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1 nteracts with SMCR8 (a protein of previously unknown function).
2 nct protein 'phamilies', 77% of which are of unknown function.
3 acterized Tsr4 as a 40S biogenesis factor of unknown function.
4 thway and both the COG complex and a gene of unknown function.
5 FAM149B1 encodes a protein of unknown function.
6 eta cell/stomach-enriched nuclear protein of unknown function.
7 ith poorly defined ligands, is a receptor of unknown function.
8 portant information about gene products with unknown function.
9 sity, many tectiviral proteins are ORFans of unknown function.
10 unusual rotating intracellular structure of unknown function.
11 pgf) that can encode immunogenic proteins of unknown function.
12 structures present on alpha-dystroglycan of unknown function.
13 in fibroblasts and smooth muscle cells with unknown function.
14 tions among 24 proteins, of which 12 have an unknown function.
15 utrients and secreting conserved proteins of unknown function.
16 on FAU, a poorly characterized protein with unknown function.
17 Pet10p is a yeast lipid droplet protein of unknown function.
18 onB-dependent receptors and many proteins of unknown function.
19 te at the H3-H3' dimerization interface with unknown function.
20 s of malaria parasites contain many genes of unknown function.
21 nce was noted, of which 200 were proteins of unknown function.
22 surface proteins and exported proteins with unknown function.
23 evant model for the screening of variants of unknown function.
24 s, about 14,000 of which involve proteins of unknown function.
25 roteases, or excretory-secretory proteins of unknown function.
26 Many of the differential proteins were of unknown function.
27 (PLD) domain, a DUF1998 domain and a gene of unknown function.
28 _3827 as putative targets of the series with unknown function.
29 nd its substrate Sip5, a protein of hitherto unknown function.
30 secretory cell-specific Munc13-4 paralog of unknown function.
31 h to investigate WipB, a Dot/Icm effector of unknown function.
32 haracterized long noncoding transcripts with unknown function.
33 to the presence of three loop insertions of unknown function.
34 generating a variety of RNA classes, most of unknown function.
35 is coding for a small Ras GTPase with so far unknown function.
36 regulation, as well as predicted proteins of unknown function.
37 s in 5'UTRs, the vast majority of which have unknown function.
38 al species identifies several core smORFs of unknown function.
39 ule, and a C-terminal unclassified module of unknown function.
40 eins, among which YDR089W is the only one of unknown function.
41 ly have low-complexity N-terminal regions of unknown function.
42 d oligodendrocytes express NMDA receptors of unknown function.
43 ncodes at least 44 miRNAs, most of them with unknown function.
44 thyl uridine; and RSAD1 and viperin, both of unknown function.
45 inases, protein phosphatases and proteins of unknown function.
46 ative pyridoxal phosphate-binding protein of unknown function.
47 ch encodes a PLP-binding protein of hitherto unknown function.
48 nthocytes deficient in chorein, a protein of unknown function.
49 , an overlapping open reading frame (ORF) of unknown function.
50 ed in neurodevelopmental disorders or are of unknown function.
51 work for characterizing bacterial systems of unknown function.
52 ch C-terminal extension of ~70 residues with unknown function.
53 es XPD, XPB or TTDA, and in TTDN1, a gene of unknown function.
54 fant hospitalization, encodes a viroporin of unknown function.
55 d orphan genes, and the vast majority are of unknown function.
56 a C-terminal PX-associated B (PXB) domain of unknown function.
57 prising 37 annotated Arabidopsis proteins of unknown function.
58 , an ATPase-domain protein, and a protein of unknown function.
59 itro functional data among star alleles with unknown function.
60 d identify activities for several domains of unknown function.
61 etch of ~919 amino acid at the N-terminus of unknown function.
62 PD-L1 has been detected in the nucleus, with unknown function.
63 re not required for lytic growth, and are of unknown function.
64 ICC-SS), a population of ICC with previously unknown function.
65 is highly conserved in cyanobacteria, but of unknown function.
66 98-kDa type 1 transmembrane glycoprotein of unknown function.
67 ter genes and several open-reading frames of unknown function.
68 es a heterogeneous group of RNA molecules of unknown function.
69 egP and a serine/threonine protein kinase of unknown function.
70 ving a tungsten-containing oxidoreductase of unknown function.
71 s C-terminal domain adopt an Ig-like fold of unknown function.
