ライフサイエンスコーパス: uncoupling protein 1

1 ture via thermogenesis, mainly through UCP1 (uncoupling protein 1).

2 ceptor Gamma Coactivator 1-Alpha), and Ucp1 (Uncoupling Protein 1).

3 of heat through the actions of mitochondrial uncoupling protein 1.

4 genes characteristic of brown fat, including uncoupling protein 1.

5 f thermogenic adipose tissues independent of uncoupling protein 1.

6 wn adipose tissue respiration independent of uncoupling protein 1.

7 tissue-derived AAMs expressed high levels of uncoupling protein 1.

8 restriction caused by ectopic expression of uncoupling protein-1.

9 ch encodes the key thermogenic mitochondrial uncoupling protein-1.

10 om these mice showed increased expression of uncoupling protein 1, a mitochondrial enzyme that dissip

11 ative phosphorylation from ATP generation by uncoupling protein 1, a tissue-specific protein present

12 MTII treatment also stimulated uncoupling protein 1 activity in the brown adipose tissu

13 Uncoupling protein-1 acts in brown adipose tissue (BAT)

14 ducible beige adipocytes as the emergence of uncoupling protein 1 after cold exposure was restricted

15 ivated receptor gamma coactivator 1alpha and uncoupling protein 1 and 3, and these changes can be rev

16 temperature as a result of higher levels of uncoupling protein 1 and a low abundance of the proinfla

17 validation, CU was used to study the role of uncoupling protein 1 and nitric oxide synthases in the a

18 s involved in the function and regulation of uncoupling protein 1 and the ADP/ATP carrier, the two pr

19 press markers of brown and beige fat such as uncoupling protein 1 and transmembrane protein 26.

20 vated receptor-gamma-coactivator-1alpha, and uncoupling protein-1 and -2 were increased in WAT.

21 apular brown fat but increased expression of uncoupling protein-1 and -2.

22 n uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismuta

23 ed high body temperature via upregulation of uncoupling protein-1 and mitochondrial oxygen consumptio

24 Conversely, the expression of uncoupling protein-1 and of the same mitochondrial genes

25 was associated with increased expression of uncoupling protein-1 and preferential lipid utilization

26 enic fat cell that express the mitochondrial uncoupling protein-1 and thus represent a powerful targe

27 low in adipocytes, are up-regulated, as are uncoupling proteins 1 and 2.

28 ets, including PPARgamma coactivator 1alpha, uncoupling protein 1, and carnitine palmitoyltransferase

29 ubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regul

30 ein alpha (C/EBPalpha), fatty acid synthase, uncoupling protein-1, and glucose transporter 4.

31 ontaining protein 5 (a precursor of irisin), uncoupling protein 1 as an index of thermogenic capacity

32 Uncoupling protein 1(+) beige adipocytes are dynamically

33 neither presence nor thermogenic function of uncoupling protein 1(+) beige adipocytes contributed to

34 h number of mitochondria and the presence of uncoupling protein 1, brown fat adipocytes can be termed

35 dipose tissue (WAT) were stained for CB1 and uncoupling protein-1 by immunofluorescent staining.

36 Based on cell-specific markers and on uncoupling protein-1 (characteristic of both BAT and bei

37 Moreover, the abundance of uncoupling protein 1 competent brite cells in white adip

38 This increased uncoupling protein-1 content in brown adipose tissue, bu

39 uced a smaller increase in BAT blood flow in uncoupling protein 1-deficient mice than in wild-type mi

40 increase BAT blood flow, CU was performed in uncoupling protein 1-deficient mice with impaired BAT ac

41 mitochondrial uncoupling and thermogenesis (uncoupling protein-1, deiodinase-2, and peroxisome proli

42 enetic deletion of the lncRNA Lexis enhances uncoupling protein 1-dependent (UCP1-dependent) and -ind

43 ipose tissue (BAT)-deficient obese UCP1-DTA (uncoupling protein 1-diphtheria toxin A) mice.

44 loss was significantly associated with less uncoupling protein 1 expression (P = 0.006, R(2) = 0.09)

45 Cytochrome c oxidase activity, uncoupling protein 1 expression and maximal norepinephri

46 rd white adipocytes while directly elevating uncoupling protein 1 expression and pre-adipocyte differ

47 cGMP-dependent protein kinase signaling and uncoupling protein 1 expression in adipocytes, we sought

48 Pep19 induced uncoupling protein 1 expression in both white adipose ti

49 evation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose

50 Uncoupling protein 1 expression induced by Pep19 in 3T3-

51 ific defect in proton leak due to attenuated uncoupling protein 1 expression.

52 acids, glycolysis, fatty acid synthesis, and uncoupling protein 1 expression.

