ライフサイエンスコーパス: unchecked

1 excitation or depression of circuits if left unchecked.

2 n host macrophages and can be lethal if left unchecked.

3 he damage that would result if mistakes went unchecked.

4 it can have detrimental consequences if left unchecked.

5 entral tolerance, and can cause T1DM if left unchecked.

6 eration of cancer cells proceeds essentially unchecked.

7 ic plasticity or contribute to epilepsy when unchecked.

8 significant morbidity and mortality if left unchecked.

9 allows the inflammatory response to continue unchecked.

10 le leaving piriform-mediated odor clustering unchecked.

11 formed and disengaged; leaders' authority is unchecked.

12 olling infections but can cause disease when unchecked.

13 hotoreceptors and the underlying RPE if left unchecked.

14 ephensi could establish if allowed to spread unchecked.

15 become an unprecedented panzootic continues unchecked.

16 ury, although it may also cause harm if left unchecked.

17 llow them to evade apoptosis and proliferate unchecked.

18 can cause tissue damage and organ failure if unchecked.

19 es, either alone or collaboratively, if left unchecked.

20 reated patients, and Th17 responses remained unchecked.

21 cur, and intracellular bacterial growth goes unchecked.

22 e resistant strain to persist or to multiply unchecked.

23 If unchecked, a runaway inflammatory response can cause sig

24 REAM-deficient mice displayed persistent and unchecked A20 expression in response to endotoxin.

25 Unifying characteristics include unchecked abilities of tumor cells to proliferate and sp

26 However, their unchecked accumulation is associated with genome instabi

27 Unchecked accumulation of reactive oxygen species (ROS)

28 alterations in tissue homeostasis, including unchecked activation of immune and nonimmune cells leadi

29 and neurological symptoms of FXS result from unchecked activation of mGluR5, a metabotropic glutamate

30 a decrease in function of the PD-1 pathway, unchecked activation of the immune system and autoimmuni

31 t these defects are due in large part to the unchecked activity of dE2F2, since they can be suppresse

32 e2f1 mutant cells is severely reduced due to unchecked activity of the repressor dE2F2 in these cells

33 oss of the EpCAM protein, which is caused by unchecked activity of the serine protease matriptase (ST

34 hality of Spint2-deficient mice is caused by unchecked activity of the serine protease matriptase.

35 When left unchecked, algae can cause declines in seagrass producti

36 These mechanisms, if left unchecked, allow wealth concentration to result in state

37 Unchecked amino acid accumulation in living cells has th

38 that loss of the piRNA machinery allows for unchecked amplification of siRNA populations, originatin

39 r expression is tightly regulated to prevent unchecked amplification.

40 e process, coagulation is allowed to proceed unchecked and contributes to the pathogenesis of cerebra

41 form sub-optimally when comparisons are left unchecked and when there are too many similar options.

42 ccurred in IFN-gamma gko mice, the virus was unchecked, and the infection led to death.

43 ogen response, whose deregulation may foster unchecked AR activity in PCa.

44 Through this pathway, RB depletion induced unchecked AR activity that underpinned therapeutic bypas

45 um, and suggest that the literature includes unchecked assumptions regarding the costs, benefits and

46 associated with severe pathologies, whereas unchecked autophagy activity causes cell death.

47 eral tolerance and its absence can result in unchecked autoreactive responses, leading to diseases li

48 ea are significantly decreased, resulting in unchecked bacterial growth and perforation.

49 ed excess of peritoneal iron that allows for unchecked bacterial growth.

50 The elevation of the SL1 binding mode, unchecked by a proportionate population of binding modes

51 despread economic burden and remains largely unchecked by existing control strategies.

52 eventually die, as p53 expression continues unchecked by remethylation.

53 o robust inflammatory responses that if left unchecked can lead to autoimmune disease and other seque

54 establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation.

55 ), can elicit hypoxia-like responses that if unchecked can lead to unusual peri-implant pathologies,

56 es a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction.

57 nce and active immune suppression results in unchecked cancer growth and progression.

58 in tumor suppressor gene function, allowing unchecked cell cycle progression and, by genomic instabi

59 Because unchecked cell cycle progression leads to hyperprolifera

60 ading to increasing possibilities to control unchecked cell growth and metastasis.

