ライフサイエンスコーパス: ubiquitylation

1 cells led to an increase in non-degradative ubiquitylation.

2 e substrate binding while blocking their own ubiquitylation.

3 the active holoenzyme and promote processive ubiquitylation.

4 upporting its role as a cofactor in H2B K123 ubiquitylation.

5 e Ube2D family, and target host proteins for ubiquitylation.

6 omplexity is regulated in part by reversible ubiquitylation.

7 g degradative or non-degradative outcomes of ubiquitylation.

8 h interactions with proteins that coordinate ubiquitylation.

9 vity towards the substrate and also the self-ubiquitylation.

10 ne or in combination with SCF(Skp2)-mediated ubiquitylation.

11 cells responsible for regulation of NEIL1 by ubiquitylation.

12 hereas RACK1 regulates RPS2, RPS3, and RPS20 ubiquitylation.

13 Upon synthesis, Csr2 becomes activated by ubiquitylation.

14 ly been assumed to be determined by rates of ubiquitylation.

15 half-life of PIM1, and markedly reduced its ubiquitylation.

16 and occurred independently of PRC1-catalyzed ubiquitylation.

17 or, cooperates with UBR5 in mediating MOAP-1 ubiquitylation.

18 lation of the Ub carboxyl terminus precludes ubiquitylation.

19 sites fails to recruit PRP19 and support RPA ubiquitylation.

20 bination factors dependent on HEI10-mediated ubiquitylation.

21 e that recruits T58-phosphorylated c-MYC for ubiquitylation.

22 radigm for understanding ribosome-associated ubiquitylation.

23 e, interacts with TOP2alpha and mediates its ubiquitylation.

24 post-translationally by phosphorylation and ubiquitylation.

25 part via its NTD, to target stalled NSPs for ubiquitylation.

26 be acetylated by TIP60 in vivo, blocking its ubiquitylation.

27 in UBA1, the major E1 enzyme that initiates ubiquitylation.

28 und a single BTB domain, resulting in robust ubiquitylation.

29 Polyanions also interfere with substrate ubiquitylation.

30 ycling benefits from an intact cycle of Rab7 ubiquitylation.

31 ruption of Doc1/Apc10 function in processive ubiquitylation.

32 ntracellular distribution, and is subject to ubiquitylation.

33 inase AKT leads to strong impairment of PCNA ubiquitylation.

34 ication and repair and central among them is ubiquitylation.

35 ullin-RING E3 ligase (CRL)-catalysed protein ubiquitylation(1), which is tightly controlled by the mo

36 ious cellular proteins and render eukaryotic ubiquitylation a dynamic process.

37 reening assay to identify inhibitors of PCNA ubiquitylation, a key post-translational modification re

38 teins in inclusions, the TRIM21-mediated p62 ubiquitylation abrogates p62 oligomerization and sequest

39 converge to juxtapose the substrate and the ubiquitylation active site.

40 Unexpectedly, UBE2R2 alone had negligible ubiquitylation activity at physiological concentrations

41 bunit Cdc20 or Cdh1 generate oscillations in ubiquitylation activity necessary to maintain the order

42 g and a significant increase in the in vitro ubiquitylation activity of UBE3B.

43 o acids 758-1068) results in loss of UBE3B's ubiquitylation activity.

44 localization and enhanced H3K9me3-nucleosome ubiquitylation activity.

45 s and DNA methylation with enzymatic histone ubiquitylation activity.

46 K(1268) ubiquitylation affects DNA repair and signals RNAPII deg

47 of Proliferating Cell Nuclear Antigen (PCNA) ubiquitylation after UV requires the upstream activity o

48 Here, we report that ubiquitylation alone is not sufficient for cargo release

49 pond to S phase-specific CUL4(Ddb1)-mediated ubiquitylation alone or in combination with SCF(Skp2)-me

50 Finally, we provide evidence that H2A ubiquitylation also contributes to resistance to transcr

51 Inactivation of TLE by UBR5-dependent ubiquitylation also involves VCP/p97, an AAA ATPase regu

52 Ubiquitylation, an essential process for protein degrada

53 Lysine 104 in KRAS can be modified by ubiquitylation and acetylation, but the role of this res

54 ining specific PTMs such as phosphorylation, ubiquitylation and acetylation.

55 tant peripheral-blood cells showed decreased ubiquitylation and activated innate immune pathways.

56 enzymes that antagonize ZNF598-mediated 40S ubiquitylation and can limit RQC activation.

