ライフサイエンスコーパス: unanswered question

1 osin II within the animal cell CR remains an unanswered question.

2 hich variants lead to CKD remains a critical unanswered question.

3 tream at the ERC or remains segregated is an unanswered question.

4 occurred during planet formation remains an unanswered question.

5 evolved endothermy remains an important but unanswered question.

6 elerated to relativistic energies remains an unanswered question.

7 how important this constraint is remains an unanswered question.

8 muscles of different sizes is an essentially unanswered question.

9 ithin an intact epithelium is a central, yet unanswered question.

10 te such subcellular scaling is a fundamental unanswered question.

11 crease cancer risk has remained an important unanswered question.

12 tein (Cos2/Kif7) binding partners is a major unanswered question.

13 -strand break (DSB) is a central and largely unanswered question.

14 allo-sensitization is a clinically important unanswered question.

15 but the mechanism of their recruitment is an unanswered question.

16 ng mammalian CNS is an important but largely unanswered question.

17 ack loop is first triggered is a fundamental unanswered question.

18 ions or vice versa remains a provocative and unanswered question.

19 mportance for cellular physiology is a major unanswered question.

20 enced-based data regarding this longstanding unanswered question.

21 mmit to differentiation is a fundamental yet unanswered question.

22 in a rational, bottom-up manner is a largely unanswered question.

23 it can be adopted at target hospitals is an unanswered question.

24 ces its post-saccadic processing is still an unanswered question.

25 plan is programmed remains a fundamental yet unanswered question.

26 transport and cargo export, is a fundamental unanswered question.

27 e affected, and how many, remains a critical unanswered question.

28 are dynamic on short time scales remains an unanswered question.

29 ong the reaction coordinate is a fundamental unanswered question.

30 regulation of FAHFAs remains a pressing but unanswered question.

31 ISA from the vast molecular space remains an unanswered question.

32 imes has multiple discharges to ground is an unanswered question.

33 ain access to chromatin remains an important unanswered question.

34 marize the recent advances and highlight key unanswered questions.

35 the need of studies aimed to answer multiple unanswered questions.

36 impacts early development remain important, unanswered questions.

37 ecent advances in this area and identify key unanswered questions.

38 and molecular biology tools to explore many unanswered questions.

39 and proliferation of cells remain important unanswered questions.

40 ea, highlighting key findings and some major unanswered questions.

41 nization of the chromatin all remain largely unanswered questions.

42 own and knockout murine phenotypes have left unanswered questions.

43 tenuate or augment lifespan remain important unanswered questions.

44 d in which neurons they function are largely unanswered questions.

45 , including developing new models to address unanswered questions.

46 tastasis in different cancer types have left unanswered questions.

47 This report is concerned with two unanswered questions.

48 tive GTPase domain play in RHD3 function are unanswered questions.

49 G-specific function and articulate important unanswered questions.

50 rk in this domain by addressing two thus far unanswered questions.

51 the tail and CHD work together are critical unanswered questions.

52 to advance this research field and describe unanswered questions.

53 for clinicians and patients alike, with many unanswered questions.

54 rovide speculative models that address these unanswered questions.

55 tor in mice and humans, still raised several unanswered questions.

56 repair and stimulate further thought on many unanswered questions.

57 different species and highlighting important unanswered questions.

58 ctions control mitosis, as well as important unanswered questions.

59 remains unclear, with several long-standing unanswered questions.

60 xisting conditions are important and largely unanswered questions.

61 onse rate (95.85%) and the low percentage of unanswered questions (0.4-2.7%).

62 The present study investigates three unanswered questions: 1) Do adipose-resident T cells (AR

63 A fundamental unanswered question about bacterial MCPs is how enzymes

64 One unanswered question about ferrochelatase involves defini

65 One important but largely unanswered question about floristic responses to climate

66 The basic, still unanswered question about visual object representation i

67 This review also discusses some of the major unanswered questions about Ag-NPs, which, when answered,

68 enetics and propose a roadmap for unraveling unanswered questions about BAV through the integrated an

69 poxviral infection, and identify a number of unanswered questions about EV.

