ライフサイエンスコーパス: uncover

1 ctions of IL-34 are only now beginning to be uncovered.

2 s of mechanical force sensing continue to be uncovered.

3 this impaired NK cell function remain to be uncovered.

4 and egress at (sub)nanometer resolution were uncovered.

5 r, and transcriptome association approaches, uncovered 31 potential secondary loci for a total of 85

6 Here, we uncover a common liquid-liquid phase separation (LLPS) b

7 d that the fertile ask1 mutant allowed us to uncover a comprehensive set of SCF functions.

8 In this study, we uncover a conditional role for the endodermal and pulmon

9 Altogether, we uncover a conserved mechanism of paternal epigenetic inf

10 in accessibility and cis-regulatory elements uncover a core mRNA-ncRNA transcriptional signature shar

11 pression in embryonic neural development and uncover a crucial epigenetic mechanism balancing forebra

12 Altogether, our findings uncover a druggable pathway as a potential therapeutic t

13 Whole genome sequencing was used to uncover a frame-shift insertion affecting the alpha-L-id

14 brane turnover that is induced by stress and uncover a function for LC3 lipidation in regulating lyso

15 Our results uncover a function for ribosomes on non-coding regions o

16 These findings uncover a key survival signal in CRC through convergent

17 Our studies uncover a linear signaling pathway from HRI to ATF4 to B

18 Here, we uncover a link between INM proteome identity and membran

19 These results uncover a major cause of hepatic vascular cavernomas and

20 Our results uncover a mechanism by which an enteric pathogen subvert

21 Our resource enabled us to uncover a multi-RhoGEF complex downstream of G-protein-c

22 Our results uncover a multipronged strategy utilized by SARS-CoV-2 t

23 We also uncover a new mode of action for HU and identify potenti

24 Our findings also uncover a new pathogenic mechanism by which beta-catenin

25 Proteomic analyses uncover a new role for poly(ADP-ribosyl)ation (PARylatio

26 Altogether, we uncover a nonredundant role for IFN-gamma and its downst

27 omics data from Saccharomyces cerevisiae, we uncover a novel group of proteins trafficking from the E

28 Here, we uncover a novel mechanism by which the human papillomavi

29 Our data uncover a novel pathway that controls axon regrowth thro

30 Thus we uncover a novel relationship between FASN, RhoU and Cdc4

31 Our findings uncover a novel role for 4.1N in the axis of hypothalamu

32 viously described phage receptors as well as uncover a number of previously unknown host factors that

33 Our findings uncover a paradigm for a lipid storage response in which

34 o- and anti-inflammatory IL-2C treatment and uncover a pattern of expression that reveals potentially

35 Taken together, these results uncover a potential novel pharmacological strategy again

36 Unexpectedly, we uncover a potentially generalizable activation site that

37 These results uncover a previously unrecognized cell-autonomous, light

38 Here, we uncover a range of conformational effects in full-length

39 for genetic determinants of 2-OG levels, we uncover a redox sensitive mitochondrial lipoylation path

40 Overall, our data uncover a regulatory mechanism whose disruption by mater

41 Our results uncover a role for the beta-catenin signaling pathway in

42 These results uncover a SHF vasculogenic contribution to coronary lymp

43 issue of Developmental Cell, Ho and Treisman uncover a signal transduction pathway that coordinates m

44 Our results uncover a simple design principle of organ growth where

45 We uncover a striking phenomenon: memory associated with no

46 Thus, our results uncover a trans-dominant role for an aberrantly expresse

47 We uncover a transient structure in GABAergic population dy

48 tile state of airway smooth muscle (ASM) and uncovered a complex mechanism of odorant-evoked signalin

49 Thus, our study uncovered a complex relationship between TORC1 inactivat

50 We thus uncovered a DEL-1/alphavbeta3/RUNX1 axis that promotes T

51 We uncovered a dimeric state of UBE2S that confers autoinhi

52 ells, and ex vivo and in vivo rat models, we uncovered a function of 14-3-3zeta.