72 the Polycomb Repressive Complex 2 (PRC2), of unknown function.
73 bstrates of transiently acylated proteins of unknown function.
74 idopsis (Arabidopsis thaliana) genome are of unknown function.
75 se variants alter nonconserved residues with unknown functions.
76 nes of the novel filoviruses with previously unknown functions.
77 As that are joined head to tail with largely unknown functions.
78 non-canonical CTD, which performs completely unknown functions.
79 ng protein 6 (RanBP6), a protein of hitherto unknown functions.
80 ng for over one hundred thousand proteins of unknown functions.
81 ize across eukaryotic evolution with largely unknown functions.
82 s and miscellaneous RNAs, which have largely unknown functions.
83 liary proteins, MlaD and MlaB, of previously unknown functions.
84 ith frequently precise regulation but mostly unknown functions.
85 ) encodes a tetra-transmembrane protein with unknown functions.
86 l-established motor activity, or additional, unknown functions.
87 cid-long unique N-terminal region with still unknown functions.
88 heir C-terminal peptide exert indispensable, unknown functions.
89 from NPCs to the chromatin region to fulfill unknown functions.
90 RFB) encoding two hypothetical proteins with unknown functions.
91 l, and most of the encoded proteins comprise unknown functions.
92 of novel CL-dependent proteins (CLDPs) with unknown functions.
93 el glycosyltransferase fold from a domain of unknown function 1792 are contrasted with common propert
96 eus SufT is composed solely of the domain of unknown function 59 (DUF59) and has a role in the matura
98 he periplasmic protein PA0808, heretofore of unknown function, affords self-protection from lysis by
99 integral mitochondrial membrane protein with unknown function, although we now show that high-level e
100 w members of the mammalian opsin family with unknown function and ambiguous light absorption properti
102 d virus 2 (SIRV2), both encoding proteins of unknown function and forming an operon with ORF207 (gp19
103 ADH dehydrogenases, transcription factors of unknown function and genes for iron uptake were differen
104 can provide functional insights for genes of unknown function and is a necessary step in phylogenetic
105 ated genetic variants, especially those with unknown function and located outside protein-coding regi
106 rticularly useful in characterizing genes of unknown function and potential targets for novel small m
107 h symbiosis-induced, taxon-specific genes of unknown function and reduced numbers of plant cell wall-
108 ily, owing to its extra C-terminal domain of unknown function and the absence of the essential cataly
109 homologous to two other Arabidopsis genes of unknown function and to FRIENDLY, which was previously s
110 ction, (iii) relationships among proteins of unknown function and various types of experimental data,
111 ast majority of these RNA editing sites have unknown functions and are in noncoding regions of the ge
112 lammatory responses, and identify previously unknown functions and mechanisms of action of these cyto
114 odomain protein-1 (Chp1), Tas3 (protein with unknown function), and Argonaute (Ago1), plays an import
115 gene encodes a lysosomal membrane protein of unknown function, and CLN3 mutations cause the fatal neu
116 ferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase th
117 ctional inference for superfamily members of unknown function, and facilitate rational redesign of th
118 ty, accounting for errors made in specifying unknown functions, and (2) the partial degree of sensiti
119 ing protein; GATOR2, a positive regulator of unknown function; and Sestrin2, a GATOR2-interacting pro
123 l as in ycf2 (a giant reading frame of still unknown function), are responsible for the differences i
125 main protein, and other membrane proteins of unknown function as well as a RING U-box protein and pos
126 ein 119 (Tmem119), a cell-surface protein of unknown function, as a highly expressed microglia-specif
127 MKv), a pseudokinase of the CaMK family with unknown function, as a synaptic protein crucial for dend
129 importer MgtE, and DarB (YkuL), a protein of unknown function, as bona fide c-di-AMP-binding proteins
130 ial(6,7) mitochondrial protein of previously unknown function-as a mammalian mitochondrial NAD(+) tra
131 sults demonstrate that Bub3 has a previously unknown function at the kinetochore in activating APC/C-
132 6, we identified a novel infectivity gene of unknown function, bbk13, which encodes an immunogenic, n
135 t encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated wi
136 molybdopterin biosynthesis and two genes of unknown function (clrE, clrF) had fitness defects in poo
137 vator HCF173 and two RNA binding proteins of unknown function (CP33C and SRRP1) to be highly enriched
139 that deletion of lamA, a gene of previously unknown function, decreases heterogeneity in the populat
140 Chp chemosensory system accessory protein of unknown function, directly links the integral component
142 he toxin of the system (DarT) is a domain of unknown function (DUF) 4433, and the antitoxin (DarG) a
144 e ALDHs contain an uncharacterized domain of unknown function (DUF) near the C terminus of the polype
145 ning a putative membrane-localized domain of unknown function (DUF21) and a cystathionine-beta-syntha
146 44-amino acid protein containing a domain of unknown function (DUF2753) with three tetratricopeptide
147 o a superfamily of proteins with a domain of unknown function (DUF3237), of which no member has a pre
149 nnotations for newly discovered regions with unknown functions, e.g. the 97 new regions identified in
150 n of 1,220 A. thaliana genes with previously unknown functions, each assigned a confidence measure ca
151 est genome generated to date, 149 genes have unknown function, emphasising a universal problem; less
152 opeptide repeat domain-containing protein of unknown function encoded by a single Arabidopsis gene.
