ライフサイエンスコーパス: ultimately

1 Ultimately, 1,210 cases and 1,978 controls answered ques

2 Ultimately, a better understanding of how donor intrinsi

3 Ultimately, a randomized controlled trial is needed, exa

4 approach on other neuronal subclasses should ultimately accelerate the comprehensive classification a

5 adenocarcinoma (18.07 to 19.84 per 100 000), ultimately accounting for 22.6% of all rectal cancer cas

6 ed time periods, a cascade of decisions that ultimately accounts for subjects' perceptual reports and

7 ineating the aetiology of UC is necessary to ultimately achieve disease cure.

8 How the numerous mutations in tumor cells ultimately achieve this aberrant production is largely u

9 cited a more limited interferon response and ultimately activated over 2,800 genes, including players

10 nd experts, the decisions for guidelines are ultimately ad hoc.

11 es in management that influence P export can ultimately affect HAB severity.

12 ted to a plethora of regulatory factors that ultimately affect the release of kisspeptin, which modul

13 Ultimately, aggregate science may become an interdiscipl

14 lites might affect microbial communities and ultimately agricultural productivity in two specific sce

15 bution of mTOR to T-cell fate decisions will ultimately aid in the therapeutic targeting of mTOR in h

16 evised model of the marine oxygen cycle will ultimately allow for greater reconciliation among estima

17 These tools will ultimately allow sensitive and systematic quantitation o

18 ntified by whole genome sequencing, and will ultimately allow the study of mutational signatures in l

19 the environment, human health, property and ultimately also on various objects of cultural heritage

20 to carbonic anhydrase inhibitor therapy and ultimately amenable to treatment with intravitreal anti-

21 Ultimately, an understanding of the IgA-Biome may promot

22 Ultimately, apoptosis is an important innate mechanism b

23 ) stress, the unfolded protein response, and ultimately apoptotic cell death in breast and lung cance

24 This nutritional geography ultimately arises from gradients of climate and biogeoch

25 ranscribed RNAs initially stimulate but then ultimately arrest the process.

26 n of European peach germplasm resources and, ultimately, as a true heritage for future generations.

27 t the end of treatment even in patients that ultimately attain a sustained virologic response.

28 un phosphorylation, MMP-2 transcription and, ultimately, BC invasion.

29 anslation of GTs gain pace, success can only ultimately be realised for patients following implementa

30 eded to combat infection, this response must ultimately be terminated to prevent chronic inflammation

31 ndous diversity in eukaryotic life forms can ultimately be traced back to evolutionary modifications

32 p preclinical molecular therapies that could ultimately be translated into human trials that can corr

33 volution of hosts and their phage, which can ultimately be used to design better phage therapeutic tr

34 estriction factor of influenza virus and may ultimately be useful for understanding how to control a

35 driven by terrain, wind and vegetation, and ultimately bear little resemblance to the conditions tha

36 nitially responds to hormonal treatment, but ultimately becomes resistant and requires more potent th

37 systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products wi

38 end-labeling, and protects from DNA damage, ultimately blocking the proneoplastic effects of Nkx3.1

39 an Deltafls2.1/2.2/3 mutant plants, although ultimately, both plants were similarly susceptible.

40 drugs to modulate antibiotic properties and ultimately break antimicrobial resistance.

41 Ultimately, C starvation may lead to increased mortality

42 nutrient stores, impair insulin action, and ultimately cause hyperglycemia, a condition known to imp

43 the accumulation of misfolded proteins that ultimately causes neuronal death in many of these disord

44 ated to the degree of hepatic fibrosis which ultimately causes portal hypertension and gastroesophage

45 rted microbial growth in the dark treatment, ultimately causing slower growth in the light treatment

46 Ultimately, cell cycle progression was impaired at the G

47 complex/C5b9 formations; ROS production; and ultimately cellular death of beta-endorphin neurons.

48 struction of these hippocampal networks, and ultimately clues to their function in adulthood.

49 accumulate at stabilized G-quadruplexes and ultimately collapse.