53 on of various mismatched base pairs and have uncovered a mechanism in which the rate constant for pyr

54 Notably, genome-wide expression analysis uncovered a melanocytic plasticity signature predictive

55 In summary, we uncovered a molecular interplay that enables massive hiP

56 We uncovered a network of RNA-RNA interactions spanning ten

57 Collectively, our study uncovered a novel mechanism by which AtPRMT3 cooperates

58 Finally, we uncovered a novel role for PAR-6 in organizing non-centr

59 This work uncovered a novel role for Par3 in controlling the actin

60 Taken together, the findings from this study uncovered a novel role of Kv11.1 channels in lung functi

61 Furthermore, we uncovered a novel stress-specific cis-element in introni

62 Here, we uncovered a pathway in which delta-catenin, a component

63 ed the expression of ZFP628 in the mouse and uncovered a postmeiotic germ cell arrest at the round sp

64 Our screen uncovered a previously undisclosed, extensive network of

65 Here we uncovered a previously unrecognized communication route

66 Consequently, we uncovered a reversible pH-induced switch of the heme axi

67 Recent work has uncovered a role for B cells in the induction and activa

68 We uncovered a role for Xinbeta in signaling via the Hippo-

69 subsequent investigations in lymphomas have uncovered a significant heterogeneity of tumor-infiltrat

70 circadian period of upf-1(prd-6) mutants, we uncovered a strong influence of the Nonsense Mediated De

71 involved in heparin/heparan sulfate assembly uncovered a transcription factor-binding motif for ZNF26

72 apical extracellular matrix (aECM), we also uncovered a vast matrix associated with the developing g

73 We uncovered a whole-genome duplication that occurred in th

74 the biophysical explanation alone while also uncovering a common mechanism for phenomena observed in

75 steoclastogenesis, and trabecular bone loss, uncovering a pathological mechanism underlying the link

76 ry genes in both 2D- and 3D-culture systems, uncovering a vulnerability of spheroid cancer cells depr

77 In conclusion, the structure of RNF213 uncovers a distinct type of an E3 enzyme, highlighting t

78 This study uncovers a mechanism for integrating environmental cues

79 Taken together, this research uncovers a mechanism of chemotherapy-mediated metastasis

80 In contrast, SOS LASSO uncovers a network spanning all four lobes of the brain.

81 Our study uncovers a new role for Gravin in coordinating gamma-tub

82 This study uncovers a previously underappreciated dependency of tum

83 falciparum than previously postulated as we uncovered active de novo biosynthesis and substantial le

84 To test these hypotheses and uncover additional functions of wrapping, we investigate

85 es including primary and secondary veins may uncover additional insights.

86 To uncover additional mechanisms that specify cysteines tha

87 ptamine and 2,3-pentanedione is subsequently uncovered, allowing us to develop a five-step asymmetric

88 olism and the pentose phosphate pathway, and uncover an accompanying metabolic vulnerability for ther

89 We uncover an endogenous strategy of functional gene rescue

90 We uncover an Fe-related spectral transition of Fe:MoS(2) m

91 Further, we uncover an inverse power law behaviour of spectral measu

92 Here, we uncover an unconventional pathway that activates mTORC1

93 s and epistasis experiments in P. putida, we uncovered an 'upstream' cascade of three consecutive tra

94 The results have uncovered an antiviral mechanism through inhibitor-induc

95 Our analysis uncovered an evolutionarily conserved let-7-5p-binding s

96 Here, we uncovered an unexpected specific interaction of LOTUS do

97 omote survival following replication stress, uncovering an unexpected link between stress and sister

98 esence of these global tonotopic maps, while uncovering an unexpected local variability in the stimul

99 Our work uncovers an essential role of YTHDF3 in controlling the

100 undoped and Al and/or Ga-doped LLZO variants uncovers an interplay between the local network of atoms

101 The structure uncovers an unexpected, eukaryotic specific and dynamic

102 ose tissue in wound healing, and may help to uncover and develop fat-related wound healing treatments

103 2 to 8 months of healing, all implants were uncovered and connected to the corresponding healing abu

104 directions to fill the gaps in knowledge we uncovered and inspire further research.

