ライフサイエンスコーパス: underscore the need

1 These null findings underscore the need for a long-term approach in evaluati

2 These findings underscore the need for access to resistance testing and

3 These findings underscore the need for access to resistance testing and

4 These data also underscore the need for additional functional and famili

5 These findings underscore the need for additional quality assurance in

6 erapy in patients with stage III disease and underscore the need for adequate surveillance of patient

7 long-term durability of CMD2 resistance and underscore the need for alternative sources of resistanc

8 ps in data, modeling, and communication that underscore the need for an open, shared network to frame

9 e methodological limitations, these findings underscore the need for assessing whether dermatological

10 arding who provides specific aspects of care underscore the need for better care coordination, inform

11 e more accurate ASD prevalence estimates and underscore the need for better detection, assessment, an

12 he Journal, findings reported by Rhee et al. underscore the need for caution in drawing conclusions o

13 us effects on growth and skeletal phenotypes underscore the need for caution in high-dose EGCG supple

14 e of bariatric surgery for treating NASH and underscore the need for clinical trials in this area.

15 quiescent, chemoresistant state and thereby underscore the need for combinatorial approaches to impr

16 lubility diffusion and compartmental models; underscore the need for comparison with experiment for b

17 scale differences in phenological strategies underscore the need for considering regional climate his

18 To underscore the need for continued empirical attention to

19 Temporal changes in MATS coverage underscore the need for continued monitoring of antigen

20 replication and transmission in mammals and underscore the need for continued public health surveill

21 on dispersal in insect-pollinated trees, but underscore the need for continued research on tropical s

22 y for transmission in a direct contact model underscore the need for continued study of H7 subtype vi

23 ltiple tiers of neuroscience information and underscore the need for cultural and infrastructure chan

24 s support use of the Ayton tool for AGYW and underscore the need for diverse prognostic tools conside

25 These findings underscore the need for early clinical follow-up of surv

26 These findings underscore the need for effective interventions at the p

27 e modest efficacy, have safety concerns that underscore the need for effective peripherally acting dr

28 ure forecast a growing burden of disease and underscore the need for effective therapeutic strategies

29 encouraging, the limited clinical responses underscore the need for enrichment of T cells with desir

30 levels in sub-Saharan Africa, these findings underscore the need for expanded access to second-line A

31 Our results underscore the need for extensive and multifaceted varia

32 with CARD11 mutations in human subjects and underscore the need for functional studies to demonstrat

33 The findings underscore the need for further evaluation of air pollut

34 These data underscore the need for further investigation of ustekin

35 s of nonlinear analysis of brain signals and underscore the need for future studies to investigate th

36 tent RPE65 mutation-to-phenotype correlation underscore the need for genetic testing.

37 Our findings underscore the need for immediate planning and adaptatio

38 These observations underscore the need for improved HCV surveillance and pr

39 to decreased uniformity of test results and underscore the need for improved methodologies.

40 The purpose of this article is to underscore the need for improved nutrition and physical

41 ity and specificity of individual biomarkers underscore the need for including at least one biomarker

42 Finally, we underscore the need for increased global collaboration t

43 These findings underscore the need for increased use of validated patie

44 The results underscore the need for integration of different aspects

45 Our results underscore the need for large pooling efforts with tumor

46 ical performance of urine-based HPV sampling underscore the need for larger studies to evaluate urine

47 These findings underscore the need for mental health services for many

48 ective response to the COVID-19 pandemic and underscore the need for more basic research into this ne

49 alance and therapy-skewing genetic variance, underscore the need for more comprehensive, disease-tail

50 The results underscore the need for more detailed assessment of bior

51 The gaps in knowledge we illuminate underscore the need for more evidence to substantiate th

52 of the apparent rise in sepsis incidence and underscore the need for more reliable surveillance metho

53 nd suggest impaired cerebellar function, but underscore the need for more research to clarify the sou

54 Results underscore the need for much wider adoption of field-sca

55 The findings of this report underscore the need for new research initiatives to dete

56 The findings of this report underscore the need for new research initiatives to dete

57 tions of this short-term, noninvasive method underscore the need for new research that uses alternati

58 nmental pressures and shifting supply chains underscore the need for novel chemical activities, while

59 These findings underscore the need for novel therapies and suggest that

60 Our findings underscore the need for ongoing research in this area bu

61 strategy to augment protective antibody but underscore the need for optimal engagement of CD8 T cell

