ライフサイエンスコーパス: unfolded protein response

1 transcription factor, a critical part of the unfolded protein response.

2 otif enhances colon epithelial repair via an unfolded protein response.

3 quitylated proteins and the induction of the unfolded protein response.

4 in the ER by initiating the widely conserved unfolded protein response.

5 ntains protein homeostasis and regulates the unfolded protein response.

6 alpha at MAMs from its canonical role in the unfolded protein response.

7 expression during the adaptive phase of the unfolded protein response.

8 nd non-canonical mRNA splicing in the fungal unfolded protein response.

9 induction of caspase processing but not the unfolded protein response.

10 ATF6 is a key regulator of the unfolded protein response.

11 cell death were associated with a sustained unfolded protein response.

12 ins to populate the organelle, eliciting the unfolded protein response.

13 paB signalling, antigen presentation and the unfolded protein response.

14 nstead retained the ER where it activates an unfolded protein response.

15 way, autophagy, proteasome function, and the unfolded protein response.

16 Case activity in these cells and induced the unfolded protein response.

17 induced XBP1 splicing, a key mediator of the unfolded protein response.

18 expected, as evidenced by activation of the unfolded protein response.

19 me 1 (IRE1) is an essential component of the Unfolded Protein Response.

20 TKI resistance via induction of Jun and the unfolded protein response.

21 4E-BP1 activation promoted the mitochondrial unfolded protein response.

22 of eIF2alpha, a major defensive step of the unfolded protein response.

23 ation via mechanisms outside its role in the unfolded protein response.

24 iculum kinase (PERK), a key component of the unfolded protein response.

25 n metabolic and oxidation processes, and the unfolded protein response.

26 most evolutionarily conserved branch of the unfolded protein response.

27 several genetic rescue interventions and the unfolded protein response.

28 doplasmic reticulum processes, including the unfolded protein response, a cellular stress response of

29 during biosynthesis in the ER activates the unfolded protein response, a multiarmed program that enh

30 actor that is secreted but also mediates the unfolded protein response acting intracellularly.

31 nclude that ER Ca(2+) drainage and sustained unfolded protein response activation are key for initiat

32 reticulum (ER) stress proteins, and reduced unfolded protein response activation, while DN mutations

33 that ClpXP is required for the mitochondrial unfolded protein response, additional roles for ClpXP in

34 The importance of the mitochondrial unfolded protein response, an emerging pathway that alle

35 mechanisms: Congenital cataracts induce the unfolded protein response and apoptosis.

36 r mechanisms of tumor regression through the unfolded protein response and apoptosis.

37 B cells of the I-A(12%) mutant mouse express unfolded protein response and are extremely short lived.

38 e and burden, and elevated expression of the unfolded protein response and autophagy genes, including

39 respond to OGT inhibition by activating the unfolded protein response and by significantly increasin

40 phosphorylation likely leads to unregulated unfolded protein response and cell death.

41 ex, and showed that these are related to the unfolded protein response and changes.

42 on of two PAWHs constitutively activates the unfolded protein response and compromises stress toleran

43 the S.-japonicus-type phospholipids exhibits unfolded protein response and downregulates secretion.

44 of beta-gal, resulting in activation of the unfolded protein response and endoplasmic reticulum stre

45 of Beta-Gal, resulting in activation of the unfolded protein response and endoplasmic reticulum stre

46 resulted in vigorous activation of both the unfolded protein response and ER stress accompanied by i

47 -box binding protein 1 (XBP-1s), part of the unfolded protein response and expressed in developing ge

48 get engagement and reduced oxidative stress, unfolded protein response and fibrogenic signaling.

49 ga-3 fatty acid (omega-3)-mediated repair of unfolded protein response and here we show much broader

50 n deficiency elicits a prominent cytoplasmic unfolded protein response and impairs mitochondrial resp

51 Omega-3 fatty acids increase the unfolded protein response and improve amyloid-beta phago

52 bs target cell-surface GRP78, activating the unfolded protein response and inducing tumor cell prolif

53 activating tumor-promoting ER stress-induced unfolded protein response and inflammation.

