ライフサイエンスコーパス: uncoupling protein

1 rotein 3 (UCP3), a thermogenic mitochondrial uncoupling protein.

2 of mitochondrial biogenesis or activation of uncoupling proteins.

3 s superoxide generation through induction of uncoupling proteins.

4 thase as well as by neonatal upregulation of uncoupling proteins.

5 chemical potential, is mediated primarily by uncoupling proteins.

6 ng thermogenesis, related to the activity of uncoupling proteins.

7 nucleotides, which are antagonists of cloned uncoupling proteins.

8 lipid radicals, a species known to activate uncoupling proteins.

9 esis requires upregulation of Pgc-1alpha and uncoupling protein 1 (Ucp-1) in brown adipose tissue.

10 the expression of sirtuin-1 and thermogenic uncoupling protein 1 (UCP-1) in the iWAT.

11 In uncoupling protein 1 (UCP-1) knockout mice, the middle a

12 wn AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-l

13 orrelates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncou

14 uch as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long

15 expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription

16 expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adrenoreceptor beta 3 (A

17 dipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energ

18 (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in BA

19 m promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-

20 MDMA treated animals showed increased uncoupling protein 1 (UCP1) and TGR5 expression levels i

21 Both uncoupling protein 1 (UCP1) and UCP3 are important for m

22 h was accompanied by increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose ti

23 Physiological induction of uncoupling protein 1 (Ucp1) by cold temperatures is prec

24 Uncoupling protein 1 (UCP1) catalyzes fatty acid-activat

25 s previously reported, HFD feeding increased uncoupling protein 1 (UCP1) expression (fold increase: 3

26 ervating BAT, and dramatically increased BAT uncoupling protein 1 (Ucp1) expression and activity in a

27 eling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and

28 A 90% reduction in uncoupling protein 1 (UCP1) expression in interscapular

29 hese findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which cor

30 elective mast cell deletion of Tph1 enhances uncoupling protein 1 (Ucp1) expression in white adipose

31 ses the endogenous PGC-1alpha protein level, uncoupling protein 1 (UCP1) expression, and oxygen consu

32 nduces mitochondrial dysfunction and reduces uncoupling protein 1 (UCP1) expression.

33 ed to the enhancer of the brown fat-specific uncoupling protein 1 (Ucp1) gene through this interactio

34 ent in liver did not alter the expression of uncoupling protein 1 (Ucp1) gene, which regulates thermo

35 ses expression of the brown adipocyte marker uncoupling protein 1 (UCP1) in both adipose tissue depot

36 VMH BDNF thermogenic effects are mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

37 t production and decreased the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

38 expenditure (EE) and decreased expression of uncoupling protein 1 (UCP1) in brown adipose tissue.

39 is is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocyte

40 n through adaptive thermogenesis mediated by uncoupling protein 1 (UCP1) in mammals.

41 LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes,

42 We observed expression of uncoupling protein 1 (UCP1) in SAT exposed to PDAC exoso

43 Uncoupling protein 1 (UCP1) is highly expressed in brown

44 Uncoupling protein 1 (UCP1) is nearly absent in brown ad

45 Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshiver

46 Uncoupling protein 1 (UCP1) is the established mediator

47 nts of heat through activation of the unique uncoupling protein 1 (UCP1) located within the inner mit

48 Uncoupling protein 1 (UCP1) mediates nonshivering thermo

49 Uncoupling protein 1 (UCP1) plays a central role in nons

50 We combined an uncoupling protein 1 (UCP1) reporter system and expressi

51 tem regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adren

52 also dissipate this proton gradient through uncoupling protein 1 (UCP1) to generate heat, but the ev

53 This was associated with recruitment of uncoupling protein 1 (UCP1)(+) beige adipocytes in WAT,

54 consistently led to the ectopic formation of uncoupling protein 1 (UCP1)(+pos) adipose tissue with lo

55 s capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and br

56 al analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brow

57 n browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermoge

58 he expression of PGC1alpha, PDK4, PPARalpha, uncoupling protein 1 (UCP1), and neuron-derived orphan r

59 thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown adipose tissue ha

60 t of glucose homeostasis were independent of uncoupling protein 1 (UCP1), but required expression of

61 protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food

62 ssue (BAT), characterized by the presence of uncoupling protein 1 (UCP1), has been described as metab

