ライフサイエンスコーパス: unload

1 e pulses, a phenomenon we refer to as 'batch unloading'.

2 f mass flow and diffusion (convective phloem unloading).

3 the myocardial adaptation to overload and to unload.

4 ral wall was more loaded, and the septum was unloaded.

5 dual strain throughout the tissue, even when unloaded.

6 strand synthesis, converging CMGs are still unloaded.

7 Once DNA synthesis has ceased, PCNA must be unloaded.

8 hereafter they are rapidly and independently unloaded.

9 and restored to control levels by mechanical unloading.

10 VA-ECMO with versus without left ventricular unloading.

11 ting episodic methane emissions from liquids unloading.

12 -shelf break-up due to meltwater loading and unloading.

13 s >1 microm did not improve after mechanical unloading.

14 functional cardiac recovery after mechanical unloading.

15 sting no direct involvement in cargo loading/unloading.

16 y of Scx-mutant callus was not due to muscle unloading.

17 led; 54 underwent 8.0 +/- 1.2 months of LVAD unloading.

18 and functional recovery during chronic LVAD unloading.

19 y remodeling of the myocardium due to volume unloading.

20 s that occur to the myocardium due to volume unloading.

21 to 25 cm H2O in terms of respiratory muscle unloading.

22 in each - without any mechanical loading and unloading.

23 ative role for these Suc transporters in Suc unloading.

24 ing aging, estrogen deficiency, and skeletal unloading.

25 le and undergo spontaneously detwinning upon unloading.

26 ifested through reversible detwinning during unloading.

27 ficance during cardiac pressure overload and unloading.

28 rostin and RANKL/OPG ratio in the setting of unloading.

29 ption, or stop bone loss induced by skeletal unloading.

30 ery of failing human hearts after mechanical unloading.

31 l strength, and material strength induced by unloading.

32 ts exposed to longer durations of mechanical unloading.

33 r transporter for Suc and glucose efflux and unloading.

34 d with 255 patients without left ventricular unloading.

35 al infarction (MI) or mechanical loading and unloading.

36 ular assist device (LVAD)-induced mechanical unloading.

37 who underwent VA-ECMO with left ventricular unloading.

38 relieved when CMGs converge, leading to CMG unloading.

39 RLCs cooperate to regulate PCNA loading and unloading.

40 rization and acid-induced haemoglobin oxygen unloading.

41 CoA through ASCL1 activation and mechanical unloading.

42 t profiles in unloaded and loaded TMJ discs (unloaded, 0% strain, 20% strain).

43 Proposed mechanisms include skeletal unloading, abnormalities in calciotropic hormones, and c

44 n stress that include water mass loading and unloading above the aquifer surface.

45 reduces infarct size and that 30 minutes of unloading activates a cardioprotective program that limi

46 ane emissions (TNME) from natural gas liquid unloading activities for 18 basins in the United States

47 DNA structures did not affect PCNA unloading activity of ATAD5-RLC.

48 Here, we show the distinct PCNA loading or unloading activity of each clamp loader.

49 proteins such as Fen1 could inhibit the PCNA unloading activity of Elg1-RLC, a yeast homolog of ATAD5

50 ATAD5-RLC possesses the potent PCNA unloading activity.

51 d collar domain of ATAD5 are crucial for the unloading activity.

52 We examined the effect of human ventricular unloading after implantation of left ventricular assist

53 al and mechanical properties due to hindlimb unloading alone and simulated spaceflight.

54 edict the 3-dimensional nutrient profiles in unloaded and loaded TMJ discs (unloaded, 0% strain, 20%

55 of around 40 and 100 nm for the most optimum unloaded and oil-loaded ChNPs, was obtained by field emi

56 The association between left ventricular unloading and 30-day mortality was assessed by Cox regre

57 n, was stable for several hours after phloem unloading and could be used to study phloem transport in

58 e first exploratory study testing whether LV unloading and delayed reperfusion in patients with STEMI

59 indicates that assumptions regarding liquids unloading and estimated ultimate recovery (EUR) of wells

60 Left ventricular assist device (LVAD) unloading and hemodynamic support in patients with advan

61 ning future investigations that combine LVAD unloading and pharmaceutical therapies as a bridge to re

62 n, whereas TRPV4 activation caused a dynamic unloading and reloading of vinculin.

