ライフサイエンスコーパス: unmask

1 ture fatigue and potential muscle injury are unmasked.

2 nistrator, and study statistician (ARB) were unmasked.

3 ant unless latent inhibitory connections are unmasked.

4 f the study scheme), but clinical staff were unmasked.

5 All patients and investigators were unmasked.

6 n disorders with a severe phenotype has been unmasked.

7 vents had occurred and efficacy results were unmasked.

8 roviding treatment and the participants were unmasked.

9 directed towards pigment formation, has been unmasked.

10 er is altered or removed in a process called unmasking.

11 blockade of either D1 or mGluR2/3 receptors unmasked 10 Hz stimulation-induced LTD and LTP, respecti

12 After unmasking, 18 remaining SNs were identified (6 in the hy

13 ries of conformational changes in STIM1 that unmask a minimal Orai1-activating domain (CRAC activatio

14 We further unmask a mutual requirement for Hivep3, a zinc finger tr

15 EPCR binding properties of rhFVIIa, our data unmask a novel contribution of EPCR on the action of rhF

16 Taken together, our results unmask a previously unknown player in central regulation

17 Using male Wistar rats, we unmask a previously unrecognized regulatory pathway of e

18 eened for their potential to photochemically unmask a reactive Ru-Ru horizontal lineO intermediate.

19 rload, or muscle stress by myotonia, did not unmask a requirement for DMPK.

20 These results unmask a striking lack of correlation between AID bindin

21 on with hyperkalemia and metabolic acidosis, unmasked a complex multiprotein system that regulates el

22 Thus, our data unmasked a critical cellular biological process controll

23 Thus, we have unmasked a functional role for Agrp neurons in controlli

24 de using naltrexone in 119 of these subjects unmasked a greater tonic opioid inhibition of cortisol s

25 yretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disea

26 organs were used; adjusting for these trends unmasked a larger temporal improvement in post-transplan

27 omputational modeling of the behavioral data unmasked a learning deficit in high AQ scorers, namely,

28 Research over the past several decades has unmasked a major contribution of disrupted chromatin reg

29 Earlier human studies unmasked a neural relay that amplifies GIP-mediated insu

30 timing-dependent LTP on NMDAR activation and unmasked a novel contribution of Ca(2+)-permeable AMPARs

31 training the optimal models using these data unmasked a positive correlation between the maximal cond

32 mited growth media in a compound screen that unmasked a previously unknown hyperactivity of the old a

33 We also unmasked a retina-specific gene expression signature tha

34 The combination of these technologies unmasked a sharp TCR signaling threshold for commitment

35 ncing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergen

36 geneity in protein and fatty-acid recycling, unmasking a potential bet-hedging strategy under starvat

37 We found that mutation of the PYAP motif unmasks a critical role for the proximal tyrosine motif

38 tate MHCI from hippocampal lysates, and MHCI unmasks a cytoplasmic epitope of the insulin receptor th

39 Strikingly, the disappearance of TADs unmasks a finer compartment structure that accurately re

40 zyme-catalyzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-vinylglyoxylate, which th

41 nes and thiazolidines, under mild conditions unmasks a phenone functionality.

42 The BAL signature associated with mortality unmasks a potential role for airway basal cells in IPF.

43 Together, our study unmasks a previously unknown interplay between an E3 lig

44 Intramolecular photoreduction unmasks a reactive phenol that undergoes fast lactonizat

45 roteolytic cleavage of the N terminus, which unmasks a tethered peptide ligand that binds and activat

46 Our work unmasks Ac45 as the functional ortholog of yeast V-ATPas

47 This highly sensitive imaging strategy unmasked activated endothelial cells after experimental

48 tes to the variability of complex traits and unmasks additional genetic susceptibility quantitative t

49 cer were enrolled in TEXT or SOFT to receive unmasked adjuvant treatment with 5 years of exemestane p

50 irst use of mitochondrial enzyme activity to unmask agents for mitochondrial fluorescent imaging and

51 ies, we found that free N-glycans lacking an unmasked alpha1,3-arm GlcNAc moiety are not FUT8 substra

