ライフサイエンスコーパス: unloading

1 e pulses, a phenomenon we refer to as 'batch unloading'.

2 f mass flow and diffusion (convective phloem unloading).

3 s >1 microm did not improve after mechanical unloading.

4 functional cardiac recovery after mechanical unloading.

5 sting no direct involvement in cargo loading/unloading.

6 y of Scx-mutant callus was not due to muscle unloading.

7 led; 54 underwent 8.0 +/- 1.2 months of LVAD unloading.

8 and functional recovery during chronic LVAD unloading.

9 y remodeling of the myocardium due to volume unloading.

10 s that occur to the myocardium due to volume unloading.

11 to 25 cm H2O in terms of respiratory muscle unloading.

12 in each - without any mechanical loading and unloading.

13 ative role for these Suc transporters in Suc unloading.

14 ing aging, estrogen deficiency, and skeletal unloading.

15 ifested through reversible detwinning during unloading.

16 ficance during cardiac pressure overload and unloading.

17 rostin and RANKL/OPG ratio in the setting of unloading.

18 ption, or stop bone loss induced by skeletal unloading.

19 l strength, and material strength induced by unloading.

20 ts exposed to longer durations of mechanical unloading.

21 le and undergo spontaneously detwinning upon unloading.

22 e of ongoing atrophic remodeling during LVAD unloading.

23 ing regression of cardiac hypertrophy during unloading.

24 ery of failing human hearts after mechanical unloading.

25 ikely due, at least in part, to baroreceptor unloading.

26 r transporter for Suc and glucose efflux and unloading.

27 ion of cardiac hypertrophy during mechanical unloading.

28 and NIOV+Air, signifying respiratory muscle unloading.

29 no atrophic remodeling after prolonged LVAD unloading.

30 anical load but hypertrophy can regress upon unloading.

31 unofluorescent imaging during RBC O2 loading/unloading.

32 C-like complex (Elg1-RLC) functions in PCNA unloading.

33 ading, freezing, and thawing, and during CPA unloading.

34 much of the large deformation is removed on unloading.

35 R plays a dynamic role during ligand loading/unloading.

36 trol subjects and increased after mechanical unloading.

37 emic hemodynamics resulting in biventricular unloading.

38 esponsible for the bone loss associated with unloading.

39 d with 255 patients without left ventricular unloading.

40 al infarction (MI) or mechanical loading and unloading.

41 who underwent VA-ECMO with left ventricular unloading.

42 ular assist device (LVAD)-induced mechanical unloading.

43 relieved when CMGs converge, leading to CMG unloading.

44 RLCs cooperate to regulate PCNA loading and unloading.

45 rization and acid-induced haemoglobin oxygen unloading.

46 CoA through ASCL1 activation and mechanical unloading.

47 and restored to control levels by mechanical unloading.

48 VA-ECMO with versus without left ventricular unloading.

49 ting episodic methane emissions from liquids unloading.

50 -shelf break-up due to meltwater loading and unloading.

51 .3%, depending on the characteristics of the unloadings.

52 dominated by wells with high frequencies of unloadings.

53 of the emissions from all wells with liquid unloadings.

54 mes decreased as early as 30 days after LVAD unloading (113 vs. 77 ml/m(2), p < 0.01, and 92 vs. 60 m

55 ass decreased as early as 30 days after LVAD unloading (114 vs. 95 g/m(2), p < 0.05) and continued to

56 that the central estimate of emissions from unloadings (270 Gg/yr, 95% confidence range of 190-400 G

57 After 6 months of LVAD unloading, 34% of patients had a relative LV ejection fr

58 midday episodic emissions from manual liquid unloadings (a routine operation in this basin and elsewh

59 The rapid loading and unloading abilities demonstrated by these selective micr

60 Proposed mechanisms include skeletal unloading, abnormalities in calciotropic hormones, and c

61 n stress that include water mass loading and unloading above the aquifer surface.

