ライフサイエンスコーパス: uniporter

1 lity of the mitochondrial Ca2+ uptake sites (uniporter).

2 ted by blockage of the mitochondrial calcium uniporter.

3 werful in vivo reconstitution system for the uniporter.

4 tion system, we then reconstituted the human uniporter.

5 ane protein called the mitochondrial calcium uniporter.

6 rane protein 1 and the mitochondrial calcium uniporter.

7 interaction of NLF and mitochondrial Ca(2+) uniporter.

8 matrix after Ca2+ transport through the Ca2+ uniporter.

9 a recently identified ion channel called the uniporter.

10 an inner membrane Ca(2+) channel called the uniporter.

11 Ca(2+) affinity of the mitochondrial Ca(2+) uniporter.

12 ane-potential-dependent mechanism called the uniporter.

13 ential component of the mitochondrial Ca(2+) uniporter.

14 n that serves as a putative regulator of the uniporter.

15 e to Ru360, the most potent inhibitor of the uniporter.

16 he R181C variant exclusively functioned as a uniporter.

17 istent with mitochondrial iron uptake by the uniporter.

18 nt source of protons for inactivation of the uniporter.

19 of mPT induction at a site distinct from the uniporter.

20 at the phenomenological level of the Ca(2+) uniporter.

21 rial Ca2+ uptake via a primary effect on the uniporter.

22 ATP-sensitive K(+) channels, or [Ca(2+)](m) uniporter.

23 ly by converting the proton symporter into a uniporter.

24 .5) = 3 microm) via the mitochondrial Ca(2+) uniporter.

25 hrough the potential-dependent mitochondrial uniporter.

26 novel inhibitor of the mitochondrial calcium uniporter.

27 5 behaves as a specific low affinity glucose uniporter.

28 s the dynamicity of the mitochondrial Ca(2+) uniporter.

29 chondria occurs via the mitochondrial Ca(2+) uniporter.

30 h contributes to the gating mechanism of the uniporter.

31 ix calcium through the mitochondrial calcium uniporter.

32 g, is catalyzed by the mitochondrial calcium uniporter.

33 via an inner membrane transporter called the uniporter.

34 lls overexpressing the mitochondrial calcium uniporter.

35 ily to be classified as strict exchangers or uniporters.

36 uced accumulation of SWEET2, 4, and 12 sugar uniporters.

37 t amounts of Ca(2+) from the cytosol via the uniporter, a Ca(2+)-selective ion channel in the inner m

38 ta on the kinetics of Ca2+ transport via the uniporter, a mechanistic kinetic model of the uniporter

39 he minimal components sufficient for in vivo uniporter activity are unknown.

40 Blocking mitochondrial Ca(2+) uniporter activity compromises the ability of mitochondr

41 l membrane, we compare mitochondrial calcium uniporter activity in mouse heart, skeletal muscle, live

42 sophila flight muscle, mitochondrial calcium uniporter activity is barely detectable compared with th

43 nstrating that the induction of host sucrose uniporter activity is key to virulence of Xoo.

44 and flight muscle, low mitochondrial calcium uniporter activity is likely essential to avoid cytosoli

45 Simultaneously, low mitochondrial calcium uniporter activity may also prevent mitochondrial Ca(2+)

46 ondria, and could suggest ways of modulating uniporter activity to treat diseases related to mitochon

47 ial-dependent calcium uptake compatible with uniporter activity, and also that expression of DdMCU co

48 ents sufficient for metazoan and nonmetazoan uniporter activity, and provide valuable insight into th

49 s affected by H2PO4(-) (P(i)), Mg2+, calcium uniporter activity, matrix volume changes, and the bioen

50 expression of MCU and EMRE is sufficient for uniporter activity, whereas expression of MCU alone is i

51 icient to reconstitute mitochondrial calcium uniporter activity.

52 the gating mechanism by which MICUs control uniporter activity.

53 ly lack pharmacological agents for targeting uniporter activity.

54 ane potential-dependent mitochondrial Ca(2+) uniporter and 2) the evolutionarily conserved exchangers

55 occurs via a ruthenium red-sensitive calcium uniporter and a rapid mode of Ca(2+) uptake.