105 Sexual practice has recently been uncovered as a major source of microbiota variation, pot

106 thma provide a novel path forward to further uncovering asthma mechanisms and therapy.

107 al IL-10R2 homodimeric receptor complex, and uncovered broad receptor cross-talk of IL-22Ralpha1 and

108 nd the progression of solid tumors have been uncovered by recent studies.

109 The molecular changes uncovered by the in vitro studies were verified in both

110 sets, preserving the chemical heterogeneity uncovered by the single-cell analysis while offering the

111 models will improve our ability to correctly uncover cancer genetic dependencies and will facilitate

112 pped clonal trajectories for each sample and uncovered combinations of mutations that synergized to p

113 These findings not only uncover commonalities between homeostatic and Hebbian pl

114 Bayesian networks were estimated, to uncover complex interrelationships and confounding effec

115 ighlight that GeneTrail is well equipped for uncovering complex molecular mechanisms.

116 These discoveries also uncover complexities: Results from experiments with Arab

117 Our work uncovers components of a gene regulatory network that co

118 A novel cell polarity network is uncovered comprising TKS5, FGD1, and CDC42, directing in

119 gut microorganisms and the CNS continues to uncover critical and previously unappreciated clues in u

120 The uncovered critical behavior in sleep- and wake-related c

121 Together, our study uncovers critical roles of the actin bundler T-Plastin t

122 searches highlight the utility of LDtrait in uncovering cross-trait associations for cancer risk and

123 t of system x(c)(-), xCT (xCT(-/-) mice), we uncovered decreased neurotransmission at corticostriatal

124 We uncovered deficits in insulin secretion, partly due to r

125 We uncovered deficits in insulin secretion, partly due to r

126 ear subtypes within dystrophic myofibers and uncover degenerative and regenerative transcriptional pa

127 Here, we uncover developmental pluripotency associated 2 and 4 (D

128 These findings uncover differences in nucleotide salvage and de novo bi

129 ly explain cellular diversity, but will also uncover different ways to execute similar processes and

130 h genetic mutations to a natural environment uncovers different contributions to variations in microb

131 Our investigation uncovered differential binding of these NPC subunits, wh

132 SPR-based functional genomics approaches can uncover disease mechanisms and therapeutic targets in ne

133 We uncover dozens of kinase-disease associations spanning f

134 cal explorations of the electronic structure uncovered electronic stabilization through the opening o

135 We uncovered epidemiological patterns that highlight the im

136 lation and chromatin accessibility profiling uncovering epigenetic reprogramming at >1400 sites in ne

137 We also uncover evidence of ramping cell activity in humans, whi

138 s of filovirus entry destabilize EBOV GP and uncovered evidence that the most potent inhibitors act t

139 populations distinguished by unique CNAs and uncovering evidence of convergent evolution.

140 Here, we uncover evolutionarily conserved rules of engagement bet

141 that synchrotron-based X-ray imaging enabled uncovering finer details of the variation of particle mo

142 dispersal unit and physical environment have uncovered fluid dynamic mechanisms of seed flight, prote

143 ncing analyses in seven affected individuals uncovered four distinct heterozygous GBF1 variants, two

144 We also uncovered functional similarities and differences among

145 d pathway annotations and showed that NetPAS uncovered functional terms missed by DAVID and WebGestal

146 However, uncovering functional glycan ligands is challenging due

147 Here, we aimed to uncover genome-wide alterations in uracil pattern upon d

148 ly leverages decades of plant collections to uncover global responses in floral pigmentation linked t

149 nts with Fe-replete and Fe-limited cells, we uncover how soil Pseudomonas species reprogram their met

150 of CR as a geroprotective intervention, and uncovers how metabolic intervention can act upon the imm

151 ment and a regulator of glycine homeostasis, uncovering hyperglycinemia as a driver of HLD10 pathogen

152 Our work uncovers important roles for HDAC1 in 8-oxoG repair and

153 y, we establish the capacity of our model to uncover in vivo activity for the biotin biosynthesis inh