50 Ultimately, combination therapies addressing multiple as

51 functioning and biodiversity loss, which may ultimately compromise human wellbeing.

52 eled into multiple retinal rod pathways that ultimately connect to cone photoreceptor pathways via Cx

53 overter-defibrillator was considered but was ultimately contraindicated because of right ventricle an

54 oes beyond the computational interest; as it ultimately contributes to the overall cost reduction of

55 nts of synaptic partner choice and therefore ultimately control circuit membership.

56 Microbial communities ultimately control the fate of petroleum hydrocarbons (P

57 es protein binding and receptor trafficking, ultimately controlling synaptic transmission and plastic

58 onstitutes a prominent research frontier for ultimately controlling the electrochemical properties of

59 ent their growth according to gravity, which ultimately controls both shoot and root architecture.(1)

60 lar dialogue with the host epithelium, which ultimately converges on acquired phenotypes associated w

61 o potentially dangerous social situations is ultimately critical for survival.

62 tract facilitates systemic dissemination and ultimately death of infected C57BL/6 mice.

63 be tested, and an even smaller fraction are ultimately deemed therapeutically successful.

64 osomes relative to the crossover site, which ultimately defines the pattern of chromosome segregation

65 d randomized polymer structures before being ultimately degraded back to monomers once the fuel is co

66 DNA (rDNA) and telomere segregation, and it ultimately delays cell division.

67 syndrome (WNS), survival of the species may ultimately depend upon its capacity for adaptive change.

68 histologically defined entity is injury and ultimately depletion of podocytes, highly arborized inte

69 ently increasing thin-filament stiffness and ultimately depressing contractile force and relaxation r

70 cate specimens, like biological tissues, and ultimately destroy the transducer itself limiting the am

71 sure of the epidermis and guard cells, which ultimately determine stomatal pore size and porosity to

72 ode viruses, additional downstream factor(s) ultimately determine the host specificity and range of e

73 tein response (UPR)-a signaling network that ultimately determines cell fate.

74 morphogen sensing by a gene enhancer, which ultimately determines the final global distribution of t

75 patients with advanced HER2(+) breast cancer ultimately develop drug resistance.

76 clarify their mechanisms of toxicity and to ultimately develop safer anti-inflammatory drugs.

77 nd competition for E3 ligases will be key in ultimately developing a global picture of protein homeos

78 odels, elucidating molecular mechanisms, and ultimately developing promising new therapeutic approach

79 For three individuals ultimately diagnosed with metastatic breast, lung, or pa

80 sicular glutamate transporters (VGLUTs) that ultimately dictate glutamatergic output.

81 al pro- and anti-inflammatory roles of C5aR2 ultimately dictates disease outcomes.

82 Acyl flux through this network ultimately dictates the final oil fatty acid composition

83 eening tool for sepsis may miss patients who ultimately die.

84 We ultimately discuss the implications of our findings for

85 ealize new hybrid quantum networks(2,5) and, ultimately, distributed quantum computers(6,7).

86 ucleoporin levels within neuronal nuclei and ultimately downstream neuronal survival.

87 tests and less on the sampling methods that ultimately drive the representativeness of resulting est

88 ctory classification of arbitrary length and ultimately, early prediction of limited-length trajector

89 niche partitioning may relax competition and ultimately elevate population carrying capacity with imp

90 oduction of features at different scales and ultimately enable a more accurate mimicking of the targe

91 l exposures vastly more accessible, it could ultimately enable computational methods for chemical ass

92 of very high target recognition specificity, ultimately enabling femtomolar levels of quantification

93 ar in 44 BCE triggered a power struggle that ultimately ended the Roman Republic and, eventually, the

94 gy dissipation during tunneling events, and, ultimately, energy harvesting at the atomic scales.

95 via the DNA repair mechanism that reads and ultimately erases the oxidized base.

96 d males cooperate, kin-selected benefits are ultimately essential for the maintenance of large coalit

97 ids but for whom an infectious diagnosis was ultimately established, seven (58%) were mNGS positive.

