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1  high AdoMet concentrations, the pattern was uncompetitive.
2 ism of open-channel blockade by memantine is uncompetitive.
3 o3S4, thus rendering full cell energetically uncompetitive.
4 itive at low drug concentrations and MPyr is uncompetitive.
5 yl-ene reaction, and oxygen-atom transfer is uncompetitive.
6 -CoA inhibition of CPT-I from competitive to uncompetitive.
7 Kg dead-end analogues, respectively, and are uncompetitive against NADH and noncompetitive against al
8  subsaturating cosubstrate concentration and uncompetitive against preQ(1)-tRNA(Tyr) when AdoMet was
9                                   The use of uncompetitive (also called anticompetitive) inhibitors i
10 the ordered kinetic mechanism desulfo-CoA is uncompetitive and citrate is competitive vs alpha-ketogl
11                       The conjunction of the uncompetitive and competitive modes of inhibition indica
12 er, we offer exact mathematical solutions to uncompetitive and non-competitive inhibition, and demons
13                      Lithium acts as both an uncompetitive and non-competitive inhibitor of several l
14 , steroidal inhibitors have been shown to be uncompetitive and reversible.
15 culations) find the metallic structure to be uncompetitive, and predict a phase diagram in reasonable
16 methadol metabolites retain the higher NMDAR uncompetitive antagonism of (R)-methadone, while present
17 al neurotransmission, in part because of its uncompetitive antagonism with a fast off-rate.
18 microM memantine was close to ideal for pure uncompetitive antagonism.
19 kade of the N-methyl-D-aspartate receptor by uncompetitive antagonists has implications for symptomat
20 49 --> Leu and Arg49 --> Asp mutants) and to uncompetitive (Arg49 --> Cys mutant).
21 competitive behavior with respect to ATP and uncompetitive behavior with respect to AMP resulting in
22 type with prominent (ca. 60 % of inhibition) uncompetitive characteristics and an IC50 of 0.8 muM und
23                                           An uncompetitive component with a Ki ' of 11 mM was also fo
24 ine was evaluated for non-competitive and/or uncompetitive components of antagonism.
25 tration increases, the inhibition changes to uncompetitive, consistent with a steady state random mec
26 s primarily an uncompetitive inhibitor, with uncompetitive constant K(i)' = 37 mM and Cl(-)-competiti
27                                     Although uncompetitive engagement can be evaluated in cell-free s
28           A subset of chemotypes demonstrate uncompetitive engagement with SAM or its inhibitory meta
29 MYEL assay can also identify competitive and uncompetitive Epac inhibitors, e.g. (Rp)-cAMPS and CE3F4
30 nol-1 and ubiquinol-2 inhibit turnover in an uncompetitive fashion.
31 K channels in noncompetitive and potentially uncompetitive fashion.
32 FDA-approved drug memantine, representing an uncompetitive/fast off-rate antagonist of NMDA-type glut
33                   In contrast, inhibition is uncompetitive for the ibuprofen-ester substrate, consist
34 nhibition of horseradish peroxidase (HRP) is uncompetitive for the substrate H(2)O(2) while it is com
35 ereas the inhibition kinetics is found to be uncompetitive in terms of Q2.
36 ibition (ATP-competitive, noncompetitive, or uncompetitive) in PoA compared to IoC or show a change i
37 etitive inhibition (decreased V max), whilst uncompetitive inhibition (decreased V max and K m ) occu
38  could be fit with the equation for complete uncompetitive inhibition and that the mechanism may be a
39                                          The uncompetitive inhibition and the substrate-dependent bin
40                               Theoretically, uncompetitive inhibition arises from preferential intera
41 ated the experimental data and verified that uncompetitive inhibition arose from preferential binding
42                                              Uncompetitive inhibition by arabinose 5-phosphate (Ara5P
43  pentameric complex, which suggests that the uncompetitive inhibition by BFA and the nucleotide allos
44           Finally, we note that the apparent uncompetitive inhibition by fluoride as reported for sev
45  constant (K(ic)) of 0.12 +/- 0.02 mM and an uncompetitive inhibition constant (K(iu)) of 3.04 +/- 0.
46 how unimpaired inhibition by triclosan, with uncompetitive inhibition constants (K(i)') of 0.18+/-0.0
47    Compound 4 shows a mix of competitive and uncompetitive inhibition for both the yeast and the huma
48 utant protease showed mixed-type competitive-uncompetitive inhibition for darunavir and the chemicall
49        Biochemically, the isoxazoles display uncompetitive inhibition kinetics that are similar to an
50 inding of agonists to Epac1 and suggested an uncompetitive inhibition mechanism with respect to Epac1
51 yl-PP-GlcNAc(2)-Man(9)-Glc(3), suggesting an uncompetitive inhibition mechanism.