54 tein aggregation activates the mitochondrial unfolded protein response and PINK1-Parkin-mediated mito

55 SINE-deleted cells exhibit an activated unfolded protein response and PKR and markedly increased

56 d over 2,800 genes, including players in the unfolded protein response and proinflammatory pathways a

57 ich regulates the endoplasmic reticulum (ER) unfolded protein response and promotes cell survival upo

58 t, which limits proliferation, activates the unfolded protein response and reduces collagen synthesis

59 utrient deficit acted in turn to trigger the unfolded protein response and the amino acid response, l

60 Whereas activation of some components of the unfolded protein response and the pro-apoptotic mediator

61 vation can robustly induce the mitochondrial unfolded protein response and thus could be an appealing

62 NMD-regulated link between activation of the unfolded protein response and transcriptional activation

63 contrast, glucose starvation does not cause unfolded protein response and, in normoxic conditions, o

64 ses previously implicated in DILI, including unfolded protein responses and oxidative stress.

65 NA repair, mTORC1 signaling, features of the unfolded protein response, and altered cholesterol homeo

66 ing proteins that comprise the mitochondrial unfolded protein response, and noted 4E-BP1 overexpressi

67 ng in endoplasmic reticulum (ER) stress, the unfolded protein response, and ultimately apoptotic cell

68 Endoplasmic reticulum (ER) stress and unfolded protein response are energetically challenging

69 We identified the unfolded protein response as a predominant outcome of CA

70 GRP78 is widely used as a marker of the unfolded protein response, associated with sustained ER

71 athogens target innate immune signaling, the unfolded protein response, autophagy, and cellular metab

72 ick-borne encephalitis viruses, activate the unfolded protein response before transcription of interf

73 roliferation via both JNK activation and the unfolded protein response caused by ER stress.

74 lational reprogramming, and induction of the unfolded protein response, consistent with loss of prote

75 gene expression system through a chloroplast unfolded protein response (cpUPR).

76 IF2alpha, and HSPB8 define a novel cytosolic unfolded protein response (cUPR) essential for optimal i

77 yeast that chronic VPA treatment induces the unfolded protein response due to increasing ceramide lev

78 including activation of cell stress and the unfolded protein response during perinatal adaptation of

79 Expression of one of the unfolded protein response effectors, the spliced form of

80 nvergent pattern of differentiation, linking unfolded protein response/endoplasmic reticulum stress t

81 P or deletion of Ryr2 equivalently inhibited unfolded protein response/ER stress, activation of the C

82 IRE1alpha is a critical sensor of the unfolded-protein response, essential for initiating the

83 ion required activation of the mitochondrial unfolded protein response for neuroprotection against ro

84 transcription factor XBP1s, which regulates unfolded protein response genes(2,3)-that was activated

85 enhanced expression of canonic mitochondrial unfolded protein response genes.

86 ochondrial translation and the mitochondrial unfolded protein response, glycolysis, and the mitogen-a

87 ve been implicated in key processes like the unfolded protein response; however, they have not been s

88 Moreover, both drugs also inhibited the unfolded protein response in cells that expressed a nonp

89 ntified the first signaling component of the unfolded protein response in chloroplasts.

90 , we show that an AS15 analogue triggers the unfolded protein response in glioblastoma cells.

91 Among the myriad molecules activated by unfolded protein response in I-A(12%) B cells, Xbp1s sin

92 e 1alpha (IRE1alpha), a key component of the unfolded protein response in mammalian cells and a poten

93 derscore the importance of the mitochondrial unfolded protein response in neuroprotection against var

94 In turn, this forestalls activation of the unfolded protein response in order for circadian rhythms

95 xposure of SV-HUC cells to TEVs provoked the unfolded protein response in the endoplasmic reticulum (

96 e report that the adaptive signalling of the unfolded protein response, IRE1alpha-XBP1, protects HSCs

97 These results demonstrate that the unfolded protein response is not only a physiological re

98 reticulum stress, suggesting that an altered unfolded protein response is unlikely to account for the

99 The UPR (Unfolded Protein Response) is a well-orchestrated respon

100 pproach revealed that heat shock, unlike the unfolded protein response, leads to reduced spreading of

101 dative phosphorylation and activation of the unfolded protein response, linking the high-fat Western

102 biogenesis, triggering of the mitochondrial unfolded protein response, loss of mitochondrial membran

103 components (the ubiquitin-proteasome system, unfolded protein response, macroautophagy, mitophagy, an

104 lls with GRP78 overexpression via activating unfolded protein response-mediated apoptosis.

