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1 ncidence of SMNs was in survivors exposed to unfractionated (600-1000 cGy) or high-dose fractionated
3 utralized the anticoagulant activity of both unfractionated and low molecular weight heparins and inh
4 is the primary receptor for the clearance of unfractionated and low molecular weight heparins in the
5 bes an emerging approach for the analysis of unfractionated and low molecular weight heparins, as wel
8 subducted uranium was probably isotopically unfractionated before full oceanic oxidation, about 600
10 l surface phenotyping and transplantation of unfractionated blood, that approximately 1-5% of the tot
12 acrophages, their specific BM precursors, or unfractionated BM cells were delivered during liver inju
13 s in cord blood mononuclear cells and in the unfractionated BM of healthy and Fanconi anemia donors,
14 We demonstrate that macrophages within the unfractionated BMCs are responsible for the production o
16 the co-infusion of limited numbers of donor unfractionated BMCs with human amnion-derived multipoten
19 ntation of CD34(+) cells (n = 8 patients) or unfractionated bone marrow (BM) or peripheral blood mono
21 Despite the frequent clinical use of adult unfractionated bone marrow mononuclear cells (BMMNCs) fo
22 en expression profile as compared to plating unfractionated CD34(+)/lin(-)-enriched bone marrow monon
28 hed for long-term repopulating EpiSCs versus unfractionated cells (3.9- and 5.2-fold, respectively).
29 deed, B6/Rag(-/-) recipients of dnTGFbetaRII unfractionated cells develop features of liver disease s
30 the sera of rabbits or horses immunized with unfractionated cells isolated from pediatric human thymi
31 pproach to measuring protein levels in total unfractionated cellular proteins, and we apply this appr
33 of these pools, along with the complete EMD unfractionated compound and positive and negative contro
34 r greater in magnitude than that launched by unfractionated conventional T, invariant natural killer
39 ity (EC50 13 +/- 0.6 mug Cu/L) than were the unfractionated dissolved FAs (EC50 39 +/- 0.4 and 41 +/-
41 regimen for the Ad5 vaccine did not increase unfractionated ELISpot responses compared with the Ad5 v
42 m liver replacement after transplantation of unfractionated embryonic day (ED) 14 fetal liver stem/pr
44 responses in the gut using intact tissues or unfractionated epithelial cells, thereby limiting conclu
45 (nanoparticle tracking analysis) analyses of unfractionated exosomes were also conducted to evaluate
46 dditive toxicity was measured when comparing unfractionated extracts to fractionated extracts in pre-
47 all of the sharp peaks that were present in unfractionated extracts, along with some broad signal.
49 mpare the quality of SELDI-TOF MS data using unfractionated, fractionated plasma samples and abundant
50 The three-copy construct, GST-HB3, detected unfractionated free heparin (UFH) as low as 39ng/ml (equ
51 was observed between GTPP constituents, with unfractionated GTPP more potently preconditioning cells
53 ing enoxaparin compared with those receiving unfractionated heparin (2.3% versus 1.4%; P=0.022) but s
54 oembolism for no chemical prophylaxis (33%), unfractionated heparin (29%), dalteparin (40%), or infer
55 found in death at 30 days for enoxaparin vs unfractionated heparin (3.0% vs 3.0%; odds ratio [OR], 1
56 ary intervention were randomized to low-dose unfractionated heparin (50 U/kg) or standard-dose unfrac
57 , or 0.175 [671] mg/kg/h) or to a control of unfractionated heparin (60 IU/kg intravenous bolus follo
58 ous thromboembolism), enoxaparin (n=666) and unfractionated heparin (669) were given for 10.5 days (S
59 venous thromboembolism by 43% compared with unfractionated heparin (68 [10%] vs 121 [18%]; relative
62 ctionated heparin (50 U/kg) or standard-dose unfractionated heparin (85 U/kg or 60 U/kg with glycopro
64 th 184 (9.4%) of 1952 patients randomized to unfractionated heparin (hazard ratio [HR], 0.88; 95% con
65 fated hirugen (IC(50) = 1.2 +/- 0.2 microm), unfractionated heparin (IC(50) = 56.6 +/- 8.4 microg/ml)
66 gned randomly to eptifibatide + reduced dose unfractionated heparin (n = 298), eptifibatide + reduced
67 esigned to capture the desired attributes of unfractionated heparin (UFH) and low-molecular-weight he