63 Despite effective hemodynamic unloading and remodeling, there were no differences afte

64 establish TRAIP as a master regulator of CMG unloading and the response of the replisome to obstacles

65 eflight, combining microgravity (by hindlimb unloading) and radiation exposure.

66 he tracer solution still needs to be loaded, unloaded, and purged from the cell culture during the me

67 PS) was collected from the loading (source), unloading (apical sink region) and shoot-root junction r

68 Three twin thicknesses after unloading are 3.2, 3.5, and 16 nm, which is consistent w

69 ptional level, and muscle changes induced by unloading are counteracted by passive mechanical loading

70 reveals that methane emissions from liquids unloading are highly variable, with mean TNMEs ranging f

71 g the response of the skeleton to mechanical unloading are not completely understood.

72 ur results identify BRCA1-dependent helicase unloading as a critical, early event in ICL repair.

73 nts the normal cerebral volume and pressure 'unloading' associated with upright postures on Earth, wh

74 at entered the translocation stream and were unloaded at the root tip.

75 that cargoes are loaded at their origin and unloaded at their destination.

76 ge cumulative methane emissions from liquids unloading, attributed to the natural gas supply chain, a

77 less (-2%) than that of tumors treated with unloaded beads (+42%) and oral sunitinib (6 mg every day

78 tinib), seven received 0.05 mL of 70-150-mum unloaded beads, and seven received oral sunitinib (6 mg

79 compared with immediate reperfusion (IR), LV unloading before reperfusion improves myocardial energy

80 opriately powered pivotal trial comparing LV unloading before reperfusion to the current standard of

81 The duration of LV unloading before reperfusion was inversely associated wi

82 e proceeding to a larger pivotal study of LV unloading before reperfusion.

83 reducing left ventricular (LV) workload (LV unloading) before coronary reperfusion is emerging as a

84 f the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing

85 ch applied force accelerates dissociation of unloaded bonds and kinetically strengthens strained bond

86 was performed at P7 for WT, cKO, and muscle-unloaded (botulinum toxin A treated) attachments for qua

87 trophic myocardium in heart failure patients unloaded by continuous-flow LVADs has not been studied.

88 w velocity (2 km/s) along a segment that was unloaded by the M(w) 6.5 event.

89 nd at different time points after mechanical unloading by a left ventricular assist device (LVAD) by

90 ssion in human failing hearts resolved after unloading by a left ventricular assist device.

91 ration, which interferes with efficient PCNA unloading by ATAD5 and subsequent nucleosome deposition

92 o maintain a high turgor to drive symplasmic unloading by bulk flow.

93 The study examined whether mechanical unloading by continuous-flow LVAD leads to myocardial at

94 These findings suggest that PCNA unloading by Elg1 is necessary to limit Fbh1 and Srs2 ac

95 Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has

96 te is achieved upon drought by reduced xylem unloading by PtaSULTR3;3a and PtaSULTR1;1, and by enhanc

97 signed 50 patients with anterior STEMI to LV unloading by using the Impella CP followed by immediate

98 supports relaxation of arterial myocytes by unloading Ca(2+) into peripheral nanocourses delimited b

99 Despite robust cardiac unloading, capillary density and fibrosis are unchanged

100 NPC, a process that is probably required for unloading cargo sRNA into surrounding cells.

101 san (Ch) to tripolyphosphate (TPP), 1:1, for unloaded ChNPs and 1:1:1 for Ch to TPP to CEO, for CEO-l

102 esized that macrophages have the capacity to unload cholesterol directly onto adjacent cells.

103 ther a protocol of optimized LVAD mechanical unloading, combined with standardized specific pharmacol

104 LHCP's transmembrane domains in a productive unloading complex at the membrane.

105 he centre of the sarcomere, producing, under unloaded conditions, a filament sliding of approximately

106 that F764L has a similar duty ratio as WT in unloaded conditions.

107 speeds, run lengths, and landing rates under unloaded conditions.