105 o the ER chaperone, BiP, to alter the cell's unfolded protein response-mediated response to misfolded

106 ich leads to activation of the mitochondrial unfolded protein response (mitoUPR).

107 /-) macrophages attenuates the mitochondrial unfolded-protein response (mtUPR) as measured by express

108 The unfolded protein response of the endoplasmic reticulum (

109 tment-specific stress responses, such as the unfolded protein response of the endoplasmic reticulum (

110 te disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (

111 actors involved in the endoplasmic reticulum unfolded protein response or balancing of energy homeost

112 us processes, including pyruvate metabolism, unfolded protein response, oxidative stress response, au

113 ting mucin trafficking, thereby inducing the unfolded protein response pathway (UPR) and apoptosis.

114 he regulation of protein homeostasis and the unfolded protein response pathway (UPR).

115 a (IRE alpha)/X-box binding protein 1 (XBP1) unfolded protein response pathway and induces a shift fr

116 rated that a small-molecule modulator of the unfolded protein response pathway can prevent the reduct

117 homeostasis by activating the PERK-dependent unfolded protein response pathway to consequently facili

118 ction between age, APOE genotype, and sex on unfolded protein response pathway.

119 l, including microglial activation state and unfolded protein response pathways.

120 through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in contr

121 Infection in conditions of unfolded protein response priming leads to early activat

122 o activates the Ire1alpha-Xbp1 branch of the unfolded protein response, producing Xbp1s, the active t

123 wever, 2-DG exerts these effects by inducing unfolded protein response rather than by inhibiting glyc

124 The sensors of the unfolded protein response react to endoplasmic reticulum

125 ignaling pathway regulates lipid metabolism, unfolded protein responses, secretion of extracellular m

126 Similar to IP inhibition, inducers of the unfolded protein response selectively kill CD14(+) monoc

127 olding in the heart and thereby activates an unfolded protein response sensor and effector, activated

128 lcium channel auxiliary subunit BARP and the unfolded protein response sensor IRE1alpha, that are req

129 beta4 surface expression while IRE1alpha, an unfolded protein response sensor, enhanced alpha6beta4 r

130 show that the unfolded protein response sensor, PERK, enhances MDSC-me

131 The unfolded-protein response sensor IRE1alpha supports prot

132 zed acinar cells by suppressing the adaptive unfolded protein response signaling pathway.

133 ocesses such as those required for auxin and unfolded protein responses, signaling, and cell wall bio

134 utritional deprivation and hypoxia, activate unfolded protein response signalling, which induces eith

135 Whether unfolded-protein-response signalling plays any role in H

136 that HRI contributes to a general cytosolic unfolded protein response that could be leveraged to bol

137 this stress, cells activate a pathway called unfolded protein response that functions to maintain end

138 uce the activation of 1 of the 3 branches of unfolded protein responses, the inositol-requiring enzym

139 6) that otherwise elicited ER stress and the unfolded protein response, thereby critically reducing m

140 mpensatory hypertrophy and activation of the unfolded protein response through activating transcripti

141 enz protect cells from a tunicamycin-induced unfolded protein response to a similar degree.

142 cells expressing IRE1beta have an attenuated unfolded protein response to ER stress.

143 gulated inhibitory (HRI) induced a cytosolic unfolded protein response to prevent aggregation of inna

144 We investigated the role of the core unfolded protein response transcription factor X-box bin

145 we identify the selective activation of the unfolded protein response transducer IRE1alpha under gen

146 mal functioning of the endoplasmic reticulum unfolded protein response (UPR(ER)) promotes clearance o

147 M1 deficiency strongly induced mitochondrial unfolded protein response (UPR(mt)) and enhanced mitocho

148 DNA landscapes to activate the mitochondrial unfolded protein response (UPR(mt)) but not others.

149 , which regulates mitochondrial dynamics and unfolded protein response (UPR(mt)) in the host.