56 says, that Zn2+ is imported through the Ca2+ uniporter and directly targets major enzymes of energy p

57 2+) influx through the mitochondrial calcium uniporter and extrusion by cation exchangers across the

58 hondrial matrix Ca(2+), determined by Ca(2+) uniporter and Na(+)/Ca(2+) exchanger activities, regulat

59 del based on known kinetic properties of the uniporter and presumed Mg(2+) inhibition and Pi regulati

60 of Cac requires both the mitochondrial Ca2+ uniporter and the mitochondrial energization that drives

61 to ER solute import during ER transit, while uniporters and cation-coupled transporters carry out exp

62 ects of the strength of mitochondrial Ca(2+) uniporters and their spatial localization on intracellul

63 calization, the TcMCU (mitochondrial calcium uniporter) and TcIP3R (inositol 1,4,5-trisphosphate rece

64 ceptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.

65 o mitochondria was dependent upon the Ca(2+) uniporter, and the consequent swelling resulted from ope

66 cle cells with Ru360, a mitochondrial Ca(2+) uniporter antagonist, reversed alterations in the plasma

67 of EMRE ensures that all transport-competent uniporters are tightly regulated, responding appropriate

68 he technique that originally established the uniporter as a Ca(2+) channel.

69 dulating agents identified the mitochondrial uniporter as a critical regulatory factor in bortezomib

70 a(2+) by inhibiting the mitochondrial Ca(2+) uniporter as a novel potential therapeutic target agains

71 of MICU1, regulator of mitochondrial calcium uniporter, as a key molecule conferring cancer cells wit

72 yeast, which lacks the mitochondrial calcium uniporter, as a model system to address this problem.

73 more sensitive to the mitochondrial Ca(2)(+) uniporter blocker Ru360.

74 were abolished by the mitochondrial calcium uniporter blocker Ru360.

75 d can be prevented by the mitochondrial Ca2+ uniporter blocker Ruthenium 360; and (v) apoptosis invol

76 ngs by treatment with the mitochondrial Ca2+ uniporter blocker Ruthenium Red (10 microM) potentiated

77 lcium chelator BAPTA-AM and the Ca(2+)(mito) uniporter blocker ruthenium red prevented E2-induced cel

78 were inhibited by both ruthenium red, a Ca2+-uniporter blocker, and by high concentrations of EGTA.

79 (f) The Ca2+ uniporter blocker, Ruthenium Red, protects enzyme activi

80 d, an inhibitor of the mitochondrial calcium uniporter, both rescued mutant striatal cells from 3-NP-

81 th the IP3-induced initial activation of the uniporter but inhibited the sustained phase.

82 MICU1 confers Ca(2+)-dependent gating of the uniporter by blocking/unblocking MCU.

83 at which free ATP and free Mg2+ inhibit the uniporter can be distinguished by chymotrypsin treatment

84 ruthenium red-sensitive mitochondrial Ca(2+) uniporter catalyzes Ca(2+) uptake during beat-to-beat tr

85 In its absence, uniporter channel activity was lost despite intact MCU e

86 Knockdown of the mitochondrial Ca(2+) uniporter channel prevented the development of I(CRAC) i

87 MCU encodes the pore-forming subunit of the uniporter channel.

88 mination of IP(3)Rs or mitochondrial calcium uniporter channels suppresses ER-mitochondrial Ca(2+) fe

89 hondria is through the mitochondrial calcium uniporter complex (MCU(cx)), a Ca(2+)-selective channel

90 on as a consequence of mitochondrial calcium uniporter complex (MCUC) inhibitory subunit MCUb overexp

91 The mitochondrial Ca(2+) uniporter complex (MCUC) is a multimeric ion channel whi

92 teins that make up the mitochondrial calcium uniporter complex (MCUC) mediating Ca(2+)uptake into the

93 , colocalized with the mitochondrial calcium uniporter complex (MCUc).

