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1 e percentage of the SGNs in this strain were unmyelinated.
2 missive neuronal somata and dendrites remain unmyelinated.
3 on postnatal day 1 (P1) when WM tracts were unmyelinated.
4 ent for NRG1 type III are disproportionately unmyelinated, aberrantly ensheathed, and hypomyelinated,
5 pha3 expression is similar in myelinated and unmyelinated adult sensory neurons, suggesting that ARTN
7 ehavioral responses and neuronal activity in unmyelinated afferent fibers were assessed in monkey aft
8 eceptor within skeletal muscle (localized to unmyelinated afferent fibres) elicits increases in MAP a
11 ta-methylene ATP suggest that myelinated and unmyelinated afferent pathways engage both mGluR-GABA me
12 of the sciatic nerve to trace myelinated and unmyelinated afferent terminations, respectively, in the
13 an with a tracer that labels non-peptidergic unmyelinated afferents (Griffonia simplicifolia isolecti
14 eA neurons received inputs derived from only unmyelinated afferents [transient receptor potential cat
15 nts is particularly surprising because these unmyelinated afferents are thought to respond to the gra
16 activates a subpopulation of myelinated and unmyelinated afferents in monkey, (4) the time course of
17 elated peptide and isolectin B4, and injured unmyelinated afferents labeled with vasoactive intestina
18 additional and separate phenotypic marker of unmyelinated afferents rather than operated by TRPV1.
19 l ganglion neurons (SGNs) are small caliber, unmyelinated afferents that extend dendritic arbors hund
20 sly uncharacterized subset of myelinated and unmyelinated afferents, few of which express the proinfl
21 g views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathwa
22 ae I and IIo and in terminals of peptidergic unmyelinated afferents, it is suggested that presynaptic
32 r PNS myelination driving axonal wrapping by unmyelinated and myelinated Schwann cells and enhancing
34 morphometrically evaluated at intraorbital (unmyelinated and myelinated) and intracranial sections.
35 tive (NET-ir) axonal profiles were typically unmyelinated and occasionally were observed to form symm
36 Nociception is produced by stimulation of unmyelinated and small myelinated fibers in the joint an
37 early overlapped in laminae I-II with normal unmyelinated and thin myelinated afferents labeled with
38 odulate afferent transmission by myelinated, unmyelinated, and peptidergic afferents in the dorsal ho
40 tigate its effect on the morphology of small unmyelinated as well as myelinated sensory axons and rel
41 , neocortical auditory fields are relatively unmyelinated at birth and only attain adult-like MFLD va
42 apses; (ii) postsynaptic disorders affecting unmyelinated auditory nerve dendrites; (iii) postsynapti
43 s in which the small, lightly myelinated and unmyelinated autonomic nerve fibres are selectively targ
46 conduction delays of action potentials in an unmyelinated axon depended on the history of activity an
47 region that corresponded most closely to the unmyelinated axon initial segment, as defined by Golgi a
49 ssociated with microstructural WM injury and unmyelinated axon loss at P1, diagnosed by diffusion ten
52 odelling emphasises uncertainties about fine unmyelinated axon physiology but, when informed by biolo
55 daily to adult rats to examine its effect on unmyelinated axon-Schwann cell units in intact periphera
61 y to TAI, the present study examines whether unmyelinated axons also respond differentially to FK506,
62 xception of a small amount of GluD1-positive unmyelinated axons and axon terminals in the primate str
63 nfirmed the localization of endomorphin-2 to unmyelinated axons and axon terminals in the trigeminal
65 eurotrophins and tyrosine phosphorylation in unmyelinated axons and dendrites, where Na(V)1.2 channel
67 chwann cell proliferation and death, loss of unmyelinated axons and marked heat and cold pain insensi
68 DAT and TH were localized primarily in small unmyelinated axons and morphologically heterogeneous axo
69 omy) of the rat is highly selective, sparing unmyelinated axons and myelinated sensory axons; Walleri
70 rbB-family receptors in interactions between unmyelinated axons and non-myelinating Schwann cells in
71 rm cortex layers, which are characterized by unmyelinated axons and perisynaptic astroglial envelopes
72 athway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes
73 siological evidence, however, indicates that unmyelinated axons are more vulnerable than myelinated a
75 hough GLT1 is present on developing OLs when unmyelinated axons are prevalent in the developing rat c