154 Through a screen to uncover ion channels with roles in circadian rhythms, we

155 data distributed across several databases or uncover links between diseases and genes by analyzing th

156 We uncover local rules governing the identity of the topolo

157 new technique based on band-pass filters for uncovering local-scale signals hidden by regional subsid

158 Research in the last decade has uncovered many new paramyxoviruses, airborne agents that

159 k data sets, we illustrate that RiboDiPA can uncover meaningful pattern differences across multiple b

160 The uncovered mechanism enables a pathogen to express foreig

161 igenomics to identify regulatory programs to uncover mechanisms and key biomarkers of tumor progressi

162 Our data uncover mechanisms whereby stromal fibroblasts regulate

163 ea during gene manipulation should assist in uncovering mechanisms for tooth pulp inflammatory pain a

164 aluation of cancer and immune metabolism can uncover metabolic vulnerabilities and therapeutic window

165 phenotype, and that a lineage approach would uncover metastatic melanoma biology.

166 These findings uncover molecular determinants critical for agonist bind

167 orofacial area remains a major bottleneck in uncovering molecular mechanisms that govern inflammatory

168 These studies uncover multiple regions within Set5 that regulate its l

169 h which the ISR can be modulated promises to uncover new avenues to diminish pathologies resulting fr

170 ole of the epigenome in clonal evolution and uncover new candidate pathways associated with relapse.

171 ve disease, perform clinical prediction, and uncover new clinical and genetic correlates of cardiac a

172 , enabling visual graph mining techniques to uncover new insights from the "ocean" of known bioactive

173 Our discoveries may uncover new potential interventional strategies that blo

174 d O-GlcNAc sites in TAB1 (S395 and S396) and uncovered new sites within both proteins.

175 e, yield potent tumor suppressor activities, uncovering new therapeutic opportunities to counter this

176 f the ferrous iron-dependent interactome and uncovers new targets for the therapeutic modulation of f

177 ap in the contraceptive portfolio as well as uncover novel human sperm biology.

178 ss made using systems genetics approaches to uncover novel mechanisms and molecular bases of cardiova

179 as a translational research opportunity for uncovering novel disease mechanisms and therapies.

180 Previous studies have uncovered NTP-mediated excision mechanisms that may be r

181 Indeed, researchers have uncovered numerous examples of FOXA-dependent epigenomic

182 Notably, some phenotypes were uncovered only in physiological oxygen.

183 plexes over the thin filament surface, which uncovers or blocks myosin binding sites along F-actin.

184 spaced M1 sites, which was the linchpin for uncovering organizational principles.

185 Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial

186 These studies uncover parameters that can be tuned to maximize fluorog

187 r analysis, we show that this algorithm also uncovers phase sensitive information about the underlyin

188 aits associated with pericyte maturation and uncover PI3Kbeta activity as a checkpoint to ensure appr

189 and progression provides the opportunity to uncover potential molecular vulnerabilities that can be

190 These results uncover Pou2f1/2 as regulators of the temporal window fo

191 Using structure-guided sequence analysis we uncover previously uncharacterized CIF peptides conserve

192 The information from the morphome uncovers previously unknown effects of nanotopography on

193 This study uncovers previously unknown mechanisms of Hippo regulati

194 ructure and its condition-dependent activity uncover putative or recently discovered roles for at lea

195 A-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resi

196 ive "perturb and observe" genetic screens to uncover regulatory mechanisms driving complex mammalian

197 ility of RNA sequencing and genetic tools in uncovering RGC type-specific roles during the developmen

198 ermined rates of RNA biogenesis and decay to uncover RNA regulatory strategies during stepwise conver

199 nd E4orf6 are degraded by the proteasome, we uncovered RNA-binding proteins as high-confidence substr

200 These findings thus uncover ROCK2 as a multifaceted and therapeutically targ

201 Our analyses uncover salient features of preBotC network dynamics whe

202 Our work uncovers SETD5 as a key mediator of acquired MEKi therap

203 sk HLA-DQ2.5 and DQ8.1, the current analysis uncovers seven residues (alphaa1, alpha157, alpha196, be

204 inherited deafness in the past decades have uncovered several molecular constituents of the MT compl

205 Furthermore, our analyses uncovered several recurring UV mutations following acute

206 This uncovered several that were heavily enriched in developm

207 Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a cri

208 Collectively, these data uncover shared and unique features between neural reside

209 growing understanding of both processes has uncovered significant connections.