53 Energy expenditure and uncoupling protein-1 expression in BAT were slightly but

54 si stimulated significantly higher levels of uncoupling protein-1 expression in BAT, and completely r

55 PYko mice have higher oxygen consumption and uncoupling protein-1 expression in brown adipose tissue

56 /-) mice were maladaptive to cold challenge, uncoupling protein-1 expression was attenuated in the br

57 Both CL and Tregs induced much higher UCP-1 (uncoupling protein-1) expression in SAT from females tha

58 resembles the H(+) leak via the thermogenic uncoupling protein 1 found in brown fat.

59 The localization of uncoupling protein-1, glucose transporter-1, and norepin

60 lt, lipolysis, as well as the mRNA levels of uncoupling protein 1, guanosine monophosphate reductase,

61 POMC gene delivery enhanced uncoupling protein 1 in brown adipose tissue (BAT) by mo

62 We found that CB1 was colocalized with uncoupling protein-1 in BAT, but neither protein was fou

63 ion of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tiss

64 nterscapular region of neonates was lower in uncoupling protein 1 knockout pups employed as a positiv

65 teraction between free fatty acids and UCP1 (uncoupling protein-1) leading to de-energization of mito

66 However, uncoupling protein-1 levels were not increased in silden

67 ic markers PPARgamma coactivator 1 alpha and uncoupling protein 1, mirrored the differentiation patte

68 Moreover, CNTF(Ax15) increased uncoupling protein 1 mRNA expression in BAT and energy e

69 Uncoupling protein-1 mRNA in brown adipose tissue was re

70 Uncoupling protein-1 mRNA levels in brown adipose tissue

71 ose tissue but expresses neither brown (e.g. uncoupling protein 1) nor white adipocyte markers.

72 c acid) porphyrin], overexpression of either uncoupling protein 1 or manganese superoxide dismutase,

73 membrane potential, or by overexpression of uncoupling protein 1 or superoxide dismutase.

74 ase 1), catalase, glutathione S-transferase, uncoupling protein-1, or transcription factor liver X re

75 d body weight gain, induced the formation of uncoupling protein 1-positive beige adipocytes in white

76 short versions of the adipocyte protein 2 or uncoupling protein-1 promoters or micro-RNA target seque

77 r cellular mitochondrial content and reduced uncoupling protein 1 protein expression, brown adipocyte

78 t is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration

79 ined as multilocular adipocytes that express uncoupling protein 1, rose from undetectable to 30% of t

80 ect adipose depots associated with increased uncoupling protein 1 thermogenesis and hypoxia.

81 BAT uncoupling protein 1 (UCP-1) content was significantly d

82 esis requires upregulation of Pgc-1alpha and uncoupling protein 1 (Ucp-1) in brown adipose tissue.

83 the expression of sirtuin-1 and thermogenic uncoupling protein 1 (UCP-1) in the iWAT.

84 In uncoupling protein 1 (UCP-1) knockout mice, the middle a

85 In the present study, we have measured uncoupling protein 1 (UCP-1) mRNA, a specific marker for

86 ry interface, focusing on the involvement of uncoupling protein 1 (UCP-1), a key metabolic regulator

87 wn AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-l

88 Brown adipose tissue uncoupling protein-1 (UCP-1) mRNA levels (collected Day

89 n were prevented by overexpression of either uncoupling protein-1 (UCP-1) or manganese superoxide dis

90 mitochondrial superoxide overproduction with uncoupling protein-1 (UCP-1) or manganese superoxide dis

91 ), leptin, C/EBPalpha, and PPARgamma but not uncoupling protein-1 (UCP-1), the CD45 hematopoietic lin

92 phenotype of emotional behavior, we propose uncoupling protein-1 (UCP-1), the key component of the t

93 orrelates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncou

94 a key thermogenic organ whose expression of uncoupling protein 1 (UCP1) and ability to maintain body

95 uch as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long

96 expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription

97 expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adrenoreceptor beta 3 (A

98 f food, they cannot upregulate expression of uncoupling protein 1 (UCP1) and convert white to beige a

99 dipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energ

100 ion of miR-130b-3p or miR-301b-3p suppressed uncoupling protein 1 (UCP1) and mitochondrial respiratio

101 (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in BA

102 m promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-

103 e/beige" adipocytes that express thermogenic uncoupling protein 1 (UCP1) and secrete factors favorabl

104 tasis, lipoprotein lipase, the mitochondrial uncoupling protein 1 (UCP1) and sterol regulatory elemen

105 MDMA treated animals showed increased uncoupling protein 1 (UCP1) and TGR5 expression levels i

106 uce BAT thermogenesis through suppression of uncoupling protein 1 (UCP1) and this may contribute to t

107 Both uncoupling protein 1 (UCP1) and UCP3 are important for m

108 h was accompanied by increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose ti

109 adaptive thermogenesis and the expression of uncoupling protein 1 (UCP1) are dispensable for the incr

110 Physiological induction of uncoupling protein 1 (Ucp1) by cold temperatures is prec

111 Uncoupling protein 1 (UCP1) catalyzes fatty acid-activat

112 is occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration.