52 These studies unmask an evolutionarily conserved structural role for t

53 These results unmask an important role of TLR2 in the development of s

54 These studies unmask an unanticipated, conserved regulatory mechanism

55 CCR2 deficiency unmasked an anti-PD-1 survival benefit in KR158 glioma-b

56 chain inserts between conserved IR domains, unmasking an invariant receptor-binding surface that spa

57 provided valuable diagnostic information by unmasking an occult neuroendocrine differentiation and i

58 radation by liver endothelial cells, thereby unmasking an unanticipated link between angiogenesis and

59 48 of 52 cases once the overall grading was unmasked and the graders reevaluated the conventional mu

60 associated IRIS were included (14 infectious/unmasking and 8 paradoxical), with an overall incidence

61 w for the quantification of activity-induced unmasking and availability for active translation.

62 Randomisation (1:1) was unmasked, and was done by a statistician-generated alloc

63 increased anti-tumor efficacy compared with unmasked antibodies in mouse models of cancer.

64 Illustrating the impact of these unmasked AR-driven pathways, dihydroceramide desaturase

65 ions utilized herein for orthogonal cysteine unmasking are not restricted to ADCs and can be broadly

66 nd broader interest in PZQ, which is finally unmasked as a potent flatworm TRP channel activator.

67 mixed cation current, I(h), possibly through unmasking as dopamine release drops during nursing, may

68 were masked to group assignments, which were unmasked at the final study visit, 6 months after receip

69 es, our masked antibodies are preferentially unmasked at the tumor site and have increased anti-tumor

70 added during the course of the study, before unmasking based on new clinical and biological findings

71 icion and use of a sodium-channel blocker to unmask BrS has allowed earlier diagnoses in many patient

72 ndicate that MLG epitopes in brown algae are unmasked by a pre-treatment with alginate lyases to remo

73 e amino protecting groups can be selectively unmasked by a reduction or acid treatment, allowing the

74 r 'silent' L- and T-channels in NAc could be unmasked by elevating extracellular [Ca(2+)].

75 Whether PH and PH subtypes unmasked by exercise can be used to guide targeted thera

76 inding activity of Bad is cryptic and can be unmasked by inactivating the intrinsic nuclease activity

77 of pre-existing silent lead malfunction were unmasked by internal shock, resulting in lead failure.

78 cuits underlying executive function that are unmasked by loss of estradiol during menopause.

79 ersity through RNA splicing is independently unmasked by two studies in this issue (Jaganathan et al.

80 Nanoscopic imaging of caspofungin-unmasked C. albicans cell walls revealed that the increa

81 Caspofungin-induced unmasking caused approximately fourfold to sevenfold inc

82 tions of a sick SN, ectopic foci in AVR were unmasked, causing transient suppression of SN pacemaking

83 e and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells.

84 variance in shape response is measured, thus unmasking cell-to-cell variation in mechanical propertie

85 s to remove un-informative DNA sequences and unmask clinically and biologically useful alterations.

86 ians were masked to treatment allocation; an unmasked clinician was responsible for programming the s

87 , non-responders) after being assessed by an unmasked clinician were eligible for additional injectio

88 We did an unmasked cluster-randomised controlled trial at maternit

89 hose developed CMV-IRR after ART initiation (unmasking CMV-IRR) and 20 experienced paradoxical clinic

90 ose the case definitions for paradoxical and unmasking CMV-IRR.

91 Thus, sepsis unmasks compartment-specific proliferative and apoptotic

92 led that 14 SNs removed under ePLND or after unmasking contained radioactivity but no fluorescence.

93 ect comparisons between analogous masked and unmasked context changes.

94 enables a cascade "click" process where the "unmasked" Cp can rapidly react with dienophiles, such as

95 red to remodel the tertiary organization and unmask cryptic primary microRNA domains to facilitate th

96 of Statewide Health Planning and Development unmasked database.

97 ent members of the centre, and enacted by an unmasked DBS programming nurse).

98 De-identified (but unmasked) demographic, clinical, radiological, and genet

99 The unmasked DIBO group then reacts with the second azide-ta

100 HCWs with unmasked, direct contact with measles patients are at ri

101 re enriched for homozygous variants that may unmask dispensable regions of disease genes and unrecogn

102 n humans, and that EVHP appears necessary to unmask distinguishing features of severely injured DCD h

103 Adenosine can unmask dormant AP conduction after catheter ablation.

104 rved in nonatopic, nonallergic adults and is unmasked during exposure to an aeroallergen.