94 In mammals, the uniporter complex (uniplex) contains four core component

95 a(2+) signalling is the mitochondrial Ca(2+) uniporter complex (uniplex), an inner membrane Ca(2+) tr

96 pression did not alter mitochondrial calcium uniporter complex component levels.

97 l function, EMRE could paradoxically inhibit uniporter complex formation if expressed in excess.

98 functional unit of the mitochondrial calcium uniporter complex in metazoans, a highly selective and t

99 The mitochondrial calcium uniporter complex is essential for calcium (Ca(2+)) upta

100 porter] regulator), an mitochondrial calcium uniporter complex subunit that promotes mtCa(2+) uptake,

101 ique paralogues of the mitochondrial calcium uniporter complex TcMCU subunit that we named TcMCUc and

102 lts identify MICU2 as a new component of the uniporter complex that may contribute to the tissue-spec

103 up Ca(2+) through the mitochondrial calcium uniporter complex to regulate energy production, cytosol

104 ular composition of the mitochondrial Ca(2+) uniporter complex via Western blot, immunoprecipitation,

105 lock, but because MICU1 dissociates from the uniporter complex.

106 ulatory subunit of the mitochondrial calcium uniporter complex.

107 formation of functional mitochondrial Ca(2+) uniporter complexes.

108 erived fibroblasts, the mitochondrial Ca(2+) uniporter components MCU, MCUR1, and MICU1 remain unalte

109 0, an inhibitor of the mitochondrial calcium uniporter, consistent with mitochondrial iron uptake by

110 low volume of the ER, trace amounts of these uniporters contribute to ER solute import during ER tran

111 Calcium uptake by the mitochondrial calcium uniporter coordinates cytosolic signaling events with mi

112 ating kinetic models of mitochondrial Ca(2+) uniporter (CU), Na(+)-Ca(2+) exchanger (NCE), and Na(+)-

113 Hence, EMRE is essential for in vivo uniporter current and additionally bridges the calcium-s

114 w a dramatically lower mitochondrial calcium uniporter current density than the other tissues studied

115 oupling protein 3- and mitochondrial calcium uniporter-dependent, but leucine zipper-EF-hand containi

116 These results suggest that the uniporter displays a calmodulin-mediated facilitation.

117 Inhibition of the mitochondrial Ca(2+) uniporter disrupted the rhythmic production and extracel

118 activation and deactivation kinetics of the uniporter during IP3 receptor-mediated Ca2+ mobilization

119 ce of Deltapsim, basal mitochondrial calcium uniporter expression, and mitochondrial Ca(2+) levels, e

120 nt on modifications in mitochondrial calcium uniporter expression, inner membrane potentials, or the

121 acrophages utilize the mitochondrial calcium uniporter for profibrotic polarization.

122 elective blocker of the mitochondrial Ca(2+) uniporter) for 30 min prior to propofol treatment restor

123 e Mg(2+) inhibition and Pi regulation of the uniporter function are not well established.

124 picts the inhibitory effect of Mg(2+) on the uniporter function, in which Ca(2+) uptake is hyperbolic

125 nding of the effects of Mg(2+) and Pi on the uniporter function, we developed here a mathematical mod

126 ition mechanism for Mg(2+) inhibition of the uniporter function.

127 iology, the structure and composition of the uniporter functional unit and kinetic mechanisms associa

128 In humans, the uniporter functions as a holocomplex consisting of MCU,

129 t identification of the mitochondrial Ca(2+) uniporter gene (Mcu/Ccdc109a) has enabled us to address

130 lished, since knockdown of all the candidate uniporter genes inhibit Ca(2+) uptake in imaging assays,

131 lling proteins and the mitochondrial calcium uniporter had the highest expression early in postnatal

132 tein components of the mitochondrial calcium uniporter have been identified, including MCU, the pore-

133 The molecular components of the human uniporter holocomplex (uniplex) have been identified rec

134 tructures of the human mitochondrial calcium uniporter holocomplex (uniplex) in the presence and abse

135 eve a full molecular characterization of the uniporter holocomplex (uniplex).