62 reduces infarct size and that 30 minutes of unloading activates a cardioprotective program that limi

63 ane emissions (TNME) from natural gas liquid unloading activities for 18 basins in the United States

64 DNA structures did not affect PCNA unloading activity of ATAD5-RLC.

65 Here, we show the distinct PCNA loading or unloading activity of each clamp loader.

66 proteins such as Fen1 could inhibit the PCNA unloading activity of Elg1-RLC, a yeast homolog of ATAD5

67 These studies suggest that the unloading activity of RFC maximizes the utilization of P

68 ts aspects of its function distinct from its unloading activity.

69 ication factories, probably through its PCNA-unloading activity.

70 ATAD5-RLC possesses the potent PCNA unloading activity.

71 d collar domain of ATAD5 are crucial for the unloading activity.

72 This "unloading" activity can be enhanced by mismatches betwee

73 We examined the effect of human ventricular unloading after implantation of left ventricular assist

74 Mechanical unloading after left ventricular assist device implantat

75 by providing significant volume and pressure unloading, allow a reversal of stress-related compensato

76 al and mechanical properties due to hindlimb unloading alone and simulated spaceflight.

77 reviewed, both those demonstrated with LVAD unloading alone in patients bridged to transplantation a

78 Both mechanical overload and unloading alter t-tubule structure, but the mechanisms m

79 The association between left ventricular unloading and 30-day mortality was assessed by Cox regre

80 n, was stable for several hours after phloem unloading and could be used to study phloem transport in

81 e first exploratory study testing whether LV unloading and delayed reperfusion in patients with STEMI

82 provements accompanied by respiratory muscle unloading and dyspnea reductions in patients with severe

83 indicates that assumptions regarding liquids unloading and estimated ultimate recovery (EUR) of wells

84 Left ventricular assist device (LVAD) unloading and hemodynamic support in patients with advan

85 ement was achieved by 6 months of mechanical unloading and persisted over the 1-year follow up.

86 ning future investigations that combine LVAD unloading and pharmaceutical therapies as a bridge to re

87 n, whereas TRPV4 activation caused a dynamic unloading and reloading of vinculin.

88 injuries, ischemia-reperfusion, and hindlimb unloading and reloading.

89 Despite effective hemodynamic unloading and remodeling, there were no differences afte

90 establish TRAIP as a master regulator of CMG unloading and the response of the replisome to obstacles

91 Additional measurements of unloadings and workovers are needed to produce national

92 eflight, combining microgravity (by hindlimb unloading) and radiation exposure.

93 also improved as early as 30 days after LVAD unloading, and this improvement persisted over time.

94 sites, 27 well completion flowbacks, 9 well unloadings, and 4 workovers).

95 PS) was collected from the loading (source), unloading (apical sink region) and shoot-root junction r

96 Three twin thicknesses after unloading are 3.2, 3.5, and 16 nm, which is consistent w

97 iac myocyte physiology because of myocardial unloading are contributors to ventricular arrhythmias in

98 ptional level, and muscle changes induced by unloading are counteracted by passive mechanical loading

99 reveals that methane emissions from liquids unloading are highly variable, with mean TNMEs ranging f

100 Microgravity and unloading are known to cause osteoclast-mediated bone re

101 g the response of the skeleton to mechanical unloading are not completely understood.

102 ur results identify BRCA1-dependent helicase unloading as a critical, early event in ICL repair.

103 nts the normal cerebral volume and pressure 'unloading' associated with upright postures on Earth, wh

104 machinery, RNA function requires subsequent unloading at least into adjacent companion cells.

105 ge cumulative methane emissions from liquids unloading, attributed to the natural gas supply chain, a

106 compared with immediate reperfusion (IR), LV unloading before reperfusion improves myocardial energy

107 opriately powered pivotal trial comparing LV unloading before reperfusion to the current standard of

108 The duration of LV unloading before reperfusion was inversely associated wi

109 e proceeding to a larger pivotal study of LV unloading before reperfusion.