76 all population of type II neurons with their unmyelinated axons are undetectable with most recording
77 oexpression, we studied large populations of unmyelinated axons by using quantitative single-label EM
82 ittle is known about repolarization in thin, unmyelinated axons forming en passant synapses, which re
83 an reversibly block action potentials in the unmyelinated axons from the marine mollusk Aplysia calif
84 nderlying causes are unclear, but epidermal, unmyelinated axons have been shown to be the first to de
86 s further substantiate a distinctive role of unmyelinated axons in TAI, and suggest a highly efficaci
87 studies to assess large myelinated and small unmyelinated axons in the db/db type II diabetes mouse m
89 rily on the plasma membrane of dendrites and unmyelinated axons in the hippocampus and cerebellum, wi
90 ecently, vesicular release of glutamate from unmyelinated axons in the rat corpus callosum has been s
92 s, which resulted in the segregation of many unmyelinated axons into a 1:1 relationship with Schwann
95 ve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is acc
99 nce of the large number of thin-diameter and unmyelinated axons that connect different cortical areas
100 slow-conducting, and energetically expensive unmyelinated axons to large, fast-conducting, and energe
102 etwork of 30 multicompartmental neurons with unmyelinated axons was used to infer that: axon-axon gap
103 ure myelinating Schwann cells (SCs), whereas unmyelinated axons were aberrantly ensheathed in Remak b
104 Two phases of increase in the number of unmyelinated axons were observed at C7, while only one s
105 he area occupied by glial cell processes and unmyelinated axons which significantly increased followi
108 small- and medium-sized myelinated and small unmyelinated axons, although sensory nerve action potent
109 N2D is predominantly expressed in dendrites, unmyelinated axons, and axon terminals within the STN.
110 abeling was seen in small axon terminals and unmyelinated axons, and the postsynaptic density (PSD) f
111 labeling was also present in numerous small unmyelinated axons, axon terminals, and glial processes.
113 in this model may be the less myelinated or unmyelinated axons, extracellular matrix, or synaptic fi
114 noreactive (KOR-ir) neuronal structures were unmyelinated axons, followed by axon terminals, dendrite
115 sults are specific to signal transmission in unmyelinated axons, I suggest that the conclusions are l
118 and dendrites, but the proportion of labeled unmyelinated axons, terminals, and glia was higher than
120 cross the CC, presumably in conjunction with unmyelinated axons, to colonize the contralateral hemisp
121 ial afferents is exclusively associated with unmyelinated axons, VR1 identifies C-fiber afferent path
122 oteinase 13 (MMP-13) induces degeneration of unmyelinated axons, whereas pharmacological inhibition o
123 ain conduction times are especially great in unmyelinated axons, which may transmit information via f
131 axonal excitability and synaptic function in unmyelinated axons.SIGNIFICANCE STATEMENT Voltage-gated
132 es several new features of AP propagation in unmyelinated axons: (1) branches of a single axonal arbo
135 elinated A fibers and isolectin B4 (IB4) for unmyelinated C fibers and both labels were quantified in
137 These results further support the role of unmyelinated C fibers in injury-induced modulation of sp
138 t involved large Abeta myelinated fibers and unmyelinated C fibers were most affected by chemotherapy
139 ted with altered nerve function, we measured unmyelinated C-fiber conduction velocities (CV) in nerve
140 G neurons, whereas it was decreased in small unmyelinated C-fiber neurons as a result of diabetes.
141 with peripherin and isolectin B4 markers of unmyelinated C-fiber neurons; 68% colabeled with antibod
143 asodilation via antidromic activation of the unmyelinated C-fibers and/or the small myelinated fibers
146 myelinated dorsal root axons, but rarely in unmyelinated C-fibers, and heavily expressed in the dors
147 ry bladder consist of myelinated Adelta- and unmyelinated C-fibers, the neuronal cell bodies of which
151 bserve pruriceptive itch which includes both unmyelinated C-fibres and thinly myelinated Adelta nerve
153 to assess the changes in myelinated (A) and unmyelinated (C) cutaneous nociceptors after transection
154 olved, but motor, small myelinated (Adelta), unmyelinated (C) or autonomic fibres may also be affecte
155 inosa (SG) is a major termination region for unmyelinated (C) primary afferent fibers; however, how t
157 us (NTS) neurons via myelinated (A-type) and unmyelinated (C-type) axons in the solitary tract (ST).