98 Ultimately, every member of a research team has an impor

99 nuation correction of SPECT reconstructions, ultimately evolving to correction techniques that would

100 urnover or greater environmental change, may ultimately explain these results.

101 ion of the nonNLR plant immune receptors and ultimately facilitate informed resistance breeding.

102 aintenance of anonymity, this approach could ultimately facilitate near-real-time diagnosis and thera

103 tially expressed genes within the heart will ultimately facilitate the development of new therapeutic

104 ms with patient-specific disease signatures, ultimately facilitating the identification of new therap

105 roportions of early endpoint responders that ultimately failed and early endpoint non-responders that

106 e chromosome has to accumulate damage before ultimately failing.

107 l cellular signaling pathways are induced to ultimately fend off the attack.

108 d, neuroblasts promote cortex glia growth to ultimately form a selective membrane barrier.

109 o heterodimers (holo alphabeta forms) before ultimately forming insoluble aggregates at higher temper

110 3-dimesitylimidazol-2-ylidene) generates R*, ultimately forming R-R coupled hydrocarbons.

111 ronments, where it leads to entanglement and ultimately fragmentation of the cell body.

112 pport their activation, differentiation, and ultimately function.

113 ts by double-membraned autophagosomes, which ultimately fuse with lysosomes to enable degradation of

114 he transcriptional regulatory processes that ultimately govern stiffness-dependent NSC fate commitmen

115 dentity by exchanging lipophilic substrates, ultimately governing membrane signaling.

116 l vein thrombosis), and will be important to ultimately guide therapy in a more disease-specific mann

117 ecture, self-assembly and chemical behavior, ultimately guiding the choice of appropriate application

118 en those subjects who chose prosocially were ultimately happier if they ended up getting the money fo

119 cancer (CRC) has been established, which may ultimately help to individualize CRC therapy.

120 he key mitotic kinase, Cyclin B1:CDK1, which ultimately helps to inhibit its own degradation.

121 Management decisions in such cases ultimately hinge on individualized consideration of the

122 Intriguingly, many of these functions ultimately impinge on cell fate decisions via apoptosis-

123 vely informs health care decision making, to ultimately improve caries outcomes.

124 n many different high-throughput settings to ultimately improve power.

125 e subspecialty of transplant nephrology will ultimately improve the lives of patients suffering from

126 en up new avenues for investigation that may ultimately improve the outlook for people living with di

127 xico whence it was transported to Europe and ultimately improved into one of our favorite foods.

128 designs for precision applications, thereby ultimately improving patient outcome overall.

129 n effort to lower implementation barriers to ultimately improving power assessment in mediation studi

130 Ultimately, in synthesizing this literature, we argue fo

131 oylacetic acid transport in root tips, which ultimately increased root growth and drought resistance.

132 n increased rate of electron transfer, which ultimately increased the measured defluorination rate.

133 could be driving the behavior of An. cruzii, ultimately increasing its contact with humans.

134 ld be utilized and what the reported results ultimately indicate or, perhaps more importantly, what t

135 This ultimately induces osteogenic fate commitment.

136 lose contact along transmembrane helix 6 and ultimately inducing conformational rearrangements in the

137 ccumulation of misfolded protein aggregates, ultimately inducing immunogenic cell death in dMMR cance

138 ute towards understanding processes that can ultimately influence diapause timing.

139 ductase DsbD (nDsbD), introduces frustration ultimately influencing protein function.

140 spond to stimuli and produce neurochemicals, ultimately influencing the brain-gut-microbiome axis of

141 e surfaceome during homeostasis and disease, ultimately informing therapeutic development.

142 sms that process nociceptive information and ultimately instantiate a subjectively available experien

143 Progressive gastritis and, ultimately, intestinalized spasmolytic polypeptide-expre

144 ric fever field to accelerate, validate, and ultimately introduce 1 (or more) of these methods to fac

145 spective antigen-presenting molecules, which ultimately is associated with differing disease penetran

146 ahepatic and extrahepatic biliary cells, and ultimately larval lethality.

