

175 Ubiquitination is a reversible post-translational modifi

176 Protein ubiquitination is a very diverse post-translational modi

177 Reversible protein ubiquitination is an essential signaling mechanism withi

178 Specificity of ubiquitination is conferred by ubiquitin ligases.

179 In turn, Wingless-INT (Wnt) 3 (Wnt3) ubiquitination is decreased, while total protein levels

180 uptake complex and showed that FRO2 and AHA2 ubiquitination is independent of the non-iron metal subs

181 Protein ubiquitination is one of the most prevalent post-transla

182 Similarly, CD98 ubiquitination is required for UM7F8's capacity to block

183 inhibited expression of PML by altering the ubiquitination level of TRIM25.

184 Ubiquitination limits ion channel surface density, but t

185 ale approaches to characterize (1) the E2-E3 ubiquitination machinery driving K63-linked ubiquitin ch

186 l molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins

187 at this action may involve an MKRN3-directed ubiquitination-mediated mechanism.

188 This study investigated ribosome ubiquitination-mediated translational controls during UP

189 ere examined in two models of altered MHC II ubiquitination: MHCIIKR(KI) (/KI) mice that express a mu

190 Although processive ubiquitination might-in principle-arise from Bre1 and Ra

191 were involved in pathways related to protein ubiquitination, muscle differentiation, lipids and hormo

192 ellular homeostasis by inhibiting K63-linked ubiquitination of beclin 1 mediated by TRAF2, cIAP1 and

193 OTULIN inhibits linear ubiquitination of beta-catenin, which attenuates its Lys

194 rther verified that EMD strongly induced the ubiquitination of c-Myc and promoted protein degradation

195 ion of Y319 by Src kinases, thereby enabling ubiquitination of CD226 by CBL-B, internalization, and p

196 MARCH1-mediated ubiquitination of CD98 is required for UM7F8's capacity

197 PC/C-associated E2 that ensures the faithful ubiquitination of cell cycle regulators during mitosis.

198 rom the orphan GPCR GPR161 demonstrates that ubiquitination of ciliary GPCRs is required for their re

199 At steady-state, RNF41 ubiquitination of Clec9A facilitates interactions with E

200 hesin-interacting protein that regulates the ubiquitination of cohesin and its cell cycle regulated i

201 cally required for both deubiquitination and ubiquitination of cohesin subunits in human cells.

202 by Eps15 and promoted by phosphorylation and ubiquitination of Cx43.

203 ity, significant HMM species generation, and ubiquitination of CYP2B6 protein but did not stimulate C

204 DCX domain is necessary for KLHL15-mediated ubiquitination of DCX and doublecortin-like kinase 1 and

205 To investigate the direct role of cullins in ubiquitination of DNA-bound proteins and in gene regulat

206 macological activation of Hsp70 enhances the ubiquitination of dysfunctional but not native nNOS, and

207 r data indicate that FBXO25 neither promotes ubiquitination of ELK-1 nor impacts on its transcription

208 The findings raise the possibility that, if ubiquitination of H2A could be enforced by inhibition of

209 nsion helix as essential for RNF168-mediated ubiquitination of H2A variants.

210 olycomb Repressor Complexes and supports the ubiquitination of H2A, thereby preventing the accumulati

211 nucleosomal substrate, which accelerates the ubiquitination of H2B.

212 ding irreversible oxidation of betaCys93 and ubiquitination of Hb betaLys145 (and betaLys96).

213 ccumulation, enhanced secretion, and reduced ubiquitination of HC.

214 ively transcribed genes that depends on mono-ubiquitination of histone H2B (H2B-Ub).

215 over, depletion of nNOS-bound BH(4) triggers ubiquitination of holo-nNOS by the Hsp70:CHIP complex.

216 In conclusion, ubiquitination of IL-1alpha is associated with increased

217 However, in vitro ubiquitination of its substrate, the intracellular tail

218 phase of infection and catalyzed K-48-linked ubiquitination of Lys326 on NEMO, which resulted in its

219 enabled TMEM127 to interact with and induce ubiquitination of mature MHCII.

220 on, TMEM127, are required for SteD-dependent ubiquitination of mMHCII.

221 tion of UBR5 with MYC and reduced K48-linked ubiquitination of MYC upon loss of UBR5 in cells.

222 In addition, CSA induces ubiquitination of Ncl, enhances binding of CSB to Ncl, a

223 of USP7 and USP10 to NHE3, while increasing ubiquitination of NHE3.

224 ctive structural analog JG-258, enhances the ubiquitination of nNOS 3-fold.

225 e to hypoxia which correlates with increased ubiquitination of nuclear proteins.

226 importantly, JG-98 was shown to enhance the ubiquitination of only dysfunctional nNOS while leaving

227 action is induced by ATR and results in mono-ubiquitination of p50 by the BARD1/BRCA1 complex.

228 UBE2T levels promote GC progression via the ubiquitination of RACK1 and identified a novel potent in

229 promote cell cycle progression, and inducing ubiquitination of Rb.

230 K63 ubiquitination of ribosomes has emerged as a new posttra

231 l domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.

232 Finally, ubiquitination of RPS27a appears to depend on active tra

233 Blocking ubiquitination of Smo by an E1 ligase inhibitor or by mu

234 l space and convey these signals through the ubiquitination of specific cytoplasmic substrates.

