ライフサイエンスコーパス: unopposed

1 he E-cadherin homodimeric interactions to go unopposed.

2 low the catabolic effects of IL-1 to proceed unopposed.

3 t may destroy the actomyosin architecture if unopposed.

4 we show that the activity of ZC3H4/WDR82 is unopposed.

5 ith Hsp90, Hsp70-dependent ubiquitination is unopposed.

6 Blocking of the A2aR resulted in unopposed A1 receptor-mediated inhibitory effects and le

7 In this way, caudal (C7) motor neurons had unopposed access to vacated synaptic sites on the remain

8 ion of tumor blood vessels by permitting the unopposed action of Ang1, but decreases tumor vascularit

9 of interleukin-1-receptor antagonist allows unopposed action of interleukin-1, resulting in life-thr

10 ed to the Mtd locus may be the result of the unopposed action of the NF-kappaB homolog, Relish.

11 n of the antitoxin by proteases leads to the unopposed action of the toxin once genes encoding a TA s

12 Unopposed activation of B cells through their B-cell rec

13 ood; specifically, it is unknown whether the unopposed activation of the immune system is because of

14 TCF-4 remains nuclear; its unopposed activity is accompanied by downregulation of d

15 EN function may induce tumorigenesis through unopposed activity of the AR as well as contribute to th

16 Unopposed alloimmune injury for 10 days was associated w

17 inistration ceases, these adaptations remain unopposed and may lead to drug withdrawal.

18 imbalance between ACE and ACE2 result in an unopposed angiotensin II.

19 The impaired IL-10 reactivation leads to unopposed antimicrobial effector mechanisms which result

20 volume (MBV) and glucose extraction, whereas unopposed AT(1)R activity decreases both.

21 Unopposed AT(2)R activity increases muscle microvascular

22 However, unopposed balloon inflation in the distal thoracic aorta

23 onsequence of chondrocyte hyperplasia due to unopposed Bmp activities in these mutants such as Bmp4 a

24 gin -/- mutants, which most likely is due to unopposed BMP signaling for chondrogenesis in the peri-o

25 hat is postulated to reflect the activity of unopposed BMP signaling.

26 and the activation of TAFI were essentially unopposed by 5A-APC due to its low anticoagulant activit

27 opposite primer-A or -G at the -1 site or is unopposed by a primer base and followed by a dGTP:A mism

28 ceived, striosomal inhibition of SNc that is unopposed by excitation results in a phasic drop in dopa

29 P1-driven mitochondrial fission activity was unopposed by fusion activity in Marf-1-depleted clones,

30 ection, when viral fitness may be low but is unopposed by immune responses.

31 cytes drives inflammatory bowel disease when unopposed by interleukin-10.

32 possesses a strong oncogenic potential when unopposed by its endogenous inhibitor, HAI-1.

33 We conclude that when unopposed by NA, substance P acting at the NK1 receptor

34 terious effects with a late age of onset are unopposed by natural selection.

35 by normal thymic cortical epithelial cells, unopposed by negative selection, produces polyclonal CD4

36 ged exposure of the endometrium to estrogens unopposed by progesterone and a high body mass are well-

37 Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endome

38 ing the midfollicular phase when estrogen is unopposed by progesterone.

39 on, presumably mediated by functional AR and unopposed by the beta receptor, may have provided a stro

40 trix metalloproteinases (MMPs) is relatively unopposed by the specific tissue inhibitors of metallopr

41 ways results in productive activation, while unopposed Ca2+ signaling leads to tolerance or anergy.

42 rons to support repetitive spiking is due to unopposed calcium currents resulting from a reduction in

43 ity by approximately 100 compared with other unopposed calmodulin-stimulated processes.

44 Unopposed cAMP stimulated hyperphosphorylation of PC2 in

45 REs, a specialized compartment for prolonged unopposed canonical Wnt signaling, and enhances colony g

46 Mechanistically, CTLA4 deficiency permitted unopposed CD28 signaling and maintenance of CAR expressi

47 amatic T cell expansion mediated through the unopposed CD28 stimulation in CTLA4-deficient mice is IL

48 sterectomised women randomised to continuous unopposed CEE or placebo.