70 d host defence mechanisms, there remain many unanswered questions about fundamental processes involve

71 is noteworthy for calling attention to still unanswered questions about how the historical events of

72 on of research activities, but has left many unanswered questions about how this regulation functions

73 ed the field forward, and summarize some key unanswered questions about koniocellular pathways.

74 spite decades of study, there are still many unanswered questions about metastasis, the process by wh

75 There are many unanswered questions about the environmental fate and me

76 There are many unanswered questions about the evolution of the ancient

77 ances are accompanied by a growing number of unanswered questions about the function of the individua

78 However, there remain unanswered questions about the mechanism of channel open

79 ins unknown and adds a new dimension to many unanswered questions about the mechanism of DSB repair.

80 e anatomical features of turtles have raised unanswered questions about the origin of their unique bo

81 There are many unanswered questions about the population history of the

82 There are many unanswered questions about the role of imaging in defini

83 lene play critical roles but there are still unanswered questions about these and other TFs.

84 The review identifies important unanswered questions about these cells regarding their o

85 To resolve unanswered questions about these inhibitors, we develope

86 regulation of these functions, and the many unanswered questions about this largely unexplored mecha

87 rable attention to DNA looping by LacI, many unanswered questions about this mechanism, including the

88 We highlight unanswered questions about this remarkable cellular stru

89 ired bona fide neuronal subgroups remains an unanswered question and one important for validating ste

90 A number of unanswered questions and challenges remain, such as how

91 future directions for inquiry, highlighting unanswered questions and conceptual issues concerning ho

92 ent and function, as well as other currently unanswered questions and controversies in the field are

93 e initiation and progression, there are many unanswered questions and emerging facets of miRNA biolog

94 ut not supported by recent data, and discuss unanswered questions and future directions for research.

95 By identifying key unanswered questions and gaps in clinical data, it will

96 ew therapeutics and vaccines, and highlights unanswered questions and priorities for research, improv

97 nsequences, diagnosis and treatment), define unanswered questions and provide a road map toward their

98 atients who die in the ICU often remain with unanswered questions and suffer from lack of closure.

99 ese neuropeptides and outlines the important unanswered questions and testable hypotheses.

100 y known about depression in glioma, the main unanswered questions and the types of studies that shoul

101 w all available lines of evidence, delineate unanswered questions, and develop, if it seemed reasonab

102 ssue of the JCI, identify a number of as yet unanswered questions, and discuss some of the therapeuti

103 Here, we analyze the recent advances, unanswered questions, and potential of BacNa(V)s as temp

104 lance, 5) interventions, and 6) limitations, unanswered questions, and resource and policy needs.

105 Here we highlight some unanswered questions, and some promising areas for resea

106 We discuss advances and the unanswered questions, and ways in which progress might b

107 Two key unanswered questions are (1) whether short-term temperat

108 Important unanswered questions are whether TRPV1(+) neuron activat

109 in primary neurons is controversial, leaving unanswered questions as to how and where Parkin-mediated

110 young and aged humans, there are still many unanswered questions as to how the genetic pathways that

111 Unanswered questions as to the regulatory mechanisms and

112 Here we detail recent advances and unanswered questions at the intersection between inflamm

113 rd specific B-cell subsets in the embryo are unanswered questions, because the systemic circulation i

114 those in other midline models and highlight unanswered questions both for retinal axon growth and ax

115 This review highlights unanswered questions, challenges, recent advances, unres

116 Major unanswered questions concern the nature of the endogenou

117 An unanswered question concerning prevalence and disease se

118 ression in the brain poses an intriguing yet unanswered question concerning their roles in the nervou

119 ponse to infection; however, there are still unanswered questions concerning SARS-CoV pathogenesis.

120 ess could be adaptive in vivo, are two major unanswered questions concerning this process.