62 pitate the discontinuation of treatments and underscore the need for patient education and counseling

63 The studies underscore the need for personalized administration of R

64 The results of the study underscore the need for prevention and cessation of smok

65 uine encephalitis virus and West Nile virus, underscore the need for research aimed at characterizing

66 Those observations underscore the need for robust LTBI screening programs i

67 Those observations underscore the need for robust LTBI screening programs i

68 e any significant exposure to HPV occurs and underscore the need for screening programs that cover al

69 These findings underscore the need for standardizing QFT-GIT preanalyti

70 These results underscore the need for strategies to deal with intrasea

71 These data underscore the need for studies of controlled reoxygenat

72 These data underscore the need for sustained efforts in increasing

73 Our findings underscore the need for sustained measurements and model

74 that is critical for intestinal function and underscore the need for targeted in vivo studies to inte

75 into the cellular uptake route of Xfect, and underscore the need for the development of effective too

76 tests, and ethical concerns about animal use underscore the need for trustworthy in vitro assays.

77 Nonetheless, the results underscore the need for urgent actions being undertaken

78 These results underscore the need for validating gene targets in every

79 ancies between calculations and measurements underscore the need for validation and refinement of exi

80 of a devastating disease such as cancer has underscored the need for developing comprehensive panels

81 The recent explosion of genomic data has underscored the need for interpretable and comprehensive

82 erm treatment efficacy and side-effects have underscored the need for large numbers of patients, much

83 Participants underscored the need for optimal patient care in Europe,

84 The process of classifying these variants underscores the need for a more comprehensive and divers

85 This particular nature of the disease underscores the need for a more comprehensive evaluation

86 This outbreak underscores the need for a national surveillance system

87 erent in diversifying the research workforce underscores the need for a rigorous scientific approach,

88 Our assessment underscores the need for a strategic plan to combat trad

89 This lack of consensus underscores the need for a systematic assessment of vary

90 conditions can affect male fertility, which underscores the need for a thorough evaluation of patien

91 as a crucial regulator of mTOR signaling and underscores the need for a tightly balanced mTOR pathway

92 circa 1950 in southern and midwestern states underscores the need for additional interventions to pro

93 ises more questions than it could answer and underscores the need for additional investigations on th

94 arriers to receipt of biologic therapies and underscores the need for additional studies to further d

95 V-associated neurocognitive disorders (HAND) underscores the need for adjunctive therapy that targets

96 obal eradication is achieved, and it further underscores the need for all countries to maintain high

97 eins in the intact blood plasma/serum, which underscores the need for alternative approaches.

98 eletions, irrespective of imatinib exposure, underscores the need for alternative therapies.

99 Contemporary practice variation underscores the need for better evidence to guide the do

100 n mice with equivalent dystrophin expression underscores the need for better understanding of the epi

101 This study underscores the need for caution in targeting carcinoma-

102 apopulation models with spatial modeling and underscores the need for cautious interpretation of popu

103 Our report also underscores the need for clinical trials testing novel i

104 en upper and lower respiratory tract results underscores the need for close monitoring of the clinica

105 usage, and side-effects in spondyloarthritis underscores the need for combining data from well charac

106 relatively high rate of incident OAG and OHT underscores the need for community screening programs in

107 d variability of water stress tolerance, and underscores the need for comparative studies that seek t

108 pecies, reassort, and generate novel strains underscores the need for continued risk assessment in ma

109 H7N2 virus in the northeastern United States underscores the need for continuous surveillance of emer

110 This study underscores the need for development of additional corre

111 of group meetings was relatively common and underscores the need for DSD models to be flexible and p

112 trating impact of this inflammatory response underscores the need for early intervention to prevent p

113 ve due to limited number of studies and this underscores the need for further research.

114 implications on risk screening programs and underscores the need for high-resolution genotyping of m

115 rounding the diversity of AD pathophysiology underscores the need for holistic systems-based approach

116 genotype of CHIKV was circulating undetected underscores the need for improvements in molecular metho

117 l mutations for diverse diseases, this study underscores the need for in vivo functional evaluation o

118 ity in early access to liver transplantation underscores the need for local and national policy initi

119 Our study underscores the need for long-term clinical trials in ad

120 changing ice climate on the health of beluga underscores the need for long-term studies.

121 Our work underscores the need for measures to limit transmission

122 l nodes of the addiction neurocircuitry, and underscores the need for more research into how these co

123 icity of the NF-kappaB signaling pathway and underscores the need for more selective strategies to th

124 ing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with no

125 nceptions about diagnosis and treatment, and underscores the need for new diagnostic approaches.