153 HopAF1 is a type III effector protein of unknown function encoded in the genomes of several strai
155 05, a conserved membrane-spanning protein of unknown function, fails to evoke detectable antibody res
157 el of COPA syndrome to identify a previously unknown function for Copa in thymocyte selection and dem
165 lities of "silencing" arthropod serpins with unknown functions for investigation of their physiologic
167 sphogluconolactone, an oxiPPP byproduct with unknown function generated through intramolecular rearra
168 combinational DNA repair) and cjj81176_1449 (unknown function) genes were highly variable in all 81-1
169 phage repressor (gp47), and six proteins of unknown function (gp34, gp35, gp54, gp56, gp64, and gp65
172 More than 20 protein families, previously of unknown function, have been ascribed anti-CRISPR functio
173 the proteins encoded by algal genomes are of unknown function, highlighting the volume of functional
174 have defined a role for a conserved gene of unknown function in B. abortus envelope stress resistanc
175 t encode transcriptional regulators, some of unknown function in CD8(+) T cells, and that were differ
177 ions decipher the role of protein domains of unknown function in large macromolecular complexes?
181 ed or exhibit cis-regulatory properties with unknown function in specific processes such as heart dev
185 We also identified a number of proteins with unknown function in the heart to be triggered by paraqua
186 plicating several new proteins of previously unknown function in the P1 dar antirestriction system.
190 and defines a role for CPAMD8, a protein of unknown function, in anterior segment development, imply
191 l number of abundant novel proteins with yet unknown functions, in addition to enzyme inhibitors and
192 roteome identified several viral proteins of unknown functions, including a protein encoded by the UL
193 Ch released by motoneurons exerts a hitherto unknown function independent of myofiber contraction.
194 uperfamily member 2), a polytopic protein of unknown function, is associated with the full spectrum o
196 om the early days when AQP0 was a protein of unknown function known as Major Intrinsic Protein 26.
197 e Cdc14-interacting proteins with previously unknown functions localised to the Spindle Pole Bodies (
198 dem repeats and a C-terminal basic domain of unknown function, localizes to the connecting cilium whe
199 describe the concept that PI16, a protein of unknown function mainly produced by fibroblasts, control
200 hough the majority are orphan receptors with unknown functions, many reports have demonstrated critic
201 signaling to rDNA repair and this heretofore unknown function may be critically important in prolifer
211 Thus, this study identified a previously unknown function of STIM2beta in myogenesis and improves
212 llectively, our findings reveal a previously unknown function of STRAP in mediating the splicing netw
213 e findings provide evidence for a previously unknown function of stromal Scrib in PDZ formation, pote
215 In this work, we discovered a previously unknown function of the HPV16 E5 oncoprotein in the supp
222 ce of NAA-derived acetate, or absence of any unknown functions of the ASPA enzyme is responsible for
223 s simultaneously, thus suggesting previously unknown functions of these effector molecules in endosom
224 n the study of RanBP9 and potentially unveil unknown functions of this protein in vivo such as those
226 jority of these SNPs are located in genes of unknown function, one SNP is located in the DNA binding
228 some cases, the mutations occur in genes of unknown function or without understanding of molecular p
230 associations on 2p24 near FAM49A, a gene of unknown function (P = 4.22 x 10(-8)), and 19q13 near RHP
232 highly enriched in mature erythrocytes, with unknown functions pertaining to erythrocyte physiology.
