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1 emains vigorous, pluripotent, and relatively undifferentiated.
2 rotein, it helps to maintain precursor cells undifferentiated.
3 ion factor, and contain MCs that are largely undifferentiated.
4 in their ecology and behavior, are virtually undifferentiated.
5 ransition state (24h), compare with cells at undifferentiated (0h) and fully differentiated (48h) sta
6 %) and 90% (80%-95%), respectively; (2) mild undifferentiated, 89% (80%-95%) and 80% (70%-89.5%); (3)
7 or each scenario were as follows: (1) severe undifferentiated, 90% (89.5%-95.0%) and 90% (80%-95%), r
8 ological processes to revert tumour cells to undifferentiated aggressive states via phenotype switchi
9 results show Sox2-dependent conversion of an undifferentiated, aggressive cancer cell to a differenti
10 rom Nf1-mutant tumors, Rb1-mutant tumors are undifferentiated and aberrantly express homeobox gene cl
11 ms, whereas a rare subpopulation of cells is undifferentiated and associated with a neural stem cell
14 ratinocyte transcriptome, RNAs isolated from undifferentiated and differentiated cell populations of
15 tion under basal and regulated conditions in undifferentiated and differentiated cultures to show the
16 (+)/H(+) exchanger 3 activity was similar in undifferentiated and differentiated enteroids, and was a
20 ompare the labeling of sialoglycoproteins in undifferentiated and differentiated human erythroleukemi
21 Group 3 tumours comprised subgroup-specific undifferentiated and differentiated neuronal-like malign
25 c subpopulation or phenotypically defined as undifferentiated and highly clonogenic ALDH(+)/CD49f(+)/
27 disables ESCs, such that they remain largely undifferentiated and locked in self-renewal, even in the
28 tween higher MRP4 expression levels and more undifferentiated and malignant in vitro models of PDAC.
29 tween higher MRP4 expression levels and more undifferentiated and malignant models of PDAC and cAMP e
30 fy the potential to inadvertently develop an undifferentiated and more aggressive pancreas cancer wit
31 expression allows the cells to remain in an undifferentiated and proliferative state and is required
32 which show dissimilar expression profile in undifferentiated and sexually mature animals, suggesting
33 pecies, which have, respectively, relatively undifferentiated and strongly differentiated adult caste
35 -induced toxicity in isogenic proliferating (undifferentiated) and nonproliferating (differentiated)
37 ia (NIA), self-limiting arthritis (SLA), and undifferentiated arthritis (UA) as compared to healthy c
38 itrullinated protein Ab-positive arthralgia, undifferentiated arthritis (UA), early RA, and establish
41 res, and resulted in the manifestation of an undifferentiated basal/stem cell-associated phenotype in
43 EV-A71 protein was observed in the infected undifferentiated C2BBe1 and RD cells but not in the infe
44 t MAPK signaling is restricted to relatively undifferentiated cancer cells in PA, with implications f
45 = 1,998), small cell carcinoma (n = 1,524), undifferentiated carcinoma (n = 559), and other (n = 2,1
46 shed approach for the treatment of sinonasal undifferentiated carcinoma (SNUC); however, the optimal
47 t carcinoma with reverse polarity, sinonasal undifferentiated carcinoma and cholangiocarcinoma, which
48 , large interior cell patches expressing the undifferentiated cell marker LHX9, and a loss of differe
49 rphology observations supported retention of undifferentiated cell phenotype at 12 degrees C, transit
50 The knockdown of GATA6-AS1 did not affect undifferentiated cell pluripotency but inhibited cardiom
54 24 reduced both the levels of HPV genomes in undifferentiated cells and amplification upon differenti
55 is known about how chromosomes are packed in undifferentiated cells and how nuclear organization chan
56 y protein DNMT3L, which is only expressed in undifferentiated cells and recruits DNMT3A to initiate D
57 tured epidermal cell sheets (CES) containing undifferentiated cells are useful for treating skin burn
58 hematopoietic stem cells (HSCs) are the most undifferentiated cells at the top of the hematopoietic h
59 flow at low, nontoxic concentrations through undifferentiated cells by providing buffering storage fo
61 an up-to-date picture of how a population of undifferentiated cells develops into the complex pattern
62 onsecutive generations of differentiated and undifferentiated cells during Th2 polarization in vitro.