68 e most common pharmocoprevention strategies, unfractionated heparin (UFH) and the low-molecular-weigh
69 st effectiveness of enoxaparin compared with unfractionated heparin (UFH) as adjunctive therapy for f
70 ate whether enoxaparin (ENOX) is superior to unfractionated heparin (UFH) as adjunctive therapy for p
71 usted otamixaban regimens or weight-adjusted unfractionated heparin (UFH) before percutaneous coronar
72 safety and effectiveness of bivalirudin and unfractionated heparin (UFH) for carotid artery stenting
73 comparative outcomes between bivalirudin and unfractionated heparin (UFH) have not been well describe
74 icacy and safety of enoxaparin (ENOX) versus unfractionated heparin (UFH) in patients with ST-segment
75 all efficacy and safety of enoxaparin versus unfractionated heparin (UFH) in the SYNERGY (Superior Yi
80 rction patients that received abciximab with unfractionated heparin (UFH) or bivalirudin during percu
81 randomized to bivalirudin (n = 1,800) versus unfractionated heparin (UFH) plus a glycoprotein IIb/III
82 we characterized the interaction of PF4 with unfractionated heparin (UFH), its 16-, 8-, and 6-mer sub
87 lecular weight heparin (LMWH) is superior to unfractionated heparin (UH) for venous thromboembolism (
88 noxaparin 40 mg subcutaneously once daily or unfractionated heparin 5000 U subcutaneously every 12 h
90 ulfated, the inhibitors did not compete with unfractionated heparin alluding to a novel site of inter
93 ) occurred in 12.2 percent of patients given unfractionated heparin and 10.1 percent of those given e
94 n occurred in 14.5 percent of patients given unfractionated heparin and 11.7 percent of those given e
95 red in 4.5 percent of the patients receiving unfractionated heparin and 3.0 percent of those receivin
97 /LV) ratio >/=1.0 were randomized to receive unfractionated heparin and an USAT regimen of 10 to 20 m
98 on on noncovalent complexes formed by intact unfractionated heparin and antithrombin-III, interaction
99 he pharmacologic methods, including low-dose unfractionated heparin and low molecular weight heparin.
100 with low-molecular-weight heparin (LMWH) or unfractionated heparin and mortality, pulmonary embolism
101 MWH) prepared by partial depolymerization of unfractionated heparin are used globally to treat coagul
102 n when treated with enoxaparin compared with unfractionated heparin as adjunctive therapy with fibrin
103 eight heparin (LMWH) is modestly superior to unfractionated heparin at preventing recurrent DVT and i
105 ivative has less anticoagulant activity than unfractionated heparin but retains the inherent anti-inf
106 arin Conjugate (CHC), a compound of multiple unfractionated heparin chains, coats cells with a glycoc
108 ncreased from 77% to 84%, whereas the use of unfractionated heparin decreased from 22% to 8.4% (p < 0
109 w-molecular-weight heparin compared with bid unfractionated heparin decreases pulmonary embolism and
110 isk, P<0.001); 7.5 percent of patients given unfractionated heparin died, as did 6.9 percent of those
111 clotting time (ACT) is widely used to guide unfractionated heparin dosing during percutaneous corona
113 of TAVI has been empirically determined, and unfractionated heparin during the procedure followed by
116 ospitalization is superior to treatment with unfractionated heparin for 48 hours but is associated wi
117 ute VTE treated with low-molecular-weight or unfractionated heparin for 5 to 11 days, we compared dab
122 no differences in the association of LMWH vs unfractionated heparin for preventing mortality, pulmona
123 ter, followed by a VKA (LMWH and VKA); or 4) unfractionated heparin for the first trimester, followed
125 preferred drug-based approach over standard unfractionated heparin for the prevention of venous thro
127 rin, enoxaparin is a suitable alternative to unfractionated heparin for treatment of non-ST-elevation
128 ecurrent DVT and is at least as effective as unfractionated heparin for treatment of pulmonary emboli
129 schaemic stroke, enoxaparin is preferable to unfractionated heparin for venous thromboembolism prophy
131 occurred in 12.0 percent of patients in the unfractionated heparin group and 9.9 percent of those in
132 ic end points in the REG1 group and 1 in the unfractionated heparin group, with 1 major bleed in the