57 We show that Mcm7 ubiquitylation and CRL2(Lrr1) binding to chromatin are t

58 sly, we reported that MOAP-1 is targeted for ubiquitylation and degradation by the APC/C(Cdh1) ubiqui

59 Thr182 phosphorylation not only controls BLM ubiquitylation and degradation during mitosis but is als

60 We find that SCF-cyclin F controls E2F1 ubiquitylation and degradation during the G2/M phase of

61 rts the E3 ligase Ltn1/listerin in promoting ubiquitylation and degradation of aberrant nascent-chain

62 Overexpression of beta-TrCP induced the ubiquitylation and degradation of DMRT1.

63 ognizes an acetyl degron of GS, resulting in ubiquitylation and degradation of GS in response to glut

64 our work reveals that the COP1/SPA-mediated ubiquitylation and degradation of HECs contributes to th

65 d quality control (RQC) complex promotes the ubiquitylation and degradation of NCs remaining stalled

66 e NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 d

67 main negative regulator of NRF2 and mediates ubiquitylation and degradation of NRF2 through its NRF2-

68 c1), along with Def1, is known to facilitate ubiquitylation and degradation of RNA polymerase II (pol

69 Ubiquitylation and degradation of the antioxidant transc

70 However, light still stimulates ubiquitylation and degradation of this mutant, implying

71 binding to Kelch-like 3, targeting WNK4 for ubiquitylation and degradation.

72 te that stimulates Fbw7 binding and cyclin E ubiquitylation and degradation.

73 ing TRC35 from succumbing to RNF126-mediated ubiquitylation and degradation.

74 (CRL4(VprBP)), which we show regulate FoxM1 ubiquitylation and degradation.

75 ll survival decisions by controlling protein ubiquitylation and degradation.

76 gh defined sequence motifs that promote CDC6 ubiquitylation and degradation.

77 L-associated Cullin 2, and impairs HIF2alpha ubiquitylation and degradation.

78 hosphorylation on Ser(552), and promotes its ubiquitylation and degradation.

79 g substrates of these cellular adaptors from ubiquitylation and degradation.

80 in strongly reduced the DNA damage-dependent ubiquitylation and destruction of Rpb1.

81 To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we

82 inant CMG added to nuclear extract undergoes ubiquitylation and disassembly in the absence of any DNA

83 key chromatin regulator involved in histone ubiquitylation and DNA methylation maintenance.

84 by signaling pathways and warrant that cargo ubiquitylation and endocytosis appropriately respond to

85 This occurs, in part, through the selective ubiquitylation and endocytosis of plasma membrane protei

86 to the plasma membrane, which promotes cargo ubiquitylation and endocytosis, demonstrating a mechanis

87 nd that trans-tail regulation of histone-H2B ubiquitylation and H3K4 di-methylation potentiates subse

88 tin ligase activity also fail to support RPA ubiquitylation and HR.

89 ative stress, but sorbitol stimulates TDP-43 ubiquitylation and insolubility via a novel pathway(s) i

90 ne did suppress both SG formation and TDP-43 ubiquitylation and insolubility.

91 ation blocker emetine did not prevent TDP-43 ubiquitylation and insolubility.

92 r protein BRCA1, which acts upstream of MCM7 ubiquitylation and p97 recruitment.

93 uence of P62 accumulation, which impairs H2A ubiquitylation and perturbs ATM signaling.

94 d post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by

95 s Rad18 and compromises UV-induced PCNA mono-ubiquitylation and Pol eta recruitment to stalled replic

96 FBXL7 mediates the ubiquitylation and proteasomal degradation of active c-S

97 th the notion that the 148M variant disrupts ubiquitylation and proteasomal degradation of PNPLA3, re

98 1 autophosphorylation at S296, counters CHK1 ubiquitylation and proteasomal degradation, thereby prev

99 identifies AKT as a novel regulator of PCNA ubiquitylation and provides the proof-of-concept of inhi

100 While beta-TrCP1 promotes FBXW2 ubiquitylation and shortens its half-life, FBXW2 does th

101 SGs, accompanied by normalization of TDP-43 ubiquitylation and solubility.

102 ovide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis

103 Therefore, the ubiquitylation and subsequent degradation of HECs are si

104 ependent phosphorylation is required for the ubiquitylation and subsequent degradation of Vac17 and t

105 p53 ubiquitylation and subsequent degradation require the F-

106 plasma membrane, notably by regulating their ubiquitylation and subsequent endocytosis.