136 tructures of the human mitochondrial calcium uniporter holocomplex in inhibited and Ca(2+)-activated

137 forming and Ca(2+)-conducting subunit of the uniporter holocomplex, but its primary sequence does not

138 high sensitivity of the mitochondrial Ca(2+) uniporter in neurons to cytosolic Ca(2+).

139 ous theoretical models of mitochondrial Ca2+ uniporter in the literature in that it is thermodynamica

140 ttle is known about the mechanism underlying uniporter inactivation.

141 Downregulation of mitochondrial Ca(2+) uniporter, increased myofilament Ca(2+) affinity, and pr

142 m red, a blocker of the mitochondrial Ca(2+) uniporter, inhibited mitochondrial Rhod 2 fluorescence t

143 ial Ca(2+)uptake due to mitochondrial Ca(2+) uniporter inhibition (simulating Ru360) or elevated cyto

144 -hydrazone (FCCP); the mitochondrial calcium uniporter inhibitor KB-R7943 (carbamimidothioic acid); t

145 of Ca(2+) entry into the mitochondria by the uniporter inhibitor RU360 or by cyclosporin A significan

146 Application of the mitochondrial uniporter inhibitor Ru360 reduced mitochondrial and cyto

147 23187 in the presence or absence of the Ca2+ uniporter inhibitor ruthenium red (RR).

148 Mtb in presence of the mitochondrial calcium uniporter inhibitor ruthenium red showed increased mitoc

149 RU-360, a mitochondrial-uniporter inhibitor, abrogated mitochondrial Ca2+ accumu

150 entirely inhibited by the mitochondrial Ca2+ uniporter inhibitor, Ru-360, but not influenced by an Na

151 either a mitochondrial uncoupler or a Ca(2+) uniporter inhibitor.

152 and by Ruthenium Red, a mitochondrial Ca(2+)-uniporter inhibitor.

153 ty is sensitive to the mitochondrial calcium uniporter inhibitors Ruthenium Red and Gd(3+), as well a

154 The uniporter inhibitors ruthenium red and Ru360 prevented c

155 al channels are blocked by protein toxins, a uniporter interaction domain on MICU1 binds to a channel

156 The mitochondrial calcium uniporter is a Ca(2+) channel that regulates intracellul

157 The mitochondrial calcium uniporter is a Ca(2+)-activated Ca(2+) channel complex m

158 The mitochondrial uniporter is a Ca(2+)-channel complex resident within th

159 The mitochondrial calcium uniporter is a Ca(2+)-gated ion channel complex that con

160 llowing such entry, the mitochondrial Ca(2+) uniporter is a highly Ca(2+)-selective channel complex e

161 The mitochondrial calcium uniporter is a highly selective calcium channel distribu

162 The mitochondrial uniporter is a highly selective calcium channel in the o

163 The mitochondrial calcium uniporter is a highly selective channel responsible for

164 The uniporter is a multi-subunit Ca(2+)-activated Ca(2+) cha

165 Thus, the mitochondrial Ca2+ uniporter is a newly identified target for viral modific

166 trophysiological studies have shown that the uniporter is an ion channel with remarkably high conduct

167 The uniporter is composed of the pore-forming MCU protein, t

168 d within the context of a model in which the uniporter is considered to be a gated channel that is co

169 equent matrix Ca(2+) reuptake via the Ca(2+) uniporter is estimated to be >100-fold slower than matri

170 niporter, a mechanistic kinetic model of the uniporter is introduced.

171 rocess of Ca(2+) uptake by the mitochondrial uniporter is itself regulated by Ca(2+) in a temporally

172 Transport by the uniporter is membrane potential dependent and sensitive

173 ow that in addition to divalent cations, the uniporter is regulated by external adenine nucleotides a

174 y to demonstrate that the mitochondrial Ca2+ uniporter is strongly inhibited by external EGTA plus fr

175 The uniporter is subject to inactivation, whereby a sustaine

176 Ca2+ transport through mitochondrial Ca2+ uniporter is the primary Ca2+ uptake mechanism in respir

177 -induced increase in the permeability of the uniporter lasted longer than the Ca2+ signal.

178 partment, silencing the Mitochondrial Ca(2+) Uniporter led to oscillation inhibition.