158 taining glutamate homeostasis at a time when unmyelinated callosal axons are engaging in glutamatergi
159 of sensory neurons, including small-diameter unmyelinated cells that respond to capsaicin (but not mu
160 l conduction velocity in both myelinated and unmyelinated central axons can be bidirectionally modula
161 primary afferents but are also expressed in unmyelinated cranial visceral primary afferents linked t
162 Previous studies using reporter proteins in unmyelinated cultured neurons suggest that an ankyrinG-b
164 ng electrophysiological recordings of single unmyelinated cutaneous fibres and their compound action
165 ber tactile afferents are a subpopulation of unmyelinated cutaneous sensory neurons activated by gent
166 capable of firing at high frequencies, small unmyelinated DRG neurons typically display much lower ma
170 2 in the organ of Corti was localized to the unmyelinated efferent axons and their endings on the inn
171 we show that localized thermal inhibition of unmyelinated efferents results in a significant decrease
173 ined the effects of C-peptide replacement on unmyelinated fiber function in the hind paw, sural nerve
175 d restored the diabetes-induced reduction of unmyelinated fiber number (P < 0.01) and mean axonal siz
176 tion of the sciatic nerve revealed a loss of unmyelinated fibers and extensive ultrastructural damage
179 ements of conduction velocity indicated that unmyelinated fibers are responsible for glutamatergic si
180 es revealed early preferential loss of small unmyelinated fibers followed by prominent demyelination
181 old reduction in the density of regenerating unmyelinated fibers in LAR-/- nerves distal to the crush
183 1.2 channels were predominately localized in unmyelinated fibers in the cortex, hippocampus, spinal c
185 otion that altered potassium homeostasis and unmyelinated fibers may represent a potential vehicle fo
187 n of the labeling patterns suggests that AEN unmyelinated fibers project primarily to the ventral tip
188 eripherin (a marker of thinly myelinated and unmyelinated fibers) or calcitonin gene-related peptide
189 se to cowhage is different in myelinated and unmyelinated fibers, (5) the time of peak itch sensation
190 ngs in hypertonic P18 kits decreased only in unmyelinated fibers, despite a loss in both myelinated a
191 ever, although 65% of the AEN is composed of unmyelinated fibers, it has not been determined whether
192 he role of degeneration of myelinated versus unmyelinated fibers, we investigated the effects of an L
193 amatic proliferation in the Schwann cells of unmyelinated fibers, which resulted in the segregation o
198 Moreover, SARM1 knockout mice do not lose unmyelinated fibres in the skin or myelinated axons in t
199 ity is a functional signature of a subset of unmyelinated fibres innervating the urinary bladder.
200 e activity from different sets of peripheral unmyelinated fibres through neural circuitry that includ
202 ns of propagating action potentials in small unmyelinated fibres, such as the axons within mammalian
203 ll axons forming the optic nerve (ON) emerge unmyelinated from the eye and become myelinated after pa
204 r ablation of high-threshold, small-diameter unmyelinated group C nerve fibers (C-fibers) has limited
205 y the mechanisms underlying AP initiation in unmyelinated hippocampal mossy fibers of adult mice, we
207 positive for TRPV1 and CGRP and most likely unmyelinated, in that most colonic afferents were not po
209 es them as a poorly understood population of unmyelinated, low threshold mechanoreceptors (C-LTMRs).
210 terneurons suggests that myelinated, but not unmyelinated, LTMRs play a critical role in the expressi
212 Thus, sodium channel gating and density in unmyelinated mossy fiber axons appear to be specialized
214 but significantly improved measures of small unmyelinated nerve fiber architecture and function.
215 by the preprotachykinin A (PPT-A) gene, from unmyelinated nerve fibers (C-fibers) following noxious s
217 d objective measures of small myelinated and unmyelinated nerve fibers can improve in these diabetic
218 usor overactivity, there is up-regulation of unmyelinated nerve fibers expressing both the vanilloid
219 receptors are present on both myelinated and unmyelinated nerve fibers in human dental pulp and may p
220 d macrophages-preceded altered conduction of unmyelinated nerve fibers in SIV-infected macaques, sugg
221 and interweaving reported in humans and had unmyelinated nerve fibers within micrometers of the endo
223 phy may reveal the extent of damage to small unmyelinated nerve fibres that go undetected by NCS.
