ライフサイエンスコーパス: universally conserved

1 nto hairpin-like structures, have emerged as universally conserved.

2 in the peptidyl-transferase center, which is universally conserved.

3 iest steps of this process do not seem to be universally conserved.

4 e mode of ubiquitin recognition might not be universally conserved.

5 op in ribosomal 30 S subunits that is almost universally conserved.

6 ferase centre (PTC), is thought to be nearly universally conserved.

7 havior in WWTPs should not be expected to be universally conserved.

8 the first six of the seven nucleotides being universally conserved.

9 Receptors assemble into a universally conserved 12-nm hexagonal lattice linked by

10 codon helix in the decoding center using the universally conserved 16S ribosomal RNA bases G530, A149

11 cs, and leads to a model for the role of the universally conserved 16S RNA residues A1492 and A1493 i

12 The universally conserved 16S rRNA base A1493 and the kink i

13 tions in the decoding center by mutating the universally conserved 16S rRNA bases G530, A1492, and A1

14 In particular, universally conserved 23S ribosomal RNA bases U2492, C25

15 Valine tRNA having the universally conserved 3'-terminal adenosine replaced by

16 A single universally conserved A (number 2451) within the central

17 cross-linking to 23 S rRNA was mapped to the universally conserved A-2602.

18 talling, is in the immediate vicinity of the universally conserved A2062 of 23S rRNA.

19 All three base changes at the universally conserved A2451 conferred a dominant lethal

20 The universally conserved A272 is essential for the formatio

21 ivating protein that catalytically removes a universally conserved adenine from the alpha-sarcin/rici

22 me inactivating proteins (RIPs) depurinate a universally conserved adenine in the alpha-sarcin/ricin

23 e structural and biochemical features of the universally conserved adenine residue A2451 in 23S ribos

24 cle, as well as sulfur oxidation, are nearly universally conserved, although dissimilatory sulfur red

25 Both mutations affect universally conserved amino acids in domains of actin th

26 Most of these adenosine positions are universally conserved among all bacterial RNase P RNAs;

27 coli enzyme (Glu1153 in hamster CAD) and is universally conserved among CPSases.

28 nactivating factors and/or pathways that are universally conserved among eukaryotic organisms.

29 ologs characterized in this study are almost universally conserved among filamentous cyanobacteria, w

30 single-amino-acid substitutions to residues universally conserved among NNS RNA virus L proteins, we

31 Here we address whether this pathway is universally conserved among primate lentiviruses and can

32 However, the mechanism is not universally conserved among the gamma subdivision member

33 Amino acid residues Thr45, which is universally conserved among the small RNA phages, and Th

34 rally characterized in tRNAs, only a few are universally conserved, among them threonylcarbamoyl aden

35 dine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate

36 bunit and changes in the conformation of the universally conserved and essential bases A1492, A1493,

37 on particle (SRP) and its receptor compose a universally conserved and essential cellular machinery t

38 e signal recognition particle (SRP) RNA is a universally conserved and essential component of the SRP

39 CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme.

40 re briefly discussed in the context of these universally conserved and essential metabolic subsystems

41 cating that this recognition strategy is not universally conserved and may be relatively recent.

42 improving activity lay in the mutation of a universally conserved and mechanistically important resi

43 s posttranscriptional modification is almost universally conserved and occurs in the T arm of most tR

44 ons are composed of a catalytic core that is universally conserved and peripheral elements that are c

45 DNA-intercalating proline residue is almost universally conserved, and it is preceded by arginine an

46 TEC and we demonstrate that one of the last universally conserved archaeal proteins with unknown bio

47 ATP is universally conserved as the principal energy currency i

48 dopt different conformations to reposition a universally conserved Asp (D) residue involved in cataly

49 In addition, mutation of the universally conserved aspartic acid abolished tRNA(Leu)

50 highly conserved threonine discriminator and universally conserved aspartic acid that were mutational

51 DnaK/Hsp70 proteins are universally conserved ATP-dependent molecular chaperones

52 om the consensus at positions other than the universally conserved AUG have little effect on RegA bin