179 xpression to functionally reconstitute human uniporter machinery both in wild-type yeast as well as i

180 to constituents of the mitochondrial Ca(2+) uniporter machinery in mammals.

181 e valuable insight into the evolution of the uniporter machinery.

182 gi, and show that it has a highly simplified uniporter machinery.

183 The analyses indicate that the uniporter may have been an early feature of mitochondria

184 The Ca(2+) uniporter MCU mediates Ca(2+) uptake, whereas NCLX (mito

185 ) accumulation (via the mitochondrial Ca(2+) uniporter MCU) in CA1 but not in CA3 neurons and was mar

186 We find that the mitochondrial calcium uniporter MCU-1 is essential for rapid mitochondrial Ca(

187 -1, a regulator of the mitochondrial calcium uniporter MCU-1, in axon injury.

188 2+) influx through the mitochondrial calcium uniporter (MCU) and a rise in matrix [Ca(2+) ].

189 Mitochondria take up Ca2+ via the Ca2+ uniporter (MCU) and extrude it through the mitochondrial

190 ughs in identifying the mitochondrial Ca(2+) uniporter (MCU) and its associated proteins have opened

191 or association with the mitochondrial Ca(2+) uniporter (MCU) and MCU processing regulates higher orde

192 r identification of the mitochondrial Ca(2+) uniporter (MCU) and of unique targeted Ca(2+) probes to

193 al upregulation of the mitochondrial calcium uniporter (MCU) and the mitochondrial calcium uptake 1 p

194 ough the inner membrane mitochondrial Ca(2+) uniporter (MCU) are not known.

195 transients, as did the mitochondrial Ca(2+) uniporter (mCU) blocker, Ru360.

196 o the recently proposed mitochondrial Ca(2+) uniporter (MCU) candidate.

197 ould involve the 40 kDa mitochondrial Ca(2+) uniporter (MCU) channel or the Na(+) -Ca(2+) -Li(+) exch

198 termine how changes in mitochondrial calcium uniporter (MCU) complex (MCUC) function influence mitoch

199 The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pat

200 ake is mediated by the Mitochondrial Calcium Uniporter (MCU) complex, a macromolecular structure that

201 rongly dependent on the mitochondrial Ca(2+) uniporter (MCU) complex, has a series of key roles in ph

202 Additionally, mitochondrial Ca(2+) uniporter (MCU) currents were lower in KO myocytes, indi

203 Enhancing mitochondrial Ca(2+) uniporter (MCU) expression has been suggested to interfe

204 ked by knockdown of the mitochondrial Ca(2+) uniporter (MCU) expression.

205 The mitochondrial calcium uniporter (MCU) facilitates calcium entry into the mitoc

206 iated knockdown of the mitochondrial calcium uniporter (MCU) gene reduces mitochondrial Ca(2+) curren

207 cium homeostasis and the Mitochondria Cacium Uniporter (MCU) in cell migration were recently highligh

208 y, knockout (KO) of the mitochondrial Ca(2+) uniporter (MCU) in mice results in only minimal phenotyp

209 The role of the mitochondrial Ca(2+) uniporter (MCU) in physiologic cell proliferation remain

210 The mitochondrial calcium uniporter (MCU) is a highly selective ion channel that t

211 he recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochon

212 The mitochondrial calcium uniporter (MCU) is the ion channel that mediates Ca(2+)

213 Mitochondrial calcium uniporter (MCU) is the pore-forming and Ca(2+)-conductin

214 e identification of the mitochondrial Ca(2+) uniporter (MCU) led to an explosion of studies identifyi

215 take is undertaken by the mitochondrial Ca2+ uniporter (MCU) located in the organelle's inner membran

216 The mitochondrial Ca(2+) uniporter (MCU) mediates a rapid mitochondrial Ca(2+) tr

217 nt protein kinase II, a mitochondrial Ca(2+) uniporter (MCU) regulator, also prevented MPTP formation

218 terminal region of the mitochondrial calcium uniporter (MCU) regulatory subunit MICU1 leads to a nota

219 l Ca(2+) uptake is the mitochondrial calcium uniporter (MCU), a Ca(2+)-selective ion channel in the i