61 Unchecked cell growth is a hallmark of cancer.

62 aintain high levels of protein synthesis for unchecked cell growth.

63 ar signal transduction pathways that lead to unchecked cell growth.

64 in TG mice, together with ZD, might lead to unchecked cell proliferation and accelerated NMBA-induce

65 cyclin-dependent kinases (CDKs) can promote unchecked cell proliferation and cancer progression.

66 in D-CDK4/6 complexes are strongly linked to unchecked cell proliferation and cancer(2,3).

67 Cancer is a set of diseases characterized by unchecked cell proliferation and invasion of surrounding

68 and c-IAP1, may help to explain unwanted and unchecked cell proliferation in this disease.

69 anisms (TMMs) are cancer hallmarks, enabling unchecked cell proliferation.

70 y protumorigenic genes, consequently driving unchecked cell-cycle progression, incessant replication,

71 of increased mitotic signaling coupled with unchecked cellular growth.

72 ression and/or activation is associated with unchecked cellular proliferation, resistance to apoptoti

73 c liver disease, leading to fibrosis and, if unchecked, cirrhosis.

74 Unchecked collaboration between islet-reactive T and B l

75 regulation of C3 and C5 convertases leads to unchecked complement and coagulation activation, resulti

76 Unchecked, ComX upregulates bacteriocins and autolysins,

77 ibution of HIV in the USA, and that will, if unchecked, continue to fuel the epidemic in the future.

78 the other E. coli polymerases, which if left unchecked could hinder its ability to synthesize DNA in

79 sms, thus allowing bacterial toxins to cause unchecked, devastating physiological derangements in the

80 s who are at risk for severe consequences of unchecked disease persistence or progression." This year

81 Unchecked disease progression leads to the "pulseless" s

82 dynamically adapt to provocations and, left unchecked, drive pathological remodelling.

83 activation of CD8(+) T cells can, when left unchecked, drive severe immunopathology.

84 nt for previous developmental stages and, if unchecked during transition between developmental stages

85 its cell defenses that would be triggered by unchecked EBNA2 prooncogenic activity.

86 splicing may prevent the adverse effects of unchecked elongation or diminution of coding ends during

87 C temperature scenario more consistent with unchecked emissions growth, the corresponding values are

88 With unchecked emissions, the central warming can reach the d

89 H ratio in chronic SIV infection may lead to unchecked expansion of both TFH and GC B cells.

90 2/Id3 double-knockout mice that is caused by unchecked expansion of invariant NKT (iNKT) cells or a u

91 tion and suggest possible mechanisms for the unchecked expansion of TFH cells in HIV/SIV infection.

92 and functions as a vital barrier against the unchecked expansion of tumor stem cell pools; however, l

93 " These are hypothesized to be formed by the unchecked extension of identical but much shorter struct

94 onstant transmission of sensory information, unchecked feedback can be disruptive.

95 otects cells from excessive acidification by unchecked fermentation.

96 -estradiol-driven p27 degradation to proceed unchecked for cell cycle progression.

97 epatocytes in the inflammatory liver and, if unchecked, for promoting hepatocarcinogenesis.

98 However, unchecked free radical generation is also responsible fo

99 Unchecked glucose-mediated oxidative stress and advanced

100 cells use multiple strategies to fuel their unchecked growth.

101 In humans and pigs lacking CFTR, unchecked H(+) secretion by the nongastric H(+)/K(+) ade

102 ate inhibits histone deacetylase 11, causing unchecked HDAC6 activity and increased histone 3 acetyla

103 These observations suggest that unchecked HIV-1 replication may lead to depletion or dys

104 h IL-17 promotes barrier resistance, whereas unchecked IFN-gamma erodes it.

105 thogenesis by promoting inflammation through unchecked IL-17 production and facilitating the developm

106 tening hematologic disorder characterized by unchecked immune activation and hyperinflammation, resul

107 lly maintained by tonic signals that prevent unchecked immune responses to nucleic acids released dur

108 -DNA inside cells poses a risk of triggering unchecked immune responses.

109 event excessive tissue destruction caused by unchecked immune responses.