105 a class of immunogenic neoantigens that are unmasked during tumor immune evasion.

106 intention-to-treat cohort, all of whom were unmasked early in follow-up.

107 Detaching SN unmasked ectopic pacemaking in AVRs and pacemaker action

108 due of the substrate Leu-FC to eliminate the unmasked electrochemical reporter amino ferrocene via pr

109 This was then extended to an unmasked electrode array showing that masked SLED and la

110 evious binaural modeling work focused on the unmasking enabled by binaural cues at the periphery, and

111 1, one of negative regulators of plasticity, unmasks experience-dependent tPA elevation in visual cor

112 Conversely, the novel measure unmasked failure to provide defect-free chemoprophylaxis

113 Indeed, only the dark (active) phase unmasked fatigue-like behavior and altered novel object

114 Before unmasking, fluorescence guidance was used for intraopera

115 e demonstrate that tPA activity in V1 can be unmasked following 4 d of monocular deprivation when the

116 termined to have ATM-negative tumours before unmasking for the primary analysis (48 in the olaparib p

117 tients and physiotherapists were necessarily unmasked from intervention assignment; the statistician

118 e novel AT pig provides new opportunities to unmask functions and roles of ATM in AT disease and in p

119 hus, uncoupling SPB growth from NE insertion unmasks functions of the duplication machinery.

120 exclusively by the wild house mouse, thereby unmasking gene functions inaccessible in the domesticate

121 harmacological reduction of MOR availability unmasked genotypic differences in fentanyl sensitivity.

122 The procedure requires two unmasked half-maps and a sequence file or other source o

123 by microneedle patch, all administered by an unmasked health-care worker; or received a single dose o

124 The unmasked histone 4 tails interact with the acidic patch

125 Together, our study unmasks how variable and stable environments favor disti

126 antiretroviral therapy (ART), perhaps due to unmasking immune reconstitution inflammatory syndrome (I

127 suggest that chronic sleep restriction may "unmask" implicit racial or ethnic biases that are otherw

128 ecific aspects of spine dynamics that can be unmasked in adulthood and its regulatory molecular mecha

129 isk associated with developmental insults is unmasked in female offspring following periods of hormon

130 ormation, the ipsilateral PB is recruited or unmasked in persistent inflammation to maintain hyperalg

131 stress on TORM and glutamate receptors were unmasked in stressed females when estrogen receptors wer

132 d the ability to use spatial information for unmasking in clinical populations.

133 e of the molecule, which may lead to epitope unmasking in the IA-2 extracellular domain.

134 Binge drinking unmasked individual differences, revealing latent traits

135 aved from the reporter autonomously, thereby unmasking intense, red-shifted fluorescence emission.

136 The R161G and R161Q mutations in human CblC unmask its latent thiol oxidase activity and are correla

137 is also cleaved at an N-terminal arginine to unmask its tethered ligand, is generally regarded as a t

138 tered hemodynamics during the LT surgery can unmask latent cardiovascular disease either intraoperati

139 available for response preparation(4,5) can unmask latent habits.

140 its, during an adaptive cognitive state, can unmask latent plastic potential that durably improves re

141 es hyperactivity in degenerating retinas and unmasks light responses in RGCs.

142 face disrupts the O-antigen barrier, thereby unmasking lipid A, eliciting caspase-4 recruitment, enha

143 ividually relevant visual field locations to unmask localized structural and functional loss.

144 ISIV administration unmasked long-lasting immunity in influenza A(H5N1) pLAI

145 ort, 12% of patients met a uniformly applied unmasking lymphoma IRIS case definition.

146 Clinical characteristics and survival for unmasking lymphoma IRIS have not been described.

147 Unmasking lymphoma IRIS was defined as lymphoma within 6

148 lymphoma patients, 56 (12%) met criteria for unmasking lymphoma IRIS.