53 dorsum scrapings were amplified by PCR with universally conserved bacterial primers and cloned into

54 The NusA protein is a universally conserved bacterial transcription elongation

55 Elongation factor P (EF-P) is a universally conserved bacterial translation factor.

56 These data illustrate the importance of two universally conserved base pairs in the RNA that form el

57 sible for the 2'-O-ribose methylation of the universally conserved base U2552 in the A-loop of the 23

58 able near-cognates, the repositioning of the universally conserved bases A1492 and G530 results in in

59 within domain I of 23 S, which contains many universally conserved bases and which lies close in the

60 The 3' terminus of tRNAs has the universally conserved bases C74C75A76 that interact with

61 positions 35 and 36 in the ASL interact with universally conserved bases G530 and A1493, respectively

62 t to uncouple the mRNA-tRNA complex from two universally conserved bases in the ribosomal decoding ce

63 Two universally conserved bases of 16S ribosomal RNA that in

64 Universally conserved basic residues of the sigma subuni

65 ress, which involves the accumulation of the universally conserved biopolymer inorganic polyphosphate

66 which a 5' splice site-like sequence in the universally conserved branch site-binding region of U2 i

67 f metal ion interactions, we substituted the universally conserved bulged uridine (U51) in the P4 hel

68 n, N4,N4-dimethylcytidine (m(4)(2)C), at the universally conserved C918 in the 16S rRNA helix 31 loop

69 The universally conserved Cas1-Cas2 integrase complex cataly

70 A single substitution of a near-universally conserved catalytic residue unlocks activity

71 sertion of this glutamate finger completes a universally conserved catalytic tetrad, thereby activati

72 ed 2555 loop in domain V of 23S rRNA and the universally conserved CCA end of tRNA.

73 homolog of Protein Phosphatase 1 (PfPP1), a universally conserved cell cycle factor in eukaryotes, t

74 The signal recognition particle (SRP) is a universally conserved cellular machinery responsible for

75 The translation process involves universally conserved chemistry at almost every stage of

76 d function of the proteins reveals that such universally conserved clusters correspond to either: (i)

77 The SRP RNA is a universally conserved component of SRP that mediates key

78 A universally conserved component of SRP, SRP54 or its bac

79 Cas2 is a universally conserved core CRISPR-associated protein req

80 l RNA (rRNA) is able to find the correct and universally conserved core fold.

81 ositions G18/U55 and G19/C56 (two contiguous universally conserved D/T loop base pairs) in Drosophila

82 Homologous recombination (HR) is a universally conserved DNA repair pathway that can result

83 The J-domain of CSP shares homology with the universally conserved DnaJ family, a group of proteins t

84 While mutation of the universally conserved E285 gave a minimally functional c

85 pathogen Streptocococcus mutans of the three universally conserved elements of the SRP pathway: Ffh/S

86 tRNAs through the ribosome is catalyzed by a universally conserved elongation factor (EF-G in prokary

87 is down-regulated by phosphorylation of the universally conserved elongation factor Tu (EF-Tu).

88 idine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked

89 ntaining each of the twenty amino acids is a universally conserved, essential reaction, the absence o

90 The universally conserved eukaryotic initiation factor (eIF)

91 Vps13 (vacuolar protein sorting 13), a large universally conserved eukaryotic protein, which suppress

92 the mechanism of NusG recruitment to RNAP is universally conserved even though the regulatory outcome

93 A universally conserved event in cell division is the form

94 Universally conserved factors from NusG family bind at t

95 Notably, YrdC and YgjD are members of universally conserved families that were ranked among th

96 gs to the superfamily of ABC transporters, a universally conserved family of proteins characterized b

97 t linkage between amino acids and RNA, are a universally conserved feature of life.

98 at G-protein-cytoskeleton interactions are a universally conserved feature.

99 This CLEVR strategy makes use of universally conserved features of retroviruses and shoul

100 A universally conserved "fingerloop" lines the signal sequ

101 rotrimeric structure of RPA complexes may be universally conserved from lower to higher eukaryotes.