52  ligand binding and kinetic data best fit an uncompetitive inhibition model in which the binding of t
53 lowed by naphthol substrate, as shown by the uncompetitive inhibition of 3HNR by tricyclazole with re
54 o importantly, binding to this pocket causes uncompetitive inhibition of KSP ATPase activity.
55                       For this purpose, only uncompetitive inhibition of pyruvate export proves effec
56                                           An uncompetitive inhibition of the anaerobic reaction catal
57 m and Vmax values, suggesting a mechanism of uncompetitive inhibition on GlyT1-mediated glycine uptak
58                                         This uncompetitive inhibition suggests that the probe can int
59 -L-arginine was synthesized and demonstrated uncompetitive inhibition versus ATP and competitive patt
60 d competitive inhibition vs saccharopine and uncompetitive inhibition vs NADP.
61                                              Uncompetitive inhibition was also observed with the synt
62 ns of agonist for "pure' non-competitive vs. uncompetitive inhibition was computer simulated.
63  is unknown, the structural requirements for uncompetitive inhibition were investigated by applicatio
64 ding a series of parallel plots, typical for uncompetitive inhibition with a Ki for inhibition of app
65                                          The uncompetitive inhibition with respect to ATP is also con
66  calpains relative to other proteases, (iii) uncompetitive inhibition with respect to substrate, and
67 re also provided for competitive inhibition, uncompetitive inhibition, and mixed inhibition of ordere
68                            The appearance of uncompetitive inhibition, however, suggests that a more
69                                 RFA-P showed uncompetitive inhibition, K(i) = 0.210 mm, under varied
70                                 CO(2) showed uncompetitive inhibition, K(i) = 0.990 mm, under varied
71       At the concentrations corresponding to uncompetitive inhibition, PDPA shows positive cooperativ
72  for Ca(2+) that mediated noncompetitive and uncompetitive inhibition, respectively.
73 with urease is not compatible with classical uncompetitive inhibition.
74 han), an effector (3-indole ethanol), and an uncompetitive inhibitor (Mitomycin C).
75                          Fosmidomycin was an uncompetitive inhibitor against NADPH and gave a pattern
76 ydroxylauroyl-methylphosphopantetheine is an uncompetitive inhibitor against R-3-OHC14-ACP and a comp
77 o 6983 or bisindolylmaleimide I, but not the uncompetitive inhibitor bisindolylmaleimide IV, prevents
78                                          The uncompetitive inhibitor Li+ causes little change in the
79  of 6.0 and 9.0, fluoride ion acts as a pure uncompetitive inhibitor of AAP, and the Ki increases fro
80        At low concentrations cystamine is an uncompetitive inhibitor of caspase-3 activity, becoming
81 l derivatives of the steroid DHEA 1, a known uncompetitive inhibitor of G6PD, were designed, synthesi
82       We also found that gamma-boroGlu is an uncompetitive inhibitor of Gly-Gly-promoted transamidati
83                                 A prototypic uncompetitive inhibitor of IMPDH, mycophenolic acid (MPA
84                       We show that NaF is an uncompetitive inhibitor of MshB, consistent with a metal
85           The substrate APS acts as a strong uncompetitive inhibitor of the APS kinase reaction.
86 dies showed that TPBC is a highly efficient, uncompetitive inhibitor of the bacterial pyruvate dehydr
87               The drug brefeldin A (BFA), an uncompetitive inhibitor of the exchange reaction that bi
88 tor targeting apo LpxA, and compound 2 is an uncompetitive inhibitor targeting the LpxA/product compl
89 icate that gambogic acid is a rapid-binding, uncompetitive inhibitor targeting the PRORP1-substrate c
90 zene 1,2,4-trisphosphate, was shown to be an uncompetitive inhibitor that binds to a regulatory site
91 uncovered that 28 is an RNA-competitive, ATP-uncompetitive inhibitor that engages a novel pocket in t
92 ith respect to nicked DNA, whereas L82 is an uncompetitive inhibitor that stabilized complex formatio
93            This inhibitor was found to be an uncompetitive inhibitor to CoA and a mixed-type inhibito
94 mpetitive inhibitor versus tryptamine and an uncompetitive inhibitor versus acetyl-CoA, indicative of
95 etitive inhibitor versus cycloartenol and an uncompetitive inhibitor versus AdoMet.