210 Recent studies uncovered significant roles for intestinal microbiota in

211 Inspired by the findings, we uncovered similar concentration-independent behavior fro

212 rescent markers to simulate contamination of uncovered skin and hair of health care workers wearing p

213 FynSensor imaging uncovers spatially organized, sensitized signaling clust

214 rlying such belief updates, we need tools to uncover subjects' belief dynamics from natural behavior.

215 rally infected liver cancer TCGA cohort, and uncovered suggestive evidence that tumor neoepitopes act

216 Taken together, we uncover T cell-derived GM-CSF as a key inducer of the ch

217 of recalcitrant cancers has the potential to uncover targetable signaling networks, such as the GNAS/

218 Together, these data uncover TDRD7's novel upstream role in elevation of stre

219 In vivo studies uncover that EhActn2 plays an important role in phagocyt

220 We uncover that miR-371-373 are highly expressed in naive h

221 In addition, we uncover that mycobacteria resist antibiotic lethality th

222 Our findings uncover that the H4 basic patch has a regulatory functio

223 We uncover that this substrate selectivity is based on the

224 Hoffmann et al (2020) now uncover that when the epigenetic chromatin cycle falters

225 This uncovered that FoxO1 binds to the promoters of 60% of ca

226 Third, we uncovered that insulin-like growth factor 1 (IGF1) is pr

227 Collectively, our studies uncovered that KLF6 govern inflammatory and hypoxic resp

228 alysis of PMEL17 homologs from other mammals uncovered that long and short RPT isoforms are conserved

229 Further analysis uncovered that nuclear Parkin increases the transcriptio

230 Finally, we uncovered that the longest codon dwell times could be ex

231 rification and split-ubiquitin analyses, and uncovered that they form tripartite direct interactions.

232 ls, was surprising and further investigation uncovered that under conditions of stress the import of

233 We uncovered that V3 INs are organized into early-born [emb

234 Our work uncovered that V3 INs were organized into either early-b

235 plain how these remarkable birds can help us uncover the basic biological processes driving technolog

236 These results uncover the biochemical sequence of intermediates in a b

237 analyses with computational docking results uncover the differences between CB2 and CB1 in receptor

238 a mechanistic home range analysis (MHRA) to uncover the drivers underlying home range patterns in a

239 he transient TF-target interactions captured uncover the early mode-of-action of NIN-LIKE PROTEIN 7 (

240 Our results uncover the existence of an arousal-modulated thalamo-co

241 ted cargo internalization in cell lines, and uncover the exocyst complex as a previously unidentified

242 To uncover the function of Ddr2, we used Ddr2(slie/slie) mi

243 ing the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation o

244 e findings exploit murine organoid models to uncover the mechanism of ERG-mediated tumorigenesis and

245 MPAR epilepsy therapeutics and facilitate to uncover the mechanisms by which TARPs modulate the recep

246 res and illustrates a systematic approach to uncover the mechanisms of diverse cellular membrane remo

247 electron paramagnetic resonance measurements uncover the molecular basis of the so-called bridging gl

248 sonance energy transfer (FRET) microscopy to uncover the molecular mechanism for how surface sensing

249 Recent data have begun to uncover the molecular mechanisms by which inflammation -

250 We uncover the opposite roles by ARID1A to govern both earl

251 chroism and first-principles calculations to uncover the origin of high-temperature magnetism in thes

252 -based activity prediction and applies it to uncover the putative bioactivity of food compounds.