63 ox3 expression is required for transition of undifferentiated cells from a GFRalpha1+ self-renewing s
64 These treatments supported the survival of undifferentiated cells in dental pulp and promoted the f
66 cell niches, maintain a pool of multipotent, undifferentiated cells that divide and differentiate to
67 imarily basal stress fibers and cytoplasm in undifferentiated cells to apical membranes and microvill
68 type specification relies on the capacity of undifferentiated cells to properly respond to specific d
70 from LL and TZ cultured in DMEM give rise to undifferentiated cells with high growth capacity, and he
71 egion devoted to a slow rate of growth among undifferentiated cells, and an anterior region in which
72 ion patterns, its promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK29
75 lity of transcriptionally inactive genes: In undifferentiated cells, PBX1 is bound to the H1-compacte
76 ent of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemn
77 rated through the rearrangement of a pool of undifferentiated cells, there is nonetheless proliferati
79 ond class ('stable') were pre-established in undifferentiated cells, with enhancers constitutively ma
87 = 13.2), sympathetic ophthalmia (HR = 5.82), undifferentiated choroiditis (HR = 6.03), primary or sec
88 rada syndrome (VKH) (odds ratio [OR] = 109), undifferentiated choroiditis (OR = 9.18), sympathetic op
89 ng, and risk gene analysis for children with undifferentiated colitis, Crohn's disease, and ulcerativ
90 Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where
91 markers, suggesting these cells represent an undifferentiated component of the niche with vascular co
94 ating ESCs (serum/LIF) with more homogeneous undifferentiated culture (2i/LIF), we examine the role o
95 strated that the majority of patients had an undifferentiated death not definitively attributable to
97 ly resected dermatofibrosarcoma protuberans, undifferentiated embryonal sarcoma of the liver, or uncl
98 ncommon tumors are mesenchymal hamartoma and undifferentiated embryonal sarcoma, which have different
99 tic studies to investigate the role of Utf1 (Undifferentiated embryonic cell transcription factor 1)
101 pithelial cells expressed E-cadherin and the undifferentiated epithelial cell markers keratin 5 and 1
102 as (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymph
103 ubtype of urothelial carcinoma consisting of undifferentiated epithelial cells within a dense inflamm
105 Factors guiding management of children with undifferentiated febrile illness outside of malaria are
106 rough February 2015, for occurrence of acute undifferentiated febrile illness, with clinical and labo
108 pid diagnostic tests (RDTs) for common acute undifferentiated febrile illnesses are often used inappr
109 s not appropriate for the diagnosis of acute undifferentiated febrile illnesses with presently availa
110 lichiosis, and anaplasmosis often present as undifferentiated fever but are not treated by agents (pe
111 of Zika cases, principally characterised by undifferentiated fever or afebrile rash, were missed.
113 ls were measured in patients presenting with undifferentiated fever to hospitals in Colombo District,
114 ts in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic f
116 st, leukopenia, and any dengue warning sign; undifferentiated fever without evident cause, with or wi
118 f esophageal carcinoma; this leads to rather undifferentiated follow-up guidelines for this tumor ent
121 on pregnancy, and receiving the diagnosis of undifferentiated gastric carcinoma from the biopsy taken
122 pothesized that excessive planar division of undifferentiated germ cells promotes their self-renewal
123 feration of malignant cells, larger pools of undifferentiated glioma cells, and an increase in macrop
126 both sexes (which represents a rare case of "undifferentiated" gonochoristic species that usually go
127 ile of glycoproteins detected varies between undifferentiated HEL cells and those differentiated to m
129 at distinguished gene expression profiles of undifferentiated hESC, hESC-, fetal- and adult-ventricul
131 ithout 100% pure fetal stage I or small-cell undifferentiated histology; elevated serum alpha-fetopro
132 ke subtype with mesenchymal gene signatures, undifferentiated histopathology and worse prognosis comp
134 dministration of one small molecule depletes undifferentiated hPSCs >10(6)-fold, thus preventing tera
135 has generated teratomas (tumors arising from undifferentiated hPSCs), unwanted tissues, and other typ
138 Central to this process is the expansion of undifferentiated intermediates known as transit-amplifyi
140 To understand these lineages, we sorted undifferentiated invariant NK T progenitor cells and eac
141 ation into NSCs, the subsequent depletion of undifferentiated iPSCs from the NSCs, and concentrating
143 ent efficiency of intramyocardially-injected undifferentiated-iPSCs, day 4 mesodermal cells, and day
145 expressed at significantly greater levels in undifferentiated keratinocytes from patients with AD com
146 ntium T3SS induced an excessive expansion of undifferentiated Ki67-positive epithelial cells, which i
148 e-tracking strain in selected areas, such as undifferentiated left ventricular hypertrophy, cardio-on
149 under DF conditions, vs UF conditions, with undifferentiated levels of CTC-recruiting E-selectin und
151 nic rocks suggest that volumes of relatively undifferentiated mantle may reside in deeper, isolated r
152 osteoblasts (CFU-Os), a surrogate marker of undifferentiated mesenchymal cells able to differentiate
154 olarized epithelial organ that develops from undifferentiated mesenchyme, although the mechanisms tha
157 cer models to test the antitumor efficacy of undifferentiated monocytes loaded with protein or peptid
158 ggest that administration of tumor Ag-loaded undifferentiated monocytes may serve as a simple and eff
159 ommonly ascribed to monocytes, implying that undifferentiated monocytes would function equally well a
160 y, we now observed that macrophages, but not undifferentiated monocytes, support this interaction.