110 reducing left ventricular (LV) workload (LV unloading) before coronary reperfusion is emerging as a

111 the transport of Stx, with cargo loading and unloading being regulated by protein kinases.

112 f the immunoassay including bead loading and unloading, binding, washing, and electrochemical sensing

113 nd at different time points after mechanical unloading by a left ventricular assist device (LVAD) by

114 ssion in human failing hearts resolved after unloading by a left ventricular assist device.

115 ration, which interferes with efficient PCNA unloading by ATAD5 and subsequent nucleosome deposition

116 o maintain a high turgor to drive symplasmic unloading by bulk flow.

117 The study examined whether mechanical unloading by continuous-flow LVAD leads to myocardial at

118 These findings suggest that PCNA unloading by Elg1 is necessary to limit Fbh1 and Srs2 ac

119 Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has

120 te is achieved upon drought by reduced xylem unloading by PtaSULTR3;3a and PtaSULTR1;1, and by enhanc

121 signed 50 patients with anterior STEMI to LV unloading by using the Impella CP followed by immediate

122 supports relaxation of arterial myocytes by unloading Ca(2+) into peripheral nanocourses delimited b

123 Despite robust cardiac unloading, capillary density and fibrosis are unchanged

124 NPC, a process that is probably required for unloading cargo sRNA into surrounding cells.

125 Liquid unloadings clear wells of accumulated liquids to increas

126 ther a protocol of optimized LVAD mechanical unloading, combined with standardized specific pharmacol

127 LHCP's transmembrane domains in a productive unloading complex at the membrane.

128 Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insi

129 ss matrix subjected to a compressive loading-unloading cycle.

130 statistically similar throughout the loading-unloading cycle.

131 rom 1.64 to 2.29 GPa during multiple loading-unloading cycles.

132 d of MSNA, and was increased by baroreceptor unloading, decreased by baroreceptor stimulation and abo

133 PCNA unloading depends on the Elg1-containing alternative RFC

134 ndicated that prolonged continuous-flow LVAD unloading does not induce hypertrophy regression to the

135 ic shortening, lithospheric delamination and unloading due to deglaciation and erosion.

136 To explore the effect of LV unloading duration on infarct size, we analyzed data fro

137 TRAIP-dependent CMG unloading during mitosis is also seen in C. elegans earl

138 search of studies examining left ventricular unloading during VA-ECMO in Medline, EMBASE, and the Coc

139 m toxin (BTX) was used to investigate muscle unloading effects on callus shape.

140 f uncertainty in current estimates of liquid unloading emissions.

141 vels, we subjected osteocytes to an in vitro unloading environment achieved by the NASA rotating wall

142 Cells deficient in PCNA unloading exhibit increased chromosome breaks.

143 fines their boundaries, and that the cohesin unloading factor WAPL and its PDS5 binding partners cont

144 LVAD-associated unloading for 6 months resulted in a substantial improve

145 (cross-sectional area) decreased after LVAD unloading from 1,238 +/- 81 mum(2) to 1,011 +/- 68 mum(2

146 We conclude that apoplasmic Suc unloading from de-energized protophloem sieve elements i

147 es helped visualize Twinkle loading onto and unloading from DNA in an open-ringed configuration.

148 r mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g.

149 O(2) unloading from RBCs was considerably slower than previou

150 The SWEET transporter may facilitate Suc unloading from the phloem to the apoplast where cell wal

151 ed their broad roles in theanine loading and unloading from the vascular system, and in targeting to

152 the Elg1 complex and down-regulate its PCNA-unloading function to promote the G1/S transition.

153 ulated transcript set overlapped with muscle unloading gene expression profiles (>/=1.5-fold change;

154 of wild type (WT) and ob/ob mice to hindlimb unloading (HU).

155 usly hypertensive rat model) or the profound unloading in a chronically unloaded heart result in impa

156 underlying the importance of Suc apoplastic unloading in Arabidopsis roots and a putative role for t

157 after recovery of muscle mass from hindlimb unloading in both adult and aged rats, as well as after

158 ligand (RANKL) expression is increased with unloading in mice.