107 biquitin ligases such as cullin-5 (Cul5) for ubiquitylation and subsequent proteasomal degradation.

108 iption factor activity by altering levels of ubiquitylation and subsequent proteasome degradation or

109 a and beta-catenin by beta-TrCP causes their ubiquitylation and thereafter proteasome-mediated degrad

110 e, we demonstrate that Ccr4-Not controls the ubiquitylation and turnover of Rpb1, the largest subunit

111 odulating AQP2 trafficking, phosphorylation, ubiquitylation, and degradation.

112 hat facilitate UHRF1 chromatin targeting, H3 ubiquitylation, and DNA methylation inheritance.

113 tabilization, restored HOIP-dependent linear ubiquitylation, and protected cells from TNF-induced apo

114 cision of THF-in by APE1 in vitro by histone ubiquitylation, and that siRNA-mediated depletion of HEC

115 However, how CRLs catalyse ubiquitylation, and the basis of NEDD8 activation, remai

116 We demonstrate that uS10 and uS5 ubiquitylation are dependent upon eS10 or uS3 ubiquityla

117 Surprisingly, in vitro ubiquitylation assays indicate that Ccr4-Not does not di

118 hanism of crosstalk between linkage-specific ubiquitylation at DNA damage sites, while simultaneously

119 at affects CRL activity and client-substrate ubiquitylation at multiple levels.

120 e of any DNA, and DNA digestion triggers CMG ubiquitylation at stalled replication forks.

121 eview, we emphasize emerging concepts of how ubiquitylation brings the necessary dynamicity and plast

122 lysosomal degradation independently of EGFR ubiquitylation but dependent upon Hrs/Tsg101 that are re

123 FR target genes, from EGFR pathway-dependent ubiquitylation by a Cullin 1/SKP1-related A/Archipelago

124 is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the prot

125 ligase I interacts with and is targeted for ubiquitylation by DCAF7, a specificity factor for the Cu

126 Thus, Groucho/TLE ubiquitylation by Hyd/UBR5 is a key prerequisite that en

127 maged organelles are marked for disposal via ubiquitylation by Parkin.

128 how that PALB2 indirectly recognizes histone ubiquitylation by physically associating with ubiquitin-

129 ubiquitylate Rpb1 but instead promotes Rpb1 ubiquitylation by the HECT domain-containing ligase Rsp5

130 including phosphorylation-dependent cyclin E ubiquitylation by the SCF(Fbw7) ubiquitin ligase.

131 yotic intracellular processes employ protein ubiquitylation by ubiquitin E3 ligases for functional re

132 as a functionally relevant substrate, whose ubiquitylation by UBR5 is induced by Wnt signaling and c

133 Despite gathering evidence that ubiquitylation can direct non-degradative outcomes, most

134 early-acting regulators of the three-enzyme ubiquitylation cascade are unknown.

135 modification system, mediating a sequential ubiquitylation cascade reminiscent of the eukaryotic pro

136 DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway

137 RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation an

138 Ubiquitylation controls protein function and degradation

139 in mpkCCD14 cells resulted in increased AQP2 ubiquitylation, decreased AQP2 protein half-life, and re

140 veal that LE transport effector RILP prefers ubiquitylation-deficient Rab7, while retromer-mediated L

141 ajor roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrat

142 interaction is lost and beta-catenin escapes ubiquitylation-dependent proteasomal degradation.

143 Our findings suggest that DNA suppresses CMG ubiquitylation during elongation and that this suppressi

144 We provide kinetic insight into poly-ubiquitylation during protein quality control by showing

145 are ensured through the timely activation of ubiquitylation enzymes.

146 are consistent with the 20-30% reduction of ubiquitylation events in ask1 estimated by immunoblottin

147 CUL3 co-adaptors as important regulators of ubiquitylation events that control human development.

148 nct and overlapping regulatory 40S ribosomal ubiquitylation events.

149 geting MUC1-C downregulated BMI1-induced H2A ubiquitylation, EZH2-driven H3K27 trimethylation, and ac

150 Tethered Set1 still requires histone H2B ubiquitylation for activity.

151 ased E3 ubiquitin ligases, mediating protein ubiquitylation for subsequent proteasomal degradation.