108 ported prestress methodology to identify the unloaded configuration corresponding to the medically im

109 e approaches, which take into account of the unloaded configuration, are needed for in vivo material

110 Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insi

111 ss matrix subjected to a compressive loading-unloading cycle.

112 PCNA unloading depends on the Elg1-containing alternative RFC

113 Treatment of insulin-secreting cells with unloaded DIANAs did not impair cell viability and functi

114 ndicated that prolonged continuous-flow LVAD unloading does not induce hypertrophy regression to the

115 ic shortening, lithospheric delamination and unloading due to deglaciation and erosion.

116 To explore the effect of LV unloading duration on infarct size, we analyzed data fro

117 TRAIP-dependent CMG unloading during mitosis is also seen in C. elegans earl

118 search of studies examining left ventricular unloading during VA-ECMO in Medline, EMBASE, and the Coc

119 their "top" face (furthest from bilayer) and unload each of them selectively upon addition of a speci

120 m toxin (BTX) was used to investigate muscle unloading effects on callus shape.

121 f uncertainty in current estimates of liquid unloading emissions.

122 vels, we subjected osteocytes to an in vitro unloading environment achieved by the NASA rotating wall

123 Cells deficient in PCNA unloading exhibit increased chromosome breaks.

124 fines their boundaries, and that the cohesin unloading factor WAPL and its PDS5 binding partners cont

125 d obtain the average angular velocity of the unloaded FliJ filament within the FliI(6) stator: omega(

126 ce/group) within each genotype and HU groups unloaded for 2 weeks.

127 orway rats at 10 months of age were hindlimb unloaded for a period of 2 weeks.

128 LVAD-associated unloading for 6 months resulted in a substantial improve

129 icase is polyubiquitylated by CRL2(Lrr1) and unloaded from chromatin by the p97 ATPase.

130 (cross-sectional area) decreased after LVAD unloading from 1,238 +/- 81 mum(2) to 1,011 +/- 68 mum(2

131 We conclude that apoplasmic Suc unloading from de-energized protophloem sieve elements i

132 es helped visualize Twinkle loading onto and unloading from DNA in an open-ringed configuration.

133 O(2) unloading from RBCs was considerably slower than previou

134 The SWEET transporter may facilitate Suc unloading from the phloem to the apoplast where cell wal

135 ed their broad roles in theanine loading and unloading from the vascular system, and in targeting to

136 the Elg1 complex and down-regulate its PCNA-unloading function to promote the G1/S transition.

137 ulated transcript set overlapped with muscle unloading gene expression profiles (>/=1.5-fold change;

138 lactate, and oxygen concentration ranges for unloaded healthy human TMJ discs were 0.6 to 4.0 mM, 0.9

139 ) or the profound unloading in a chronically unloaded heart result in impaired t-tubule structure, wi

140 absence of MAT reduced bone loss in hindlimb-unloaded (HU) mice.

141 of wild type (WT) and ob/ob mice to hindlimb unloading (HU).

142 The DTU-STEMI pilot trial (Door-To-Unload in STEMI Pilot Trial) represents the first explor

143 ilar steady-state actin-activated ATPase and unloaded in vitro motility-sliding velocities, both R712

144 usly hypertensive rat model) or the profound unloading in a chronically unloaded heart result in impa

145 underlying the importance of Suc apoplastic unloading in Arabidopsis roots and a putative role for t

146 after recovery of muscle mass from hindlimb unloading in both adult and aged rats, as well as after

147 ligand (RANKL) expression is increased with unloading in mice.

148 sucrose transporters (SUTs) regulate phloem unloading in monocot stems is poorly understood and part

149 ese findings support use of left ventricular unloading in patients with cardiogenic shock treated wit

150 y aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated wit

151 in Arabidopsis (Arabidopsis thaliana), while unloading in roots is less understood.

152 e phloem-pole pericycle in regulating phloem unloading in roots.

153 we investigate the signal that triggers CMG unloading in Xenopus egg extracts using single-molecule

154 evaluate its potential roles, such as phloem unloading, in nonphotosynthetic tissues.