126 matopoietic stem cell transplantation, which underscores the need for new treatment regimens.

127 This underscores the need for novel biomarkers and diagnostic

128 Thus, this study underscores the need for novel strategies against CAUTIs

129 ring of fire-climate relationships by humans underscores the need for parameterizing thresholds of hu

130 tal pollutants may be reproductive toxicants underscores the need for prospective studies of couples

131 ional properties of macromolecular materials underscores the need for reproducible, robust, scalable,

132 imate change-mediated vector range expansion underscores the need for research aimed at developing me

133 effect of both rare and common alleles that underscores the need for revising the traditional catego

134 The heterogeneity in practice we documented underscores the need for rigorous randomized trials to d

135 This unexpected event underscores the need for robust surveillance of enterovi

136 This work underscores the need for robust, standardized analytical

137 nge of important biomolecules, which further underscores the need for sensitive and selective analysi

138 This underscores the need for special attention to this vulne

139 methods in which alpha-alkylation is favored underscores the need for the development of new processe

140 ment and prophylaxis of norovirus infections underscores the need for the development of norovirus-sp

141 Our investigation underscores the need for the development of outbreak-rea

142 This outbreak underscores the need for thorough epidemiologic and labo

143 This observation underscores the need for thorough staging of both N1 and

144 This study underscores the need for treating sex as a biological va

145 of NoVs as a major gastrointestinal pathogen underscores the need for well tolerated and effective va

146 ) on risk prediction of recurrence in NSCLC, underscoring the need for a better genomic strategy to r

147 cally infected individuals are not curative, underscoring the need for a better understanding of the

148 stitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine.

149 nerated conflicting results and predictions, underscoring the need for a synthetic global analysis.

150 he evidence that DMPA may increase HIV risk, underscoring the need for additional safe and effective

151 reported that doing so can worsen inference, underscoring the need for alternative alignment trimming

152 ssified in the LIPID MAPS database, strongly underscoring the need for automated classification.

153 nstitution have until now been unsuccessful, underscoring the need for better insight into thymic rec

154 nt compliance but lack requisite performance underscoring the need for better population screening te

155 ains the most lethal gynecologic malignancy, underscoring the need for better therapies.

156 ffective and in some cases can be addictive, underscoring the need for better therapies.

157 e recovered concomitantly from 12% of cases, underscoring the need for biopsy and/or culture.

158 utrophils can cause or worsen tissue injury, underscoring the need for calibration of activation and

159 xposure is important even in this group, and underscoring the need for chemopreventive strategies.

160 ated with poor health and functional status, underscoring the need for close follow-up of this group

161 being a urate transporter, are key advances underscoring the need for continued investigation of thi

162 ntribute to patient morbidity and mortality, underscoring the need for defining how prostate metastas

163 universally available nor always effective, underscoring the need for development of novel therapies

164 or- or recipient-derived inherited ciHHV-6A, underscoring the need for diagnostic testing for HHV-6 i

165 paths, undermining its unpredictability and underscoring the need for drift-insensitive vaccines.

166 nsed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures.

167 CFU) and resistance to multiple antibiotics, underscoring the need for efficacious vaccines and thera

168 redictions that are lower than observations, underscoring the need for further refinement of the halo

169 r acceptance patterns at transplant centers, underscoring the need for greater understanding of how c

170 rtality in developing and developed nations, underscoring the need for HPV vaccination programs with

171 r(-/-) T cells induced much less severe EAU, underscoring the need for IL-21 in the development of th

172 tastasis when the burden of disease is high, underscoring the need for improved methods of detection

173 lth care use and cost burden than HBV alone, underscoring the need for improved screening and treatme

174 orferi, the causative agent of Lyme disease, underscoring the need for improved serological assays th

175 remains a major cause of disease and death, underscoring the need for improved vaccines.

176 patients fail to respond to these therapies, underscoring the need for improvement with combination t

177 treatments are greatly underutilized in PAD, underscoring the need for improvements in patient identi

178 surpass current sediment accumulation rates, underscoring the need for including coastal-sediment man

179 ency to only report group-level differences, underscoring the need for inclusion of individual predic

180 survivors increased substantially over time, underscoring the need for lifelong subspecialty follow-u

181 uman MT family remains poorly characterized, underscoring the need for new technologies to characteri

182 al ulcers) is reaching epidemic proportions, underscoring the need for new treatment modalities.