49 Unopposed CKS1 activity in Cks2(-/-) cells leads to loss

50 e Women's Health Initiative, indicating that unopposed conjugated equine estrogen is unlikely to be c

51 ession in interstitial trophoblasts suggests unopposed constitutive GR action.

52 ned with P (either cyclic or continuous), or unopposed continuous E failed to increase spines on dlPF

53 hesized that Src-1(-/-) mice have RTH due to unopposed corepressor action.

54 Unfortunately, unopposed correction of the delay in repolarization will

55 Furthermore, unopposed CTLA-4 signaling provided by CD28 blockade pro

56 Among the unopposed EE2 groups, only the 10-microg group had incre

57 nt increase in BMD that was not present with unopposed EE2 treatment.

58 ibitory pathways would be attenuated and the unopposed effects of the excitatory inputs mobilized by

59 B11AhiCD8+ Treg cells left adaptive immunity unopposed, enabling a breakdown in tissue tolerance and

60 exhibit an elevated uterine E2 response and unopposed epithelial cell proliferation during the windo

61 ro, we showed that ESR2 c.948delT results in unopposed ERalpha mediated increased cellular proliferat

62 rylation plays a critical role in preventing unopposed ERK activation.

63 nd mortality in postmenopausal women, use of unopposed ERT for prevention of coronary heart disease i

64 lower in healthy postmenopausal women taking unopposed ERT with 17beta-estradiol than in women taking

65 al atherosclerosis was lower in those taking unopposed estradiol than in those taking placebo (-0.001

66 d controlled trials evaluated the effects of unopposed estrogen (E-alone) and estrogen plus progestin

67 l glands, which is typically associated with unopposed estrogen action and frequently occurs in older

68 phenomenon was 2.5 (95% CI, 1.2 to 5.3) for unopposed estrogen and 0.9 (CI, 0.3 to 2.6) for estrogen

69 observed decrease in risk may be limited to unopposed estrogen and may possibly be more important in

70 ion and hyperplasia occurred with increasing unopposed estrogen doses.

71 to guard against potential complications of unopposed estrogen effect.

72 ncer is preceded by endometrial hyperplasia, unopposed estrogen exposure, and genetic alterations, bu

73 served among postmenopausal women using only unopposed estrogen for 3 or more years, compared with wo

74 in for 3 or more years with women using only unopposed estrogen for 3 or more years, the authors foun

75 iation between estrogen plus progestin HT or unopposed estrogen HT and young-onset breast cancer usin

76 Long-term use of unopposed estrogen is associated with increased risk for

77 The relation between endometrial cancer and unopposed estrogen is well established.

78 Women using unopposed estrogen replacement therapy (ERT) (exclusive

79 nesis by mechanisms that are consistent with unopposed estrogen signaling in the endometrial epitheli

80 n homologue (PTEN) tumor suppressor gene and unopposed estrogen stimulation in the pathogenesis of ut

81 In type 1 endometrial cancer, unopposed estrogen stimulation is thought to lead to end

82 The uterine endometrium responds to unopposed estrogen stimulation with rapid cell prolifera

83 Later age at menopause, unopposed estrogen therapy use, and obesity were associa

84 Unopposed estrogen therapy was associated with the Rayna

85 related to breast cancer risk than is use of unopposed estrogen therapy.

86 idence, but not mortality, is increased with unopposed estrogen use but not with estrogen with proges

87 ), and the RH for MI associated with current unopposed estrogen use was 0.88 (95% CI 0.73 to 1.05).