159 sucrose transporters (SUTs) regulate phloem unloading in monocot stems is poorly understood and part

160 ese findings support use of left ventricular unloading in patients with cardiogenic shock treated wit

161 y aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated wit

162 in Arabidopsis (Arabidopsis thaliana), while unloading in roots is less understood.

163 e phloem-pole pericycle in regulating phloem unloading in roots.

164 loading in the pulmonary circulation and O2 unloading in the systemic circulation.

165 chromatin with purified Elg1-RLC causes PCNA unloading in vitro.

166 we investigate the signal that triggers CMG unloading in Xenopus egg extracts using single-molecule

167 evaluate its potential roles, such as phloem unloading, in nonphotosynthetic tissues.

168 Continuous-flow LVAD unloading induced in a subset of patients, both ischemic

169 However, whether unloading-induced atrophy in experimental normal heart m

170 Prolonged mechanical unloading induces adult human cardiomyocyte proliferatio

171 hts from studies which investigated how LVAD unloading influences the structure and function of the f

172 capacity to interact with AGO2, it mediated unloading instead of loading of let-7 family miRNAs, the

173 smata clusters, or pit fields, at the phloem unloading interfaces of Arabidopsis (Arabidopsis thalian

174 e to virus loading, movement, and subsequent unloading into distal uninfected tissues.

175 unlike termination, repair-mediated helicase unloading involves the tumor suppressor protein BRCA1, w

176 CMG unloading involves ubiquitylation of its Mcm7 subunit an

177 SOST/sclerostin up-regulation in mechanical unloading is a cell-autonomous response or a hormonal re

178 When CMG unloading is blocked, diverging CMGs do not support DNA

179 tors that are enriched on chromatin when CMG unloading is blocked.

180 of an elg1Delta mutant suggests timely PCNA unloading is critical for chromosome maintenance.

181 vitro and in vivo analysis showed that PCNA unloading is delayed in the absence of nucleosome assemb

182 f CRL2(Lrr1), Mcm7 is not ubiquitylated, CMG unloading is inhibited, and a large subcomplex of the ve

183 e novel findings identify that transvalvular unloading limits ischemic injury before reperfusion, imp

184 to background levels about 2 h after phloem unloading, making it a suitable tracer for pulse-labelin

185 In addition, there was left ventricular (LV) unloading manifested by a decrease in LV end-diastolic p

186 rospective randomized data, left ventricular unloading may be considered for appropriately selected p

187 Mechanical unloading (MU) by implantation of left ventricular assis

188 posed to 1-gravity environment or mechanical unloading (MU) for 24 hours, with or without periods of

189 sults demonstrate that Elg1-RLC functions in unloading of both unmodified and SUMOylated PCNA during

190 tly reduced, but not fully eliminated, while unloading of Ca2+ stores by thapsigargin treatment in th

191 ontrol the loading, active concentration and unloading of cargo on this track network, or to trigger

192 SRP*SR complex, and most significantly, the unloading of cargo onto the target membrane.

193 editor," capable of fine-tuning loading and unloading of CD1d molecules.

194 , whereas longer chains are required for the unloading of CMG by the p97 ATPase, which enables the Fa

195 Depletion of Klf4 leads to unloading of cohesin at the Oct4 enhancer and disrupts l

196 in the intestine, unlike the diffusion based unloading of most controlled release devices for small m

197 al OB-folds allow CST to mediate loading and unloading of partner proteins to facilitate various aspe

198 actor C-like complex, Elg1/ATAD5-RLC, in the unloading of PCNA during replication in yeast and human

199 checkpoint kinases regulate strand-specific unloading of PCNA from stalled replication forks to main

200 Although premature unloading of PCNA generally increases mutation rate, the

201 ement is likely functionally relevant in the unloading of PE-PPE heterodimers at the secretion machin

202 In conclusion, unloading of pulmonary arterial baroreceptors reduced ba

203 y of the DNA replication machinery, and that unloading of Rad51 by Srs2 helicase is required for effi

204 We also report that unloading of RPA from sites of ICL induction is perturbe

205 mathematical modelling) to show that phloem unloading of solutes in Arabidopsis roots occurs through

206 mics the headward fluid shift and axial body unloading of spaceflight.