102 We propose a universally conserved function for IF2 in facilitating t

103 Surprisingly, neither the universally conserved G nor the highly conserved A are r

104 dues at all positions tested, except for the universally conserved G-residue at the guanosine-binding

105 ons appended to the core ring structure of a universally conserved G37, adjacent to the anticodon of

106 We conclude that the universally conserved GAF domain Tyr residue, with which

107 vide a method to increase immune response to universally conserved Gag epitopes, using the p24CE immu

108 for a transcriptional network anchored by a universally conserved gene called var2csa that coordinat

109 n from published genomes to search for other universally conserved genes that have the same phylogene

110 ; it also suggests a model for the role of a universally conserved GGQ motif in the catalysis of pept

111 release factor, resulting in docking of the universally conserved GGQ motif in the PTC of the 50S su

112 firms that the backbone amide of Q230 of the universally conserved GGQ motif is positioned to contrib

113 the main-chain amide group of Gln 230 in the universally conserved GGQ motif of the factor is positio

114 shows that upon stop-codon recognition, the universally conserved GGQ motif packs tightly into the p

115 The MMP1680 protein encodes a universally conserved glucosamine-6-phosphate synthase.

116 role in MCM regulation; 2) interaction of a universally conserved glutamine in the N-terminal Allost

117 Movement of a universally conserved Gly at the N terminus of Switch II

118 the structure-function relationships of the universally conserved GroE chaperone machine.

119 Here, we identify a universally conserved GTPase (HflX) as a bona fide disso

120 The universally conserved GTPase elongation factor G (EF-G)

121 One insertion caused partial loss of the universally conserved GTPase, obgE/yhbZ gene.

122 protein encoded by the gene ychF is 1 of 11 universally conserved GTPases and the only one whose fun

123 YchF is one of these eight universally conserved GTPases; however, its cellular fun

124 ted the first glycine to an aspartate in the universally conserved GXXG motif of the KH domain as an

125 bunit head and the proper positioning of the universally conserved head proteins Rps3, Rps15, Rps20,

126 Although the universally conserved heat-shock response regulated by t

127 les of specific rRNA elements, including the universally conserved helix 69 (H69) of 23S rRNA, which

128 displays a predicted structure in which the universally conserved helix 8 contains an unprecedented

129 g phosphate oxygens at nucleotide A67 in the universally conserved helix P4.

130 s integrate directly via Nup120/160 into the universally conserved heptameric Y-complex, the critical

131 ia or Sec61alphabetagamma of eukaryotes is a universally conserved heterotrimeric protein channel com

132 The universally conserved His-66 of elongation factor Tu (EF

133 Mutation of its universally conserved histidine residue, which is critic

134 The universally conserved HPD motif appears to form a His-Pr

135 e interactions are not only dependent on the universally conserved IEI motif but also on arginine 133

136 These modifications are universally conserved in all domains of life.

137 loading AT domain to an Arg residue that is universally conserved in all extender unit AT domains fa

138 n the ribosome, a large RNA-protein assembly universally conserved in all forms of life.

139 gest that alpha(L) residue Glu-310, which is universally conserved in all I domain-containing integri

140 These four residues are universally conserved in all known KSs.

141 ntity) is not primarily due to protein sites universally conserved in all linages.

142 identified and found to share the HK97-fold universally conserved in all previously solved dsDNA pha

143 Whereas the core subunits of RNAPs are universally conserved in all three domains of life-indic

144 One of these two base-pairs is universally conserved in all TS sequences, and is identi

145 ns found in the Bacteria and Eukarya are not universally conserved in archaea.

146 motif that is recognized by K130, a residue universally conserved in beta- and gamma-proteobacteria.

