ライフサイエンスコーパス: ucOC

1 %ucOC values were compared with 140 healthy subjects aged

2 In substudy A, %ucOC decreased with phylloquinone supplementation (P < 0

3 Changes in serum osteocalcin and ucOC are associated with an improvement in insulin secre

4 concentrations were higher (P < 0.001) and %ucOC values were lower (P = 0.001) after the broccoli an

5 osteocalcin concentrations (P < 0.05), and %ucOC was positively associated with NTx and bone-specifi

6 cant difference in plasma phylloquinone and %ucOC between the 2 groups after either the broccoli or o

7 In substudy B, %ucOC decreased in all supplemented groups by week 1 (P f

8 Concomitantly, baseline %ucOC was highest in the young and lowest in the old men

9 Phylloquinone supplementation decreased %ucOC dose-dependently; %ucOC was significantly different

10 mentation decreased %ucOC dose-dependently; %ucOC was significantly different between the 250- micro

11 ship between osteocalcin, or its derivative (ucOC), and glucose homeostasis in this model.

12 Subjects with CF had a higher %ucOC with low [45% (10%, 76%)] and medium [41% (3%, 66%)

13 Despite a decrease of approximately 200% in ucOC concentrations, HOMA-IR was similar in the 2 groups

14 Changes in ucOC concentrations do not alter glucose metabolism in w

15 We determined whether changes in ucOC concentrations in humans were associated with chang

16 % CI: 0.23, 5.52; P = 0.033), and changes in ucOC were linked to a decrease in HOMA-IR (beta coeffici

17 n secretion and action despite reductions in ucOC concentrations.

18 K status (high plasma phylloquinone and low %ucOC) was associated with lower bone resorption and form

19 Among all supplemented groups, mean %ucOC decreased from 7.6% to 3.4% without significant dif

20 hylloquinone concentration and percentage of ucOC) did not change significantly in response to the su

21 Under-gamma-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose

22 Serum undercarboxylated osteocalcin (ucOC) and total osteocalcin, N:-telopeptides of type I c

23 entrations of undercarboxylated osteocalcin (ucOC), in both males and females compared with control l

24 percentage of undercarboxylated osteocalcin (ucOC), was determined in 38 men and women with rheumatoi

25 teocalcin and undercarboxylated osteocalcin (ucOC)], plasma phylloquinone, urinary gamma-carboxygluta

26 ercentage of undercarboxylated osteocalcin (%ucOC) was measured at baseline and weeks 1 and 2.

27 entage serum undercarboxylated osteocalcin (%ucOC), and urinary gamma-carboxyglutamic acid in respons

28 ercentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein

29 ercentage of undercarboxylated osteocalcin (%ucOC)] was measured at baseline in a study of 245 health

30 Total serum osteocalcin, ucOC, glucose, and insulin concentrations were measured

31 placebo or phylloquinone, total osteocalcin, ucOC, glucose, and insulin concentrations and HOMA-IR (1

32 e were no alterations in total or percentage ucOC concentrations during the phylloquinone-restricted

33 In subjects with CF, the median (range) %ucOC was 35% (3%, 76%) and the median (range) for PIVKA-

34 At 6 mo, serum ucOC concentrations in the experimental group were 0.96

35 At 12 mo, serum ucOC concentrations were 0.92 +/- 0.09 ng/mL and 3.13 +/

36 associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6.

37 r islet morphology, demonstrating that while ucOC is impacted by insulin signaling in osteoprogenitor

38 (HOMA-IR) was calculated and correlated with ucOC concentrations.

39 ith plasma phylloquinone and inversely with %ucOC.