155 However, whether unloading-induced atrophy in experimental normal heart m

156 Prolonged mechanical unloading induces adult human cardiomyocyte proliferatio

157 capacity to interact with AGO2, it mediated unloading instead of loading of let-7 family miRNAs, the

158 smata clusters, or pit fields, at the phloem unloading interfaces of Arabidopsis (Arabidopsis thalian

159 e to virus loading, movement, and subsequent unloading into distal uninfected tissues.

160 unlike termination, repair-mediated helicase unloading involves the tumor suppressor protein BRCA1, w

161 CMG unloading involves ubiquitylation of its Mcm7 subunit an

162 SOST/sclerostin up-regulation in mechanical unloading is a cell-autonomous response or a hormonal re

163 When CMG unloading is blocked, diverging CMGs do not support DNA

164 tors that are enriched on chromatin when CMG unloading is blocked.

165 vitro and in vivo analysis showed that PCNA unloading is delayed in the absence of nucleosome assemb

166 f CRL2(Lrr1), Mcm7 is not ubiquitylated, CMG unloading is inhibited, and a large subcomplex of the ve

167 (Myo1b) and Myosin-Ic (Myo1c), have similar unloaded kinetics and sequences but substantially differ

168 Most wells without plunger lifts unload less than 10 times per year with emissions averag

169 e novel findings identify that transvalvular unloading limits ischemic injury before reperfusion, imp

170 to background levels about 2 h after phloem unloading, making it a suitable tracer for pulse-labelin

171 rospective randomized data, left ventricular unloading may be considered for appropriately selected p

172 nts contain metal transporters that load and unload metals.

173 Unloaded mice exhibited high serum levels of the bone re

174 id bilayers can propel actin filaments in an unloaded motility assay, its ability to develop forces a

175 Mechanical unloading (MU) by implantation of left ventricular assis

176 sin ATPase cycle limits contraction speed in unloaded muscles (V0).

177 iciency; there was a 31% and 23% increase in unloaded myocardial oxygen consumption in healthy and po

178 The increased unloaded myocardial oxygen consumption was confirmed in

179 5-5.3 and 6.7-10.5 meq O(2)/kg in loaded and unloaded nanoemulsions, respectively.

180 ontrol the loading, active concentration and unloading of cargo on this track network, or to trigger

181 , whereas longer chains are required for the unloading of CMG by the p97 ATPase, which enables the Fa

182 al OB-folds allow CST to mediate loading and unloading of partner proteins to facilitate various aspe

183 checkpoint kinases regulate strand-specific unloading of PCNA from stalled replication forks to main

184 Although premature unloading of PCNA generally increases mutation rate, the

185 ement is likely functionally relevant in the unloading of PE-PPE heterodimers at the secretion machin

186 In conclusion, unloading of pulmonary arterial baroreceptors reduced ba

187 y of the DNA replication machinery, and that unloading of Rad51 by Srs2 helicase is required for effi

188 We also report that unloading of RPA from sites of ICL induction is perturbe

189 mathematical modelling) to show that phloem unloading of solutes in Arabidopsis roots occurs through

190 mics the headward fluid shift and axial body unloading of spaceflight.

191 an important factor for the study of phloem unloading of Suc.

192 though the processes involved in loading and unloading of sugars and amino acids are well characteriz

193 s of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results i

194 roteins (Rad51 and Rad52) to RTS1 depends on unloading of the polymerase sliding clamp PCNA from DNA

195 ts the sensor viscosity based on loading and unloading of the sensor and calculating the fractional t

196 the sequential recruitment, remodeling, and unloading of the targeting complex at membrane transloca

197 cursors (GAPs) at the arrest of fruit phloem unloading of two white grape Vitis vinifera cvs.

198 altered sympathetic activity in addition to unloading on cardiac hypertrophy and function.

199 -DTU) trial and then tested the effect of LV unloading on ischemia and reperfusion injury, cardiac me

200 s study was to test the effect of mechanical unloading on mitochondrial mass, DDR, and cardiomyocyte

201 istinct nanoswitches, a copper-loaded and an unloaded one {= state (0,0)}, was actuated with stoichio

202 28% of annual methane emissions from liquids unloading over all basins despite representing only ~0.4

203 ift generated by the solid-Earth response to unloading over short time scales close to ice-sheet grou

204 0.01) and ejection fraction increases during unloading (P<0.01).