207 an important factor for the study of phloem unloading of Suc.

208 though the processes involved in loading and unloading of sugars and amino acids are well characteriz

209 n advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired ca

210 Mechanical unloading of the failing myocardium reverses adipose tis

211 Therefore, unloading of the heart may contribute to the beneficial

212 s of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results i

213 roteins (Rad51 and Rad52) to RTS1 depends on unloading of the polymerase sliding clamp PCNA from DNA

214 ts the sensor viscosity based on loading and unloading of the sensor and calculating the fractional t

215 the sequential recruitment, remodeling, and unloading of the targeting complex at membrane transloca

216 G actively drives the efficient delivery and unloading of translating ribosomes at the target membran

217 cursors (GAPs) at the arrest of fruit phloem unloading of two white grape Vitis vinifera cvs.

218 ect of left ventricular assist device (LVAD) unloading on cardiac endothelium and microvasculature is

219 altered sympathetic activity in addition to unloading on cardiac hypertrophy and function.

220 igate the impact of gravitational mechanical unloading on ECs phenotype as determined by patterns of

221 -DTU) trial and then tested the effect of LV unloading on ischemia and reperfusion injury, cardiac me

222 stigations have described the impact of LVAD unloading on key structural features of cardiac remodeli

223 s study was to test the effect of mechanical unloading on mitochondrial mass, DDR, and cardiomyocyte

224 The effects of LVAD unloading on myocardial function, electrophysiologic pro

225 s-flow left ventricular assist device (LVAD) unloading on myocardial structure and systolic and diast

226 lenge to predict the impact of LV mechanical unloading on postoperative right ventricular (RV) functi

227 28% of annual methane emissions from liquids unloading over all basins despite representing only ~0.4

228 ift generated by the solid-Earth response to unloading over short time scales close to ice-sheet grou

229 0.01) and ejection fraction increases during unloading (P<0.01).

230 Transiting from an apoplasmic to symplasmic unloading pathway as the stem matures, SbSUT1 and SbSUT5

231 does not have an apparent function in either unloading process.

232 parated when they exit the phloem during the unloading process.

233 of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly

234 Analysis of the distribution of O(2) unloading rates in HS RBCs identified a subpopulation of

235 switch from symplasmic to apoplasmic phloem unloading, reconciling previously conflicting reports, a

236 two phases, reinforcing the hypothesis that unloading (recovery) may be a good surrogate for loading

237 is classically performed during loading, the unloading (recovery) response of cartilage may also enab

238 In preclinical models, LV unloading reduced the expression of hypoxia-sensitive pr

239 was used to apply an equibiaxial loading and unloading regimen to fibroblast-seeded tissue equivalent

240 e-state model for CMR where both loading and unloading regulate the transition of bonds among the sho

241 NF-kB binding site is involved in the muscle unloading regulation of MuRF1.

242 h can be described as time-dependent forces (unloading/reloading cycles) acting on the Earth.

243 g therapy and left ventricular assist device unloading results in significant myocardial recovery, su

244 For each basin, six discrete liquid-unloading scenarios are considered, consisting of combin

245 frequently in patients with left ventricular unloading: severe bleeding in 98 (38.4%) versus 45 (17.9

246 Unloading shoes were not associated with increased proba

247 In addition, LVAD unloading significantly increased interstitial and total

248 The unloading slope during the unstable slip follows the sti

249 During unloading, solutes and proteins are diverted into the ph

250 for FT trafficking exists in the post-phloem unloading step.