147 motif (oct), 5'-GGAAGAGC-3', which is almost universally conserved in coronaviruses and is therefore

148 and TIP49) nuclear ATP binding proteins are universally conserved in eukaryotes and essential for vi

149 In addition, the 13B5 binding site is universally conserved in HCMV, contains a previously des

150 gma implicated in promoter melting, to those universally conserved in housekeeping sigmas relaxed the

151 Meiotic recombination is almost universally conserved in its broad strokes, but specific

152 INDING PROTEIN-LIKE (SPL) gene family appear universally conserved in land plants, but the specific f

153 Notch signaling is universally conserved in metazoans where it is important

154 Strikingly, this G-C base pair is universally conserved in phylogenetically diverse TS-cod

155 is the only membrane ATP-dependent protease universally conserved in prokaryotes, and the only essen

156 Fourth, Arg313, although universally conserved in protein kinases, and essential

157 gical function of viral m(6)A methylation is universally conserved in several families in nonsegmente

158 nition of the promoter, R91, D81 and D84 are universally conserved in sigma28 orthologues.

159 maturation machinery from M. acetivorans is universally conserved in the Archaea, our evolutionary a

160 LEDGF/p75 dependence is universally conserved in the retroviral genus Lentivirus

161 yladenosine (t(6)A) is a modified nucleoside universally conserved in tRNAs in all three kingdoms of

162 Thus, although t(6)A is universally conserved in tRNAs, its role in translation

163 subunits-a process that is catalysed by this universally conserved initiation factor.

164 s prebiotic chemistry in relation to another universally conserved intermediate, acetyl phosphate (Ac

165 mbly chaperone Acl4 that initially binds the universally conserved internal loop of newly synthesized

166 The universally conserved kinase-associated endopeptidase 1

167 striking exception to this divergence is the universally conserved KsgA/Dim1p enzyme family, which mo

168 The universally conserved L39/H89 interaction is a long-rang

169 A change of a universally conserved leucine to valine in the DNA-bindi

170 which microtubule attachment, mediated by a universally conserved 'linchpin' residue in kinesin (N25

171 Pro98 lies in a universally conserved linker between the calmodulin-bind

172 In particular, thiolation of the universally conserved methyl-uridine at position 54 stab

173 The universally conserved methyltransferase KsgA modifies tw

174 d mutagenesis of active site residues in two universally conserved Mg(2+)-binding domains and the ide

175 However, the universally conserved minor capsid gene vp3 could be del

176 -protein interactions, the evolution of this universally conserved molecule remains unclear.

177 The universally conserved N6-threonylcarbamoyladenosine (t6A

178 undation for understanding the function of a universally conserved nucleobase in biology and disease.

179 C1054, a virtually universally conserved nucleotide in the 16 S (small subu

180 ants carrying mutations at A2602 and another universally conserved nucleotide in the peptidyl transfe

181 we investigated the effect of mutations at a universally conserved nucleotide of the active site of 2

182 m were tested in the ribosome by mutation of universally conserved nucleotides at 1406 to 1408 and 14

183 ion of mutant ribosomes and analysis of four universally conserved nucleotides in the innermost layer

184 ate demonstrate that the identity of several universally conserved nucleotides is not essential for f

185 aled that the antibiotic makes contacts with universally conserved nucleotides of 16S rRNA in the E s

186 e of the large subunit of the ribosome where universally conserved nucleotides surround the CCA ends

187 NA, site-directed mutations were made at the universally conserved nucleotides U2552 and G2553 of 23S

188 Here we show that there is no universally conserved number of SNARE complexes involved

189 erial virulence factor RfaH, a member of the universally conserved NusG family.

190 ed approach to predict fold switching in the universally conserved NusG transcription factor family,

191 RfaH, a two-domain protein from a universally conserved NusG/Spt5 family of regulators, is

192 ed directly from OP sediment DNA by PCR with universally conserved or Bacteria-specific rDNA primers

193 EMC3 belongs to the universally conserved Oxa1 superfamily of membrane prote

194 gnal recognition particle (SRP) pathway is a universally conserved pathway for targeting polypeptides

195 argeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis.

196 hiff base-forming Lys-246 and the other to a universally conserved "perturbing" Lys-194 (E. coli numb

197 g, via a conserved peptidic sequence, into a universally conserved pocket.