63 uce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with

64 of brown adipose thermogenic markers such as uncoupling protein 1 (UCP1), PR domain containing 16, an

65 high glucose after overexpression of either uncoupling protein 1 (UCP1), superoxide dismutase 2 (SOD

66 ering thermogenesis is mediated primarily by uncoupling protein 1 (UCP1), the development of the UCP1

67 Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 (UCP1)-based) and skeletal muscle (

68 ogram and fatty acid oxidation, 2) stimulate uncoupling protein 1 (UCP1)-independent respiration in s

69 attributed to its role in fuel oxidation and uncoupling protein 1 (UCP1)-mediated thermogenesis.

70 ession localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Ald

71 sion analyses and found that a population of uncoupling protein 1 (UCP1)-positive human adipocytes po

72 haracterized by the appearance of pockets of uncoupling protein 1 (UCP1)-positive, multilocular adipo

73 omys tridecemlineatus) express mitochondrial uncoupling protein 1 (UCP1).

74 fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1).

75 ein DeltaPsi is intrinsically low because of uncoupling protein 1 (UCP1).

76 r thermogenic energy expenditure mediated by uncoupling protein 1 (UCP1).

77 of PGC-1alpha is required for activation of uncoupling protein 1 (UCP1).

78 lipids, through activation of mitochondrial uncoupling protein 1 (UCP1).

79 thermogenesis, which requires mitochondrial uncoupling protein 1 (UCP1).

80 both electron transport chain components and uncoupling protein 1 (UCP1).

81 on the principal effector of thermogenesis: uncoupling protein 1 (UCP1).

82 steine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).

83 ough thermogenic respiration, which requires uncoupling protein 1 (UCP1).

84 ng thermogenesis involved the stimulation of uncoupling protein 1 (UCP1; P<0.01), peroxisome prolifer

85 ducible beige adipocytes as the emergence of uncoupling protein 1 after cold exposure was restricted

86 ivated receptor gamma coactivator 1alpha and uncoupling protein 1 and 3, and these changes can be rev

87 temperature as a result of higher levels of uncoupling protein 1 and a low abundance of the proinfla

88 validation, CU was used to study the role of uncoupling protein 1 and nitric oxide synthases in the a

89 press markers of brown and beige fat such as uncoupling protein 1 and transmembrane protein 26.

90 Moreover, the abundance of uncoupling protein 1 competent brite cells in white adip

91 loss was significantly associated with less uncoupling protein 1 expression (P = 0.006, R(2) = 0.09)

92 Cytochrome c oxidase activity, uncoupling protein 1 expression and maximal norepinephri

93 rd white adipocytes while directly elevating uncoupling protein 1 expression and pre-adipocyte differ

94 Pep19 induced uncoupling protein 1 expression in both white adipose ti

95 Uncoupling protein 1 expression induced by Pep19 in 3T3-

96 acids, glycolysis, fatty acid synthesis, and uncoupling protein 1 expression.

97 ific defect in proton leak due to attenuated uncoupling protein 1 expression.

98 resembles the H(+) leak via the thermogenic uncoupling protein 1 found in brown fat.

99 nterscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positiv

100 Uncoupling protein 1(+) beige adipocytes are dynamically

101 neither presence nor thermogenic function of uncoupling protein 1(+) beige adipocytes contributed to

102 om these mice showed increased expression of uncoupling protein 1, a mitochondrial enzyme that dissip

103 ative phosphorylation from ATP generation by uncoupling protein 1, a tissue-specific protein present

104 ets, including PPARgamma coactivator 1alpha, uncoupling protein 1, and carnitine palmitoyltransferase

105 ubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regul

106 h number of mitochondria and the presence of uncoupling protein 1, brown fat adipocytes can be termed

107 ined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of t

108 ramembraneous segments and the mitochondrial uncoupling protein 1, which is a transmembrane protein e

109 uced a smaller increase in BAT blood flow in uncoupling protein 1-deficient mice than in wild-type mi

110 increase BAT blood flow, CU was performed in uncoupling protein 1-deficient mice with impaired BAT ac

111 d body weight gain, induced the formation of uncoupling protein 1-positive beige adipocytes in white

112 tissue-derived AAMs expressed high levels of uncoupling protein 1.

113 of heat through the actions of mitochondrial uncoupling protein 1.