205 hose that modulate nociception, stabilize or unload painful structures, influence physiological proce

206 Transiting from an apoplasmic to symplasmic unloading pathway as the stem matures, SbSUT1 and SbSUT5

207 ecule measurements, we reveal that ATAD5-RLC unloaded PCNA through one intermediate state before ATP

208 photriesters accelerates dissociation of the unloaded phosphorus-oxygen bond orthogonal to the pullin

209 While unloaded PLGA MPs inherently increase levels of pro-infl

210 parated when they exit the phloem during the unloading process.

211 does not have an apparent function in either unloading process.

212 of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly

213 en geometry and performance (measured by the unloaded quality factor, Q(0)).

214 How IFT trains attain speeds that exceed the unloaded rate of the slower, KIF3AB motor remains unknow

215 Analysis of the distribution of O(2) unloading rates in HS RBCs identified a subpopulation of

216 switch from symplasmic to apoplasmic phloem unloading, reconciling previously conflicting reports, a

217 two phases, reinforcing the hypothesis that unloading (recovery) may be a good surrogate for loading

218 is classically performed during loading, the unloading (recovery) response of cartilage may also enab

219 In preclinical models, LV unloading reduced the expression of hypoxia-sensitive pr

220 e-state model for CMR where both loading and unloading regulate the transition of bonds among the sho

221 h can be described as time-dependent forces (unloading/reloading cycles) acting on the Earth.

222 those regions where axons can be loaded and unloaded reversibly and those where axons are injured du

223 For each basin, six discrete liquid-unloading scenarios are considered, consisting of combin

224 Response time of the unloaded server is about 90 s for a 300-residue eukaryot

225 frequently in patients with left ventricular unloading: severe bleeding in 98 (38.4%) versus 45 (17.9

226 Unloading shoes were not associated with increased proba

227 ast muscle) and provides novel insights into unloaded shortening velocities (declining with increasin

228 Accordingly, the unloaded shortening velocity (V0 ) is already set at the

229 e observed before disuse, whereas Po/CSA and unloaded shortening velocity reached a higher level.

230 specific force (PO /CSA) and an increase in unloaded shortening velocity, which could be a result of

231 a loss of specific force and an increase in unloaded shortening velocity.

232 e (isometric force/cross-sectional area) and unloaded shortening velocity; (iii) myosin/actin ratio a

233 ery low rate of ATP utilization found during unloaded shortening.

234 gy landscape, and skewing it in favor of the unloaded side, and in some situations adding loads to th

235 The unloading slope during the unstable slip follows the sti

236 During unloading, solutes and proteins are diverted into the ph

237 Surprisingly, at stalled forks, PCNA is unloaded specifically from lagging strands.

238 ize, we analyzed data from the STEMI-Door to Unload (STEMI-DTU) trial and then tested the effect of L

239 the efficacy and safety of left ventricular unloading strategies during VA-ECMO in adult patients wi

240 2%) receiving a concomitant left ventricular unloading strategy while on VA-ECMO (intra-aortic balloo

241 Unloading sugar from sink phloem by transporters is comp

242 icularly the mechanisms by which macrophages unload surplus cholesterol (a process referred to as "ch

243 ells, thereby contributing to the ability to unload surplus cholesterol.

244 (conventional and unconventional) and liquid-unloading systems (nonplunger, manual plunger lift, and

245 ry signals ultimately control when and where unloading takes place.

246 electron microscopy (TEM) and cyclic loading-unloading tests.

247 re the cargo in the cytosol and productively unload the cargo at the membrane.

248 Here we show that BRCA1 is required to unload the CMG helicase complex from chromatin after rep

249 rather than strictly focusing on agents that unload the heart or target systemic neurohormones.

250 % of them had an intraaortic balloon pump to unload the left ventricle).