198 t demonstrated that polyphosphate (polyP), a universally conserved polyanion, significantly accelerat

199 The universally conserved positions G690 and U697 are genera

200 Although universally conserved positions in the barcode allow the

201 ur Nigerian children were PCR amplified with universally conserved primers and spirochetal selective

202 were examined by PCR using 16S and 23S rRNA universally conserved primers.

203 etection, and demonstrated that there are no universally conserved priming sequences among viruses an

204 Cotranslational protein translocation is a universally conserved process for secretory and membrane

205 function of virtually all cilia require the universally conserved process of intraflagellar transpor

206 while the reduction division of meiosis is a universally conserved process, the pre-meiotic associati

207 ynthesis genes with xanthophores, suggesting universally conserved processes.

208 BipA is a universally conserved prokaryotic GTPase that exhibits d

209 The universally conserved prophase I arrest is released by a

210 Of these, TsaC and TsaD are members of universally conserved protein families.

211 00 bacterial homologs of the RecA family - a universally conserved protein involved in DNA recombinat

212 tion by signal recognition particle (SRP), a universally conserved protein targeting machine.

213 ion in eukaryotes and prokaryotes involves a universally conserved protein translocation channel form

214 ent chain complex to the Sec61 translocon, a universally conserved protein-conducting channel in the

215 The Sec61 or SecY channel, a universally conserved protein-conducting channel, transl

216 alization of these proteins is mediated by a universally conserved protein-targeting machinery, the s

217 unoanalytical method to identify ancient and universally conserved protein/peptide sequences as targe

218 ily (COG0533) has been on the top-10 list of universally conserved proteins of unknown function for o

219 rRNA which, in the mature form, fold into a universally conserved pseudoknot.

220 escent-shaped molecule with two domains, the universally conserved Psi synthase catalytic domain and

221 ies show that an archael Pus10 catalyzes the universally conserved Psi55 in tRNA.

222 gene conversion reactions in which RAD51, a universally conserved recombinase, catalyses homology-di

223 that catalytically inactivate ribosomes at a universally conserved region of the large ribosomal RNA.

224 tra-domain interactions, the location of the universally conserved regions, the regions involved in p

225 -glycosidase activity directed solely at the universally conserved residue A4324 in the sarcin/ricin

226 We further demonstrated that His384, a universally conserved residue among protein tyrosine kin

227 hypervariable region; rpoC1 (TsX) changed a universally conserved residue and corresponds to yeast r

228 n this binding interaction map well onto the universally conserved residues of sMMO enzymes from diff

229 at domain II of RRF initially interacts with universally conserved residues of the 23S rRNA helices 4

230 ound conformations of the RNA shows that two universally conserved residues of the A site of 16 S rRN

231 ative amounts of label incorporated into the universally conserved residues U2506 and U2585 depend on

232 nza virus neuraminidase (NA) is formed by 11 universally conserved residues.

233 These findings suggest that universally conserved RfaH homologs may change folds to

234 The W255C mutation of the universally conserved ribosomal protein uL3 has diverse

235 Here, we show that a corridor of 20 universally conserved ribosomal RNA bases interacts with

236 the DUF143 family have been suggested to be universally conserved ribosomal silencing factors, actin

237 he E (exit) site in a process catalyzed by a universally conserved ribosome-dependent GTPase [elongat

238 The crystal structure of the universally conserved RNA-protein core of the Escherichi

239 Rps2 (uS5) is a universally conserved RP that assembles into nuclear pre

240 h folding of the central pseudoknot (CPK), a universally conserved rRNA structure of the small riboso

241 Within the act CLF, neither the universally conserved S145 residue nor Q171, which align

242 and the beta7-beta9 loop as well as with two universally conserved SAG residues (Leu(137) and Tyr(144

243 translation by site-specific cleavage of the universally conserved Sarcin-Ricin loop (SRL) in 23S rRN

244 es the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin-ricin loop (SRL) leading to

245 ormation traverse the membrane by way of the universally conserved Sec pathway, whereas the twin argi

246 nto and across hydrophobic membranes via the universally conserved Sec pore.