150 The mitochondrial unfolded protein response (UPR(mt)) is a mitochondrial-t

151 The mitochondrial unfolded protein response (UPR(mt)) is activated when mi

152 illance mechanisms such as the mitochondrial unfolded protein response (UPR(mt)) to detect and respon

153 MNRR1 in DW7 cells induces the mitochondrial unfolded protein response (UPR(mt)), autophagy, and mito

154 stress-response mechanism, the mitochondrial unfolded protein response (UPR(MT)).

155 the SIRT/FOXO/SOD2 axis of the mitochondrial unfolded protein response (UPR(mt)).

156 exposed to IR, to assess epithelial damage, unfolded protein response (UPR) activation, and inflamma

157 action, ERK1/2 and CREB phosphorylation, and unfolded protein response (UPR) activation.

158 The unfolded protein response (UPR) adjusts the cell's prote

159 Meanwhile, UL148 activates the unfolded protein response (UPR) and causes large-scale r

160 induction of the IRE1alpha/XBP1 axis of the unfolded protein response (UPR) and culminating in termi

161 Loss of PDI expression induced the unfolded protein response (UPR) and decreased cell survi

162 ), which is associated with induction of the unfolded protein response (UPR) and disruption of autoph

163 f procollagen I ER export could activate the unfolded protein response (UPR) and drive HSC apoptosis.

164 Previous work showed involvement of unfolded protein response (UPR) and endoplasmic reticulu

165 ignancies exhibit dramatic activation of the unfolded protein response (UPR) and ER stress response v

166 The integrated unfolded protein response (UPR) and ER-associated degrad

167 lding capacity of the ER is regulated by the unfolded protein response (UPR) and ER-associated degrad

168 Glafenine induced the unfolded protein response (UPR) and inflammatory pathway

169 e folding capacity of the ER, activating the unfolded protein response (UPR) and restoring the ER to

170 seases, ER stress leads to activation of the unfolded protein response (UPR) and subsequent adaptatio

171 These comprise, in particular, the unfolded protein response (UPR) and the DNA damage respo

172 study, we evaluated the pathway linking the unfolded protein response (UPR) and the endoplasmic reti

173 The unfolded protein response (UPR) and the heat shock respo

174 ding networks associated with activating the unfolded protein response (UPR) and the proinflammatory

175 ular MUC1-fs accumulation activated the ATF6 unfolded protein response (UPR) branch.

176 gly, we found a decoupling between different unfolded protein response (UPR) branches in stressed sen

177 ence of galactose, lithium ions activate the unfolded protein response (UPR) by inhibiting phosphoglu

178 pha regulatory subunit of PI3K modulates the unfolded protein response (UPR) by interacting with and

179 se RNF5 exhibit attenuated activation of the unfolded protein response (UPR) components, which coinci

180 f endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) consistent with elevated

181 The unfolded protein response (UPR) detects and restores def

182 rmacologic activation of the ATF6 arm of the unfolded protein response (UPR) during reperfusion, a ty

183 sing an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal

184 of primary CD34 cells, quantitative PCR for unfolded protein response (UPR) genes, and single-cell R

185 ion of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cance

186 The unfolded protein response (UPR) has been reported during

187 The unfolded protein response (UPR) has been shown to be act

188 healing in colitis via the activation of an unfolded protein response (UPR) in colon epithelial cell

189 or ATF4 as part of the endoplasmic reticulum unfolded protein response (UPR) in Drosophila We show th

190 g to light the distinctive complexity of the unfolded protein response (UPR) in plants.