235 This was associated with increased ubiquitination of STING and elevated phosphorylation of

236 9X from complexes with TAK1 and promotes K63 ubiquitination of TAK1 thus activating AMPK on damaged l

237 BD and Alzheimer's disease, it is found that ubiquitination of tau can mediate inter-protofilament in

238 This leads to the degradative K48 ubiquitination of TBK1 via its K372 residue in a DTX4-de

239 ously showed that the lack of Ube3a-mediated ubiquitination of the Ca(2+)-activated small conductance

240 Our results reveal that ubiquitination of the CDC42 regulator IQGAP1 alters its

241 Legionella pneumophila effector MavC induces ubiquitination of the E2 ubiquitin-conjugating enzyme UB

242 ission of recycling endosomes by controlling ubiquitination of the ESCRT-III (endosomal sorting compl

243 d that these mutations strongly decrease the ubiquitination of the kidney-specific isoform KS-WNK1 by

244 mechanism promoting 3' US in cancer through ubiquitination of the mRNA 3' end processing complex pro

245 ndently of parkin, enhances parkin-dependent ubiquitination of the outer mitochondria membrane protei

246 cin-induced ER stress enhanced the levels of ubiquitination of the ribosomal proteins uS10, uS3 and e

247 Peli1 mediates non-degradative ubiquitination of TSC1, thereby promoting TSC1-TSC2 dime

248 d that acetylation inversely correlates with ubiquitination of TULP3.

249 tunicamycin, whereas E3 ligase Hel2-mediated ubiquitination of uS10 was not.

250 Our results demonstrate that the ubiquitination of ZIKV E is an important determinant of

251 Ubiquitination of Zta affects the protein's stability an

252 RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage

253 However, the influence of protein ubiquitination on macrophage polarization has not been w

254 gs help uncover the molecular effects of K63 ubiquitination on ribosomes, providing a model of transl

255 Blockade of CD79A or CD79B ubiquitination or Cbls ligase activity is sufficient to

256 hat has investigated the targeting of Zta by ubiquitination or its role in Zta function.IMPORTANCE Ep

257 g by proteasome inhibitors and inhibitors of ubiquitination or p97/VCP.

258 enriched in proteins involved in the protein ubiquitination pathway and phagosome maturation.

259 tochondrial functioning, protein folding and ubiquitination pathways.

260 iquitination site that regulates the overall ubiquitination pattern of RIPK1 and its DD-mediated inte

261 Histone ubiquitination plays an important role in the DNA damage

262 y involved in TBS-induced endocytosis, while ubiquitination predominantly inhibits SK2 recycling.

263 we have identified a correlation between the ubiquitination profile and recycling of the GCGR.

264 Using ubiquitin proteomics, we found that ubiquitination profiles are different among polarized mu

265 efficient Okazaki fragment maturation, PCNA-ubiquitination protects fork integrity and promotes the

266 We also reported that SMAD ubiquitination regulatory factor 2 (SMURF2) ligase activ

267 echanism, regulation, and effects of cohesin ubiquitination remain poorly defined.

268 ring lysosomal membrane damage abrogate such ubiquitination responses.

269 el lectins detect membrane damage leading to ubiquitination responses.

270 s afforded by low levels of Histone 2A (H2A) ubiquitination resulting from lowered RNF168 levels.

271 Loss of PCNA-ubiquitination results in DNA2-dependent but MRE11-indep

272 veal an allosteric communication between the ubiquitination site K644, the Ig3-protease interaction s

273 equivalent K612 in murine RIPK1-DD is a key ubiquitination site that regulates the overall ubiquitin

274 6, -1155, -1230, -1465, -1475, and -1528) as ubiquitination sites in IQGAP1.

275 ylation sites, 92 acetylation sites, and two ubiquitination sites.

276 ions of p53 along with biologically relevant ubiquitination sites.

277 e E3 ubiquitin ligase responsible for MHC II ubiquitination specifically in thymic epithelial cells.

278 during Hedgehog signaling by regulating the ubiquitination state of the receptor.

279 We hypothesized that the ubiquitination status of key proteins in inflammatory pa

280 , we report on a mechanism that explains how ubiquitination stimulates adaptor function and how this

281 The requirement for the HSP70 ATP cycle in ubiquitination suggests a possible model of triage in wh

282 the precise mechanistic roles of A20 and the ubiquitination system remain largely unknown in this dis

283 itination, indicating that these are primary ubiquitination target sites.

284 residue stabilizes FAAP20 by preventing its ubiquitination, thereby protecting it from proteasome-de

285 regulated by its DD-mediated interaction and ubiquitination, though underlying mechanisms remain inco

286 1)-iLTD relies on both protein synthesis and ubiquitination to elicit structural changes that underli

287 se findings link glucose deprivation and H2A ubiquitination to regulation of the ER stress response i

288 In addition to driving substrate ubiquitination together with ubiquitin ligases (E3s), ma

289 Ubiquitination-triggered proteasomal degradation of DNA-

290 LZTR1-mediated dysregulation of CHMP1B ubiquitination triggers endosomal accumulation and subse

291 quitin system and regulation of NF-kappaB by ubiquitination using A20 as a representative molecule an

292 After ubiquitination, vacuole membrane proteins are sorted int

293 cidate the biological consequences of IQGAP1 ubiquitination, we converted each of these lysines to ar

294 ones were directly involved in Ubr1-mediated ubiquitination, we developed a bead-based assay with cov

295 interaction and subsequently repressing p53 ubiquitination, whereas knockdown of RBM10 decreased p53

296 D also underwent TMEM127- and WWP2-dependent ubiquitination, which both contributed to its degradatio

297 of vacuole membrane proteins is initiated by ubiquitination, which is accomplished by the coordinatio

298 cile in vitro method for Hsp70:CHIP-mediated ubiquitination will be beneficial for testing other Hsp7

299 e ELISA to measure Hsp70:CHIP-dependent nNOS ubiquitination without interference from direct ubiquiti

300 hese adaptors are elevated when they undergo ubiquitination, yet the mechanism whereby ubiquitination