147 nd the TME may reduce treatment efficacy and ultimately lead to acquired drug or radio resistance.

148 ectly detect shear stress profiles that will ultimately lead to atheroprotective or atherogenic respo

149 omplex series of pathological processes that ultimately lead to death.

150 initial efficacy of targeted therapies could ultimately lead to prolonged treatment responses in canc

151 spatial cues that enable MICOS assembly and ultimately lead to proper physical and functional organi

152 y a novel host-microbe interaction which may ultimately lead to the development of a microbial peptid

153 Our findings could ultimately lead to the development of new immunotherapie

154 exon eight skipping in most mRNA molecules, ultimately leading to a truncated TANGO1 protein was ide

155 function of NAc and related reward circuits, ultimately leading to addictive behaviors.

156 thus impairing its interaction with BCL2 and ultimately leading to an increase in cellular apoptosis.

157 with biochemical and behavioral adaptations ultimately leading to enhanced sensitization of reward c

158 ilized by the addition of a second molecule, ultimately leading to full decoration of the actin filam

159 ation orientations within LCR22A and LCR22D, ultimately leading to NAHR.

160 premature zymogen activation, and necrosis, ultimately leading to pancreatitis.

161 bacterial load and exacerbated organ damage, ultimately leading to premature deaths.

162 ection of malignant cells from chemotherapy, ultimately leading to relapse.

163 lysis to large-scale conformational changes, ultimately leading to substrate translocation across bio

164 mesodermal rather than neural fate(7), this ultimately leads to activation of mesodermal transcripti

165 ation of neuroinflammation during SAE, which ultimately leads to delirium and cognitive dysfunction,

166 lytic function and promote cell death, which ultimately leads to fewer T(RM) cells in the lung.

167 crostructure and properties of the host, and ultimately leads to structural disintegration at the int

168 Perception of cytokinin ultimately leads to the activation of proteins belonging

169 he precise wiring of the nervous system that ultimately leads to the generation of complex functions

170 rastic revision of the synthetic design that ultimately led to the development of a novel stepwise cy

171 revealed a number of enriched features which ultimately led to the discovery of a 1 nM inhibitor of t

172 Such an exercise has ultimately led to the realization that we still have man

173 1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment of granulocytic myeloi

174 details of the evolution of strategies that ultimately led to the total synthesis of phomactins A, K

175 uasiparticle density, which we predict would ultimately limit the coherence times of superconducting

176 This competition ultimately limits the rate of formin-mediated elongation

177 Ultimately, linking the engineered niches with advances

178 Developing a causal physics-based model that ultimately links descending vocal motor control to tissu

179 Ultimately, material fabrication and exploration of inte

180 ng long-term critical research in the field, ultimately maximizing the return on investment: scientif

181 nal design of optimized ThyX inhibitors that ultimately may serve as antibiotics.

182 Of the 3948 articles identified, 24 ultimately met the inclusion criteria.

183 matory cascade, apoptosis, genotoxicity, and ultimately necrosis of neuronal cells.

184 Ultimately, NO accumulation leads to suppression and los

185 Reported in Nature, this system may ultimately pave the way to study human intestinal develo

186 ependent manner by creating linkers that can ultimately perform logical operations at the molecular l

187 of this immune-related adverse event and to ultimately predict or prevent its development, but also

188 was used to train a classification model to ultimately predict the impact of unknown compounds on th

189 rstanding the drivers of this variation and, ultimately, predicting the outcome of infection.

190 ch cases, the presence of armed conflict may ultimately prevent incursions to a greater extent than t

191 cing mortality, would also be ineffective in ultimately preventing ICUs from becoming overwhelmed and

192 xing to >110 samples representing 15 organs, ultimately profiling ~4 million single cells.

193 cells into a pre-metaplastic phenotype that ultimately progressed to metaplasia.

194 h promote hypertension and organ damage, and ultimately progressive kidney failure.