113 Mutants of mitochondrial uncoupling protein 1 (ucp1) displayed a similar phenotyp

114 Uncoupling protein 1 (UCP1) dissipates energy and genera

115 Uncoupling protein 1 (UCP1) diverts energy from ATP synt

116 s previously reported, HFD feeding increased uncoupling protein 1 (UCP1) expression (fold increase: 3

117 ervating BAT, and dramatically increased BAT uncoupling protein 1 (Ucp1) expression and activity in a

118 Increased mitochondrial uncoupling protein 1 (UCP1) expression and function lead

119 eling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and

120 enditure, which was accompanied by decreased uncoupling protein 1 (UCP1) expression in brown/beige ad

121 A 90% reduction in uncoupling protein 1 (UCP1) expression in interscapular

122 hese findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which cor

123 elective mast cell deletion of Tph1 enhances uncoupling protein 1 (Ucp1) expression in white adipose

124 ses the endogenous PGC-1alpha protein level, uncoupling protein 1 (UCP1) expression, and oxygen consu

125 nduces mitochondrial dysfunction and reduces uncoupling protein 1 (UCP1) expression.

126 Uncoupling protein 1 (UCP1) gene expression was strongly

127 ed to the enhancer of the brown fat-specific uncoupling protein 1 (Ucp1) gene through this interactio

128 ent in liver did not alter the expression of uncoupling protein 1 (Ucp1) gene, which regulates thermo

129 lic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.

130 Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue o

131 ses expression of the brown adipocyte marker uncoupling protein 1 (UCP1) in both adipose tissue depot

132 VMH BDNF thermogenic effects are mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

133 t production and decreased the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT

134 bese Mc4r-null females were unable to induce uncoupling protein 1 (UCP1) in brown adipose tissue in r

135 expenditure (EE) and decreased expression of uncoupling protein 1 (UCP1) in brown adipose tissue.

136 is is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocyte

137 from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat(2-6) and ADP/AT

138 etal muscle and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissu

139 n through adaptive thermogenesis mediated by uncoupling protein 1 (UCP1) in mammals.

140 LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes,

141 We observed expression of uncoupling protein 1 (UCP1) in SAT exposed to PDAC exoso

142 Mitochondrial uncoupling protein 1 (UCP1) is activated in BAT during c

143 Uncoupling protein 1 (UCP1) is highly expressed in brown

144 Uncoupling protein 1 (UCP1) is nearly absent in brown ad

145 Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechan

146 Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshiver

147 Uncoupling protein 1 (UCP1) is the established mediator

148 We used BAd-CRISPR to create an inducible uncoupling protein 1 (Ucp1) knockout mouse to assess the

149 nts of heat through activation of the unique uncoupling protein 1 (UCP1) located within the inner mit

150 Uncoupling protein 1 (UCP1) mediates nonshivering thermo

151 Uncoupling protein 1 (UCP1) plays a central role in nons

152 dependent transcription of the mitochondrial uncoupling protein 1 (UCP1) promoter by beta(3)AR requir

153 We combined an uncoupling protein 1 (UCP1) reporter system and expressi

154 tem regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adren

155 also dissipate this proton gradient through uncoupling protein 1 (UCP1) to generate heat, but the ev

156 is a heater organ that expresses thermogenic uncoupling protein 1 (UCP1) to maintain high body temper

157 readipocytes and increases the expression of uncoupling protein 1 (UCP1) to promote mitochondrial act

158 This was associated with recruitment of uncoupling protein 1 (UCP1)(+) beige adipocytes in WAT,

159 consistently led to the ectopic formation of uncoupling protein 1 (UCP1)(+pos) adipose tissue with lo

160 via the expression of mitochondrial protein uncoupling protein 1 (UCP1)(1).

161 etic activation via persistent expression of uncoupling protein 1 (UCP1)(1,2).