88 Unopposed estrogen use was inversely associated with the

89 cancer, which has long been associated with unopposed estrogen use, can be successfully prevented wi

90 on, adjusted for age, county, energy intake, unopposed estrogen use, income, and, in separate models,

91 There was no association with duration of unopposed estrogen use.

92 cancer findings from the randomized trial of unopposed estrogen with those from the large WHI observa

93 To recapitulate the situation in women with unopposed estrogen, we implanted 17beta-estradiol pellet

94 tially mediated via increased total lifetime unopposed estrogen.

95 nocarcinoma, which are likely the product of unopposed estrogen.

96 If so, the findings support the "unopposed" estrogen hypothesis for the etiology of endom

97 The partial PR agonism and no signs of unopposed estrogenicity makes EC313 a candidate for the

98 er among long-term users (> or = 8 years) of unopposed estrogens was particularly high for the least

99 l contraceptives, fertility drug use, use of unopposed estrogens, a history of diabetes mellitus or h

100 ho were never pregnant or who had never used unopposed estrogens.

101 ons (AgRP neurons) within the PBN results in unopposed excitation of the PBN, which in turn inhibits

102 ory signaling onto target neurons results in unopposed excitation that is responsible for the activat

103 ck of neuroinhibitory function may result in unopposed excitotoxic neuronal damage in amyotrophic lat

104 Because unopposed (free) neutrophil elastase (NE) released into

105 g Drp1 specifically at mitochondria, causing unopposed fusion events at mitochondria along with elong

106 out the expression and possible functions of unopposed gap junction hemichannels in the brain.

107 the lungs of IL-4/13(-/-) mice compared with unopposed growth of H99 in the lungs of wild-type mice.

108 age of the ability of Cx46 to function as an unopposed hemichannel to examine the basis of Cx charge

109 which might prevent interference or provide unopposed homeostatic compensation when it is needed mos

110 with cerebral HIV-1 infection could lead to unopposed hydrolysis of matrix and surface proteins.

111 y of both type 1 and type 2 diabetes because unopposed hyperglucagonemia is a pertinent contributor t

112 by BAL cells from SSc patients differs from unopposed IFNgamma production found in healthy BAL cells

113 This resulted in unopposed IL-1 signaling.

114 d risk of developing FA and, therefore, that unopposed IL-1beta and/or excessive TNF-alpha may play a

115 o lose primary elections, more likely to run unopposed in the general election, more likely to run fo

116 haustion of presynaptic release of GABA, and unopposed increased glutamatergic responses.

117 opposed inflammatory response, and a largely unopposed inflammatory response (with anti-IL-10) result

118 , severe sepsis is associated with a largely unopposed inflammatory response, and a largely unopposed

119 ed cells and as a host strategy to induce an unopposed innate response in replication-nonpermissive b

120 ritic cells and the subsequent production of unopposed interferon-alpha, following a triggering event

121 irway fluids displayed high and consequently unopposed levels of S100A12; a potent mucosa- and neutro

122 ng 'neuroplasticity imbalance' manifested by unopposed LTD in the setting of impaired capacity for ne

123 ctivation of the other, a situation that, if unopposed, may result in tissue damage or even multiorga

124 novel mechanism by which TGF-beta can induce unopposed MC survival and oxidant stress in early DN, th

125 Unopposed micronized 17beta-estradiol (1 mg/d) or placeb

126 at a time corresponding to 3 or 4 cycles of unopposed mitochondrial fission.

127 t-translational modification responsible for unopposed mitochondrial fusion in response to low glucos

128 f two Drp1 phosphorylation sites, leading to unopposed mitochondrial fusion.

129 which prevented AMPK activation and enabled unopposed mTORC1 signaling.

130 Our findings indicate that unopposed NE activity can be found in both alpha1-AP-def

131 (OB), but only 8 of the 38 subjects without unopposed NE activity had OB (p = 0.002; Fisher exact te

132 However, the presence of unopposed NE activity in BAL from lung allografts of pat

133 antiprotease (alpha1-AP) concentrations, and unopposed NE activity in bronchoalveolar secretions from

134 Unopposed NE activity was found in BALF from 14 recipien

135 Unopposed NE activity was present in bronchoalveolar lav

136 cient in the majority of patients to prevent unopposed NE activity.