191 ) in the cytosol and nucleus, as well as the unfolded protein response (UPR) in the endoplasmic retic

192 ndicated that RTA inhibits activation of the unfolded protein response (UPR) in yeast and in mammalia

193 kine-exposed beta-cells revealed an adaptive unfolded protein response (UPR) including a marked immun

194 ulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-fol

195 The unfolded protein response (UPR) is a cellular homeostati

196 The unfolded protein response (UPR) is a conserved adaptive

197 The unfolded protein response (UPR) is a cytoprotective path

198 The unfolded protein response (UPR) is a shared pathway util

199 The unfolded protein response (UPR) is activated in plants i

200 The unfolded protein response (UPR) is activated to cope wit

201 ns, an adaptive signaling network termed the unfolded protein response (UPR) is activated.

202 The unfolded protein response (UPR) is an evolutionarily con

203 The unfolded protein response (UPR) is commonly associated w

204 The unfolded protein response (UPR) is emerging as the possi

205 The unfolded protein response (UPR) is essential for physiol

206 nslation initiation factor eIF2alpha via the unfolded protein response (UPR) kinase PERK.

207 Evidence has been presented that the unfolded protein response (UPR) leads to EBV lytic gene

208 The unfolded protein response (UPR) monitors and adjusts the

209 Unfolded protein response (UPR) of the endoplasmic retic

210 cting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive ce

211 The IRE1alpha/XBP1 branch of unfolded protein response (UPR) pathway has a critical f

212 uction of high mannose is dependent upon the unfolded protein response (UPR) pathway, a pathway previ

213 oxidative stress and aberrant activation of unfolded protein response (UPR) pathway, which was parti

214 at KDM1A inhibitors induce activation of the unfolded protein response (UPR) pathway.

215 ers of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways are increased i

216 The unfolded protein response (UPR) plays a central role in

217 Anticipatory activation of the unfolded protein response (UPR) prepares cells for the o

218 reticulum (ER) stress and activation of the unfolded protein response (UPR) promote growth and invas

219 The PERK arm of the unfolded protein response (UPR) regulates cellular prote

220 he induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential n

221 ng and molecular dynamics simulations, human unfolded protein response (UPR) RT(2) PCR profiler array

222 The unfolded protein response (UPR) senses defects in the en

223 3-19K glycoprotein specifically triggers the unfolded protein response (UPR) sensor IRE1alpha in the

224 nockdown in pancreatic cancer cells enhanced unfolded protein response (UPR) signaling and cell death

225 critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in nor

226 that triggers a conserved pathway called the unfolded protein response (UPR) that mitigates damage, a

227 animals use a survival pathway known as the unfolded protein response (UPR) that signals between the

228 We have investigated the unfolded protein response (UPR) to endoplasmic reticulum

229 d a set of signaling mechanisms known as the unfolded protein response (UPR) to increase the folding

230 Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic

231 In response, the cell initiates the unfolded protein response (UPR) to reestablish homeostas

232 the ER folding capacity, which activates the unfolded protein response (UPR) to restore ER homeostasi

233 the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis.

234 endoplasmic reticulum (ER) and activate the Unfolded Protein Response (UPR) to trigger adaptive resp

235 creased antibody synthesis by activating the unfolded protein response (UPR) under the control of the

236 hock response - indicating activation of the unfolded protein response (UPR) with downstream inflamma

237 tant is associated with the induction of the unfolded protein response (UPR), a common response to vi

238 is condition, known as ER stress, evokes the unfolded protein response (UPR), a cytoprotective signal

239 tion, known as ER stress, is buffered by the unfolded protein response (UPR), a set of signaling path

240 proteostasis surveillance is mediated by the unfolded protein response (UPR), a signal transduction p

241 ied the improved workflow to proteins of the unfolded protein response (UPR), a signaling pathway of

242 ng protein glycosylation, causes a sustained Unfolded Protein Response (UPR), a significant attenuati

243 RE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanis

244 The unfolded protein response (UPR), an endoplasmic reticulu

245 revented beta-cell death, propagation of the unfolded protein response (UPR), and dysfunctional gluco

246 placenta is susceptible to activation of the unfolded protein response (UPR), and we hypothesized thi

247 fail, stress response pathways, such as the unfolded protein response (UPR), are induced.

