ライフサイエンスコーパス: uncharacterized

1 ut the enzymes catalyzing N-acylation remain uncharacterized.

2 (28) -dependent promoter recognition remains uncharacterized.

3 nd morphology is causal in longevity remains uncharacterized.

4 ir interactions with bacteria remain largely uncharacterized.

5 thout synaptic function and several that are uncharacterized.

6 stasis-intrinsic dependencies remain largely uncharacterized.

7 Sox10-dependent tumorigenesis remain largely uncharacterized.

8 er, brain lipid bioenergetics remain largely uncharacterized.

9 of fruit ripening by calcium remains largely uncharacterized.

10 omic systems, but most plant proteins remain uncharacterized.

11 ded for maintaining yeast prions are largely uncharacterized.

12 on during microbial infection remain largely uncharacterized.

13 half of apicomplexan proteins are unique and uncharacterized.

14 the maternal immune response remains largely uncharacterized.

15 rdiovascular biology and disease are largely uncharacterized.

16 disorders and cancer but it remains largely uncharacterized.

17 ct systems, multiple CRISPR-Cas types remain uncharacterized.

18 ctural interaction between m102.4 and NiV is uncharacterized.

19 s with other diverse partners remain largely uncharacterized.

20 cognitive skills during development remains uncharacterized.

21 t mitotic checkpoint function remain largely uncharacterized.

22 osphatases that dephosphorylate Atg13 remain uncharacterized.

23 rious MGEs for functions that remain largely uncharacterized.

24 he signals that regulate them remain largely uncharacterized.

25 ng proviral landscape in ART-treated NHPs is uncharacterized.

26 ations in GLDC, of which 206 remain entirely uncharacterized.

27 mulating these substantial Suc levels remain uncharacterized.

28 d cancer initiation, yet they remain largely uncharacterized.

29 hese metabolites on host pathways is largely uncharacterized.

30 echanisms of ZIP transporters remain largely uncharacterized.

31 underlying these properties are still mostly uncharacterized.

32 of the underlying T cell repertoire remains uncharacterized.

33 as cAMP-dependent signal transducers remains uncharacterized.

34 ranscription via mechanisms that are largely uncharacterized.

35 o other CD4(+) T cell subsets remains mostly uncharacterized.

36 mammalian organ development remains largely uncharacterized.

37 al functions in beta-cells remain relatively uncharacterized.

38 es in body weight and energy balance remains uncharacterized.

39 ble sex-determining genetic pathways remains uncharacterized.

40 within water storage sediment remain largely uncharacterized.

41 e methyltransferases of both pathways remain uncharacterized.

42 duals with NPS-TTD have remained genetically uncharacterized.

43 chanisms in the cytoplasm remains relatively uncharacterized.

44 n nature, but its enzymatic pathway is still uncharacterized.

45 ose contributions to cocaine aversion remain uncharacterized.

46 nocifensive responses have remained largely uncharacterized.

47 V), but candidate genes in these loci remain uncharacterized.

48 differentiation at a population level remain uncharacterized.

49 e NS levels and pathway flux remains largely uncharacterized.

50 antipodal metabolites, have remained largely uncharacterized.

51 ide bio-diversity but remained nutritionally uncharacterized.

52 found in members of phylum Bacteroidetes, is uncharacterized.

53 and unfavorable interactions are relatively uncharacterized.

54 d severity of these diseases remains largely uncharacterized.

55 he context of viral infection remain largely uncharacterized.

56 structures where Ca(2+) signaling is largely uncharacterized.

57 finished chocolate is anecdotal and largely uncharacterized.

58 influence of SOR on T cell immunity remains uncharacterized.

59 and yet, its genomic targets remain largely uncharacterized.

60 et half of their protein-coding genes remain uncharacterized(1,2).

61 Here, we discover that a previously uncharacterized 54-amino acid microprotein PIGBOS regula

62 To this end, we investigated the role of the uncharacterized ACLY C-terminal citrate synthase homolog

63 ence of mutations, but discerning previously uncharacterized activating "driver" mutations that will

64 phenotypes and in vitro functional assays of uncharacterized AIPL1 variants.