96                    Pyruvate functioned as an uncompetitive inhibitor versus ATP, and inclusion of ADP
97                           Acetaldehyde is an uncompetitive inhibitor versus oxygen, indicating that a
98 tial velocity studies show that IIAGlc is an uncompetitive inhibitor with respect to both substrates,
99 d that benzyl isocyanide was the most potent uncompetitive inhibitor with respect to heme with a KI =
100 titive inhibitor with respect to NADH and an uncompetitive inhibitor with respect to the substrate 2-
101 tudied the binding of fluoride ion (F(-); an uncompetitive inhibitor) and L-arginine, L-valine, dinor
102 strate, inosine monophosphate (IMP), and the uncompetitive inhibitor, mycophenolic acid, to inosine m
103                              PPi is a linear uncompetitive inhibitor, suggesting that it dissociates
104 ntrations lower than 0.25 microM, PDPA is an uncompetitive inhibitor, while at PDPA concentrations hi
105 act PSII revealed that I(-) was primarily an uncompetitive inhibitor, with uncompetitive constant K(i
106 s may have facilitated the discovery of this uncompetitive inhibitor.
107 zyme-substrate complex, Topotecan acts as an uncompetitive inhibitor.
108 ol dehydrogenase-NADH complex and are potent uncompetitive inhibitors against alcohol.
109 inetic analyses revealed that EAEP generated uncompetitive inhibitors against alpha-glucosidase, whil
110 They bind to the enzyme-NADH complex and are uncompetitive inhibitors against varied concentrations o
111                                     They are uncompetitive inhibitors against varied concentrations o
112                                        Using uncompetitive inhibitors of ALPs and fluorescent D-tetra
113 t contain D-ArgNO2 (8-10, 12, 13), which are uncompetitive inhibitors of iNOS but competitive inhibit
114 ate kinetics, we have shown that halides are uncompetitive inhibitors of XaDHL with 1, 2-dichloroetha
115 s were competitive inhibitors versus ATP and uncompetitive inhibitors versus GST-ATF2.
116 to be competitive inhibitors against NAD and uncompetitive inhibitors with respect to aldehyde.
117 nhibition model (behaving closely to that of uncompetitive inhibitors) when evaluated spectrophotomet
118                          These compounds are uncompetitive inhibitors, binding the gamma-glutamyl enz
119                          Using two model ATP-uncompetitive inhibitors, monastrol and ispinesib, we re
120 l shikimic acids both act as competitive and uncompetitive inhibitors.
121 sing basis for the systematic design of such uncompetitive inhibitors.
122            Although ketamine has unequivocal uncompetitive inhibitory effects on N-methyl-d-aspartate
123                         Then we explored the uncompetitive inhibitory mechanism of brefeldin A (BFA)
124 er varied PRPP and saturated pABA, and again uncompetitive, K(i) = 0.300 mm, under saturated PRPP and
125 ighly reduced K(m) and V(max) reminiscent of uncompetitive kinetics with 4-cholesten-7alpha-ol-3-one
126 provide insights into a structural basis for uncompetitive lithium inhibition and substrate recogniti
127                                          The uncompetitive low-affinity NMDA receptor antagonist, mem
128 treat multiple sclerosis, inhibits ATX in an uncompetitive manner and slows the hydrolysis reaction,
129  the glutamine acceptor dimethylcasein in an uncompetitive manner with respect to dimethylcasein util
130 led that LOX-PP inhibits FGF-2 binding in an uncompetitive manner.
131                                           In uncompetitive markets, 6.8% (n=857) underwent free flap
132        These compounds inhibit LMPTP with an uncompetitive mechanism and are highly selective for LMP
133 tor is selective for APEH, shows an uncommon uncompetitive mechanism of inhibition, and in solution a
134 er in the inhibitor structure resulted in an uncompetitive mechanism of inhibition, which further res
135 ent and selective inhibitors of SapM with an uncompetitive mechanism of inhibition.
136 + lowered both the Vmax and Km of SGC via an uncompetitive mechanism through direct interaction with
137 KR1B1 and inhibits SCoR2 potently through an uncompetitive mechanism.
138 ions of DMSO led to lipase activation via an uncompetitive mechanism.
139 ng starch as the substrate, HPA exhibited an uncompetitive mode of inhibition with an apparent K(i) o
140         Providing biochemical support for an uncompetitive mode of inhibition, in vitro binding studi
141 was to evaluate the effects of MRZ 2/579, an uncompetitive N-methyl-D-aspartate antagonist, on infarc
142                                          The uncompetitive N-methyl-D-aspartate receptor (NMDAR) anta
143 EL-1017 may exert antidepressant effects via uncompetitive N-methyl-D-aspartate receptor (NMDAR) chan
144 ine, a low to moderate affinity open channel uncompetitive N-Methyl-d-aspartate receptor antagonist,
145    Memantine is a low- to moderate-affinity, uncompetitive N-methyl-D-aspartate receptor antagonist.
146                                          The uncompetitive NMDA antagonist AR-R15896AR inhibited effl
147                   These results suggest that uncompetitive NMDA antagonists, more specifically open c
148  effect commonly produced by competitive and uncompetitive NMDA antagonists.