114 genes characteristic of brown fat, including uncoupling protein 1.

115 wn adipose tissue respiration independent of uncoupling protein 1.

116 Based on cell-specific markers and on uncoupling protein-1 (characteristic of both BAT and bei

117 ), leptin, C/EBPalpha, and PPARgamma but not uncoupling protein-1 (UCP-1), the CD45 hematopoietic lin

118 issipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates

119 In mammals, uncoupling protein-1 (UCP1) in brown and beige adipocyte

120 ous finding that LXRs serve as repressors of uncoupling protein-1 (UCP1) in classic brown adipose tis

121 ice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in the artery wall.

122 Uncoupling protein-1 (UCP1) is abundantly expressed in t

123 Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in w

124 BAT activation, namely increased lipolysis, uncoupling protein-1 (UCP1) mRNA, and glucose uptake, ar

125 Uncoupling protein-1 (UCP1) plays a central role in ener

126 ulation of thermogenic adipocytes expressing uncoupling protein-1 (Ucp1) regulates energy dissipation

127 vated receptor-gamma-coactivator-1alpha, and uncoupling protein-1 and -2 were increased in WAT.

128 ed high body temperature via upregulation of uncoupling protein-1 and mitochondrial oxygen consumptio

129 enic fat cell that express the mitochondrial uncoupling protein-1 and thus represent a powerful targe

130 dipose tissue (WAT) were stained for CB1 and uncoupling protein-1 by immunofluorescent staining.

131 This increased uncoupling protein-1 content in brown adipose tissue, bu

132 Energy expenditure and uncoupling protein-1 expression in BAT were slightly but

133 si stimulated significantly higher levels of uncoupling protein-1 expression in BAT, and completely r

134 PYko mice have higher oxygen consumption and uncoupling protein-1 expression in brown adipose tissue

135 /-) mice were maladaptive to cold challenge, uncoupling protein-1 expression was attenuated in the br

136 We found that CB1 was colocalized with uncoupling protein-1 in BAT, but neither protein was fou

137 However, uncoupling protein-1 levels were not increased in silden

138 short versions of the adipocyte protein 2 or uncoupling protein-1 promoters or micro-RNA target seque

139 lood vessels after exposure to cold, whereas uncoupling protein-1 was expressed in the cytoplasm unde

140 Expression levels of the tissue-specific uncoupling protein-1 were 180 times higher in BAT than i

141 Both CL and Tregs induced much higher UCP-1 (uncoupling protein-1) expression in SAT from females tha

142 mitochondrial uncoupling and thermogenesis (uncoupling protein-1, deiodinase-2, and peroxisome proli

143 The localization of uncoupling protein-1, glucose transporter-1, and norepin

144 ase 1), catalase, glutathione S-transferase, uncoupling protein-1, or transcription factor liver X re

145 t is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration

146 restriction caused by ectopic expression of uncoupling protein-1.

147 ch encodes the key thermogenic mitochondrial uncoupling protein-1.

148 ion of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tiss

149 trated that global deletion of mitochondrial uncoupling protein 2 (UCP2(-/-)) in mice impaired glucag

150 Additionally, intracellular glutathione and uncoupling protein 2 (UCP2) gene expressions were quanti

151 Uncoupling protein 2 (UCP2) has been shown to conduct ca

152 Uncoupling protein 2 (UCP2) is a mitochondrial protein t

153 Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane prot

154 Uncoupling protein 2 (UCP2) is involved in various physi

155 Here we show that voluntary exercise induces uncoupling protein 2 (UCP2) mRNA expression and mitochon

156 Uncoupling protein 2 (UCP2) plays a regulating role in h

157 Mechanistically, ROS promoted uncoupling protein 2 (UCP2) protein expression and phosp

158 The mitochondrial uncoupling protein 2 (UCP2) relieves oxidative and neuro

159 atty acids (FFAs) and elevated expression of uncoupling protein 2 (UCP2) without concomitant increase

160 Uncoupling protein 2 (UCP2), a mitochondrial anion carri

161 of glucose sensing in POMC neurons involves uncoupling protein 2 (UCP2), a mitochondrial protein tha

162 ICU1), mitochondrial Ca(2+) uniporter (MCU), uncoupling protein 2 (UCP2), and leucine zipper EF-hand-

163 pendent on the mitochondrial redox state via uncoupling protein 2 (UCP2)-dependent alterations in mit

164 n evoke strong upregulation of mitochondrial uncoupling protein 2 (UCP2).