65 Overall, our findings reveal a previously uncharacterized and essential role of NAD(+) capping in

66 ss the splicing activity of 34 inteins (both uncharacterized and known) using a rapid split fluoresce

67 he immunoglobulin superfamily (IgSF) remains uncharacterized and underrepresented in databases.

68 Lsi3, an efflux Si transporter, belong to an uncharacterized anion transporter family having a signif

69 on malaria transmission potential of novel, uncharacterized Anopheles cryptic species in western Ken

70 we first evaluated the ability of a panel of uncharacterized anti-gH/gL MAbs to block binding to gD a

71 ea var. aurantiaca, we discovered previously uncharacterized antibiotics everninomicin N and O, compr

72 likelihood of presence of novel, previously uncharacterized, antibody specificities in a given serum

73 microti antigens, including some previously uncharacterized antigens.

74 we reconstructed and analysed genomes of an uncharacterized archaeal phylum (Candidatus Undinarchaeo

75 place in dystrophin's absence remain largely uncharacterized, as they are potentially obscured by the

76 vidence that C. bescii may have a completely uncharacterized aspect to its redox metabolism, involvin

77 Tepidanaerobacter acetatoxydans and a novel, uncharacterized bacterium.

78 Our results expose a previously uncharacterized basis of circuit malfunction, and a poss

79 cted ventilator-associated pneumonia remains uncharacterized because of the absence of a disease defi

80 We also observed previously uncharacterized behavior-related activity as well as pat

81 urrently underdeveloped with low potency and uncharacterized binding modes.

82 interacting proteins and multiple previously uncharacterized binding proteins.

83 chain fatty acids, neurotransmitters, as-yet-uncharacterized biochemicals, and derivatives of neuromo

84 sifier predicted beta-lactone synthetases in uncharacterized biosynthetic gene clusters conserved in

85 The vast majority of these TCS are uncharacterized both in terms of the signals that activa

86 The FAS-like PKS family represents an uncharacterized branch of polyketide and fatty acid meta

87 ial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted

88 ir gene PARP1, identifying both expected and uncharacterized buffering and synthetic lethal interacti

89 Mechanistically, IRF2 bound to a previously uncharacterized but unique site within the GSDMD promote

90 architectures and diverged RuvC sequences of uncharacterized Cas12 proteins suggest unexplored functi

91 In genetically uncharacterized cases of the type I interferonopathy Aic

92 ype annotation, identification of previously uncharacterized cell types in heterogeneous single-cell

93 t single-cell characterization of previously uncharacterized cell types, including human subplate neu

94 vestigate enhancer topologies, especially in uncharacterized cell types.

95 at gastrulation, demonstrating a previously uncharacterized cell-autonomous role.

96 This study identified a previously uncharacterized cellular mechanism that explains the maj

97 ation capture approach can reveal previously uncharacterized changes in the targeting and spreading o

98 channel from Clostridium difficile, and the uncharacterized channel from Escherichia coli (EcYfdC) t

99 ative pathways, one of which is a previously uncharacterized chlorophyll-to-carotenoid energy transfe

100 Surprisingly, KAP1/TRIM28 uses a previously uncharacterized chromatin reader cassette to bind hypo-a

101 ided sequence analysis we uncover previously uncharacterized CIF peptides conserved among higher plan

102 dometrial cell types, including a previously uncharacterized ciliated cell type, during four major ph

103 Here, we first define uncharacterized cis-regulatory elements likely containin

104 A SYNTHASE (KCS) belonging to a functionally uncharacterized clade of KCS enzymes involved in cuticul

105 is substantially influenced by a previously uncharacterized common coding variant (Arg462Gln) at the

106 Ribosome profiling revealed an uncharacterized complexity of translation in this archae

107 orward genetic approach to define previously uncharacterized components of flowering control pathways

108 -dimensional spheroid models and established uncharacterized crosstalk with RAB/RHO.

109 l, Lowey et al. describe SAVED-a widespread, uncharacterized cyclic nucleotide sensor protein domain

110 y we identified a candidate gene encoding an uncharacterized cytochrome P450, CYP71A27 Loss of this g

111 and identified a gene encoding a previously uncharacterized cytoplasmic protein kinase, termed Mars1

112 molluscan shell production remain relatively uncharacterized, despite the clear evolutionary and soci

113 rately predict disease genes for molecularly uncharacterized diseases.