220 ium uptake through the mitochondrial calcium uniporter (MCU), a multi-protein complex whose assembly

221 N or C terminus of the mitochondrial calcium uniporter (MCU), a recently identified channel whose top

222 =13), an inhibitor of the mitochondrial Ca2+ uniporter (mCU), and (3) 2-aminoethoxydiphenylborane (10

223 cium uptake, through a mitochondrial calcium uniporter (MCU), is important not only for the regulatio

224 ane-spanning subunits--mitochondrial calcium uniporter (MCU), its paralog MCUb, and essential MCU reg

225 a(2+) uptake 1 (MICU1), mitochondrial Ca(2+) uniporter (MCU), uncoupling protein 2 (UCP2), and leucin

226 yclophilin D (CypD), or mitochondrial Ca(2+) uniporter (MCU), which implicates a mitochondria-origina

227 chondria occurs via the mitochondrial Ca(2+) uniporter (MCU), which is regulated by three mitochondri

228 ecific deletion of the mitochondrial calcium uniporter (Mcu), which is required for mitochondrial cal

229 Mitochondrial calcium uniporter (MCU), which is the core channel subunit of MC

230 ase properties through Mitochondrial Calcium Uniporter (MCU)-dependent Ca2+ clearance.

231 e pore-forming subunit mitochondrial calcium uniporter (MCU).

232 ncode homologues of the mitochondrial Ca(2+) uniporter (MCU).

233 the matrix through the mitochondrial Ca(2+) uniporter (MCU).

234 and is mediated by the mitochondrial calcium uniporter (MCU).

235 ected by silencing the mitochondrial calcium uniporter (MCU).

236 d by the inhibition of mitochondrial calcium uniporter (MCU).

237 naptic calcium via the mitochondrial calcium uniporter (MCU).

238 gative (DN) form of the mitochondrial Ca(2+) uniporter (MCU).

239 SLC25A23 interacts with mitochondrial Ca(2+) uniporter (MCU; CCDC109A) and MICU1 (CBARA1) while also

240 09A, that we now call 'mitochondrial calcium uniporter' (MCU).

241 ia with CCCP or blocking mitochondria Ca(2+) uniporters (MCUs) enhanced sAHP amplitude and duration,

242 do-steady-state influx rates of Ca2+ via the uniporter measured under a wide range of experimental co

243 This uniporter-mediated mitochondrial Ca(2+) transport is als

244 embrane protein 1- and mitochondrial calcium uniporter-mediated, but uncoupling protein 3-independent

245 The MCU (mitochondrial Ca(2+) uniporter) mediates mitochondrial Ca(2+) influx, and its

246 al measurements showed that it operates in a uniporter mode.

247 a(2+) entry through the mitochondrial Ca(2+) uniporter modulates mitochondrial transport, and mitocho

248 g alters gating of the mitochondrial calcium uniporter (mtCU) in a MICU1-dependent fashion to reduce

249 The mitochondrial calcium uniporter (mtCU) is an ~700-kD multisubunit channel resi

250 he inner mitochondrial membrane (IMM) Ca(2+) uniporter (mtCU).

251 perly carry out physiological functions, the uniporter must stay closed in resting conditions, becomi

252 uptake pathway, which is neither the Ca(2+) uniporter nor the rapid mode of Ca(2+) uptake.

253 achomatis Npt1 (Npt1(Ct)) and the nucleotide uniporter Npt2(Ct), which transports GTP, UTP, CTP, and

254 ate that SWEET17 functions as a Fru-specific uniporter on the root tonoplast.

255 g either mitochondrial Ca(2+) uptake via the uniporter or Ca(2+) release via the mitochondrial Na(+)/

256 e irreconcilable, and any passive asymmetric uniporter or cotransporter model system, e.g., Na-glucos

257 nsport in cells that appear not to have urea uniporters or channels.

