ライフサイエンスコーパス: unprecedented

1 This finding, if correct, would be unprecedented.

2 This type of selectivity is unprecedented.

3 scientific discovery related to COVID-19 is unprecedented.

4 by a halogen bond donor molecular switch, is unprecedented.

5 Nanangelenin A (1), containing an unprecedented 3,4-dihydro-1-benzazepine-2,5-dione-N-pren

6 gamma-irradiation of TOF-16 to an unprecedented 4 MGy dose resulted in no apparent bulk st

7 +), Ho(3+), Er(3+), Yb(3+)), that display an unprecedented (4, 8)-coordinated ken net based on nonanu

8 tive component which was determined to be an unprecedented 42-residue cysteine-rich peptide named rec

9 The unprecedented ability of computations to probe atomic-le

10 Sequencing technologies now provide unprecedented access to genomic information in archival

11 These tools offer unprecedented access to specific circuits and neuronal s

12 owerful new neuroscience tools have provided unprecedented access to this elusive nucleus, revealing

13 scattering map from triclinic lysozyme with unprecedented accuracy and detail, clearly resolving bot

14 epresentation, we achieve, to our knowledge, unprecedented accuracy in prediction of ADMET properties

15 , scRCAT-seq demarcates RNA transcripts with unprecedented accuracy.

16 f the start of the pandemic, it will mark an unprecedented achievement for noninfluenza viral vaccine

17 ytum mirabile (Balanophoraceae) revealed the unprecedented acquisition of a large amount of mitochond

18 This material is water-stable and exhibits unprecedented adsorption kinetics, up to 50 times faster

19 etal halide perovskites (MHPs) have provided unprecedented advances in interdisciplinary fields of ma

20 ith the broader sustainability agenda but of unprecedented ambition and coordination, could enable th

21 Small island states receive unprecedented amounts of the world's plastic waste.

22 phenylene-1,3-diamines can be converted into unprecedented analogues of rhodamine and malachite green

23 riments allowed structural assignment of the unprecedented and densely functionalized (Z)-alpha-phosp

24 We present the first example of an unprecedented and fast aryl C(sp(2))-X reductive elimina

25 Here, an unprecedented approach is reported for low-temperature p

26 spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cell

27 Today, we have access to an unprecedented array of developmental data from across th

28 aim at creating music that is as complex and unprecedented as possible without relying on shared plan

29 allowed us to produce crystals that provided unprecedented atomic detail.

30 s) and a new class of materials featuring an unprecedented backbone structure, the polyallophanates (

31 en by a superconducting accelerator provides unprecedented beam stability within a pulse train.

32 e most extreme event on record (1997) is not unprecedented, because at least one event that was appro

33 This unprecedented behavior extends the tunable properties th

34 ve for the past 50 years and is now enjoying unprecedented bench-to-bedside clinical success.

35 dicted to have a WD40-like fold catalyzes an unprecedented benzilic acid rearrangement involving migr

36 .S. President Trump's reliance on Twitter is unprecedented, but the underlying implications for agend

37 ely developed in recent decades due to their unprecedented capability of representing a sample elemen

38 ly affected by Hurricane Michael in 2018, an unprecedented Category 5 storm.

39 dle-income, and low-income countries present unprecedented challenges for all settings; however, a gl

40 l SARS-CoV-2 coronavirus has already brought unprecedented challenges for public health and resulted

41 Academic medicine is in the midst of unprecedented change.

42 ocks this well-known reaction and enables an unprecedented chemoselective C(sp(2))-Ar sigma-bond inse

43 mensional structure of a primary cilium with unprecedented clarity.

44 c, magnetic and optical systems now offer an unprecedented combination of complexity, small size and

45 ant small-molecule libraries, harnessing the unprecedented combination of NP-derived fragments as an

46 For this study, we use an unprecedented combination of observed data from the Unit

47 work using similar approaches will enable an unprecedented comparative examination of magmatic system

48 This provides unprecedented comprehensive molecular definition of thes

49 that its F0-F1 di-subdomain displays another unprecedented constellation, whereby the F0-F1-F2 adopts

50 Unprecedented control in time and space over H(2)O solva

51 and unfamiliar individuals, and why humans' unprecedented cooperative flexibility is nevertheless cu

52 This is an unprecedented coordination mode for an allyl ligand boun

53 The methodology has been extended to the unprecedented coupling of acetone with phenol derivative

54 It now provides unprecedented data coverage under an open access data po

55 ti-layer high-dimensional omics data provide unprecedented data resources for prediction studies, the

56 metallaphotoredox conditions and involves an unprecedented decarboxylative radical addition/cross-cou

57 Despite recent findings of unprecedented declines in biodiversity and ecosystem ser

58 2016, domoic acid contamination prompted an unprecedented delay in the opening of California's Dunge

59 However, due to the growing unprecedented demand of LIBs for commercialization in EV

60 ach, we quantified the shape of the skull in unprecedented detail across 354 extant and 37 extinct av

61 llent tool for studying heart development in unprecedented detail and throughput.