233 in a two-gene locus that encodes a domain of unknown function (Pfam: PF10070) and a putative cation t
234 ers of the DUF1537 protein family (domain of unknown function; Pfam families PF07005 and PF17042) and
235 cytoplasmic membrane proteins of previously unknown functions, play an essential synergistic role in
236 we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and inste
237 lic and linear oligonucleotides of known and unknown functions, potentiating fundamental and applied
238 uberculosis lacking three different genes of unknown function previously shown to be necessary for op
241 ires an ancestral gene encoding a protein of unknown function, r5.7, V. tasmaniensis cytotoxicity is
243 tein 2 (MOSPD2), a protein with a previously unknown function, regulates monocyte migration in vitro.
244 with Coq11, a recently identified protein of unknown function required for efficient Q(6) biosynthesi
245 ode 4D-Ca(v)/Na(v)s [4] but also proteins of unknown function, resembling prokaryote single-domain, v
246 ted gene (PACRG), which encodes a protein of unknown function, shares a bidirectional promoter with P
247 reD(2,6,7), as well as a membrane protein of unknown function (SPD_0768) that we have named CozE (coo
248 calyceal processes, which are microvilli of unknown function surrounding the base of the photorecept
249 We previously identified a small protein of unknown function, SutA, in a screen of proteins synthesi
250 roteomics analysis yielded seven proteins of unknown function (termed SiMat proteins) together with f
251 g1), as well as Thg1-like proteins (TLPs) of unknown function that are broadly distributed, with fami
253 perons encode up to 10 different proteins of unknown function that are not present in conventional AB
254 1, two homologous, secreted glycoproteins of unknown function that are predominantly expressed in bra
257 nd function of a widely conserved protein of unknown function that is an important regulator of antim
258 uter segment (OS) disc-specific protein with unknown function that is associated with retinitis pigme
259 ins a conserved N-terminal region (RH5Nt) of unknown function that is cleaved from the native protein
260 f polycystin-2 by its TOP domain-a site with unknown function that is commonly altered by missense va
261 thway with CLN6, an ER-associated protein of unknown function that is defective in a different Batten
263 t allele of a gene that encodes a protein of unknown function that is homologous to two other Arabido
264 urgdorferi encodes a hypothetical protein of unknown function that is predicted to contain an N-termi
267 FV encodes a secreted glycoprotein (GP38) of unknown function that is the target of a protective anti
268 by IreK and IreP is IreB, a small protein of unknown function that is well conserved in low-GC Gram-p
269 e coexpression analysis to identify genes of unknown function that may contribute to both conserved a
270 -Like1 (AFL1) is a stress-induced protein of unknown function that promotes growth during low water p
271 The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through
272 g16550, which is a plant-specific protein of unknown function that we termed LDIP (LDAP-interacting p
274 nriched with unique processes and genes with unknown functions that hold the potential to improve str
275 BAC was discovered as a cellular activity of unknown function, there are now many lines of evidence c
276 many of the EIEC lineage-specific genes have unknown functions, those with predicted functions includ
277 creen we found pals-22, a gene of previously unknown function, to be a repressor of the cul-6/cullin
278 ies a role for a viral tegument protein with unknown function, UL88, in maintaining the proper tegume
280 roughput screening of 177 protein modules of unknown function was used to determine the complete CBMo
283 pstS, and pstS and its adjacent gene g247 of unknown function were the only phage genes that were enr
286 I1-Interactor 1 (HIN1), a nuclear protein of unknown function which could be dephosphorylated by HAI1
287 aches, we define CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivatio
288 tabases (ORFans), being putative proteins of unknown function, which hinders the understanding of the
290 urface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an interface for yet
291 operons, iron-regulated genes, and genes of unknown function, which may or may not be controlled by
292 omosome 1, encode a family of 18 proteins of unknown function, whose expression is largely restricted
293 AtGET1 and identified a membrane protein of unknown function with low sequence homology but high str
294 notation to prioritize mutations in genes of unknown function with potential effects on the immune sy
295 e single-exon gene HPDL encodes a protein of unknown function with sequence similarity to 4-hydroxyph
297 binding may occur via additional domains of unknown function within the nonrepeat region, one of whi
298 We also establish that an ABC transporter of unknown function, YadH, together with the Mla system pre
300 in mutant cells was a protein of previously unknown function (YddW), which we have identified as a d