224 By contrast, Pik3c3-deficient small-diameter unmyelinated neurons accumulated excessive numbers of ly
225 restingly, HRP3-II remained in the nuclei of unmyelinated neurons and glial cells, suggesting the exi
226 VGLUT3-persistent neurons are small-diameter unmyelinated neurons that are further divided into two s
227 mmetrical junction-like contacts between the unmyelinated neurons, 3) abnormal expression patterns fo
230 by myelinated (NF200+) sensory neurons, and unmyelinated (NF200-) sensory neurons that were either p
231 sitivity accompanied by marked neuropathy of unmyelinated nociceptive sensory axons terminating in th
232 ptic glomeruli, assumed to be the endings of unmyelinated nociceptive terminals, were found on these
233 ss MOR mRNA below this level, whereas small, unmyelinated nociceptors are likely to express above it.
238 ed receptor B4 marks a rare subpopulation of unmyelinated, nonpeptidergic sensory fibers that exclusi
239 le sources of the PERG bioelectric field are unmyelinated optic nerve axons adjacent to the sclera.
240 a clustering in the inner central retina and unmyelinated optic nerve regions, with microglia activat
245 iously reported findings, we also found that unmyelinated pathways contain only CB, whereas myelinate
246 , the vast majority of 5-HT1D-IR neurons are unmyelinated peptidergic afferents that distribute perip
247 sory neurons, slowing conduction velocity in unmyelinated peripheral nerve fibers, and stimulating re
248 on along the axonal membrane of nociceptive, unmyelinated peripheral nerve fibers, but clarifying the
251 scopic level, opsin labeling was confined to unmyelinated preterminal axons and small terminals that
253 mmunoelectron microscopy results, imply that unmyelinated primary afferent fibers terminating in the
254 L5 DRG that were labeled by IB4, a marker of unmyelinated primary afferent neurons, were largely abse
256 receive monosynaptic input from a subset of unmyelinated primary afferents and connect to other lami
257 imed to determine whether the elimination of unmyelinated primary afferents of the adjacent uninjured
261 of Wallerian and retrograde degeneration of unmyelinated retinal ganglion cell axons in living rats
262 de RGC dendrites, cell bodies and axons, the unmyelinated retinal nerve fiber layer and the myelinate
266 ament transport in contiguous myelinated and unmyelinated segments of axons in long-term myelinating
268 ger cross-sectional area than the contiguous unmyelinated segments, and this correlated with a local
270 pic analysis further revealed hypertrophy of unmyelinated sensory axons and a subset of myelinated ax
271 (>25 mm) regeneration of both myelinated and unmyelinated sensory axons with topographically correct
272 s is characterized by distal degeneration of unmyelinated sensory axons, similar to the "dying back"
274 anosensitive terminals of myelinated but not unmyelinated sensory fibers, whereas HCN2 and HCN4 were
275 ns between non-myelinating Schwann cells and unmyelinated sensory neuron axons that are critical for
280 eviously, we identified a rare population of unmyelinated sensory neurons in mice that express the G-
281 xpresser mice had increased numbers of small unmyelinated sensory neurons that express the tyrosine k
283 cteristics, including 1) large aggregates of unmyelinated SGNs in the apical and middle turns, 2) sym
284 a high degree of the "human-like" feature of unmyelinated SGNs that aggregate into neural clusters.
286 f axons in LKB1 mutants was most dramatic in unmyelinated small sensory fibers, whereas motor axons w
287 nitial myelinated part gives rise to several unmyelinated small-diameter branches that have a high nu
291 7.3 at heminodes, nodes, internodes, and the unmyelinated synaptic terminal segments beneath IHCs in
294 to contact a single inner hair cell, whereas unmyelinated type II afferents are fewer in number and r
296 the possibility that glutamate release from unmyelinated vagal afferents may be regulated by a disti
298 provides excellent contrast visualization of unmyelinated white matter in the immature mouse brain.
299 is to functional electrical connectivity in unmyelinated WM fibers by conducting a longitudinal stud