114 ons illuminate the role played by previously uncharacterized disulfide-bridge and domain-swapped inte

115 biochemical analyses to explore this largely uncharacterized diversity.

116 onally, we identified TFs that bind to three uncharacterized DNA motifs identified in DNase footprint

117 n factor (TF) binding to noncoding variants, uncharacterized DNA motifs, and repetitive genomic eleme

118 inal endonuclease domain with the C-terminal uncharacterized domain of the RdRp.

119 erminal endonuclease domain and a C-terminal uncharacterized domain that harbors a binding site for t

120 kept in an inactive state by two previously uncharacterized dormancy factors that specifically targe

121 a phylogenetically conserved, but previously uncharacterized Doublesex/Mab-3 related transcription fa

122 screening, we identify akt1 and a previously uncharacterized Drosophila gene CG8108, which is homolog

123 the majority of alternative isoforms remains uncharacterized due to (i) vast differences of overall l

124 We aimed to investigate a novel and uncharacterized E3 ubiquitin ligase in skeletal muscle a

125 resented a more natural environment with yet uncharacterized effects on plant growth and metabolism.

126 estors through the emergence of a previously uncharacterized 'enhancer of microexons' (eMIC) protein

127 zed genes, we infer the function of multiple uncharacterized envelope proteins, some of which have ro

128 Here, we identify the uncharacterized Escherichia coli protein YcaQ as an ICL

129 Here, we studied the structurally uncharacterized Evasin-4, which neutralizes a broad rang

130 Whole exome sequencing in a further 37 uncharacterized families (43%) allowed us to rationalize

131 on of 825 new families based on their set of uncharacterized families (EUFs).

132 PRDM10 is a yet uncharacterized family member, and its function in vivo

133 this study, we demonstrate the importance of uncharacterized fission yeast proteins Mso1 and Sec1 in

134 However, complement-fixing antibodies remain uncharacterized for Plasmodium vivax malaria.

135 operon kdp and an ABC transporter operon of uncharacterized function.

136 We systematically looked for previously uncharacterized fusion proteins featuring a PUA or DUF34

137 reen identified a mutation in the previously uncharacterized gene F01D4.5-homologous with human trans

138 f DNA polymerase delta (POLD3), a previously uncharacterized gene in plants.

139 This previously uncharacterized gene is present at both ends of the geno

140 PIC30 is a previously uncharacterized gene that encodes a major facilitator su

141 ons at the gene level, for LOC388780 (20p13; uncharacterized gene), and for VEPH1 (3q25), a gene impl

142 Here we show that a previously uncharacterized gene, ENLARGED VESSEL ELEMENT (EVE), con

143 discovery that the deletion of a previously uncharacterized gene, I177L, from the highly virulent AS

144 f-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930.

145 and PNS caused by a mutation in a previously uncharacterized gene, slc12a2b, predicted to encode a Na

146 The screen revealed MRX6, a largely uncharacterized gene, whose deletion resulted in a marke

147 models of expression for several previously uncharacterized genes and uncover new regulation by the

148 racy of our library and revealed many so far uncharacterized genes essential for development.

149 We suggest that these uncharacterized genes identified by us are also likely t

150 nstrated by the identification of previously uncharacterized genetic determinants of complex phenotyp

151 alleles of sup-45, a previously molecularly uncharacterized genetic locus.

152 colours Silverblue and Hedlund white remain uncharacterized genetically.

153 to sulfite and acetaldehyde by a previously uncharacterized glycyl radical enzyme (GRE), isethionate

154 Together, this study uncovers a previously uncharacterized histone deacetylase complex in plant imm

155 ever, HOAP[yak] fails to rescue a previously uncharacterized HOAP function: silencing of the speciali

156 ion of SCARECROW 1 (ZmSCR1) and a previously uncharacterized homeologue: ZmSCR1h.