134 ecent trials comparing use of enoxaparin and unfractionated heparin in ACS have yielded less robust e
135 d controlled trials comparing enoxaparin and unfractionated heparin in non-ST-segment elevation ACS w
136 ticoagulation with bivalirudin compared with unfractionated heparin in patients undergoing peripheral
137 3 randomized trial compared bivalirudin with unfractionated heparin in patients undergoing transfemor
138 um of ACS, enoxaparin is more effective than unfractionated heparin in preventing the combined end po
139 ular-weight heparin is more efficacious than unfractionated heparin in preventing VTE (0.25% vs 0.68%
140 e improved the efficacy and safety of dosing unfractionated heparin in ST-segment elevation myocardia
141 se findings should be considered when dosing unfractionated heparin in support of fibrinolytic therap
142 MI at 30 days was observed for enoxaparin vs unfractionated heparin in the overall trial populations
143 omen was reduced by enoxaparin compared with unfractionated heparin in women (15.4% versus 18.3%; P=0
144 ents are receiving preoperatively apart from unfractionated heparin include low-molecular-weight hepa
145 Fondaparinux as compared with usual care (unfractionated heparin infusion or placebo) significantl
147 ylaxis using low-molecular-weight heparin or unfractionated heparin is more likely in ICU patients wi
149 hylaxis with low molecular weight heparin or unfractionated heparin is recommended in acute ischaemic
151 ous coronary intervention when compared with unfractionated heparin monotherapy was associated with l
153 Despite the use of a standard weight-based unfractionated heparin nomogram in ST-segment elevation
157 mes to one of three antithrombotic regimens: unfractionated heparin or enoxaparin plus a glycoprotein
159 to receive bivalirudin (n=1928) or heparin (unfractionated heparin or enoxaparin; n=1870) plus a GPI
160 EACS) treated with eptifibatide/reduced-dose unfractionated heparin or eptifibatide/reduced-dose enox
163 ologically mediated adverse drug reaction to unfractionated heparin or, less commonly, to low-molecul
164 ere randomized to bivalirudin (n = 1,800) or unfractionated heparin plus a glycoprotein IIb/IIIa inhi
166 ty in those taking bivalirudin compared with unfractionated heparin plus a glycoprotein IIb/IIIa inhi
167 (310 of 5466 patients) randomized to receive unfractionated heparin plus eptifibatide (adjusted relat
168 duce the rate of ischemic events relative to unfractionated heparin plus eptifibatide but did increas
170 in mortality with bivalirudin compared with unfractionated heparin plus glycoprotein IIb/IIIa inhibi
171 ortality and cardiac mortality compared with unfractionated heparin plus glycoprotein IIb/IIIa inhibi
172 ban (bolus and infusion, at 1 of 2 doses) or unfractionated heparin plus, at the time of percutaneous
176 myocardial uptake suppression protocol with unfractionated heparin was performed in all patients.
177 24 h before the examination, and 50 IU/kg of unfractionated heparin were administered intravenously 1
178 possibility to study interactions of intact unfractionated heparin with a client protein carried out
179 ctive as the current standard combination of unfractionated heparin with glycoprotein IIb/IIIa inhibi
180 -molecular-weight heparin (LMWH) or low dose unfractionated heparin with graded stockings has been va
181 were observed in the 14 trials that compared unfractionated heparin with low-molecular-weight heparin
182 both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of
183 w-molecular-weight heparin (in comparison to unfractionated heparin) thromboprophylaxis lowered pulmo
188 ing a hirudin peptide (exosite 1 ligand) and unfractionated heparin, heparin octasaccharide, and gamm
189 ute ischaemic stroke that compared heparins (unfractionated heparin, heparinoids, or low-molecular-we
192 icoagulation therapy (initial treatment with unfractionated heparin, low-molecular-weight heparin, or
193 sion stockings, pneumatic compression boots, unfractionated heparin, low-molecular-weight heparin, or
195 tic dosages of low-molecular weight heparin, unfractionated heparin, or fondaparinux at admission.
196 nt of VTE with low-molecular-weight heparin, unfractionated heparin, or fondaparinux in hospitalized
197 favorable in-hospital outcomes compared with unfractionated heparin, the current standard of care.