110 When unchecked, immune-mediated repair programs are co-opted

111 lower at baseline, the production of cGMP is unchecked in eNOS-/- and nNOS-/-, eNOS-/- mice upon neur

112 es have been occurring for months, seemingly unchecked in most affected states.

113 Although differentiation proceeds unchecked in the absence of patS and hetN expression, di

114 to determine why an immunogenic tumor grows unchecked in the anterior chamber (a.c.) of the eye.

115 We show that tumors grow unchecked in the omenta of microbe-replete mice due to i

116 oliferation and tumorigenesis accompanied by unchecked inactivation of the retinoblastoma tumor suppr

117 e during the peak of infection, but not with unchecked inflammation or with increased cellular respon

118 from neurotrauma but is also responsible for unchecked inflammation that causes neuronal cell death,

119 Unchecked inflammation, impaired keratinocyte differenti

120 (ARDS) provokes three pathologic processes: unchecked inflammation, interstitial/alveolar protein ac

121 However, when allowed to continue unchecked, inflammation may result in autoimmune or auto

122 Although the precise origin of the unchecked inflammatory response in obesity is unclear, i

123 disease and diabetes, may develop because of unchecked inflammatory responses that have maladapted ov

124 enuates wound healing pathways that, if left unchecked, interfere with microglial physiological funct

125 merged during the 20th century and continues unchecked into the 21st century.

126 homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload.

127 ulation of protein aggregates; however, when unchecked, it can be detrimental and cause autophagic ce

128 in response to various stimuli, but if left unchecked, it can inflict oxidative damage on all types

129 PI3K isoforms in pancreatic cancer leads to unchecked KRAS-independent PI3K signaling, highlighting

130 er than 10% in some regions of the world (if unchecked), lack of data and the observed heterogeneity

131 es coordinate antimicrobial immunity and, if unchecked, lead to autoimmune disease.

132 erosis, these repair processes appear to run unchecked, leading to aberrant remodeling and fibrosis o

133 ositive regulation of IL-12 by IFN-gamma, if unchecked, leads to excessive cytokine production and to

134 ike differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmuni

135 that EBV-infected B cells proliferate in an unchecked manner due to suppression of cytotoxic T cells

136 collective U-turn, divergent migration, and unchecked migration against an obstacle.

137 containing the transcription factor YY1, and unchecked miR-134 expression following SIRT1 deficiency

138 However, unchecked mitochondrial fission and mitophagy may compro

139 n-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy.

140 ways through the basal ganglia, resulting in unchecked movements via thalamic disinhibition.

141 rculatory system or vascular endothelium and unchecked neutrophil transmigration.

142 Unchecked NF-kappaB signalling can engender autoimmune p

143 ceptor may protect against excitotoxicity of unchecked NMDA receptor recruitment during induction and

144 dy identifies let-7 as a central hub linking unchecked oncogenic signaling to impaired AT2 cell plast

145 itutively active GTP-bound form that drives, unchecked, oncogenic downstream signaling.

146 aintenance of neuronal homeostasis; however, unchecked or dysregulated autophagy can lead to cell dea

147 ICSBP-deficient mice exhibited unchecked parasite replication in vivo and rapidly succu

148 ls to progress towards the endocrine lineage unchecked, particularly as part of the secondary transit

149 ensitive to a ciliopathic insult, undergoing unchecked passage through the cell cycle and subsequent

150 with low market size, highlights gaps where unchecked patent quality and high prices persist, and ca

151 bit immunosurveillance and thereby allow the unchecked persistence and proliferation of premalignant

152 hy mitochondrial domains from elimination by unchecked PINK1-Parkin activity.

153 Left unchecked, plant-parasitic nematodes have the potential

154 ui society collapsed because of centuries of unchecked population growth within a fragile environment

155 en an acquired BRAF(V600E) mutation triggers unchecked proliferation and subsequent arrest in melanoc

156 One current concept suggests that unchecked proliferation of clonally selected precursors

157 ulations could be driven to extinction by an unchecked proliferation of TEs.

158 ed MCMV susceptibility mutation that permits unchecked proliferation of the virus, causing death.

159 upts epithelial organization and also causes unchecked proliferation.