157 The large sample size revealed previously uncharacterized hotspot missense mutations within the SM

158 We identify numerous previously uncharacterized human-adaptive mutations.

159 s synthetic methylotroph alleviated a so far uncharacterized hurdle, DNA-protein crosslinking (DPC),

160 Here, we identified a hitherto uncharacterized hypoxia-induced lncRNA RAB11B-AS1 in bre

161 viral responses, we show that DVGs induce an uncharacterized IFN-independent innate response(s) that

162 ases and atherosclerosis but remains largely uncharacterized in cancer.

163 activated C-H bonds in bacteria, they remain uncharacterized in the plant kingdom.

164 tant class of developmental proteins, as yet uncharacterized in vertebrates.

165 this evolutionarily conserved pathway remain uncharacterized, including where MR1 acquires ligands an

166 by next-generation sequencing of a group of uncharacterized individuals with NPS-TTD.

167 tic defects in children causing a previously uncharacterized inherited bone marrow failure and pre-le

168 The previously uncharacterized interaction between two HAT units is med

169 tioning experiments indicating specific, yet uncharacterized interactions must be operating prior to

170 n contrast, herein we report that the so-far-uncharacterized intermembrane space protein Mix23 is con

171 ipulating Lsr2 activity in model species and uncharacterized isolates resulted in the production of n

172 M6) structure embedded in a lipid bilayer is uncharacterized, let alone the molecular mechanism of th

173 governing the PDR response and a previously uncharacterized link between PDR and cell cycle regulati

174 This is demonstrated on the uncharacterized lncRNA GATA6-AS1 in dilated cardiomyopat

175 ate-flowering mutants in pea that define two uncharacterized loci, LATE BLOOMER3 (LATE3) and LATE4, a

176 72A475 is synonymous with Sad6, a previously uncharacterized locus required for avenacin biosynthesis

177 The uncharacterized locus scfCDE was transcribed as an opero

178 PPP3R1 (protein coding), in addition to four uncharacterized long non-coding (lnc) RNA genes and part

179 tiple RNA species including novel and as yet uncharacterized long noncoding transcripts with unknown

180 erentially abundant metabolite features were uncharacterized, many could be assigned putative roles t

181 single ionization source, so the presence of uncharacterized material is unavoidable.

182 (2020) report a previously uncharacterized mechanism by which DNMT3A loss confers i

183 y identified family of human ATPases with an uncharacterized mechanism of action.

184 networks of organisms through an, as of yet, uncharacterized mechanism.

185 ational reprogramming mediated by previously uncharacterized mechanisms of translational regulation.

186 An uncharacterized member of the human MBL family, MBLAC2,

187 ficity of XPR1 regulation by a comparatively uncharacterized member of the inositol pyrophosphate (PP

188 dence from Setaria viridis and maize that an uncharacterized member of this family, CRM Family Member

189 At this time, several other uncharacterized members of this phylum have been detecte

190 l for discovering and identifying previously uncharacterized metabolites.

191 s-which suggests an unexpectedly diverse and uncharacterized microbial reservoir of bioactive N-nitro

192 s can be applied to the study of agents with uncharacterized MoAs and to rare or understudied disease

193 where they form connections with previously uncharacterized, modality-specific Dm neurons: two morph

194 ylases belong to a distinct group of largely uncharacterized molybdenum-dependent enzymes that likely

195 re-guided approach in assigning functions of uncharacterized multidomain proteins, which can potentia

196 One such mutant carried an uncharacterized mutation in tel2, a gene encoding an ess

197 barley PHR1 ortholog and a TF containing an uncharacterized MYB domain.

198 Here, we describe the role of an uncharacterized N-terminal acetyltransferase, NAA50, in

199 found that FIH1 modifies Asn(35) within the uncharacterized N-terminal ubiquitin-associated (UBA)-li

200 genome sequencing has revealed a plethora of uncharacterized natural antibiotics that remain to be di

201 screen, which we used to identify previously uncharacterized network adaptations of Mycobacterium tub

202 signaling is a key regulator of a previously uncharacterized neuronal population within the PVH that

203 he proteins involved and the substrates into uncharacterized nuclear bodies (NBs) remains poorly unde

204 Furthermore, we identified the uncharacterized OMM protein Fmp32 and the ectopically ex

205 n of dyskeratosis congenita mutations remain uncharacterized or poorly understood.