198 infarction were randomized to enoxaparin or unfractionated heparin, the latter dosed according to th
200 dard of care (low-molecular-weight heparins, unfractionated heparin, vitamin K antagonists or fondapa
213 d to determine the constituents of GAGs from unfractionated heparin/HS from various bovine and porcin
216 S) of active pharmaceutical ingredient (API) unfractionated heparins (UFHs) from six different manufa
218 s derived from Asp-N and Glu-C digestions of unfractionated histones from calf thymus and acid-extrac
220 development of infections permits lifesaving unfractionated HLA-identical or T cell-depleted haploide
221 novel approach to the analysis of glycans in unfractionated human biospecimens has been developed tha
222 dendritic cell coculture system, which uses unfractionated human PBMCs as the starting material.
225 he survival of murine IEL subpopulations and unfractionated IEL derived from human intestines, an eff
228 ls possess regulatory activity, whereas both unfractionated LP lymphocytes and purified LP CD4(+) T c
232 We demonstrate that targeted analysis of unfractionated lysates (2 hr) accurately reproduces the
234 also inhibited the farnesylation of HDJ-2 in unfractionated mononuclear cells and purified myeloma ce
235 mature myotubes, as observed previously with unfractionated MPCs containing both SP and MP cells.
237 D146(+) perivascular cells, as compared with unfractionated MSCs and CD146(-) cells, to sustain human
241 weight-average molecular weight, Mw, for the unfractionated NOM was 23,300 g/mol, determined by size
245 .S. patients were randomized to: 1) heparin (unfractionated or enoxaparin) + GPI; 2) bivalirudin + GP
246 syndromes (ACS) were randomized to heparin (unfractionated or enoxaparin) plus glycoprotein IIb/IIIa
247 tively randomly assigned to receive heparin (unfractionated or enoxaparin) plus glycoprotein IIb/IIIa
248 nd high-risk ACS were randomized to heparin (unfractionated or enoxaparin) plus glycoprotein IIb/IIIa
250 ion to pharmacologic thromboprophylaxis with unfractionated or low-molecular-weight heparin (pneumati
251 ect of bivalirudin monotherapy compared with unfractionated or low-molecular-weight heparin plus opti
252 ) in ambulance to bivalirudin monotherapy vs unfractionated or low-molecular-weight heparin plus opti
253 primary PCI to receive either bivalirudin or unfractionated or low-molecular-weight heparin with opti
254 tic therapy, including aspirin, clopidogrel, unfractionated or low-molecular-weight heparin, and glyc
255 erated coagulation in the presence of either unfractionated or low-molecular-weight heparins more pot
256 Surprisingly, we found that incubation of unfractionated PBMC with IL-15 for 48 h resulted in the
257 ESI-MS/MS analyses, each using 250 ng of the unfractionated peptide mixture, at 95% confidence (FDR <
258 As observed by other investigators using unfractionated peripheral blood cells from patients with
259 s as well as CD4(-)CD8(-) cell fractions and unfractionated peripheral blood mononuclear cell samples
260 K cells (P = .02), overall K562 cytolysis by unfractionated peripheral blood mononuclear cells was no
261 eration sequencing of HIV-1 DNA derived from unfractionated peripheral blood mononuclear cells, ex vi
265 roteins, present in complex materials (e.g., unfractionated plasma); (ii) select ligands to multiple
271 observations, preincubation of bacteria with unfractionated properdin, followed by the addition of pr
273 Quantitative comparisons with proteomes of unfractionated proplastids and chloroplasts facilitated
275 the purified 170-kDa ZmpB/ZmpC fraction and unfractionated S. pneumoniae culture supernatant generat
277 2/3, and 19 glycoforms of IgG4) directly in unfractionated samples of human plasma and we detect tra
280 nerate high-throughput proteomic profiles of unfractionated serum samples using an immobilized metal
281 increase in genotoxicity was measured in the unfractionated soil extract, as well as in four polar so
283 tive transfer studies, transferring Ly5.1(+) unfractionated spleen cell CD4(+) or CD8(+) T cells from
286 e developed a simplified technique that used unfractionated splenocytes as a precursor population and
289 found that Treg expansion occurred only with unfractionated splenocytes, suggesting that accessory ce
294 erefore represent a potential alternative to unfractionated T cells for promotion of allogeneic engra
298 enriched 16.8-fold in tumorigenic cells over unfractionated (UNF) cells, such that 1 in 21,000 cells