149 study was to characterize the effects of the uncompetitive NMDA receptor antagonist memantine on pala
150 n sheath formed by oligodendrocytes, that an uncompetitive NMDAR antagonist has successfully passed h
151                             Furthermore, the uncompetitive NMDAR antagonist memantine attenuates NMDA
152 nduced by mitochondrial dysfunction and that uncompetitive NMDAR blockade may be used as a neuroprote
153                We tested the hypothesis that uncompetitive NMDAR blockade with memantine prevents mit
154  L180M/M204V did not fit either competitive, uncompetitive, noncompetitive, or typical mixed inhibiti
155 was apparently competitive versus AdoMet and uncompetitive/noncompetitive versus DNA at </=20 microM
156  also how this can lead to a noncompetitive, uncompetitive or cooperative binding mechanism.
157 in many cases is achieved via a competitive, uncompetitive or non-competitive mechanism.
158 arying concentrations of dansyl-GCIIL and an uncompetitive pattern against GGPP.
159                                           An uncompetitive pattern is also obtained with dPFK for Ara
160 ibition by phosphopeptide product yielded an uncompetitive pattern when ATP was the varied substrate.
161 ptide concentrations yielded parallel lines (uncompetitive pattern).
162  bind in the active site yet exhibit non- or uncompetitive patterns of inhibition.
163 hium chloride, which has been reported to be uncompetitive, remains unchanged.
164                                   The weaker uncompetitive site suggests the existence of a transient
165 was estimated as 1 mM, and the K(i)' for the uncompetitive site was estimated as 8 mM.
166 the active site but also to bind to a second uncompetitive site.
167 knowledge, ECSI#6 is the first example of an uncompetitive SLC inhibitor.
168                                 In addition, uncompetitive substrate inhibition by alpha-Kg and doubl
169                     Data are consistent with uncompetitive substrate inhibition by naphthol as a resu
170  of purealin was concentration dependent and uncompetitive, supporting the hypothesis that it does no
171 to mechanistically characterize and quantify uncompetitive target engagement as well as ternary compl
172             Their mechanism of inhibition is uncompetitive toward both the peptide substrate and NAD(
173 Inhibition by GlcNAc-GlcNAc-P-P-dolichol was uncompetitive toward UDP-GlcNAc and competitive toward d
174  H3-20 K14A was competitive versus H3-20 and uncompetitive versus acetyl-CoA.
175 enol was competitive versus cycloartenol and uncompetitive versus AdoMet.
176 s demonstrate that l-histidine inhibition is uncompetitive versus ATP and noncompetitive versus PRPP.
177 oncompetitive versus ubiquinone and both are uncompetitive versus DHO.
178        Product inhibition by saccharopine is uncompetitive versus NADH, suggesting a practical irreve
179                 Inhibition by methionine was uncompetitive versus preQ(1)-tRNA(Tyr), but noncompetiti
180 tamate and is competitive vs L-glutamate and uncompetitive vs L-AASA and NADPH.
181 L-AASA is noncompetitive vs saccharopine and uncompetitive vs NADP.
182 alogue of L-AASA and is competitive vs AASA, uncompetitive vs NADPH, and noncompetitive vs L-glutamat
183 eak rate) will determine the contribution of uncompetitive vs. non-competitive actions, respectively.
184 netic field renders the overall logic scheme uncompetitive when compared with complementary metal-oxi
185 ition; inhibition by inorganic phosphate was uncompetitive, whereas inhibition by fructose 6-phosphat
186 he inhibition type for RPE65 was found to be uncompetitive with K(i) = 53 mum.
187 4+/-0.9 microM, while inhibition of A124V is uncompetitive with K(i)' = 0.81 +/- 0.11 microM.
188 plex, we find that the inhibitory peptide is uncompetitive with regard to SAM.
189 ncompetitive inhibitor versus tryptamine and uncompetitive with respect to acetyl-CoA.
190                   Inhibition was reversible, uncompetitive with respect to ATP, and non-competitive w
191 on-competitive with syntide-2 substrate, and uncompetitive with respect to ATP.
192    Binding of triclosan to wild-type InhA is uncompetitive with respect to both NADH and trans-2-dode
193 te, noncompetitive with respect to Mg2+, and uncompetitive with respect to fructose 1,6-bisphosphate.
194 is competitive with respect to phosphite and uncompetitive with respect to NAD(+).
195 itor with respect to glucose 1-phosphate and uncompetitive with respect to phosphate.
196  activation of catalysis by these amines was uncompetitive with respect to superoxide, interpreted as
197 s competitive with the protein substrate and uncompetitive with the isoprenoid substrate; the Ki for
198                             Because they are uncompetitive with the substrate, halide ions do not bin

 
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