248 ion of misfolded proteins, activation of the unfolded protein response (UPR), decreased protein synth

249 Master regulators of the unfolded protein response (UPR), IRE1alpha and PERK, pro

250 an ER membrane-associated protein mediating unfolded protein response (UPR), is required for transdu

251 species (mtROS) production and, in turn, the unfolded protein response (UPR), leading to a distinct t

252 s induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death

253 Chronic activation of the unfolded protein response (UPR), notably the branch comp

254 Here, we show that activation of the unfolded protein response (UPR), specifically phosphoryl

255 In the unfolded protein response (UPR), stress in the endoplasm

256 he perinuclear area led to activation of the unfolded protein response (UPR), suggesting that specifi

257 uding the endoplasmic reticulum (ER)-induced unfolded protein response (UPR), the ubiquitin-proteasom

258 signaling pathways, collectively termed the unfolded protein response (UPR), to maintain a productiv

259 asmic reticulum stress and activation of the unfolded protein response (UPR), triggering death of neu

260 argets various cell processes, including the unfolded protein response (UPR), which acts to attenuate

261 This activates the unfolded protein response (UPR), which alters the expres

262 gnaling processes, collectively known as the unfolded protein response (UPR), which are designed to r

263 the endoplasmic reticulum (ER) activate the unfolded protein response (UPR), which enhances protein

264 metabolic homeostasis via the activation of unfolded protein response (UPR), which is instructed by

265 the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)-a signaling network that

266 stress is thought to activate autophagy via unfolded protein response (UPR)-mediated transcriptional

267 and refolding malformed proteins through the unfolded protein response (UPR).

268 ers a dynamic signaling pathway known as the unfolded protein response (UPR).

269 tivation of a signaling network known as the unfolded protein response (UPR).

270 t as primary sensor in the activation of the unfolded protein response (UPR).

271 n of ER stress coping responses, such as the unfolded protein response (UPR).

272 onventional splicing of HAC1 mRNA during the unfolded protein response (UPR).

273 in complexes with an established link to the unfolded protein response (UPR).

274 Ala92-D2) caused ER stress and activated the unfolded protein response (UPR).

275 th endoplasmic reticulum (ER) stress and the unfolded protein response (UPR).

276 he endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR).

277 rom endoplasmic reticulum stress through the unfolded protein response (UPR).

278 oplasmic reticulum (ER) stress and activates unfolded protein response (UPR).

279 ER calcium depletion robustly activates the unfolded protein response (UPR).

280 on the set of genes that is activated by the unfolded protein response (UPR).

281 of a second proteotoxic stress response, the unfolded protein response (UPR).

282 athway leading to ER stress and an activated unfolded protein response (UPR).

283 tute potential cross-talk between HD and the unfolded protein response (UPR).

284 or extrinsic factors, can be resolved by the unfolded protein response (UPR).

285 epression by various stresses, including the unfolded protein response (UPR).

286 s endoplasmic reticulum stress that leads to unfolded protein response (UPR).

287 ve phosphorylation, vesicle traffic, and the unfolded protein response (UPR).

288 butes to the activation of the mitochondrial unfolded protein response (UPR).

289 to cause ER stress, which then activates the unfolded protein response (UPR).

290 d activates a signaling network known as the unfolded protein response (UPR).

291 and bZIP60 but not bZIP17 and bZIP28 in the unfolded protein response (UPR).

292 nstrated that CXL146 treatment activated the unfolded protein response (UPR); as evidenced by the act

293 globulin M heavy chain (mu(s)) thanks to the unfolded protein response (UPR; Bakunts et al., 2017).

294 requires DRH-1 as well as the mitochondrial unfolded protein response (UPRmt).

295 te stress response such as the mitochondrial unfolded protein response, UPRMT.

296 Unfolded protein responses (UPRs) safeguard cellular fun

297 tion is required for ER-phagy to repress the unfolded protein response via IRE1alpha.

298 subfamily B couples translation rate to the unfolded protein response, which has implications for un

299 We find that P0Q215X does not elicit an unfolded protein response, which is a key mechanism for

300 ed diverse cellular processes, including the unfolded protein response, Wnt signalling and RNA metabo