258 that HKT family members are sodium-selective uniporters or sodium-potassium symporters is widely held

259 60, an inhibitor of the mitochondrial Ca(2+) uniporter, or with EGTA acetoxymethyl ester, but not wit

260 The uniporter passes Ca2+ down the electrochemical gradient

261 y KCl or carbachol, indicating that the Ca2+ uniporter pathway played a role in the first, but not in

262 ffect evoked a large further increase in the uniporter permeability.

263 Thus, the uniporter plays a key role in regulating mitochondrial C

264 MICU1 interacts with the uniporter pore-forming subunit MCU and sets a Ca(2+) thr

265 , EMRE (essential MCU [mitochondrial calcium uniporter] regulator), an mitochondrial calcium uniporte

266 The molecular nature of the uniporter remained unknown for decades.

267 nion channel 1 and the mitochondrial calcium uniporter, respectively.

268 ial Na+/Ca2+ exchanger or by reversal of the uniporter responsible for energy-dependent Ca2+ uptake.

269 on, an inhibitor of the mitochondrial Ca(2+) uniporter (RU-360) attenuated mitochondrial Ca(2+) uptak

270 tor of the mitochondrial Ca(2+) (and Fe(2+)) uniporter, Ru360, protected against PDT plus bafilomycin

271 In mammalian cells the uniporter's activity is regulated by Ca(2+) due to conce

272 Although the uniporter's biophysical properties have been studied ext

273 cterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and reg

274 The mitochondrial calcium uniporter shapes cytosolic Ca(2+) signals, controls mito

275 Conversely, enhancing uniporter stability rescues survival and function in Com

276 Protease-resistant EMRE mutants produce uniporter subcomplexes that induce constitutive Ca(2+) l

277 er membrane protein EMRE was identified as a uniporter subunit absolutely required for Ca(2+) permeat

278 The results highlight the dynamic nature of uniporter subunit assembly, which must be tightly regula

279 e findings support the idea that a conserved uniporter system, with composition and regulation distin

280 the Trypanosoma brucei mitochondrial calcium uniporter (TbMCU) is essential for the regulation of mit

281 l is extended from our previous model of the uniporter that is based on a multistate catalytic bindin

282 rimarily by two major transporters: a Ca(2+) uniporter that mediates Ca(2+) uptake and a Na(+)/Ca(2+)

283 m uptake occurs through a channel called the uniporter that resides in the inner mitochondrial membra

284 Most insect cell membranes seem to contain uniporters that facilitate the diffusion of amino acids

285 t identification of the mitochondrial Ca(2+) uniporter, the channel allowing rapid Ca(2+) accumulatio

286 on and silencing of the mitochondrial Ca(2+) uniporter, the major mitochondrial Ca(2+) uptake protein

287 Ca(2+) mediated by the mitochondrial calcium uniporter through a process involving the translocation

288 MCU-MICU1 interactions, thereby opening the uniporter to import more Ca(2+).

289 ial calcium uptake via mitochondrial calcium uniporter to promote ROS(mito) production leading to mel

290 atrix through the MCU (mitochondrial calcium uniporter) to regulate bioenergetics and reactive oxygen

291 ease sites, because the mitochondrial Ca(2+) uniporter was homogeneously distributed, and elevated [C

292 Because RuR inhibits mitochondrial Ca(2+) uniporter, we tested whether the NLF acts via the mechan

293 GLT1 and functions as a low affinity glucose uniporter, were expressed as individual proteins in Xeno

294 ochondrial Ca (mCa) overload through the mCa uniporter, which can ultimately lead to apoptosis and gr

295 d into respiring mitochondria via the Ca(2+) uniporter, which is known to be inhibited by Mg(2+).

296 ort by H322N mutant; how H322 mutants become uniporters; why exchanging Lys-319 with Asp-240 paradoxi

297 re FCCP or blocking the mitochondrial Ca(2+) uniporter with Ru360 as well as blocking the respiratory

298 yphenylhydrazone or inhibition of the Ca(2+) uniporter with Ru360 prevented rapid onset of the swelli

299 t not by inhibiting the mitochondrial Ca(2+) uniporter with Ru360.

300 e for Zn(2+) entry, the mitochondrial Ca(2+) uniporter (with ruthenium red [RR]) or Zn(2+) chelation