206 estigate the biochemical function of its yet uncharacterized paralogue FAM173A.

207 omolecule, such as internalized CuMbn or its uncharacterized partner protein, MbnP.

208 and reveal its participation in a previously uncharacterized pathway for the synthesis of oxidized ph

209 ntify and functionally validate a previously uncharacterized Pax7-bound enhancer hub that regulates t

210 ctions of large swaths of the experimentally-uncharacterized PCAD-Memo families.

211 on in Escherichia coli identified the so far uncharacterized permease YbeC as the major serine transp

212 s limitations of our approach when examining uncharacterized phages, as well as usefulness of the met

213 mofeev and colleagues show that a previously uncharacterized phosphorylation in the p53 core DNA-bind

214 , while narrow pili are composed of a so-far uncharacterized pilin which we name PilA5.

215 which is expressed in pre-optic neurons and uncharacterized pineal gland cells and whose function is

216 Here, we investigate a previously uncharacterized piRNA biogenesis factor, Daedalus (Daed)

217 ogical substrates of poorly characterized or uncharacterized PKMTs.

218 A previously uncharacterized plant protein, NbP3IP, was shown to inte

219 ce for homology between GRLs and a family of uncharacterized plant proteins containing the DUF3537 do

220 This functionally uncharacterized plasticity of the bat influenza A virus

221 In conclusion, we identified a previously uncharacterized population of extrafollicular B helper T

222 edict the bipotent phenotype of a previously uncharacterized population of peritoneal basophil-mast c

223 novel alleles derived from extinct or as yet uncharacterized populations.

224 Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that i

225 membrane protein 165), belonging to UPF0016 (uncharacterized protein family 0016), a family of second

226 Here, we describe the role of an uncharacterized protein in Drosophila, salto/CG13164, in

227 Choi et al. now report that a largely uncharacterized protein known as calmodulin-like protein

228 Among those, the uncharacterized protein NCBP2-AS2 that we renamed HIAR (

229 PDI family member P4HB and the functionally uncharacterized protein NT5DC2, a member of the haloacid

230 l approach that allowed for the detection of uncharacterized protein regions, which preclude traffick

231 -Interacting Protein1 (Eip1p)/Orf19.955p, an uncharacterized protein specific to Candida species.

232 CopG is an uncharacterized protein ubiquitous in Gram-negative bact

233 We validated one uncharacterized protein, ARMC10, and demonstrated that t

234 vered sixty proteins, including a previously uncharacterized protein, CARMIL3, which interacts in viv

235 Because uncharacterized proteins involved in prokaryotic oxidati

236 The uncharacterized proteins that emerged from our analyses

237 nsferases, zinc finger proteins, and several uncharacterized proteins.

238 insights into the function(s) of previously uncharacterized proteins.

239 mes that included both known RC proteins and uncharacterized proteins.

240 ing ligand-binding sites within structurally uncharacterized proteins.

241 However, uncharacterized proteolysis during brewing followed by t

242 s of potential is lost from MS datasets when uncharacterized PTMs are found to be significantly regul

243 osstalk, highlighting how SUB1, a previously uncharacterized RBP, drives aberrant tumor expression an

244 g so, we identified and validated previously uncharacterized RBPs that modulate stress granule abunda

245 Our study identifies a previously uncharacterized receptor kinase gene that is important f

246 an active isoform that lacks the N-terminal uncharacterized region of Dnmt3a1 including a nuclear lo

247 ion between the WD40 domain and a previously uncharacterized regulatory site within COP1.

248 entation strategy that exploits a previously uncharacterized resolvase from Bartonella bacilliformis

249 rdingly, recent studies unraveled previously uncharacterized response mechanisms in gingival epitheli

250 Here, we show that a largely uncharacterized ribosomal protein, RPL26, is the princip

251 First, we identify a previously uncharacterized RING domain protein in the TRIM family w

252 llus subtilis NCIB 3610 encodes a previously uncharacterized RNase HI protein, RnhP, on the endogenou

253 dings indicate that SIRT6 plays a previously uncharacterized role as a DNA damage sensor, a critical

254 Moreover, we revealed a previously uncharacterized role for the hub domain as an allosteric

255 th an IC(50) of 7 uM suggesting a previously uncharacterized role of FhTIM in the mechanism of action

256 Here, we describe a previously uncharacterized role of TET-mediated m(5)C oxidation in

257 ar processes with significant but previously uncharacterized roles in the modulation of yeast PDR.