251 s and mild lateral-wedge insoles designed to unload the medial knee and worn daily (intervention) ver

252 Shoes with modified midsoles to unload the medial knee conferred no additional benefit o

253 egase plays a critical role in ICL repair by unloading the CMG complex from chromatin.

254 Unloading the LA and augmentation of LA function may be

255 parison with reperfusion alone, mechanically unloading the left ventricle (LV) before reperfusion red

256 a potentially favorable energetic effect of unloading the left ventricle, and thus reduction of wall

257 remove unwanted ions; (3) final washing for unloading the lithium chloride ions.

258 embrane, disrupts the endosomal vesicles and unloads the cargo at its destination site, namely the nu

259 to a DUPA-drug conjugate, PSMA internalizes, unloads the conjugate, and returns to the surface.

260 Based on evidence that Elg1 unloads the DNA replication clamp PCNA from DNA, we test

261 The Impella unloads the left ventricle.

262 Subsequently, Fap7 ATPase activity unloads the uS11:eS26 subcomplex onto its rRNA binding s

263 When subjecting a sensor to loading and unloading, the subsequent calculation of the fractional

264 an extract lipids from membrane vesicles and unload them to other vesicles.

265 nditions and greater energy consumption when unloaded, therefore promoting robustness.

266 rary circulatory support, but the mechanical unloading they offer also results in significant reverse

267 lunger lifts are automatically triggered and unload thousands of times per year and these wells accou

268 ly bendable under load and can recover after unloading, thus, warranting high adhesion strength, 34 N

269 ifferences in reactivity to methacholine and unloaded tissue shortening velocity (Vmax) compared with

270 th IOP at 0-40 mmHg and remained longer than unloaded tissues after being unpressurized.

271 Upon unloading to 10 GPa, -KCl3 transforms to a yet unknown s

272 both gross- and fine-tuning of tissue oxygen unloading to meet the distinct metabolic requirements of

273 propose that coupling of fork speed and PCNA unloading to nucleosome assembly provides a simple mecha

274 rsus delayed reperfusion after 30 minutes of unloading (U-DR).

275 ATAD5-RLC could unload ubiquitinated PCNA.

276 that GH treatment will rescue the hind limb unloading (UL)-induced skeletal deficit in TBI mice.

277 ith VA-ECMO with or without left ventricular unloading using an Impella at 16 tertiary care centers i

278 We report that LV unloading using the Impella CP device with a 30-minute d

279 e different myosin-1C isoforms measuring the unloaded velocities of constructs lacking the C-terminal

280 andard conditions, both move with comparable unloaded velocities toward either the microtubule minus

281 that differ between these two families: the unloaded velocity, the load dependence of detachment, an

282 ents with heart failure receiving mechanical unloading via left ventricular assist devices show incre

283 ng of the longitudinal electric field of the unloaded wake up to 83 GV m(-1) to a similar degree of a

284 f cardiac function in response to mechanical unloading was assessed by echocardiography during turndo

285 In observational studies, left ventricular unloading was associated with decreased mortality in adu

286 In the matched cohort, left ventricular unloading was associated with lower 30-day mortality (ha

287 , multicenter cohort study, left ventricular unloading was associated with lower mortality in patient

288 Left ventricular unloading was used in 337 of the 686 patients (49%).

289 matching, 255 patients with left ventricular unloading were compared with 255 patients without left v

290 Similar levels of unloading were observed for neurally adjusted ventilator

291 s place in loading, and detwinning occurs in unloading, which expounds the high ductility observed in

292 (54%) versus without (65%) left ventricular unloading while on VA-ECMO (risk ratio: 0.79; 95% confid

293 ding and complete plastic strain recovery on unloading, while the same experiments on single-crystall

294 eft ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clini

295 was attenuated in failing hearts chronically unloaded with a left ventricular assist device.

296 LV unloading with a transvalvular pump (TV-P) but not with

297 the impact of medical therapy or ventricular unloading with assist devices are important next steps.

298 pitulated the in vivo response to mechanical unloading with increased expression of SOST (3.4 +/- 1.9

299 While solutes are unloaded without restriction, large proteins are release

300 tubules along the axon specifies a localized unloading zone that ensures the accurate delivery of SVP