121 handful of plant ARF-GEFs, a fundamental yet unanswered question concerns the extent to which their f

122 A major unanswered question concerns the mechanism by which the

123 ermanent microbial habitat; thus, an age-old unanswered question concerns the origin of fruit and fer

124 A foundational unanswered question concerns whether different domains o

125 We addressed the critical but unanswered question, does network structure explain demo

126 emokine recognition has been a long-standing unanswered question due to the challenges of structure d

127 A very important unanswered question, especially in the very elderly, is

128 ymmetric gut morphogenesis and highlight key unanswered questions for future investigation.

129 ically ill adults and highlights fundamental unanswered questions for future research about fluid the

130 renal disease are discussed, and we explore unanswered questions for future research.

131 on these factors, and to highlight important unanswered questions for the field.

132 Since their discovery in 1958, a fundamental unanswered question has been how electrons can be accele

133 st research effort, guided by a focus on key unanswered questions, has the potential to yield high-im

134 ble of tumor initiation raised two important unanswered questions: how do PGCCs acquire such stemness

135 An unanswered question, however, is how the activity of a p

136 An important unanswered question, however, is whether aPFC is a homog

137 One important unanswered question, however, is whether these strategie

138 A major unanswered question, however, relates to how positive al

139 A major unanswered question in biology and medicine is the mecha

140 ogress to clinical relevance remains a major unanswered question in cancer biology.

141 cle traffic is achieved remains an important unanswered question in cell biology.

142 An important unanswered question in chromatin biology is the extent t

143 An unanswered question in developmental physiology is to wh

144 efits of biodiversity remain a critical, but unanswered question in ecology.

145 echanisms regulates this enzyme, and a major unanswered question in glucokinase biology is how post-t

146 An unanswered question in neuroscience concerns which dimen

147 A major unanswered question in neuroscience is whether there exi

148 represented within the brain is an important unanswered question in neuroscience.

149 A key unanswered question in plant biology is how a plant regu

150 both mechanisms is required, has remained an unanswered question in radiation belt physics.

151 A key unanswered question in SCA3 and other polyglutamine dise

152 A central unanswered question in stem cell biology, both in plants

153 An essential unanswered question in the design of carbon monoxide rel

154 A major unanswered question in the field is how expression of th

155 fall experiences booms and busts, remains an unanswered question in the field of global change biolog

156 One fundamental unanswered question in the field of polyglutamine diseas

157 This has become a long-standing unanswered question in the fragile X field, which is als

158 ifying a suitable mechanism has become a key unanswered question in the origin of life.

159 An unanswered question in the SMR field is how the dimeriza

160 Why we sleep remains one of the enduring unanswered questions in biology.

161 Yet, the breadth of important unanswered questions in ccRCC research far exceeds the a

162 to begin to address some of the fundamental unanswered questions in epilepsy, to dissect epileptic n

163 One of the major unanswered questions in evolutionary biology is when and

164 One of the critical unanswered questions in genome biophysics is how the pri

165 d by newly developed technologies to address unanswered questions in high-altitude adaptation at a ge

166 th state-of-the-art genetic tools to address unanswered questions in melanoma in vivo See related com

167 kling and we conclude by listing a series of unanswered questions in microbial symbiosis that can pot

168 discussed the current state of knowledge and unanswered questions in order to propose therapeutic app

169 definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing.

170 One of the central unanswered questions in prostate cancer research is the

171 We will conclude with a discussion of unanswered questions in redox signalling in skeletal mus

172 icle concludes with an overview of important unanswered questions in SSc research that might inform t

173 We also discuss some of the key unanswered questions in the field of DNA methylation and

174 ene promoters they control, and we highlight unanswered questions in the field, such as the potential

175 ow it influences cellular function are major unanswered questions in the field.

176 e development of AD, and highlight important unanswered questions in the field.

177 these areas and conclude with challenges and unanswered questions in the field.

178 rmalities characterizing ASRD and highlights unanswered questions in the literature and potential fut

179 Two unanswered questions in the proposed mechanistic pathway

180 tive, we highlight recent advances and major unanswered questions in the realm of bacterial vector-bo

181 nsights and provides a perspective on future unanswered questions in this exciting field.

182 l of providing insights into some of the key unanswered questions in this field.

183 genome for damage is one of the fundamental unanswered questions in this field.

