ライフサイエンスコーパス: underexpressed

1 ched normal samples (13 overexpressed and 28 underexpressed).

2 ulted in identification of one band that was underexpressed.

3 ger and, due to decreased mRNA stability, is underexpressed.

4 verexpressed while hundreds of others become underexpressed.

5 ke breast cancer (BLBC), in which ERalpha is underexpressed.

6 ematically and persistently overexpressed or underexpressed.

7 of identified miRNAs by miRNA profiling were underexpressed.

8 al responses in patients in which morgana is underexpressed.

9 -carbon metabolism, were hypermethylated and underexpressed.

10 X) activity in disorders where PGC-1alpha is underexpressed.

11 mean expression were designated as over- or underexpressed.

12 the monosomy 3 group, whereas two spots were underexpressed.

13 In comparison to MC, the genes were over- or underexpressed.

14 f these, 747 were overexpressed and 416 were underexpressed.

15 ng hormone receptor (GHRHR) and Homer-2 were underexpressed.

16 ly overexpressed, while p16 was consistently underexpressed.

17 s chlorophyll a/b binding protein (CAB) gene underexpressed 1 (cue1) mutant underexpresses light-regu

18 Two mRNAs were underexpressed 20-35%, including the f-subunit of mitoch

19 with or without VPF/VEGF overexpressed 9 and underexpressed 6 genes in comparison with their senescen

20 genes were overexpressed and 120 genes were underexpressed after budesonide treatment.

21 L8, IFIH1, NFKB1A, IL6, ISG15, and EGFR were underexpressed and ACTB, HSP90AA1, RAB7A, and RPS27A wer

22 ges, where IFN gamma-up-regulated genes were underexpressed and down-regulated genes were overexpress

23 Thus, both underexpressed and harmful B cell receptors can undergo

24 ven genes were overexpressed, two genes were underexpressed and one gene was lost.

25 re-examined the phenotype of three cue (cab-underexpressed) Arabidopsis mutants, defective in chloro

26 rsus negative cases (55 overexpressed and 97 underexpressed at P < 0.001).

27 Allele B, which is underexpressed at the RNA level, contains a one-nucleoti

28 glycosylation was seen in proteins that were underexpressed based on the reversed-phase chromatogram

29 gene of typical MLL fusion oncoproteins was underexpressed before and at MDS diagnosis.

30 xpressed (17 were overexpressed, and 27 were underexpressed) between malignant high-grade astrocytoma

31 , DNMT3A, was aberrantly hypermethylated and underexpressed, but not mutated in myeloma.

32 hsa-miR-203, hsa-miR-210, hsa-miR-205*) were underexpressed by > 2-fold in diseased vs. healthy gingi

33 Genes over- and underexpressed by Fuchs' endothelium were limited to P <

34 SAM analysis identified 11 genes that were underexpressed by macular RPE cells.

35 involved in proliferation and migration and underexpressed cartilage matrix genes.

36 y nodes of empirical networks with over- and underexpressed centrality relative to a null baseline.

37 ipt abundance in F1 hybrids (either over- or underexpressed compared to both parent species) did not

38 ct groups of genes that were either over- or underexpressed compared with normal thyroid, whereas the

39 Over- and underexpressed components of previously published gene s

40 urodegenerative disorders were significantly underexpressed during fetal life (N=46 genes, p=1.67x10-

41 BMP-2 had no effect in three cell lines that underexpressed either the BMP receptors or Smad1.

42 e was used to estimate the cellular level of underexpressed FliK, which could partly restore function

43 rkedly elevated in the NSCLC cell lines that underexpressed gamma-catenin relative to those lines tha

44 ansgenic plants that either overexpressed or underexpressed GAST1 RNA exhibited no phenotypic differe

45 receptor-2 (DR5) was the most differentially underexpressed gene in the TP53 mutated cases.

46 r nitrogen assimilation, whereas many of the underexpressed genes are amino acid permeases.

47 using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene fam

48 rliest stage of metanephric development, and underexpressed genes corresponding to later stages.

49 ion at their transcription start sites while underexpressed genes featured hypomethylation at polycom

50 Semaphorin 3F (SEMA3F), is among the top 1% underexpressed genes in HNSCC, and that genomic loss of

51 Highly underexpressed genes include CD26, Stat-4, and the IL-1

52 alpha regulatory subunit, and IGFBP6, while underexpressed genes included NeuroD and nicotinic choli

53 ncluding 2 TET2-mutated cases, significantly underexpressed genes known to be downregulated in angioi

54 includes, at least in part, a collection of underexpressed genes that encode proteins that inhibit c

55 erexpressed genes and 13 of 28 clusters with underexpressed genes were concordant with previously rep

56 cDNAs were overexpressed and 303 cDNAs were underexpressed greater than 2-fold, compared with B10.RI

57 n oncogenic v-ras(Ha) gene, and RARalpha was underexpressed in a benign keratinocyte cell line carryi

58 elevance because the UBQLN1 gene is lost and underexpressed in a large percentage of human cancer cel