165 PPARalpha target gene encoding mitochondrial uncoupling protein 2 (UCP2).

166 d was accompanied by increased expression of uncoupling protein 2 (UCP2).

167 al respiration in mice that are dependent on uncoupling protein 2 (UCP2).

168 MAF BZIP transcription factor A (MafA), and uncoupling protein 2 (Ucp2).

169 f proton transport mediated by mitochondrial uncoupling protein 2 (UCP2).

170 ty from inflammation via upregulation of the uncoupling protein 2 (UCP2).

171 elated peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2).

172 is increased the expression of mitochondrial uncoupling protein 2 and raised the AMP-to-ATP ratio, th

173 ochondria, ATP-hydrolyzing mitochondria, and uncoupling protein 2 are not significant contributors to

174 tor gamma co-activator alpha (Pgc1alpha) and uncoupling protein 2 expression, suggesting mechanisms f

175 ransgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) h

176 agouti-related peptide, neuropeptide Y, and uncoupling protein 2 in the hypothalamus, but no increas

177 anoxia and reoxygenation tolerance following uncoupling protein 2 or 3 and combined 2 and 3 RNAi show

178 ion through the AMP-activated protein kinase-uncoupling protein 2 pathway.

179 ation of neuropeptide expression, as well as uncoupling protein 2, and abnormal responses to a metabo

180 to chemotherapy, increase the expression of uncoupling protein 2, and decrease the entry of pyruvate

181 nzymes involved in ROS scavenging, including uncoupling protein 2, catalase, and copper zinc superoxi

182 tty-acid-induced activation of mitochondrial uncoupling protein 2.

183 by scavenging of the ROS or by inhibition of uncoupling protein 2.

184 Cardiac transcripts of genes encoding uncoupling proteins 2 and 3 are up-regulated in parallel

185 nction of the cardiac enriched mitochondrial uncoupling proteins 2 and 3 during delayed ischemic prec

186 a(2+) fluxes, have been described: the novel uncoupling proteins 2 and 3, the leucine zipper-EF-hand

187 bility to replenish ATP due to overexpressed uncoupling protein-2 (UCP-2) or (2) induction of growth

188 nscription factor-3 (Atf3) and mitochondrial uncoupling protein-2 (Ucp2) are highly induced in Tsc2-d

189 We show that genetic manipulation of uncoupling protein-2 (UCP2) directly affects substantia

190 our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with B

191 Mitochondrial uncoupling protein-2 (UCP2) is highly expressed in steat

192 Here, we demonstrated that the mitochondrial uncoupling protein-2 (UCP2) regulates NLRP3-mediated cas

193 Lipid-laden hepatocytes highly express uncoupling protein-2 (UCP2), a mitochondrial carrier tha

194 to preventing insulin release, ROS activates uncoupling protein-2 (UCP2), a mitochondrial inner membr

195 ive response in cancer cells to be linked to uncoupling protein-2 (UCP2), a mitochondrial suppressor

196 The endocrine regulation of uncoupling protein-2 (UCP2), an inner mitochondrial prot

197 developmental and nutritional programming of uncoupling protein-2 (UCP2), glucocorticoid receptor (GR

198 ation in the TCA cycle, and independently of uncoupling protein-2 (UCP2), sirtuin-2 (SIRT2), the G pr

199 In the cytoprotective hierarchy, uncoupling protein-2 appears to play a greater role than

200 Uncoupling protein-2 depletion alone significantly atten

201 ed uncoupling protein depletion and isolated uncoupling protein-2 depletion augments ROS production i

202 iac derived myoblasts is abolished following uncoupling protein-2 depletion by RNA-interference.

203 ypes of mice with targeted disruption of the uncoupling protein-2 gene (Ucp2-/-) is greater macrophag

204 Previous work in our lab has shown that uncoupling protein-2 is a major mediator of I/R in steat

205 is hypothesis, we see a dramatic increase in uncoupling protein-2 levels in the combination treated a

206 ism for modified bioenergetics that involves uncoupling protein-2 that is up-regulated in aged cells

207 nd -4, catalase, superoxide dismutase-2, and uncoupling protein-2.