162 s capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and br

163 al analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brow

164 n browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermoge

165 Uncoupling protein 1 (UCP1), a mitochondrial H(+) transp

166 Brown and beige adipocytes express uncoupling protein 1 (UCP1), a mitochondrial protein tha

167 he expression of PGC1alpha, PDK4, PPARalpha, uncoupling protein 1 (UCP1), and neuron-derived orphan r

168 thermogenesis mediated by the expression of uncoupling protein 1 (UCP1), but brown adipose tissue ha

169 t of glucose homeostasis were independent of uncoupling protein 1 (UCP1), but required expression of

170 protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food

171 ssue (BAT), characterized by the presence of uncoupling protein 1 (UCP1), has been described as metab

172 uce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with

173 of mitochondrial uncoupling markers, such as uncoupling protein 1 (UCP1), peroxisome proliferator-act

174 of brown adipose thermogenic markers such as uncoupling protein 1 (UCP1), PR domain containing 16, an

175 c receptors (beta-ARs) induces expression of uncoupling protein 1 (UCP1), promoting nonshivering ther

176 high glucose after overexpression of either uncoupling protein 1 (UCP1), superoxide dismutase 2 (SOD

177 ering thermogenesis is mediated primarily by uncoupling protein 1 (UCP1), the development of the UCP1

178 The level of uncoupling protein 1 (UCP1), the key thermogenic protein

179 Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 (UCP1)-based) and skeletal muscle (

180 ogram and fatty acid oxidation, 2) stimulate uncoupling protein 1 (UCP1)-independent respiration in s

181 nesis (NST) in brown and beige fat relies on uncoupling protein 1 (UCP1)-mediated heat generation, al

182 attributed to its role in fuel oxidation and uncoupling protein 1 (UCP1)-mediated thermogenesis.

183 ession localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Ald

184 sion analyses and found that a population of uncoupling protein 1 (UCP1)-positive human adipocytes po

185 haracterized by the appearance of pockets of uncoupling protein 1 (UCP1)-positive, multilocular adipo

186 r thermogenic energy expenditure mediated by uncoupling protein 1 (UCP1).

187 ein DeltaPsi is intrinsically low because of uncoupling protein 1 (UCP1).

188 of PGC-1alpha is required for activation of uncoupling protein 1 (UCP1).

189 ) dissipates chemical energy as heat through uncoupling protein 1 (UCP1).

190 onical BAT-mediated thermogenesis occurs via uncoupling protein 1 (UCP1).

191 e electron transport chain and activation of uncoupling protein 1 (UCP1).

192 ough the action of the mitochondrial protein uncoupling protein 1 (UCP1).

193 lipids, through activation of mitochondrial uncoupling protein 1 (UCP1).

194 thermogenesis, which requires mitochondrial uncoupling protein 1 (UCP1).

195 both electron transport chain components and uncoupling protein 1 (UCP1).

196 on the principal effector of thermogenesis: uncoupling protein 1 (UCP1).

197 steine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).

198 ough thermogenic respiration, which requires uncoupling protein 1 (UCP1).

199 omys tridecemlineatus) express mitochondrial uncoupling protein 1 (UCP1).

200 fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1).

201 Uncoupling protein 1 (UCP1, SLC25A7) is responsible for

202 In mammalian brown adipose tissue (BAT), uncoupling protein 1 (UCP1, SLC25A7), a member of the SL

203 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inn

204 ng thermogenesis involved the stimulation of uncoupling protein 1 (UCP1; P<0.01), peroxisome prolifer

205 issipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates

206 etrakis (4-benzoic acid) porphyrin (MnTBAP), uncoupling protein-1 (UCP1) HVJ-liposomes, or manganese

207 In mammals, uncoupling protein-1 (UCP1) in brown and beige adipocyte

208 ous finding that LXRs serve as repressors of uncoupling protein-1 (UCP1) in classic brown adipose tis

209 ice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in the artery wall.

210 Uncoupling protein-1 (UCP1) is a brown fat-specific mito

211 Uncoupling protein-1 (UCP1) is abundantly expressed in t

212 Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in w

213 Uncoupling protein-1 (UCP1) mRNA in brown adipose tissue

214 BAT activation, namely increased lipolysis, uncoupling protein-1 (UCP1) mRNA, and glucose uptake, ar

215 Uncoupling protein-1 (UCP1) plays a central role in ener

216 and induced browning, signified by increased uncoupling protein-1 (UCP1) protein expression (8.5-fold

217 ulation of thermogenic adipocytes expressing uncoupling protein-1 (Ucp1) regulates energy dissipation

218 known, as they lack brown adipose tissue and uncoupling protein-1 (UCP1), which mediate adaptive non-

219 mice and in mice with impaired BAT function (uncoupling protein 1 [Ucp1]-deficient mice).

220 eta3 agonists in nonprimate species leads to uncoupling protein 1 up-regulation and weight loss, the

221 lood vessels after exposure to cold, whereas uncoupling protein-1 was expressed in the cytoplasm unde

222 Expression levels of the tissue-specific uncoupling protein-1 were 180 times higher in BAT than i

223 ramembraneous segments and the mitochondrial uncoupling protein 1, which is a transmembrane protein e

224 o up-regulate and activate the mitochondrial uncoupling protein 1, which mediates a proton conductanc

225 ction and brown adipose tissue expression of uncoupling protein-1, which is regulated by sympathetic