152 study we reveal the importance of K63-linked ubiquitylation for the assembly of decapping factors, P-

153 nal analysis revealed detailed mechanisms of ubiquitylation for UHRF1, a key chromatin regulator invo

154 ty and, to our surprise, did not require H2B ubiquitylation (H2Bub); in contrast, H2Bub was required

155 thylation, phosphorylation, SUMOylation, and ubiquitylation, have emerged as important contributors i

156 ly, our observations suggest that reversible ubiquitylation helps switch Rab7 between its various fun

157 en HSP101, stress granules, proteasomes, and ubiquitylation imply that dynamic coordination between p

158 13), which regulate clock period and protein ubiquitylation in a manner opposite to ZTL, associate wi

159 We show that MLN7243 rapidly inhibits ubiquitylation in a variety of cell lines and can profou

160 mechanism and results in unrestrained FGFR1 ubiquitylation in cells.

161 ng, we identify the sites of KEAP1-dependent ubiquitylation in MCM3, and these sites are on predicted

162 indings demonstrate that the requirement for ubiquitylation in MHC class I-restricted Ag processing v

163 Altogether, these findings uncover a role of ubiquitylation in mitochondrial import regulation and su

164 domide and to identify proteins modulated by ubiquitylation in models of basal and luminal human brea

165 er that RNF168 links the HR machinery to H2A ubiquitylation in S/G2 cells.

166 degradative outcomes, most investigations of ubiquitylation in T cells have focused on degradation.

167 RNF11 and SMURF2 dramatically reduced SMURF2 ubiquitylation in the cell.

168 The role of ubiquitylation in this process is increasingly recognize

169 ethods for highly multiplexed measurement of ubiquitylation in tissues and primary cells using sub-mi

170 Targets showing elevated ubiquitylation in USP30(-/-) iNeurons are concentrated i

171 ieved, it remains unclear how RNF168-induced ubiquitylation influences HR.

172 orming conditions induced very strong TDP-43 ubiquitylation, insolubility, and reduced splicing activ

173 emically trapped complex that represents the ubiquitylation intermediate, in which the neddylated CRL

174 Ubiquitylation is a cardinal cellular modification and i

175 Ubiquitylation is a form of Post-Translational Modificat

176 Ubiquitylation is a tightly regulated process that is es

177 kinetochore kinases, are demonstrating that ubiquitylation is a versatile modification that can be u

178 The misregulation of protein ubiquitylation is associated with many human diseases, a

179 Consequently, SCF(Met30) substrate ubiquitylation is blocked and triggers a downstream casc

180 This ubiquitylation is carried out in normally growing cells

181 Cat-domain ubiquitylation is dependent on Ptr3 and the integral PM

182 monoubiquitin fusion, indicating that CENP-A ubiquitylation is essential for viability.

183 s have stalled or undergone termination, CMG ubiquitylation is followed by its extraction from chroma

184 translation termination factor GSPT1] whose ubiquitylation is induced by immunomodulatory drugs.

185 Protein ubiquitylation is involved in a plethora of cellular pro

186 a mutant NEIL1 protein lacking residues for ubiquitylation is more stable than the wild type protein

187 r to other post-translational modifications, ubiquitylation is reversible in a process dependent on a

188 S is recruited via the Nrd1 CID, histone H2B ubiquitylation is still required for efficient H3K4 meth

189 urified budding yeast proteins, we show that ubiquitylation is tightly repressed throughout elongatio

190 Our study establishes that oxyester-linked ubiquitylation is used as an intracellular signaling mec

191 nts of the mitochondrial translocon, and the ubiquitylation kinetics of the vast majority of Parkin t

192 activity of DNA PKcs, without affecting PCNA ubiquitylation levels in unperturbed cells.

193 for an indispensable role of neddylation, a ubiquitylation-like protein modification, in inhibiting

194 We show that the ubiquitylation machinery and the proteasome control diff

195 We found dependency on the ubiquitylation machinery including the ubiquitin-activat

196 D8 can trigger NEDD8 conjugation through the ubiquitylation machinery.

197 ACRG was accompanied by a decrease in linear ubiquitylation mediated by the linear ubiquitin chain as

198 ytosis of transporters is triggered by their ubiquitylation mediated by the Rsp5 ubiquitin-ligase, re

199 We previously reported that CENP-A K124 ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex

200 crosstalk pathway involving the consecutive ubiquitylation, methylation, sumoylation and deacetylati

201 motic stress-induced SG formation and TDP-43 ubiquitylation occurred rapidly and coincided with coloc

202 on is associated with immediate increases in ubiquitylation of AgDD itself, along with that of endoge

203 of specific peptide generation reveals that ubiquitylation of defective ribosomal products is rate l

204 tylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I by Cul4-DDB1 and DCAF7.