183 se disorders, treatment options are limited, underscoring the need for new, effective medications.

184 mal models could not be translated to humans underscoring the need for novel approaches.

185 g to development-distinct effects on growth, underscoring the need for novel risk assessment strategi

186 tastatic disease despite standard treatment, underscoring the need for novel therapeutic targets and

187 ost candidate off-target sites will be rare, underscoring the need for prescreening of patients throu

188 uthern and eastern Africa and Latin America, underscoring the need for routine national HIV drug-resi

189 ergencies increased after bariatric surgery, underscoring the need for screening for suicide risk dur

190 the stop codon, modulate readthrough levels, underscoring the need for systematic investigation of re

191 and their quality of life on a daily basis, underscoring the need for these parameters to ideally be

192 ifferent backgrounds are joining this field, underscoring the need for unity regarding the use of ter

193 otential vulnerability to future infections, underscoring the need for widespread vaccination.

194 This underscores the need of understanding these effects in t

195 chlorinated solvents (e.g., 0.5 to 8 mg/L), underscoring the need of surveying both PRM and THM-enco

196 romise in vitro and in vivo, these outbreaks underscore the need to accelerate drug discovery.

197 tor-based regimens in sub-Saharan Africa and underscore the need to accelerate the study and approval

198 These findings underscore the need to account for individual glacier ge

199 lnerability of black Americans, our findings underscore the need to address the potential impact of m

200 These patterns underscore the need to adopt a sociocentric perspective

201 These studies underscore the need to apply multiple biophysical and bi

202 These findings underscore the need to assess exposure to NIS inhibitors

203 These findings underscore the need to assess the selectivity of small-m

204 Cost containment pressures underscore the need to better understand how nursing res

205 le and rapid growth in shale gas development underscore the need to better understand its environment

206 These findings underscore the need to better understand the biochemical

207 rganisms play within the coral holobiont and underscore the need to consider all of the components of

208 These results underscore the need to consider antibiotic concentration

209 ect breeding bird phenology and fitness, and underscore the need to consider sensory pollutants along

210 Our findings underscore the need to consider the microbiome when eval

211 Finally, we discuss future directions that underscore the need to consider victimization a social s

212 the return of results to all individuals and underscore the need to develop innovative approaches and

213 clinical translation of EZH2 inhibitors and underscore the need to develop novel EZH2 inhibitors to

214 The findings underscore the need to develop sustainable synthesis rou

215 The findings presented here underscore the need to evaluate a nonlive RSV vaccine ca

216 These results underscore the need to expand exploration beyond the fro

217 Results underscore the need to explicitly integrate microbes int

218 These results underscore the need to further characterize the balance

219 nts of mTORC pathways in fibrotic states and underscore the need to further delineate mTORC2 signalin

220 These studies underscore the need to further elucidate the mechanisms

221 These data underscore the need to further investigate the processes

222 n dynamics and ecological interactions, that underscore the need to further understand how trait-medi

223 ies in sustaining O. formigenes colonization underscore the need to identify the derived factors indu

224 g principles of precision medicine in stroke underscore the need to identify, value, organise and ana

225 ojections from the World Health Organization underscore the need to improve outcomes in these patient

226 Our findings underscore the need to improve transitions to hospice fo

227 These findings underscore the need to improve treatment of patients wit

228 Therefore, we underscore the need to incorporate behavioral ecology in

229 Thus, these data underscore the need to incorporate population history wh

230 These results underscore the need to increase efforts to identify HIV-

231 These findings underscore the need to increase sampling and reporting e

232 with cascading impacts on marine ecosystems, underscore the need to link macroecology with evolutiona

233 Our results underscore the need to minimize noise overexposure and f

234 These findings underscore the need to move beyond richness as a surroga

235 bsyndromal mood symptoms in all four classes underscore the need to optimize treatment.