208 They also exhibit decreased uncoupling protein 3 (UCP3) and mitochondrial uncoupling

209 ve stress, and despite a twofold increase in uncoupling protein 3 (UCP3) content, ATP-to-O ratios and

210 Uncoupling protein 3 (UCP3) expression increases dramati

211 Uncoupling protein 3 (UCP3) has been postulated to dissi

212 ers have shown previously that mitochondrial uncoupling protein 3 (UCP3) improves functional recovery

213 These studies investigate the role of uncoupling protein 3 (UCP3) in cardiac energy metabolism

214 Uncoupling protein 3 (UCP3) is highly selectively expres

215 Uncoupling protein 3 (UCP3) is the skeletal muscle enric

216 ion, fatty acid oxidation, and mitochondrial uncoupling protein 3 (UCP3) levels, while increasing gly

217 with a 38-58% decrease in the mitochondrial uncoupling protein 3 (UCP3) levels.

218 tivator of fatty acid oxidizing enzymes, and uncoupling protein 3 (UCP3), a thermogenic mitochondrial

219 lex IV subunit 1 (COX1) was tightly bound to uncoupling protein 3 (UCP3), but this complex was disrup

220 eases free radicals through up-regulation of uncoupling protein 3 (UCP3).

221 Conversely, restoration of uncoupling protein 3 expression attenuated reactive oxyg

222 ture associated with increased expression of uncoupling protein 3 in brown and white adipose tissues

223 Uncoupling protein 3 was markedly downregulated in Gq or

224 me proliferator-activated receptor alpha and uncoupling protein 3, increases in mitochondrial protein

225 switches mitochondrial Ca(2+) uptake from an uncoupling protein 3- and mitochondrial calcium uniporte

226 itochondrial calcium uniporter-mediated, but uncoupling protein 3-independent pathway.

227 d cell death were abrogated by knock down of uncoupling protein 3.

228 ls, as well as a reduction in the content of uncoupling protein 3.

229 mics signature in mice overexpressing muscle uncoupling protein 3.

230 ity was increased by 25% in O vs YA muscles, uncoupling protein-3 (UCP-3) protein level was upregulat

231 ous system, increasing fatty acid oxidation, uncoupling protein-3 (UCP3) expression, and thus, energy

232 e showed that the glutathionylation state of uncoupling protein-3 (UCP3) modulates the leak of proton

233 f pyruvate dehydrogenase kinase-4 (PDK4) and uncoupling protein-3 (UCP3), genes that are known to be

234 ttenuates anoxia-reoxygenation tolerance but uncoupling protein-3 depletion does not reduce anoxia to

235 rotein-2 appears to play a greater role than uncoupling protein-3 in modulating ischemia/anoxia toler

236 RNAi of uncoupling protein-3 partially attenuates the capacity t

237 ranscription factor 1, citrate synthase, and uncoupling protein-3, although KPF itself is not a direc

238 y mouse neurons and test the hypothesis that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are sp

239 with the observed 1.5-fold increase in brain uncoupling proteins 4 and 5.

240 mitochondrial factors revealed that loss of uncoupling protein 5 (UCP5) modifies the energy balance

241 0 nM), which has been reported to facilitate uncoupling protein activity, also antagonized this actio

242 ein 3 (UCP3) is the skeletal muscle enriched uncoupling protein and has previously been shown to conf

243 ion, lipolysis, and thermogenesis, including uncoupling proteins and peroxisome proliferator-activate

244 structures of mitochondrial transporters and uncoupling proteins are 3-fold pseudosymmetrical, but th

245 In conclusion, mitochondrial uncoupling proteins are necessary components of ischemia

246 Mitochondrial carriers, including uncoupling proteins, are unstable in detergents, which h

247 tion in this setting as a membrane potential uncoupling protein, but instead acted to control routing

248 endent of adenine nucleotide translocase and uncoupling proteins, decreased mitochondrial membrane po

249 anti-oxidant administration ameliorates the uncoupling protein-depleted anoxia-susceptible phenotype

250 In parallel combined uncoupling protein depletion and isolated uncoupling pro

251 e density was increased in insulin-resistant uncoupling protein-diphtheria toxin A (UCP-DTA) transgen

252 Mitochondrial uncoupling proteins dissociate ATP synthesis from oxygen

253 reactive oxygen species as proposed for the uncoupling protein family members (UCP).