205 ns, as well as levels of phosphorylation and ubiquitylation of EGFR in tumors in vivo closely resembl

206 e found that EYFP tagging induces additional ubiquitylation of EYFP-CENP-A K124R, which allows the mu

207 hat targeting MUC1-C suppresses BMI1-induced ubiquitylation of H2A and thereby derepresses homeobox H

208 Ubiquitylation of H2AK15 by RNF168 inhibits chromatin ac

209 PIF1 enhances the poly-ubiquitylation of HFR1 by COP1 in vivo and in vitro In a

210 creases HIF1alpha stability and enhances the ubiquitylation of HIF1alpha by a von Hippel-Lindau prote

211 ty on APC/C function, stimulating processive ubiquitylation of high-affinity substrates and suppressi

212 -regulation in the pathway that controls the ubiquitylation of histone H2A (UbiH2A) and blocking this

213 This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and t

214 Dynamic regulation of RNF168-mediated ubiquitylation of histone H2A Lys13,15 (H2AK13,15ub) at

215 hromatin by recognizing RNF168-mediated mono-ubiquitylation of histone H2A Lys15 in the nucleosome co

216 SCML2-associated mono-ubiquitylation of histone H2A lysine 119 (H2AK119ub1) an

217 PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of oth

218 Mono-ubiquitylation of histone H2B (H2Bub1) and phosphorylati

219 A central player in these events is the mono-ubiquitylation of histone H2B (H2Bub1), which has been s

220 Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a

221 MT1 to sites of newly replicated DNA through ubiquitylation of histone H3.

222 IL-1-induced formation of K63-Ub chains and ubiquitylation of IRAK1, IRAK4, and MyD88 was abolished

223 CMG unloading involves ubiquitylation of its Mcm7 subunit and the action of the

224 e show that a key point of regulation is the ubiquitylation of JAM-C by the E3 ligase Casitas B-linea

225 of high-affinity substrates and suppressing ubiquitylation of low-affinity substrates.

226 These enhancers potentiate the ubiquitylation of mutant beta-Catenin by beta-TrCP in vi

227 ating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysin

228 orylation by SRPK stimulates RNF12-dependent ubiquitylation of nuclear transcription factor substrate

229 uscle ring-finger protein-1 (MURF1)-mediated ubiquitylation of peroxisome proliferator-activated rece

230 Here, we present evidence that Asr1-mediated ubiquitylation of pol II is required for silencing of su

231 Asr1-mediated oligo-ubiquitylation of pol II leads to ejection of two core s

232 is accompanied by Hel2-dependent regulatory ubiquitylation of ribosomal proteins.

233 responses are connected by the finding that ubiquitylation of RNAPII itself, at a single lysine (RPB

234 The ubiquitylation of RPA by PRP19 and RFWD3 facilitates ATR

235 ZNF598 primarily mediates regulatory ubiquitylation of RPS10 and RPS20, whereas RACK1 regulat

236 biquitin ligases MULAN and MARCH5 coordinate ubiquitylation of SLC25A46 L341P, leading to degradation

237 n-RING ubiquitin ligases (CRLs) catalyze the ubiquitylation of substrates many of which are degraded

238 K11 ubiquitin chains on mitochondria and by ubiquitylation of subunits of the translocase of outer m

239 tic pathway in yeast, facilitating selective ubiquitylation of target proteins by the E3 ubiquitin li

240 Within these processes, OTUB1 reduces the ubiquitylation of target proteins in two distinct ways,

241 We here report that transport-elicited ubiquitylation of the arginine transporter Can1 is promo

242 oys outer membrane protein B (OmpB) to block ubiquitylation of the bacterial surface proteins, includ

243 Ubiquitylation of the eukaryotic sliding clamp, PCNA, ac

244 The deletion of UBP15 leads to hyper-ubiquitylation of the main nuclear export receptor Mex67

245 n F-box protein, Mdm30, is found to regulate ubiquitylation of the Sub2 component of TREX (transcript

246 tecture that is both robust, to enable rapid ubiquitylation of the substrate, and fragile, to enable

247 Ubiquitylation of the Vac17 adaptor at the bud cortex pr

248 ligase E3C (UBE3C) to the 26S proteasome and ubiquitylation of two key proteasomal ubiquitin receptor

249 ificantly reduced, associated with increased ubiquitylation of VEGF protein.