149 signed (1:1) using a web-based system, in an unmasked manner, to receive oral pazopanib (if patients

150 We used a biophysical model to unmask mechanisms underlying the history-dependence of c

151 eveals novel aspects of partial agonism, and unmasks molecular actions of classically defined partial

152 nter-surround organization but disinhibition unmasks more excitatory input to excitatory neurons.

153 s effect of EGFR antibodies--that would have unmasked most patients and investigators to treatment.

154 of the IRIS event in HIV-infected patients, unmasking Mycobacterium avium complex infection after st

155 urants, alkylators, and detergents failed to unmask N-terminal NOTCH3 epitopes.

156 recting group that can be readily cleaved to unmask net beta,gamma-dicarbofunctionalized carboxylic a

157 ammatory activity with intrathecal anti-IL10 unmasks neuropathic pain behavior in infant nerve injure

158 Overall, the results in this paper unmask new nonequilibrium behaviors of amphiphiles at LC

159 translational findings in rats and patients unmask novel, weight-independent mechanisms of cardiovas

160 After 4 weeks of follow-up (study week 16), unmasking occurred and patients in the deferred treatmen

161 ther amino acid permeases similarly involves unmasking of a cytosolic Art1-target region coupled to a

162 The present system allows for the unmasking of a highly reactive [L(Ph)Ni(I)(2)](-) interm

163 hesis that regulatory potency is enhanced by unmasking of a ligand-binding site in the C-terminal CCP

164 Notch activation requires unmasking of a metalloprotease cleavage site remote from

165 Selective unmasking of a single hydroxyl group precedes solid-phas

166 ific N-terminal proteolytic cleavage and the unmasking of a tethered ligand.

167 signaling mechanism involves the proteolytic unmasking of an N-terminal receptor sequence that acts a

168 The unmasking of beta(1-3)-glucan also results in increased

169 n-sensing prodrug platform for the selective unmasking of bioactive agents in hypoxic cells.

170 UV irradiation at 250 nm leads to unmasking of both MAEs.

171 ccurred degradation of total chlorophyll and unmasking of carotenoids from 31st days after anthesis.

172 te specificities compatible with proteolytic unmasking of cryptic CendR motifs, the strategy describe

173 Here we report that unmasking of cryptotopes by unfolding whole cytomegalovi

174 This approach utilizes sequential unmasking of cysteine residues with orthogonal protectio

175 The kinetic unmasking of inhibited binding reflected in the increase

176 Candidate neurobiological mechanisms include unmasking of latent synaptic connections and rapid synap

177 Photochemical unmasking of model compounds was studied at different wa

178 ctral-domain OCT and may be explained by the unmasking of normal background RPE AF.

179 The unmasking of silent lead malfunction in the internal car

180 lts from changes in synaptic strength and/or unmasking of subthreshold intermodal connections.

181 onal evidence that such RIAM-mediated steric unmasking of talin triggers integrin activation.

182 ng step in mRNA cleavage frequently involves unmasking of target sites by translating ribosomes.

183 fficking regulation that we term "controlled unmasking of targeting elements" (CUTE).

184 restoration of the choroidal blood flow and unmasking of the big choroidal vessels.

185 s in the C-terminal domain did not result in unmasking of the catalytic domain.

186 removing the potential for metabolism-based unmasking of the embedded aniline.

187 aving greyish, granular, depigmented fundus, unmasking of the large choroidal vessels and optic atrop

188 terminus of full-length ARTEMIS resulted in unmasking of the N terminus and in increased ARTEMIS act

189 photolysis of the indane rotaxane results in unmasking of the polyyne thread to form a rotaxane with

190 nt with intravitreal Bevacizumab resulted in unmasking of the pre-existing ILM drape sign at 12 weeks

191 ng and remodeling by Mvp1 therefore requires unmasking of the PX and BAR domain lipid-interacting sur

192 After unmasking of the SPECT/CT images, the number of missed S

193 s efficiently with minimal toxicity, because unmasking of their hydrophobic domains selectively occur

194 xes are excellent reagents for the effective unmasking of thiazolidine, enabling its complete removal

195 nitoring committee, treatment assignment was unmasked on Dec 11, 2017, due to futility and the numeri

196 Participants were unmasked once they had provided all outcome data at week

197 Thus, the way we move unmasks one of our well-guarded secrets: how much we val

198 uded from the analysis because of procedural unmasking or no autopsy data, as were 24 cases with a cl

199 ism of these phosphonamidates to release the unmasked PAg monophosphonate species.