195 Ultimately, projections of end of century upper trophic

196 intenance of mitochondrial respiration, thus ultimately protecting the fetus from the potentially dir

197 SAED ultimately proved the complete transformation of face-ce

198 prove communication between stakeholders and ultimately provide a clearer interpretation of patient e

199 omains and its relation to phase separation, ultimately providing a platform for identifying the key

200 e for analyzing a large panel of pesticides, ultimately providing us the opportunity to evaluate the

201 pel the Ca battery technology to reality and ultimately reach its full potential for energy storage.

202 partners, and policy makers are critical to ultimately reduce the burden of cardiovascular disease a

203 n lactate transport, reduced glycolysis, and ultimately reduced cell proliferation.

204 esponsible for cleaving the Ar-F bond and is ultimately regenerated using H(2) and base.

205 The diagnosis of HFpEF is challenging and ultimately relates to the conceptual definition of heart

206 The deployment of BECCS is ultimately reliant on the availability of sufficient, su

207 minant polycystic kidney disease (ADPKD) and ultimately renal failure.

208 Redistribution ultimately renders the donating optic nerve vulnerable t

209 in proliferation, apoptosis, and cell death ultimately renders them hot targets in cancer therapy.

210 The achievement of terminal differentiation ultimately requires the in vivo transplantation of, usua

211 function of tumor-specific CD4 T cells, and ultimately requires tumor-intrinsic IFN-gamma signaling,

212 mpts at medical and surgical management, and ultimately requiring allograft nephrectomy.

213 d precision (guided by the radioisotope) and ultimately resected under real-time optical guidance (fl

214 ofibroblasts are scar-forming cells that are ultimately responsible for the excessive synthesis, depo

215 to an increased concentration of defects and ultimately result in a large temperature spread of the a

216 FDA) new-drug application (NDA) process that ultimately resulted in approval of (68)Ga-DOTATOC in Aug

217 o result in steady shrinkage of the cell and ultimately resulted in hemolysis.

218 to a sedentary agricultural lifestyle, which ultimately resulted in the development of complex societ

219 ssfully drives intratumoral cDC1 maturation, ultimately resulting in durable tumor cures.

220 ins in spectrum of inhibition were achieved, ultimately resulting in QPX7728 (35).

221 ion of the head and pharyngeal muscle cells, ultimately resulting in rapid necrosis of the entire ner

222 ck autophagosome accumulation and mitophagy, ultimately resulting in reduced axonal mitochondrial con

223 membrane proteolysis of the sigma regulator, ultimately resulting in transcriptional regulation.

224 that they exhibit unique LTR dynamics, which ultimately results in differences in the magnitude of vi

225 Activation of caspases ultimately results in programmed execution of cell death

226 The peroxidase activity ultimately results in the release of cyt c into the cyto

227 sma kallikrein directly activates FIX, which ultimately results in thrombin generation.

228 UV-illumination ultimately results to resistive switching, without invol

229 onstrate that domain wall profile shapes are ultimately sensitive to the nature of the order paramete

230 nt methylation of two 16S rRNA residues, and ultimately serves to coordinate subunit joining through

231 We ultimately show that species interactions can be importa

232 but reporting on the distribution of values, ultimately showing how bulk properties arise from the co

233 DEC-205 using solution-based techniques and ultimately solved the 4.9 angstrom cryo-EM structure of

234 While the best interventions to control and ultimately stop the pandemic are prophylactic vaccines,

235 ailed and early endpoint non-responders that ultimately succeeded were similar (6.0% vs 8.4%, respect

236 acturers in a single study population, which ultimately supported first-in-class FDA clearance for ex

237 y coordinated non-lytic cell death response, ultimately supports the inflammatory breakdown of infect

238 nd understanding of disease pathogenesis and ultimately targeted therapies.

239 Ultimately, TBL1XR1 alterations lead to a striking extra

240 activation by host cellular kinases to yield ultimately the bioactive nucleoside analogue triphosphat

241 transcription and nuclear organization, and ultimately the function of a cell.

242 nderlie the altered regulatory phenotype and ultimately the pathogenesis of DCM.