247 The universally conserved Sec system is the primary method c

248 In bacteria, the universally conserved SecA ATPase binds a large repertoi

249 This process is facilitated by the universally conserved secretion (Sec) system, a multi-su

250 branes of specific proteins occurs through a universally conserved secretory channel.

251 ally inserted into the lipid bilayer via the universally conserved SecY complex and they access the l

252 The major mechanism for this process is the universally conserved SecY/Sec61 pathway.

253 The only universally conserved sequence among all influenza A vir

254 HSF) transiently induces the expression of a universally conserved set of proteins, the heat shock pr

255 The universally conserved signal recognition particle (SRP)

256 The universally conserved signal recognition particle (SRP)

257 The universally conserved signal recognition particle (SRP)

258 The universally conserved signal recognition particle (SRP)

259 ting of membrane proteins is mediated by the universally conserved signal recognition particle (SRP).

260 viously found that a single base change at a universally conserved site in this region of the Tetrahy

261 tations, A794G, G926A, and A1519C, mapped to universally conserved sites in the 16 S RNA gene.

262 KsgA, a universally conserved small ribosomal subunit (SSU) rRNA

263 of the SRP-substrate complex occurs via the universally conserved SRP receptor (Sralpha/beta and Fts

264 Intriguingly, the otherwise universally conserved SRP RNA is missing in a novel chlo

265 This otherwise universally conserved SRP RNA is missing in the chloropl

266 ue in that it does not contain the otherwise universally conserved SRP RNA, which accelerates the ass

267 Moreover, membrane localization of the universally conserved SRP subunit SRP54, the key binding

268 The universally conserved ssDNA overhang is sequence-specifi

269 translating ribosome encounters one of three universally conserved stop codons: UAA, UAG or UGA.

270 All organisms have stress proteins, and universally conserved stress proteins can be regarded as

271 The protein binds on top of a universally conserved structural module in P RNA and int

272 w the formation of the central pseudoknot, a universally conserved structure which connects all domai

273 In the other (closed state), the universally conserved switch 2 glycine forms a hydrogen

274 The universally conserved switch-2 may have the same role in

275 P450cin lacks the almost universally conserved threonine residue believed to be i

276 rRNA nucleotides studied have been virtually universally conserved throughout evolution.

277 Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway

278 s recruited to the TGN by the Arf1 GTPase, a universally conserved trafficking regulator.

279 This universally conserved transcription elongation factor is

280 NusG/Spt5 is the only universally conserved transcription elongation factor sh

281 Among other hits, we found that the universally conserved transcription factor NusG is cruci

282 Spt5p is a universally conserved transcription factor that plays mu

283 e elongation regulator NusG-Spt5 is the only universally conserved transcription factor.

284 rotein EF-P, we propose that eIF5A/EF-P is a universally conserved translation elongation factor.

285 Previous studies identified two universally conserved translation elongation factors, EF

286 eIF1 is a universally conserved translation factor that is necessa

287 Elongation factor G (EF-G) is a universally conserved translational GTPase that promotes

288 base G966 and position 36 interacts with the universally conserved tRNA base U33 during translocation

289 of N6-threonylcarbamoyladenosine (t(6)A), a universally conserved tRNA modification found on all ANN

290 A universally conserved tryptophan is ideally positioned t

291 Surprisingly, the universally conserved type I topoisomerase domain which

292 site-specific nitration of the critical and universally conserved Tyr(35).

293 t transactivates both -2 and -1 PRF, and the universally conserved Tyr111 and Arg114 in nsp1beta are

294 We find that the universally conserved Tyr34 that has a pK above 11.5 in

295 mma-phosphate of GTP and centered around the universally conserved tyrosine 837 (Saccharomyces cerevi

296 responsible for the 2'-O methylation of the universally conserved U2552 in the A loop of 23S rRNA.

297 RPR] to investigate the functional role of a universally conserved uridine in a bulge-helix structure

298 s composed of phosphate backbone moieties, a universally conserved uridine nucleobase, and at least t

299 Ten helical regions of the RNA are universally conserved while other regions vary significa

300 The universally conserved YidC protein mediates this process