200 During adulthood, stress unmasked persistent changes in DHPG-induced LTD and beha

201 tors, other study site staff (except for the unmasked pharmacist), and patients were masked to pembro

202 concealed identity to the masked staff by an unmasked pharmacist.

203 cetal directing groups and directly provides unmasked phenol products and, thus, useful functional gr

204 All patients were able to recognize unmasked point-light displays and their perceptual thres

205 To unmask possible mechanisms associated with this phenomen

206 g and machine learning method can be used to unmask potential strategies employed by the brain to ada

207 ino esters starting from the corresponding N-unmasked precursors via a carbamoylation reaction in the

208 ng precision neuroimaging and arm casting to unmask previously unknown pulses of spontaneous activity

209 were masked to the treatment group while the unmasked programmer was responsible for programming and

210 To test the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy a

211 Exercise testing is useful in unmasking QT prolongation in disorders associated with a

212 In this unmasked randomised controlled trial, we randomly assign

213 An unmasked randomized clinical trial involving 3 residenti

214 aldehyde followed by hydrolysis to eliminate unmask redox reporter N-alkylated aminoferrocene (AAF) t

215 presentatives that exhibit modest and strong unmasking, respectively.

216 rs increased the sensitivity of most RGCs by unmasking rod signals, which were suppressed.

217 on of LAIV responses in the sexes separately unmasked sex-specific differences in response to exposur

218 We also unmasked slow spillover currents in mature neurons in th

219 o once daily for 24 weeks by an independent, unmasked, statistical team.

220 Treatment was administered by an unmasked study investigator not involved in the manageme

221 nocentric, retrospective, non-randomized and unmasked study.

222 Immune activation may unmask subclinical infections.

223 challenged muscle metabolism, to potentially unmask subtle phenotypes.

224 Treatment was administered by an unmasked surgeon, with a masked gastroenterologist and r

225 directed the buckling during the subsequent unmasked swelling process.

226 were masked to treatment allocation, and an unmasked team of nurses administered the vaccines.

227 tigation of live-cells in microfluidics that unmasked that cellular noise can affect the compartmenta

228 enetic control of VMH neuronal circuitry, we unmasked that this mitochondrial adaptation determines t

229 ected mutagenesis and structural modeling to unmask the binding sites for albumin blocking antibodies

230 ic clinical testing and regular follow-up to unmask the cause.

231 uman primate (NHP) models, with potential to unmask the complex biology of human disease not revealed

232 These results unmask the critical B cell-intrinsic role of ATM in main

233 GTPBP2 as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-enc

234 lter gene function in a targeted manner will unmask the effects of homoeolog redundancy and allow the

235 articular, these cells hold the potential to unmask the effects of mutations on contractile behaviour

236 ents with strain UNSWDHB were both unable to unmask the intrinsic KIE of the reductive dehalogenase (

237 roaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety

238 etic profiling could be a useful approach to unmask the original primary tumour site of cancer of unk

239 The AP enables melting of the duplex to unmask the PQS, adopting a G-quadruplex fold in which ap

240 To unmask the role of NDCBE, we generated Ndcbe/Ncc double-

241 is likely a practical enzymatic strategy to unmask the strong oxidizing power of sMMO-Q necessary to

242 uch binding events relieve autoinhibition to unmask the VCA segment and activate the Arp2/3 complex.

243 ple and urine-derived podocyte-lineage cells unmasked the COL4A5 mutation only in the podocyte-lineag

244 le and urine-derived podocyte-lineage cells, unmasked the COL4A5 mutation only in the podocyte-lineag

245 Blockade of either excitation or inhibition unmasked the opposite effect, suggesting that MOP recept

246 This unmasked the phenotypic diversity amplification by the c

247 Collectively, our results unmasked the regulatory dominance of the melanophilin ad

248 s vaccination programmes has correspondingly unmasked the significant burden of disease associated wi

249 Chemoselective conditions unmasked the thioester functionality and cyclized the de

250 Unmasking the addition products gives acyl cyanide inter

251 ed natural products are thus useful tools in unmasking the cryptic functions of conventional enzymes

252 ceptions of service members' tobacco use and unmasking the forces perpetuating those perceptions.