160 mmunity but highlight the risk of unleashing unchecked proliferative responses.

161 timicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis.

162 t, expansion of these apical cells proceeded unchecked, reaching rates as high as 6% h(-1) to produce

163 If unchecked, recurrent episodes of acute pancreatitis may

164 damage checkpoint and, when mutated, permit unchecked replication of damaged DNA in S-phase.

165 Additionally, proliferation continues unchecked, resulting in two types of tumors also found i

166 If unchecked, ROS production and oxidative stress mediate t

167 macrophages in endotoxemic mice and induced unchecked severe inflammatory injury.

168 ibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens.

169 evated plasma TPO levels, which serves as an unchecked stimulus to drive the observed excessive megak

170 Unchecked, sustained mTOR activity results in defects in

171 monstrated that mortality is associated with unchecked tachyzoite replication.

172 ntimicrobial resistance estimates that, left unchecked, ten million people will die annually from dru

173 zeta; PTN inactivates RPTPbeta/zeta, leaving unchecked the continued endogenous activity of tyrosine

174 entrenched over time; if current trends are unchecked, the consequences for individual and societal

175 If left unchecked, the deleterious effects of oxidative stress r

176 If unchecked, the expression of the GRFs in the stem cell n

177 Left unchecked, the inherent reactivity of enamines and imine

178 If past obesity trends continue unchecked, the negative effects on the health of the U.S

179 If unchecked, the temperature-driven increases in resting C

180 If anthropogenic emissions continue unchecked, the warming increase may reach 8-10 degrees C

181 recurring weekly contributions unless donors unchecked them.

182 lated; however, when matrix replacement goes unchecked, there is unwanted and irreversible tissue sca

183 may leave the oncogenic activities of Runx2 unchecked, thereby driving promiscuous expression of Run

184 Left unchecked, these emotional changes might have a wide arr

185 When unchecked, these same immune cells drive diseases such a

186 If unchecked, these trends will lead to a steep decline in

187 If unchecked this can lead to an immune-deficient state and

188 If left unchecked, this bias is likely to skew data interpretati

189 Left unchecked, this causes titration of RNA polymerase and a

190 Unchecked, this cooling would lead to massive accumulati

191 Left unchecked, this LTP may interfere with DG-dependent lear

192 Unchecked, this side reaction will also prevent applicat

193 to 72 hours often die from complications of unchecked thrombosis rather than shock, and survivors ar

194 Myeloid cell proliferation proceeds unchecked throughout the course of mycobacterial infecti

195 ation, compromised PI(3)K activity allows an unchecked TLR-induced inflammatory responses and constit

196 Unchecked TLR4 activation might result in autoimmune dis

197 ck of IL-4 in the deficient mice resulted in unchecked TNF-alpha production, which appeared to cause

198 s impeding incisor abrasion and resulting in unchecked tooth elongation.

199 lta mutant, plasmid instability results from unchecked transcription elongation, which can be suppres

200 This syndrome is due to unchecked transfer of iron into the bloodstream in the a

201 ends upon adaptive control mechanisms, since unchecked transposon activity can impact long-term fitne

202 from endogenous retroelements that, if left unchecked, trigger elevated production of type I interfe

203 infection in glioblastoma may contribute to unchecked tumor growth in glioblastoma by increasing imm

204 Immune evasion and suppression lead to unchecked tumor growth in glioblastoma.

205 Left unchecked, two insects could destroy up to 50% of 1 ton

206 des), initiating a trophic cascade involving unchecked urchin population growth and the widespread lo

207 t months have made visible the stakes of the unchecked use of AI: The parents of 16-year-old Adam Rai

208 lay of innate immune responses, allowing for unchecked viral growth and ultimately severe immunopatho

209 s whose immune systems have been suppressed, unchecked virus replication can cause severe disease.

210 nate and adaptive immune system that if left unchecked will lead to the rejection of transplanted cel

211 e limits suggests that biodiversity loss, if unchecked, will undermine efforts toward long-term susta

212 By 2050 these dietary trends, if unchecked, would be a major contributor to an estimated

213 from reactive chemical species that, if left unchecked, would cause mutagenic DNA damage.

214 tion results in an oxidative burden that, if unchecked, would lead to cell death.