163 vitro-differentiated osteoblasts, and not to undifferentiated MSCs, and emit NIR fluorescence for fun
169 combinant viruses replicated well in BHK and undifferentiated neural cells but viruses with 14 or mor
170 used a greater degree of hypermethylation in undifferentiated neural progenitor cells than in mature
171 High-risk neuroblastoma is characterized by undifferentiated neuroblasts and low schwannian stroma c
172 rresponded to regions dense in proliferative undifferentiated neuroblasts, whereas regions characteri
173 INV replication in differentiated but not in undifferentiated neuronal cells or mouse embryo fibrobla
175 eport that IL-33 expression is induced in an undifferentiated, non-dividing esophageal epithelial cel
176 MBD1 deficiency leads to the accumulation of undifferentiated NSCs and impaired transition into the n
177 inal pigment epithelium, choroidal thinning, undifferentiated nuclear layers of the retina, and a per
178 as softened and was enhanced when the 'soft' undifferentiated nucleus was stiffened through pharmacol
180 deficiency in the larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, cir
181 vealed a reduction of differentiated but not undifferentiated oligodendrocytes cellular markers.
182 hNSCs, but not in UC-MSCs and ADSCs, either undifferentiated or differentiated, though IFNgamma rece
183 nction of the cells' differentiation status (undifferentiated, or undergoing adipogenesis, osteogenes
184 required for both the initial transition of undifferentiated P19 cells to neural progenitors and the
185 at 12 degrees C showed similar viability and undifferentiated phenotype as the non-stored control sug
186 activation signature in a context of gaining undifferentiated phenotype in a p53-null sarcoma system
190 ailable GLS inhibitor, successfully inhibits undifferentiated pleomorphic sarcoma (UPS) tumour growth
192 d increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiate
193 both Rb and p53 renders myxofibrosarcoma and undifferentiated pleomorphic sarcoma dependent on Skp2,
194 showed encouraging activity in patients with undifferentiated pleomorphic sarcoma or dedifferentiated
196 e, including four (40%) of ten patients with undifferentiated pleomorphic sarcoma, two (20%) of ten p
198 ristics of a specific histotype of sarcomas: undifferentiated pleomorphic sarcomas with incomplete mu
201 osed of a cellular hierarchy initiating from undifferentiated populations, which undergo impaired dif
202 regulated in mature adipocytes compared with undifferentiated preadipocytes in both human and mouse s
203 plexity and integration emerge from uniform, undifferentiated precursor tissues remains limited.