254 This novel protective consequence of uncoupling protein inhibition may lead to new therapeuti

255 erformance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoup

256 f the matrix and are therefore not caused by uncoupling protein or by the opening of a nonspecific ch

257 regulators of mitochondrial function are the uncoupling proteins, particularly UCP2.

258 wn adipocytes enhances the expression of the uncoupling protein PGC-1alpha, UCP1, and a series of mit

259 the transcriptional and protein abundance of uncoupling proteins that mediates thermogenesis, and it

260 ansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitocho

261 associated with a cell-specific increase in uncoupling protein (UCP) 2 and 4 expression.

262 The mitochondrial carrier uncoupling protein (UCP) 2 belongs to the family of the

263 cle mitochondrial function and expression of uncoupling protein (UCP) 3, ADP/ATP carrier protein (AAC

264 tential and the increase in this leak due to uncoupling protein (UCP) activation by ROS.

265 regulated gene ucp-4, the sole mitochondrial uncoupling protein (UCP) in nematodes.

266 pathetic stimulation, activate mitochondrial uncoupling protein (UCP)-1 and oxidize fatty acids to ge

267 expression of the brown fat signature genes uncoupling protein (UCP)-1 and peroxisome proliferator-a

268 the C/EBPbeta(-/-) mice as was the level of uncoupling protein (UCP)-1 and UCP-3 in the muscle.

269 on of caloric excess through the activity of uncoupling protein (UCP)-1.

270 rylation and the expression of mitochondrial uncoupling protein (UCP)-2.

271 Indeed, BAT dissipates energy as heat via uncoupling protein (UCP)1.

272 Uncoupling protein (UCP)2 is a mitochondrial inner membr

273 Pase-2a activity, expression of mitochondria uncoupling proteins (UCP) and glucose transporters (GLUT

274 affect protein levels of brain mitochondrial uncoupling proteins (UCP-2, 4, and 5).

275 lity of yeast ADP/ATP carrier AAC2 and ovine uncoupling protein UCP1 allow optimal conditions for sta

276 the well-known betaAR-dependent increase of uncoupling protein UCP1 expression and expansion of beig

277 own fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia a

278 thermogenesis via enhanced expression of the uncoupling protein UCP1.

279 ediated by beige adipocytes that express the uncoupling protein UCP1.

280 a the unique expression of the mitochondrial uncoupling protein UCP1.

281 gy in the form of heat via the mitochondrial uncoupling protein UCP1.

282 ogenic pathways encoded by the mitochondrial uncoupling protein (Ucp1) and mitochondrial glycerol-3-p

283 By stimulating proton leak, mitochondrial uncoupling proteins (UCP1-3) increase mitochondrial resp

284 r strategy to a structure of isoform 2 of an uncoupling protein (UCP2) binding an inhibitor recently

285 The novel uncoupling proteins (UCP2-5) are implicated in the mitoc

286 21+/-1 vs. 18+/-1%; P<0.05), although muscle uncoupling protein (UCP3) content and maximal mitochondr

287 scle mitochondria, associated with increased uncoupling protein (UCP3) levels.

288 disease, downregulated the expression of two uncoupling proteins (UCP4 (SLC25A27) and UCP5 (SLC25A14)

289 Moreover, upregulated uncoupling protein UCP4C in intestinal stem cells and en

290 A novel uncoupling protein, UCP5, has recently been characterize

291 Uncoupling proteins (UCPs) are a family of proteins loca

292 Mitochondrial uncoupling proteins (UCPs) are involved in body weight r

293 Uncoupling proteins (UCPs) occur in the inner mitochondr

294 Uncoupling proteins (UCPs) oppose this phenotype by indu

295 Uncoupling proteins (UCPs) regulate energy expenditure i

296 s superoxide generation through induction of uncoupling proteins (UCPs), and transgenic overexpressio

297 he aim of this study was to evaluate whether uncoupling proteins (UCPs), located in the inner membran

298 uggesting that these changes are mediated by uncoupling proteins (UCPs).

299 2(+/-)) mice leads to increased expresson of uncoupling proteins (UCPs).

300 by increased expression of the mitochondrial uncoupling protein uncoupling protein 2 (UCP2) in Foxa1-

301 nd that NBI-12i normalizes the expression of uncoupling protein, which is normally upregulated in ure