251 the efficacy and safety of left ventricular unloading strategies during VA-ECMO in adult patients wi

252 2%) receiving a concomitant left ventricular unloading strategy while on VA-ECMO (intra-aortic balloo

253 Unloading sugar from sink phloem by transporters is comp

254 (conventional and unconventional) and liquid-unloading systems (nonplunger, manual plunger lift, and

255 ry signals ultimately control when and where unloading takes place.

256 electron microscopy (TEM) and cyclic loading-unloading tests.

257 pletions and conventional natural gas liquid unloadings that need to be further addressed.

258 egase plays a critical role in ICL repair by unloading the CMG complex from chromatin.

259 Unloading the LA and augmentation of LA function may be

260 parison with reperfusion alone, mechanically unloading the left ventricle (LV) before reperfusion red

261 These data support that first unloading the left ventricle despite delaying coronary r

262 a potentially favorable energetic effect of unloading the left ventricle, and thus reduction of wall

263 remove unwanted ions; (3) final washing for unloading the lithium chloride ions.

264 ormalization of ventricular diameters during unloading, the pre-explant left ventricular ejection fra

265 When subjecting a sensor to loading and unloading, the subsequent calculation of the fractional

266 rary circulatory support, but the mechanical unloading they offer also results in significant reverse

267 ur by design (condensate flashing and liquid unloadings), they occur more than an order of magnitude

268 ly bendable under load and can recover after unloading, thus, warranting high adhesion strength, 34 N

269 Upon unloading to 10 GPa, -KCl3 transforms to a yet unknown s

270 both gross- and fine-tuning of tissue oxygen unloading to meet the distinct metabolic requirements of

271 propose that coupling of fork speed and PCNA unloading to nucleosome assembly provides a simple mecha

272 rsus delayed reperfusion after 30 minutes of unloading (U-DR).

273 that GH treatment will rescue the hind limb unloading (UL)-induced skeletal deficit in TBI mice.

274 ith VA-ECMO with or without left ventricular unloading using an Impella at 16 tertiary care centers i

275 We report that LV unloading using the Impella CP device with a 30-minute d

276 ents with heart failure receiving mechanical unloading via left ventricular assist devices show incre

277 f cardiac function in response to mechanical unloading was assessed by echocardiography during turndo

278 In observational studies, left ventricular unloading was associated with decreased mortality in adu

279 In the matched cohort, left ventricular unloading was associated with lower 30-day mortality (ha

280 , multicenter cohort study, left ventricular unloading was associated with lower mortality in patient

281 Volume unloading was seen after stage II, as expected, but ejec

282 Left ventricular unloading was used in 337 of the 686 patients (49%).

283 matching, 255 patients with left ventricular unloading were compared with 255 patients without left v

284 ecies to the filling grain and their spatial unloading were investigated.

285 Similar levels of unloading were observed for neurally adjusted ventilator

286 Methane emissions from liquid unloadings were measured at 107 wells in natural gas pro

287 A reduction in cell size occurs after LVAD unloading, which does not necessarily correlate with imp

288 s place in loading, and detwinning occurs in unloading, which expounds the high ductility observed in

289 as local release of isometric tension/force unloading, which is directly coupled to reactive oxygen

290 Unloading, which is probably regulated, only occurs afte

291 Emissions from liquid unloadings, which are observed in subsets of wells, can

292 (54%) versus without (65%) left ventricular unloading while on VA-ECMO (risk ratio: 0.79; 95% confid

293 ding and complete plastic strain recovery on unloading, while the same experiments on single-crystall

294 eft ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clini

295 an occur that can be marked after myocardial unloading with a left ventricular assist device (LVAD).

296 LV unloading with a transvalvular pump (TV-P) but not with

297 mal breathing (NB), 5 min respiratory muscle unloading with a ventilator, and 5 min of NB.

298 the impact of medical therapy or ventricular unloading with assist devices are important next steps.

299 pitulated the in vivo response to mechanical unloading with increased expression of SOST (3.4 +/- 1.9

300 tubules along the axon specifies a localized unloading zone that ensures the accurate delivery of SVP