184 te and efficiently identify solutions to the unanswered questions in urology cancer care.

185 This review discusses key unanswered questions in ZIKV immunity and in the pathoge

186 Unanswered questions include the number and effect sizes

187 Unanswered questions include those relating to the diver

188 identify recent evidence in order to address unanswered questions including the accuracy and effectiv

189 amin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a p

190 This mutant enables new research into unanswered questions, including the existence of potenti

191 itophagy to neurodegenerative processes, and unanswered questions inspiring future research that woul

192 f such transitions in gene activity, a major unanswered question is how cells regulate the timing of

193 A key unanswered question is how cellular EADs partially synch

194 A major unanswered question is how division plane orientation is

195 One unanswered question is how infection is controlled and c

196 A key unanswered question is how lymphatic reprogramming by th

197 An unanswered question is how plants might overcome pathoge

198 An unanswered question is how polar septation activates a t

199 Yet an unanswered question is how the transfer of information b

200 A fundamentally important, presently unanswered question is if nucleation begins as classical

201 A major unanswered question is the mechanism of MDV-induced tumo

202 y the identity of the NR2 subunit, a crucial unanswered question is the role of subunit composition i

203 An unanswered question is therefore: Are universally prefer

204 le reduction of pain is important, a largely unanswered question is what other benefits NGF blockade

205 An unanswered question is whether an altered repertoire of

206 However, a fundamental unanswered question is whether cell sorting is dictated

207 An important unanswered question is whether ICAM-1-activated signalin

208 A key unanswered question is whether IgG4, a relatively weak a

209 A key unanswered question is whether infection with SARS-CoV-2

210 A longstanding, unanswered question is whether nuclear organization is s

211 A major unanswered question is whether pharmacological inhibitio

212 A major unanswered question is whether plasma exchange is effect

213 One unanswered question is whether risk-taking preference is

214 However, a key unanswered question is whether sparing or sharing farmin

215 A key unanswered question is whether systemic GM-CSF (sargramo

216 A critical unanswered question is whether task set shifts in these

217 A key unanswered question is whether the circadian oscillation

218 A more basic, yet unanswered question is whether the Met(20) loop adopts a

219 A critical unanswered question is whether the MinION and its protei

220 However, a crucial, but previously unanswered question is whether the nucleation and growth

221 An unanswered question is whether the sgmRNAs, which appear

222 A long-unanswered question is whether these local transient hem

223 However, a critical and largely unanswered question is whether these models generalize f

224 One key unanswered question is whether we can select for a plant

225 Therefore, an unanswered question is why a current/former smoker of ab

226 s context, one of the most important and yet unanswered questions is whether and how HNO is produced

227 Nevertheless, unanswered questions need to be addressed in clinical tr

228 dian homeostasis in other tissues remains an unanswered question of conceptual and biomedical importa

229 icide clusters are seriously hampered by the unanswered question of why such outbreaks occur.

230 I further consider the as-yet unanswered questions of how much of the mind and brain a

231 recent findings as well as to highlight key unanswered questions of the field.

232 Despite this many unanswered questions on its cause, management and outcom

233 acute diarrheal disease, yet there are many unanswered questions on norovirus immunity, particularly

234 known about ColdU, and we present important unanswered questions on the epidemiology, underlying pat

235 We suggest that identifying key unanswered questions on the relationship between science

236 The current dilemmas, unanswered questions, operational issues, challenges, an

237 This unanswered question originated with the idea of ecologic

238 egulation in the heart, there are still many unanswered questions, particularly concerning mitochondr

239 throughout the world, and yet there are many unanswered questions regarding both the mechanisms of th

240 We pose unanswered questions regarding HCC susceptibility and pa

241 bal proteomics have the potential to address unanswered questions regarding microRNA-mRNA interaction

242 er-forming and membrane protein pilins leave unanswered questions regarding pilin structures, assembl

243 gaps in current knowledge and focused on the unanswered questions regarding pulmonary AMR.