59 protein-tyrosine phosphatase 1B (PTP1B) was underexpressed in a panel of ovarian carcinoma-derived c

60 Furthermore, miR-21 was found to be underexpressed in a subset of Cdc25A-overexpressing colo

61 2 (NRF2) pathway signature was significantly underexpressed in AdCC of submandibular compared to paro

62 ent of a male-predominant transcript that is underexpressed in adult male hybrids of Drosophila pseud

63 The selected genes are relatively underexpressed in all of the organs examined and belong

64 BVES was found to be underexpressed in all stages of human colorectal carcino

65 Both cytosolic CK forms (CKM and CKB) were underexpressed in blood from asthmatics compared with co

66 MiRNA-136 was underexpressed in both OSCC vs. HCs and OSCC vs. OSCC-R.

67 miR-708 was underexpressed in CD44(+) cells from prostate cancer xen

68 on analysis, that miR-34a, a p53 target, was underexpressed in CD44(+) prostate cancer cells purified

69 that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integra

70 overexpressed while only hsa-miR-598-3p was underexpressed in CF.

71 Genes underexpressed in cortical regions that exhibit this acc

72 8 miRNAs are overexpressed and 28 miRNAs are underexpressed in cSCC compared to normal epidermis.

73 one (cDNA clone 56-1) that was significantly underexpressed in cystic kidneys.

74 demonstrated that miR-193b was significantly underexpressed in DDLS compared with normal fat.

75 We also demonstrate that MeCP2 is underexpressed in DS brain specimens isolated from eithe

76 cantly more genes are overexpressed than are underexpressed in dystrophic muscle, with dystrophin und

77 One class of genes underexpressed in endocrine-resistant tumors (relative t

78 A hemoglobin cluster was identified that was underexpressed in ERA patients but overexpressed in syst

79 osine monophosphate (cAMP) signaling and are underexpressed in GC-resistant or relapsed ALL patients.

80 rotein 45 (IIp45) we recently identified was underexpressed in glioblastoma multiforme, the most mali

81 one transcriptional regulator that was both underexpressed in GR(369-) larvae and consistently overe

82 ses, microRNA-218 (miR-218) was specifically underexpressed in HPV-positive cell lines, cervical lesi

83 The glucose transporter 1 (GLUT1) protein is underexpressed in human glioblastoma multiforme and is o

84 sed in synovial sarcoma cells but relatively underexpressed in human iPSC-derived cardiomyocytes, lev

85 analysis, miR-375 was identified as the most underexpressed in human oral tumor versus controls.

86 t ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression

87 more, nine miRNAs were overexpressed and one underexpressed in integrated HPV-16 cell lines compared

88 All of these genes were underexpressed in males with no sperm, including a numbe

89 PTEN encodes a lipid phosphatase that is underexpressed in many cancers owing to deletions, mutat

90 Notably, we found that SMCHD1 is underexpressed in many types of human hematopoietic mali

91 We demonstrate that DOCK4 is underexpressed in MDS bone marrow samples and that the r

92 nist FRZB was aberrantly hypermethylated and underexpressed in MDS stroma.

93 croRNA 218 (miR-218), which is significantly underexpressed in medulloblastoma, was evaluated.

94 LMNA was significantly underexpressed in mRNA from peripheral blood and myocard

95 MPC1 is deleted or underexpressed in multiple cancers and correlates with p

96 d concomitantly deleted, hypermethylated and underexpressed in multiple independent lung tumor data s

97 tic tissues, whereas FABP-1 is paradoxically underexpressed in NASH, suggesting a new potential mecha

98 oup (128%, P < 0.001), but was paradoxically underexpressed in NASH-mild versus SS (73%, P < 0.001),

99 xoacyl CoA thiolase, and ubiquitin also were underexpressed in NASH.

100 actor early growth response gene 1 (EGR1) is underexpressed in non-small-cell lung cancer (NSCLC) com

101 miRNAs were overexpressed and 16 miRNAs were underexpressed in OAD mice on day 15.

102 The 279 genes that are underexpressed in older liver samples are highly enriche

103 ify two miRNAs, miR-15a and miR-16, that are underexpressed in ovarian cell lines and in primary ovar

104 RNPS1, ADD1, and PLXNA3 were underexpressed in OVCA cell lines compared to HOSE cell

105 EN, SV3a is the most consistently relatively underexpressed in patients compared with controls.

106 th recent observations that these miRNAs are underexpressed in primary cancers support the idea that

107 us to identify 11 genes that were frequently underexpressed in prostate cancer and that co-localized

108 d hepatocyte growth factor, and is generally underexpressed in prostate cancer specimens.

109 Genes underexpressed in PTC included tumor suppressors, thyroi

110 ctivation, metabolism, and survival that are underexpressed in resting memory T cells from MHC class

111 sets were found to be significantly over- or underexpressed in RPE, respectively, compared with retin

112 family, some of which phosphorylate pRb, are underexpressed in senescent cells, others are expressed

113 BRD2 is underexpressed in some subtypes of human lymphoma and th

114 CG5762 is underexpressed in sterile backcross males compared with

115 The ROS and NRF2 pathways are underexpressed in submandibular and minor AdCCs compared

116 tumors identified miR-30c-2* and miR-497 as underexpressed in TAp63-deficient cuSCC.