243 te reimbursement/cost-offsetting models, and ultimately, the active participation of pathologists to

244 Ultimately, the approach will allow many more placentas

245 to be done over the next few years so that, ultimately, the benefits of genetic and genomic research

246 Ultimately, the combination of controlled release micros

247 Ultimately, the combination of expanded treatment option

248 vels of NAD(+) impair energy generation and, ultimately, the core kidney function of selective solute

249 Ultimately, the development of new synthetic methods to

250 Ultimately, the differing proteome and biologic processe

251 Ultimately, the findings from this study help us underst

252 Ultimately, the high detection sensitivity and separatio

253 Ultimately, the incorporation of big data and experiment

254 Ultimately, the lack of AMPKbeta1 impairs, whereas defic

255 Ultimately, the methodology and results from this study

256 Ultimately, the recent collapse of most agricultural bel

257 Ultimately, the synthesis of Pu-UiO-66 demonstrates adep

258 The persistence of viral pathogens, and ultimately their ecology and dispersion, hinges on their

259 Ultimately, these findings illustrate a potential decoup

260 Ultimately, these findings support the use of weedmats i

261 Ultimately, these molecular models deepen our understand

262 Ultimately, these results suggest that, by modulating pa

263 ity of states) when 2D materials are used as ultimately thin interfaces.

264 pqm-1 mutants increase survival of mothers, ultimately this loss is detrimental to progeny survival.

265 Ultimately this represents a quantum electrodynamic syst

266 Ultimately, this approach can accelerate the development

267 Ultimately, this generates chromosomal abnormalities and

268 Ultimately, this in-depth study unravels the principles

269 Ultimately, this led to deficient oxidative phosphorylat

270 Ultimately, this MS(n) platform paired with ion/ion chem

271 Ultimately, this strategy failed to protect macaques fro

272 Ultimately, this study demonstrated the utility of condu

273 Ultimately, this technique enables three-dimensional man

274 Ultimately, this would enable mechanism-based stratifica

275 populations could further fragmentation, and ultimately threaten population stability as seen in othe

276 Ultimately, through ongoing research and increased clini

277 ch reaction in the cascade in a cellular and ultimately tissue context, toward deciphering the connec

278 t on occult micrometastatic disease, leading ultimately to a better outcome.

279 in the services that ecosystems support, and ultimately to impacts on human health and society.

280 eloped, first to synthesize single genes but ultimately to massively edit or write from scratch entir

281 eam propagation of preBotC network activity, ultimately to motoneurons, is dependent on the strength

282 aryl silyl ethers), to phenolate salts, and ultimately to simply unprotected phenols, sorted by the

283 s developed to predict patient response and, ultimately, to help select those most likely to benefit.

284 isintegration, alveolar bone resorption, and ultimately tooth loss.

285 ake interactions lead to fault weakening and ultimately triggering larger earthquakes later in the pr

286 in 80%-90% of patients, the explored LNs are ultimately tumor-free, meaning most patients are unneces

287 Ultimately, two major approaches were selected: (1) the

288 Ultimately, type I and III IFN signaling drove the expre

289 eas given their extensive recurrence, and of ultimately understanding how odor representations are li

290 ar composition of the immune environment and ultimately, vulnerability to CBT.

291 Ultimately, we demonstrate that ecosystem photosynthesis

292 Ultimately, we discuss how some highly conserved DNA MTa

293 Ultimately, we envision providing better access to cutti

294 Ultimately, we identified 399 compounds with EC(50) <= 5

295 Ultimately, we show that an as-yet-unidentified nonsecre

296 ription of ligand-receptor interactions that ultimately will inform new approaches to structure-based

297 Combination of these strategies ultimately will lead us closer to the large-scale applic

298 ptimization of microelectronic circuits and, ultimately, wireless communication capabilities, have pr

299 ence is driven by a gene-tracking allele and ultimately with outputs of other means of spatial mappin

300 energy and electron transfer reactions that ultimately yield charge separated states with lifetimes