244 Unanswered questions regarding RSV epidemiology need to

245 e of Cx-based channels, there are still many unanswered questions regarding structure-function relati

246 eview will discuss current knowledge and key unanswered questions regarding the blood-brain barrier i

247 One of the primary unanswered questions regarding the dispersal of Romani p

248 Despite its importance, there are still many unanswered questions regarding the formation and evoluti

249 ells is still under investigation, with many unanswered questions regarding the interaction of virus-

250 s of YD-boundary nanodiamonds have left many unanswered questions regarding the nature and occurrence

251 There are still many unanswered questions regarding the precise physiological

252 We also discuss major unanswered questions regarding the role that defects in

253 However, there are several unanswered questions regarding the sources of Earth's vo

254 One of the most challenging unanswered questions regarding the structural biology of

255 ve evolutionary approaches, we discuss major unanswered questions regarding their functional and comp

256 ation systems, and suggest the most pressing unanswered questions related to understanding these impo

257 Unanswered questions remain about how common chronic rar

258 Many unanswered questions remain about how to design duty-hou

259 Unanswered questions remain about the interactions betwe

260 air deficient (MMRD) solid tumors, important unanswered questions remain about the role of immune che

261 late (OCP)(-) is not well explored, and many unanswered questions remain about this ligand in this co

262 Many unanswered questions remain and additional work is requi

263 and experimental structure-function studies, unanswered questions remain regarding the transport mech

264 Although an evidence base exists, unanswered questions remain regarding the use of thrombo

265 broad literature describing p53 binding DNA, unanswered questions remain, due partly to the need for

266 However, important unanswered questions remain--for example, we do not know

267 ed trials exist in this area of medicine and unanswered questions remain.

268 ried protocols for administration; thus many unanswered questions remain.

269 trials are currently underway and important unanswered questions remain.

270 nterconnected pathways, and identify the key unanswered questions remaining in this field.

271 There are a number of unanswered questions remaining, however, which will need

272 re effective; however, there are many as yet unanswered questions such as why some patients with vest

273 dard and novel therapies are promising, many unanswered questions, such as duration of therapy and op

274 ity of the response to asbestos and the many unanswered questions suggested the need for a systems bi

275 tically ill patients, presents the facts and unanswered questions surrounding gut-derived sepsis, and

276 Here, we review the available data and unanswered questions surrounding hospital-acquired pneum

277 However, there are still unanswered questions surrounding PARP inhibitors, namely

278 There remain unanswered questions surrounding surgical checklists as

279 explore the history, recent discoveries, and unanswered questions surrounding the relationship betwee

280 ns from a structural prospective and discuss unanswered questions surrounding this fascinating class

281 controls these logical processes remains an unanswered question that has been merely superficially a

282 ese activities and loop formation is another unanswered question that should keep investigators occup

283 y and immunodeficiency, and pose a series of unanswered questions that are expected to be central in

284 There are still many unanswered questions that challenge our understanding of

285 We conclude by discussing the critical unanswered questions that face this field in the coming

286 timing of ERK activation remain fundamental unanswered questions that limit understanding of how arr

287 of this signaling module as well as several unanswered questions that may guide future investigation

288 of JAK2-targeted therapy, and the important unanswered questions that need to be addressed to improv

289 areas of analysis to explore the expanse of unanswered questions that remain regarding the phenomena

290 fic agent and this one trial or the numerous unanswered questions that remain, BETs have emerged as n

291 en conquered, there are critically important unanswered questions that remain.

292 This paper presents nine unanswered questions that researchers and educators migh

293 making it possible to begin to address major unanswered questions: the extent of natural methylation

294 to modulate the microbiome, and present key unanswered questions to be addressed in ongoing and futu

295 aw attention to new findings and some of the unanswered questions, unresolved issues, and controversi

296 acity electrodes with anionic redox, a still unanswered question was remaining regarding the importan

297 wever, the field is grappling with a central unanswered question: what exactly is a cell type?

298 a patient case that illustrates two of many unanswered questions: which sarcoma patients are most li

299 mitochondrial dynamics emerged and consider unanswered questions whose dissection might lead to mito

300 tists are hopeful that many of the currently unanswered questions will be addressed.