253 ses such as in designing clinical trials for unmasking the maximum benefits and minimizing risks asso

254 fic activity of cellular ribonucleases or by unmasking the mRNA-degrading activity of cellular toxins

255 r presence of the NMDAR blocker, APV, hereby unmasking the NMDAR component in this process.

256 ractions by binding to the pchA CDS, thereby unmasking the pchA RBS and promoting PchA expression.

257 Finally, unmasking the repertoire and control of such energetic r

258 , devitrifies sugar--releasing the cargo and unmasking the substrate surface--thus triggering substra

259 t class the hom-thrCB operon was derepressed unmasking the threonine dehydratase activity of the thre

260 has recently emerged as a viable option for unmasking the underlying tumor heterogeneity.

261 loss of high affinity ligands on GC B-cells unmasks the binding site of CD22 relative to naive and m

262 e probes to a perfectly complementary target unmasks the initiator, enabling the generation of an amp

263 the endothelial adhesion molecule P-selectin unmasks the pathological events that take place in the s

264 tion/oxidative addition equilibrium smoothly unmasks the powerful 2-electron reductant 4 from either

265 rich repeat domain of FBXL2 and PTAR1, which unmasks the structural basis of the substrate-enzyme spe

266 rdered motif region in which phosphorylation unmasks the surface of a series of residues on a stable

267 circuit-specific long-term depression (LTD) unmasks the therapeutic power of EE to achieve long-last

268 ion of endogenous retroviral (ERV) elements, unmasking this cellular source of "self" double-stranded

269 patients, investigators, and clinicians were unmasked to allocation.

270 pecialists, and primary care physicians were unmasked to assignment.

271 ration and administration of injections were unmasked to group allocation, but were not included in t

272 Allocation was computer generated and unmasked to participants and therapists delivering treat

273 is (cutoff date Oct 31, 2016), the study was unmasked to patients and investigators, and patients in

274 inal 12 month visit, at which time data were unmasked to the analysis team.

275 Only the trial coordinator was unmasked to treatment allocation before patient progress

276 n label; all patients and investigators were unmasked to treatment allocation.

277 Patients and investigators were unmasked to treatment allocation.

278 anting physician, and study participant were unmasked to treatment assignment.

279 Investigators and participants were unmasked to treatment assignment.

280 Participants and investigators were unmasked to treatment.

281 Vaccine administrators were unmasked to treatment; medical staff performing safety a

282 (nucleus tractus solitarius and caudal VLM) unmasked tonic glycinergic inhibition in the RVLM.

283 solitarius and/or disinhibition of the CVLM unmasked tonic glycinergic inhibition of the RVLM.

284 The trial was double-blinded; some unmasking took place at age 2 years for an interim analy

285 expression driven by a program of selective unmasking, translation, and degradation of maternal mRNA

286 rbidity for the mother or baby), assessed by unmasked trial surveillance personnel.

287 on, and the observation periods of previous (unmasked) trials have typically been at least 5 years.

288 Unmasking ultradian rhythms in gene expression.

289 driven by a reduced number of naive T cells unmasking underlying memory clonality.

290 of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate

291 ry contacts between the N- and C-termini and unmask UvrA recognition determinants.

292 to proceed quickly at room temperature after unmasking via mechanical force.

293 ction that harnesses tetrazine reactivity to unmask vinyl ether caged fluorophores spanning the visib

294 ast to SCIP-VTE-2, our novel quality measure unmasked VTE chemoprophylaxis failures in 18% of colecto

295 eas pharmacological disinhibition of the ECN unmasked wake-related reafference, twitch-related reaffe

296 Nanoscale changes to the cell wall during unmasking were explored in live cells with atomic force

297 ne decomposes during attempted photochemical unmasking, whereas photolysis of the indane rotaxane res

298 ong-term potentiation prompts transient mRNA unmasking, which depends on factors active during synapt

299 f the possible residual confounding that was unmasked with falsification outcomes.

300 increased phagocytosis efficiency of DCs for unmasked yeasts.