253 ltisource satellite imagery with modeling to uncover the rapid development of damage areas in the she

254 The goal of this study was to uncover the role of FIR in ECFCs function and to reveal

255 Here we use live and fixed cell imaging to uncover the role of Nek8445 in regulating Giardia cell d

256 To uncover the sources of SARS-CoV-2 introductions and patt

257 nd cellular levels, creates opportunities to uncover the underlying mechanisms of stress-related dise

258 Sequencing of RNA from the endothelial cells uncovered the activation of Gene Ontology (GO) pathways

259 Studies in recent years have uncovered the crucial function of neuroimmune interactio

260 ion single-cell profiling in tissue, we have uncovered the diverse landscape of CD8(+) T cells in pso

261 e assembly and re-sequencing 453 genomes, we uncovered the genetic architecture of traits that have b

262 Although biochemical studies have uncovered the mechanisms involved in controlling transcr

263 bacterial species and the in-depth analysis uncovered the presence of several antimicrobial resistan

264 eam imaging by time of flight (MIBI-TOF), we uncovered the spatial organization of metabolic programs

265 Uncovering the different activities and downstream effec

266 lity of our in vitro organoid approaches for uncovering the early consequences of oncogenic KRAS expr

267 This paper focuses on uncovering the feedbacks responsible for the WPS.

268 cell division (FtsW-FtsI), and we are still uncovering the importance of the other seemingly redunda

269 Uncovering the molecular mechanisms and function of HE4

270 quilibrium ET dynamics, which is critical to uncovering the molecular nature of many biological funct

271 Uncovering the muscle-specific role of TRIM32 in LGMD2H

272 Uncovering the principles of this dynamism, including ne

273 re techniques such as Hi-C, have been key in uncovering the quantitative information needed to determ

274 in 2007(1), much effort has been devoted to uncovering the sources of the extragalactic, millisecond

275 Uncovering the underlying metabolic networks is essentia

276 ad to the genesis and progression of tumors, uncovering the underlying molecular mechanisms and poten

277 developed PHI1, a BRAF inhibitor that fully uncovers the allosteric site.

278 ization mass spectroscopy (SVUV-PIMS), which uncovers the existence of gas-phase radical pathways.

279 the broad functional repertoires of PRDs and uncovers the impact of posttranslational modifications i

280 ignaling between these two tumor populations uncovers the paracrine crosstalk from tumor core that pr

281 rystals from charge density projections, and uncovers the structures of sublayer surfaces and their e

282 Furthermore, the mutational analysis uncovers the TM1 region of Mgr2 critically required for

283 We uncovered therapeutic genetic variation among eukaryotic

284 ds to sufficiently explore genomic datasets, uncover this signal, and accurately infer evolutionary h

285 Uncovering this link might open novel ways of treatment

286 Recent meta-transcriptomic studies have uncovered thousands of leviviral genomes, but most of th

287 Single-cell RNA sequencing uncovered three epicardial subpopulations with specific

288 generated by the Tabula Muris consortium to uncover transcriptional networks that maintain tissue-sp

289 ingle-cell RNA-sequencing profiling, we have uncovered transcriptional regulators and downstream gene

290 nce by pinpointing resistance mechanisms and uncovering transmission patterns.

291 ly controlled CRISPR-Cas9-mediated knockouts uncovered two distinct functions of Hmga1 in neural cres

292 Mutational analysis uncovered two dsRNA-binding domains of RHA that are nece

293 clerosis studies are missed opportunities to uncover underlying sex-specific mechanisms.

294 ultifinality pose considerable challenges to uncovering underlying mechanisms and understanding varie

295 Moreover, ligand-bound TRPM8 structures have uncovered unforeseen binding sites for both cooling agon

296 Further transcriptional profiling uncovered unique upregulation of the inhibitors of diffe

297 enetic relationship among targeted trees was uncovered utilizing GBS (Genotyping by Sequencing) platf

298 us, cell-to-cell heterogeneity can be simply uncovered via the determination of metals in the individ

299 Uncovering whether convergent adaptations share a geneti

300 Recent studies have uncovered whole genome sequence of SARS-CoV-2 (causing C