204 This data highlights how far the proteome of undifferentiated precursors have progressed to acquire a
207 cyte genes and represses hepatocyte genes in undifferentiated progenitor cells in vitro and in embryo
208 le for Siah2 in the early events that signal undifferentiated progenitor cells to become mature adipo
209 OUP-TFII protein expression level is high in undifferentiated progenitors and gradually declines duri
210 ied neurons survive as well in vivo as their undifferentiated progenitors, and undergo less prolifera
213 ese safety studies show the lack of residual undifferentiated PSC, negligible tumorigenic potential b
221 hown to be oncogenic in chondroblastomas and undifferentiated sarcomas by inhibiting H3K36 methyltran
223 range of other pediatric cancers, including undifferentiated sarcomas, gliomas, papillary thyroid ca
224 veloping SCs displayed hyperproliferation of undifferentiated SCs incompatible with normal myelinatio
227 and overall titers similar to those seen in undifferentiated SH-SY5Y cells and the related SK-N-SH c
228 tive" (DVR highest in surrounding NAWM), or "undifferentiated" (similar DVR across lesion, perilesion
230 tal cells, less differentiated embryonal and undifferentiated small cells (SCU) progressively lose EG
231 such as asthma masquerading as anaphylaxis, undifferentiated somatoform disorder, panic attacks, glo
232 that allowed purification of human primitive undifferentiated spermatogonia (uSPG) highly enriched fo
234 el, which expands and normalizes the pool of undifferentiated spermatogonia between Plzf (+/+) and Pl
236 ling resulted from an arrest of entry of the undifferentiated spermatogonia into S phase; and (3) ret
237 ial stem cells (SSCs) are a subpopulation of undifferentiated spermatogonia located in a niche at the
238 regulates expression of cell cycle genes in undifferentiated spermatogonia post-transcriptionally an
242 o polyadenylated RNAs in primary cultures of undifferentiated spermatogonia were captured with oligo
244 file of PLZF and SALL4 regulatory targets in undifferentiated spermatogonia, including SSCs, which wi
250 duction of GDNF by PM cells is essential for undifferentiated spermatogonial cell development in vivo
252 in the male germline led to reduction of the undifferentiated spermatogonial population and a block i
253 spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is compo
254 nctional link between the Reissner fiber and undifferentiated spinal neurons contacting the CSF (CSF-
256 2 mutant mice, and myofibrils remained in an undifferentiated stage at the onset of the often excessi
257 plays a key role in maintaining VSMCs in an undifferentiated stage in order to promote their prolife
258 r cells with the ECM to maintain cells in an undifferentiated stage in the hematopoietic tissue (HPT)
260 highly expressed in hESCs to maintain their undifferentiated state and prevent default neural fate.
261 dopsis root, stem cells are maintained in an undifferentiated state by a less mitotically active popu
262 ella stem cells (CSCs), are maintained in an undifferentiated state by the QC-expressed transcription
263 -steroidogenic progenitor cells retain their undifferentiated state during fetal stage and become adu
265 intaining dividing cells in a proliferative, undifferentiated state for a longer period of time.
266 e generated prenatally and then remain in an undifferentiated state for long periods, being detectabl
269 essary for maintenance of the proliferative, undifferentiated state in vitro Characterizing successfu
270 ed the proliferation rate and maintained the undifferentiated state of the LSCs in a concentration de
271 olfactory tissue, activated HBCs in a P63(+) undifferentiated state similarly contribute to inflammat
272 al pathways by which these cells maintain an undifferentiated state while preserving their capacity t
276 mature neurons (cINs) retain developmentally undifferentiated states in adulthood, though they are ge
277 uncover a role for Prmt5 in maintaining the undifferentiated status of female germline stem cells.
278 old higher yield of cardiomyocytes from each undifferentiated stem cell as compared with 3D-standard
279 al and basal myoepithelial cells, as well as undifferentiated stem cells and more restricted progenit
280 eads to highly aggressive tumours containing undifferentiated stem cells and their differentiated der
282 nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in
283 We digitally reconstructed all 802 "small undifferentiated" (SU) neurons and assigned them to the
284 nfections with other pathogens that cause an undifferentiated systemic febrile illness, including inf
285 orls of three separate perianth organs each (undifferentiated tepals), more than two whorls of three
286 sistent NOTCH activity favors maintenance of undifferentiated TEPCs at the expense of cTEC differenti
288 ) is expressed in well-differentiated and in undifferentiated thyroid cancer types but not in normal
289 in and nucleosome occupancy in these largely undifferentiated tissues and classify at least 1.6% of t
290 noxanthin and beta-cryptoxanthin, which were undifferentiated to date during the MS characterization
293 vivo germ cell ablation, we demonstrate that undifferentiated type A spermatogonia are the cells that
296 "discontinuation due to inefficacy," whereas undifferentiated uveitis was a predictor for "discontinu
297 nting to Auckland District Health Board with undifferentiated uveitis who underwent screening for sar
299 actorial design, varied by infection source (undifferentiated vs genitourinary) and severity (mild vs
300 a-catenin exhibited a perinuclear pattern in undifferentiated wild-type cells, it predominantly local