117 ysis revealed that 187 genes were relatively underexpressed in the absence of SigF in early stationar

118 P1) and 14-3-3final sigma, were consistently underexpressed in the adenocarcinomas, suggesting that t

119 Morgana is also underexpressed in the BM of a portion of patients affect

120 Moreover, we found that morgana is underexpressed in the BM of patients affected by atypica

121 Of those, 382 and 296 were either over- or underexpressed in the SP cells, respectively.

122 Many of these loci are significantly underexpressed in tumors with MYCN amplification, which

123 yomiR), including miR-22, which was strongly underexpressed in tumors.

124 of calcium-binding proteins, is known to be "underexpressed" in cultured breast carcinoma-derived cel

125 esults and find that CaN19 is also markedly "underexpressed" in several carcinoma-derived cell lines

126 erentially expressed (4 overexpressed and 12 underexpressed) in patients with cirrhotic-stage NASH.

127 e A2, and phospholipase D were significantly underexpressed, in breast cancer cells compared with HME

128 Genes that were significantly underexpressed included genes important for maintaining

129 higher bacterial burdens than control mice, underexpressed indoleamine-2,3-dioxygenase (Ido1) in lun

130 1254 and 363 were overexpressed (>2-fold) or underexpressed (<0.5-fold), respectively, in the SP.

131 he transcriptional regulatory regions of the underexpressed metabolic genes, and we then hypothesized

132 signature included overexpressed miR-155 and underexpressed miR-144 and miR-451.

133 ic homolog 4 (Smad4), whereas two frequently underexpressed miRNA families, miR-26 and miR-29, cooper

134 unctional overexpression of miR-31, the most underexpressed miRNA in serous ovarian cancer, repressed

135 SCC patients compared to HCs: 11 miRNAs were underexpressed (miRNA-136, miRNA-147, miRNA-1250, miRNA-

136 Fifteen overexpressed and 8 underexpressed miRNAs differentiated pancreatic cancer f

137 Underexpressed miRNAs in cancers, such as let-7, functio

138 497 showed the highest fold change among the underexpressed miRNAs.

139 Conventional RCCs underexpressed mitochondrial and distal nephron genes, a

140 s cue (chlorophyll a/b-binding [CAB] protein-underexpressed) mutants.

141 sis identified several genes that are either underexpressed or overexpressed in the Dd-STATb null str

142 A total of 23 microRNAs were underexpressed or overexpressed.

143 In contrast, the 75 genes underexpressed (or DOWN genes) in MDD were associated wi

144 eptors, such as those that are autoreactive, underexpressed, or that fail to promote positive selecti

145 Of the remainder, consistently underexpressed pathways included sporulation and amino a

146 ocalized in the chloroplast, and plants that underexpressed PMSR4 were more susceptible.

147 s of cell growth, survival, and cycling, and underexpressed proinflammatory and apoptotic pathways, i

148 ted, or mutated proteins as well as over- or underexpressed proteins have been implicated in many dis

149 occurs either when alpha-tubulin is modestly underexpressed relative to beta-tubulin or when beta-tub

150 nd 93 genes that were significantly over- or underexpressed, respectively, compared with mature-DC.

151 ptor-3), 2 genes that were also silenced and underexpressed, respectively.

152 Isolated sJIA monocytes underexpressed the IL-1 inhibitor aryl hydrocarbon recep

153 with the risk allele, exon 5 is consistently underexpressed, thereby providing a mechanism by which t

154 Klf6, Klf9, Nid2, Ntn4, Per1, and Txnip) and underexpressed those associated with aggressive disease

155 NHF-HRAS(G12V) cells underexpressed thymidylate synthase (TS) and ribonucleot

156 genes overexpressed (PILRB, STS-1, SPRY1) or underexpressed (TSPAN16, ADAMTSL4) in p185BCR-ABL-positi

157 ncrease) in all samples, while 41 genes were underexpressed (two-fold reduction).

158 where hPepT1 expression was either over- or underexpressed, using an inducible adenovirus system or

159 ions of the neural tube where Pax-3 had been underexpressed were found subsequently to contain high c

160 genesis (50 genes overexpressed and 58 genes underexpressed) were modulated back to normal levels aft

161 However, multiple immunoglobulins were underexpressed when comparing smokers and ex-smokers to

162 ressed in dystrophic muscle, with dystrophin underexpressed, whereas other genes encoding muscle stru

163 Runx1, ephrin B2, cyclin D1, and Gata1 were underexpressed while P16/Ink4a, P21, GSK-3beta, Il-6, Ff

164 hich degrades HER2, is frequently mutated or underexpressed, while the client-protective co-chaperone

165 significant of which was APOD, and 17 genes underexpressed with age.