258 is a potent CDK9 inhibitor with a previously uncharacterized scaffold, caused MYC loss through both t

259 f the BRD2-specific activity to a previously uncharacterized short segment predicted to harbor a coil

260 siderophore BGCs to identify both known and uncharacterized siderophore-like BGCs in genomes from me

261 on adjacent lysosomes, revealing previously uncharacterized signaling cross-talk between vesicular c

262 e, we report the identification of an as-yet uncharacterized silent gene cluster of the fungus Asperg

263 n rate that also capture rate variation from uncharacterized sources.

264 S) for tracking neural activity in a largely uncharacterized spatiotemporal regime.

265 all human mt-tRNAs, including 14 previously-uncharacterized species.

266 ymes and mutants thereof revealed previously uncharacterized SSR interactions, including specificity

267 RNA translocase that releases RNA by forcing uncharacterized structural changes in the elongating com

268 We also find a previously uncharacterized structural latch spanning the first two

269 hemical networks that generate extensive yet uncharacterized structure space.

270 at receptor kinase belonging to a previously uncharacterized subfamily that features two extra pairs

271 ver, Song and colleagues report a previously uncharacterized subpopulation of brown adipocytes that d

272 erase revealed the structure of a previously uncharacterized TERT domain (TRAP) with unanticipated in

273 aches are not able to identify insertions of uncharacterized TEs, nor can they assemble the full sequ

274 er Zn(2+)-induced assembly into a previously uncharacterized tetramer.

275 ansgenic seedlings overexpressing previously uncharacterized TF genes increased total glucan hydrolys

276 sically disordered by itself, and previously uncharacterized, the E6AP-binding domain in hRpn10 locks

277 of cancer-associated PIK3CA mutations remain uncharacterized, their sensitivity to PI3K inhibitors un

278 We identify a previously uncharacterized transcription factor, RGF1-INDUCIBLE TRA

279 duction in bacteria and the role, a hitherto uncharacterized transcription factor, YcjW, plays in lin

280 Driven by both known and uncharacterized transcription factors, neutrophils gradu

281 We identified hundreds of previously uncharacterized transcripts and thousands of alternative

282 profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding

283 In summary, our findings have revealed an uncharacterized TRAPPII-specific component, C7orf43/TRAP

284 owed that AtTRAPPC11/ROG2 defines a hitherto uncharacterized TRAPPIII complex in plants.

285 aim of this study was to identify novel and uncharacterized TTSPs with differential expression in br

286 the screen and among them, we focused on an uncharacterized two-component sensory system that we ter

287 Here, we investigated the previously uncharacterized type I-D interference complex and reveal

288 ne attack complex/PerForin) and a previously uncharacterized type of domain.

289 so suggests the potential existence of a yet uncharacterized type of methanogenesis linked to short-c

290 tinct CNs, which included several previously uncharacterized types, likely involved in computations s

291 we analyzed DNA samples from 183 previously uncharacterized, unrelated HHT and suspected HHT cases u

292 A previously uncharacterized V787E mutation in UL54 was identified in

293 y evolved isolates, and represent previously uncharacterized variation in the reference genome.

294 aeruginosa accessory genome is enriched with uncharacterized virulence genes.

295 ere, we report the discovery of a previously uncharacterized virus gene, which when deleted completel

296 as also diminished by loss of the previously uncharacterized WD repeat domain 83 opposite strand (WDR

297 ument proteins in HCMV, many of which remain uncharacterized, will contribute to our understanding of

298 diatric liver transplantation remains mostly uncharacterized, yet there is increasing concern about t

299 eight subgroups, two of which belong to the uncharacterized YfdC-alpha and YfdC-beta groups.

300 Here we identify the so far functionally uncharacterized YfiP protein as the SAM-dependent 3-amin