250 th the E3 ligases RNF43 and ZNRF3 to inhibit ubiquitylation of Wnt receptors.

251 domain alpha1-helix, which further undergoes ubiquitylation on a conserved lysine residue.

252 e CMG (CDC45/MCM2-7/GINS) helicase undergoes ubiquitylation on its MCM7 subunit, dependent on the E3

253 ons such as phosphorylation, methylation and ubiquitylation on other proteins, and are themselves car

254 s in the ubiquitin ligase that mediates Gcn4 ubiquitylation or by inhibition of the proteasome, leadi

255 Protein ubiquitylation participates in a number of essential cel

256 is is, in part, due to the complexity of the ubiquitylation pathways and the lack of robust quantitat

257 Site-specific histone ubiquitylation plays a central role in orchestrating the

258 icate that ZNF598, RACK1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosom

259 vating Ltn1 or by analyzing NCs with limited ubiquitylation potential, suggesting that inefficient ta

260 s thereby able to exert a major influence on ubiquitylation processes.

261 aperones often work collaboratively with the ubiquitylation-proteasome system (UPS) to facilitate the

262 r calcium signaling in mitochondrial protein ubiquitylation, protein turnover, and disease.

263 est that control of pol II by nonproteolytic ubiquitylation provides a mechanism to enforce silencing

264 he quantitative comparisons of SCF-dependent ubiquitylation reactions with physiological enzyme conce

265 iew details our current understanding of how ubiquitylation regulates CD4(+) T cell effector identity

266 eled by binding partners to achieve temporal ubiquitylation regulating cell division.

267 o support the emerging view that transporter ubiquitylation relies on combinatorial interaction rules

268 Expression of a ubiquitylation-resistant form of PNPLA3 in mice caused a

269 biquitylation are dependent upon eS10 or uS3 ubiquitylation, respectively, suggesting that a hierarch

270 ction or mutations that block RPS10 or RPS20 ubiquitylation result in defective resolution of stalled

271 increased AQP2 protein t1/2 and reduced AQP2 ubiquitylation, resulting in greater levels of AQP2 and

272 RQC) pathway stimulates regulatory ribosomal ubiquitylation (RRub) on distinct 40S ribosomal proteins

273 ich catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 comp

274 pport the hypothesis that complex eukaryotic ubiquitylation signalling pathways have developed from c

275 the genome and is controlled by a variety of ubiquitylation signals on substrate proteins.

276 his phenotype to AKT ability to inhibit PCNA ubiquitylation, since the targeted knockdown of PCNA E3-

277 alysis of CSB identified lysine (K) 991 as a ubiquitylation site.

278 tocol termed UbiFast for quantifying ~10,000 ubiquitylation sites from as little as 500 mug peptide p

279 of dynamically regulated phosphorylation and ubiquitylation sites, indicating that dramatic remodelin

280 Therefore, TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal

281 ified a number of influential proteins whose ubiquitylation status is modified during this switch.

282 tin regulatory mechanism whereby histone-H2B ubiquitylation stimulates histone sumoylation, which in

283 eins it is less clear how complex eukaryotic ubiquitylation system arose and diversified from these p

284 RAC2, a novel ubiquitylation target of HACE1, could compensate for the

285 eased degradation of the Mfn2 protein, a key ubiquitylation target of Parkin on mitochondria.

286 Collectively, we expand the catalog of ubiquitylation targets in Arabidopsis and show that this

287 ent of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 an

288 show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole.

289 decades of study, the importance of protein ubiquitylation to peptide generation remains uncertain.

290 hat RNF168 couples PALB2-dependent HR to H2A ubiquitylation to promote DNA repair and preserve genome

291 ich initiates on the vacuole, converges with ubiquitylation to release the vacuole from Myo2.

292 Until now, the regulation that restricts CMG ubiquitylation to termination was unknown, as was the me

293 HeDNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail a

294 emplate switching (TS), are activated by the ubiquitylation (ub) of PCNA through components of the RA

295 Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1)

296 dynamics and specificity of Parkin-dependent ubiquitylation under endogenous expression conditions.

297 ilized reporters that undergo misfolding and ubiquitylation upon removal of a stabilizing ligand to e

298 K-e-GG) have improved the ability to monitor ubiquitylation using mass spectrometry, methods for high

299 its protein half-life through promoting its ubiquitylation via atypical K11-linkage.

300 kb coincided with reductions in histone H2B ubiquitylation within this region.