137 %) with other indications for transplant had unopposed NE in BALF.

138 Ten of the 14 recipients with unopposed NE in bronchoalveolar lavage (BAL) had develop

139 nchoscopies had at least one BALF containing unopposed NE, usually associated with the presence of >

140 In summary, functionally unopposed, network-dependent microglial MMP-1/-3 gene ex

141 Large numbers of neutrophils with unopposed neutrophil elastase (NE) proteolytic activity

142 The mean value of unopposed neutrophil elastase activity in upper-lobe BAL

143 Neutrophil influx and unopposed neutrophil elastase for a given region correla

144 These papers, which won Krogh an unopposed Nobel Prize for Physiology or Medicine in 1920

145 This phenotype may be ascribed to unopposed occupancy of the IL-4 promoter by NFATc.

146 ogen plus progestin hormone therapy (6%) and unopposed oestrogen (5%) being the most common types.

147 rmones (for > 6 months), women who had taken unopposed oestrogen had a four-fold increase (95% CI 3.1

148 The effect of short-term unopposed oestrogen replacement to correct this impairme

149 se is much smaller than that associated with unopposed oestrogen, but needs to be confirmed.

150 Compared with never users, women taking unopposed oral estrogen therapy had increased risks of b

151 Unopposed, oral 17B-estradiol increased the risk of stro

152 e conclude that defective Smad signaling and unopposed p38(MAPK)/ERK signaling, as a consequence of m

153 phenotypes that arise from hysteresis due to unopposed positive feedback.

154 Use of unopposed postmenopausal estrogen from ages 50-60 years

155 Use of unopposed postmenopausal hormones for 10 years significa

156 Ablation of syndecan-1 in mice led to unopposed progression of liver injury upon APAP overdose

157 ed from sphingolipid rafts, resulting in the unopposed proinflammatory signaling thought to promote S

158 pression in cancer could cause gradations of unopposed prolactin-mediated LF stimulatory function and

159 by convergence forces in Ptk7 mutants, this unopposed radial intercalation resulted in excessive thi

160 subchondral bone, where they are exposed to unopposed RANKL and TNF-alpha.

161 se inhibition by alpha1-antitrypsin, and its unopposed release destroys tissue at sites of inflammati

162 ty of the dm null phenotype is likely due to unopposed repression by dMnt on a subset of genes critic

163 rlapping pathogenesis involving IFNgamma and unopposed T-cell activation causing severe inflammatory

164 suggesting the GVL effect is due to largely unopposed Tcon alloantigen recognition in bone marrow.

165 ORgammat over Foxp3 and thus establishing an unopposed Th17 differentiation program.

166 halts the transcription of uPA mRNA, leaving unopposed the deleterious effects of Abeta on the synaps

167 Ang-1), a vessel stabilizing factor, leaving unopposed the effects of endothelial Ang-2, a vessel-bra

168 eases the synaptic abundance of uPA, leaving unopposed the harmful effects of Abeta on the synapse.

169 avascular coagulation in larvae secondary to unopposed thrombin activity and fibrinogen consumption,

170 In contrast, unopposed tongue protrusion dilates the oropharynx, but

171 on of tumor growth, modest proliferation, or unopposed tumor growth.

172 r, whereas in mice lacking type I NKT cells, unopposed type II NKT cells could suppress tumor immunit

173 lated NO synthesis is impaired, resulting in unopposed vasoconstriction.

174 across conditions, as did MEPs evoked during unopposed weak flexion of the index finger.

175 on leaves CF intestinal absorptive processes unopposed, which results in net fluid hyperabsorption, d

176 ergo long-term potentiation (LTP), which, if unopposed, will degrade pattern separation because MF ac

177 ing this relevant pathophysiological pathway unopposed with currently available drugs.

178 this resulted in increased signaling due to unopposed Wnt activity.