236 nd its association with subsequent mortality underscore the need to promote awareness of this complic

237 Our analyses underscore the need to quantify the transmissibility of

238 vated incidence of diarrheagenic E. coli and underscore the need to redouble efforts to prevent the t

239 Importantly, our results underscore the need to sample across taxonomic groups to

240 Survey results underscore the need to standardize practices.

241 These data underscore the need to strengthen programmes and target

242 he cause of tip-to-base conduit widening and underscore the need to study plant hydraulic systems lea

243 ging land uses or pesticide applications and underscore the need to test for climate impacts at both

244 Lastly, we underscore the need to understand the complex interactio

245 aning of protective immunity with time, have underscored the need to develop strategies to enhance th

246 and human immunodeficiency virus (HIV) have underscored the need to generate memory T cells for robu

247 These experiences underscored the need to optimize preparation for and res

248 st predation (and therefore, nest predators) underscores the need to acknowledge the potential comple

249 This observation underscores the need to address fatigue as a significant

250 The observed heterogeneity underscores the need to better understand assumptions th

251 origin (e.g., H5N1 and H7N9) in recent years underscores the need to better understand the factors dr

252 This recent outbreak underscores the need to better understand the pathogenes

253 This recent outbreak underscores the need to better understand the pathogenes

254 influenza A(H7N9) in China since March 2013 underscores the need to better understand the pathogenic

255 rdised approach to assessment and management underscores the need to collect baseline data to support

256 higher radiation doses than do dental x-rays underscores the need to conduct a detailed radiation exp

257 vity that occurs in 3beta-HSD deficiency and underscores the need to consider a bile acid synthetic d

258 ntial implications for public health, and it underscores the need to consider the genetic context of

259 denoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny.

260 nstitutes a major bioterrorism threat, which underscores the need to develop antiviral drugs for rapi

261 quency of LD caused by Lp and non-Lp species underscores the need to expand our knowledge of evolutio

262 Consideration of transgender health underscores the need to explicitly consider sex and gend

263 exposure to oil and/or hypoxia matters, and underscores the need to further investigate the impacts

264 l disease and primary sclerosing cholangitis underscores the need to further understand the role of e

265 Low donor heart availability underscores the need to identify all potentially transpl

266 lity in patients with undiagnosed HAE-C1-INH underscores the need to identify these patients and diag

267 Our study further underscores the need to interpret altered TSPO binding i

268 The continued spread of the HIV epidemic underscores the need to interrupt transmission.

269 This outbreak underscores the need to maintain high vaccination covera

270 This underscores the need to reconsider the role of motor sim

271 al Cre-driven PTHrP deletion, a finding that underscores the need to subject the mouse articular cart

272 tric) generation requiring water for cooling underscores the need to understand controls on this wate

273 inst NiV and other important paramyxoviruses underscores the need to understand viral entry mechanism

274 This underscores the need to use a means for assessment of OI

275 ly enhanced NO-mediated leishmanial killing, underscoring the need to accurately assess oxygenation i

276 cal homeostatic cellular functions of SIRT6, underscoring the need to better understand which catalyt

277 atients with advanced age and a PS of >/= 2, underscoring the need to carefully consider the risk-to-

278 in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways.

279 lity was missing from plot-based approaches, underscoring the need to combine plot and remote-sensing

280 tations could play an essential role in GBM, underscoring the need to connect non-coding genomic vari

281 lowering the risk for autoimmune disease and underscoring the need to consider host genetics and base

282 ons and are an important therapeutic target, underscoring the need to define how these connections ar

283 d risk of early thrombotic complications and underscoring the need to define strategies associated wi

284 nal figures and not for programmatic access, underscoring the need to deposit network maps in communi

285 le if colorectal cancer is identified early, underscoring the need to detect the earliest stages of m

286 could expose many to unnecessary treatments, underscoring the need to enhance predictive accuracy wit

287 substantially from current recommendations, underscoring the need to establish clear purpose for rec

288 trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively fo

289 T to the Medicare population may be limited, underscoring the need to evaluate real-world effectivene

290 matopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanism

291 ovement in vision in a minority of patients, underscoring the need to identify additional therapeutic

292 e analogs, have limited therapeutic effects, underscoring the need to identify effective therapeutic

293 important for controlling inflammation, thus underscoring the need to identify mechanisms regulating

294 an impact cognitive and behavioral outcomes, underscoring the need to identify therapies that control

295 previously reported using in vitro studies, underscoring the need to measure such data on living cel

296 the flux of resources across space and time, underscoring the need to redefine habitat to include its

297 eting T-cell progenitors in T-ALL while also underscoring the need to tightly regulate Notch signalin

298 ase and death in immunocompromised patients, underscoring the need to understand how latency is contr

299 cities and low lattice thermal conductivity, underscoring the need to understand the interplay betwee

300 rials of nicotinic agonists have been mixed, underscoring the need to understand the mechanisms for i