62 n of the 2D Hubbard model can be revealed in unprecedented detail by using the imaging and the interf

63 al data to unveil the catalytic mechanism in unprecedented detail, including the degree of proton tra

64 mature human retinal cells to be studied in unprecedented detail.

65 d theoretical approaches, culminating in the unprecedented detection and quantification of the true b

66 romising photovoltaic materials due to their unprecedented development, with their record power conve

67 l high-temperature polymers, and features an unprecedented discharged energy density of 5.7 J cm(-3)

68 Arctic research faces unprecedented disruptions due to COVID-19.

69 gem-difluoromethylene alkynes as effectors, unprecedented diverse C-H activation/[4+2] annulations o

70 n-surface synthesis protocol, we achieved an unprecedented double-stranded hexagonal cycloarene conta

71 Here, a single-component system with an unprecedented drop of Young's modulus by up to six order

72 loss in the Southeast Asian region following unprecedented drought and wildfires.

73 c disturbance through a tropical heatwave of unprecedented duration.

74 ene, and butyne/1,3-butadiene mixtures, with unprecedented dynamic separation selectivities of 100, 9

75 to provide valuable beta-amino ketones with unprecedented ease.

76 y enabling targeted genome modification with unprecedented ease.

77 to degrade a variety of cancer targets with unprecedented efficacy against a multitude of tumor type

78 ynes as substrates for cyclopropenation with unprecedented efficiencies and stereoselectivities (up t

79 The ASM extended storage to 3 months with unprecedented endothelial cell quality: no OC corneas re

80 The United States is in the midst of an unprecedented epidemic of opioid substance use disorder,

81 We show that this unprecedented event was caused and sustained by phreatom

82 }] (4) by thermolysis; thereby, providing an unprecedented example of reductive cycloaddition reactiv

83 gnificant technical advances have allowed an unprecedented exploration of genomes, transcriptomes, pr

84 ransgenic and mutant mouse lines, and for an unprecedented exploration of the molecular mechanisms th

85 demic is stressing healthcare services to an unprecedented extent.

86 itian topology and for manipulating waves in unprecedented fashions.

87 The unprecedented features of 2-pyridone ligands in asymmetr

88 These unprecedented findings strengthen recent assessments of

89 ge-sensitive fluorescent probes has provided unprecedented flexibility for choosing regions of intere

90 NPs, 87.2 +/- 2.9% for 1.6 nm Au NPs, and an unprecedented full 100% Ag for 0.9 nm diameter Au NPs.

91 ty of this tree through an unpredictable and unprecedented future.

92 c group is particularly demanding and so far unprecedented, given the similarity between their enviro

93 me coronavirus-2 (SARS-CoV-2) has created an unprecedented global crisis for the infrastructure secto

94 The COVID-19 pandemic has caused an unprecedented global public health and economic crisis.

95 The COVID-19 pandemic has prompted an unprecedented global research effort to better understan

96 Following an unprecedented global spread(3), the World Health Organiz

97 The past decade has seen unprecedented growth in the development of new chemical

98 Recent weather extremes including the unprecedented heat wave in Siberia contribute to the dec

99 Unprecedented heatwave-drought concurrences in the past

100 Novel unprecedented helical foldamers have been effectively de

101 bC(8) via [2+2+1] cycloaddition, produces an unprecedented hexathorium complex [{Th(Tren(TIPS) )}(6)

102 of global-scale seismic wave propagation at unprecedented high frequency, here we explain the origin

103 O is manifested in epitaxial thin films with unprecedented high purities.

104 Subsequently, ABX-GMFETs exhibited unprecedented high sensitivity with a limit of detection

105 e-site distance and 33 % vacancies exhibited unprecedented high turnover frequency of 29.5 h(-1) in v

106 Nebulosins feature an unprecedented highly substituted thiolane ring leading t

107 n other peripheral membrane proteins with an unprecedented impact in drug discovery/development strat

108 evelopment of cancer therapies has led to an unprecedented improvement in survival outcomes and a wid

109 n pathways through molecular engineering, is unprecedented in electrocatalysis.

110 f sensitivity for whole E. coli detection is unprecedented in label-free biosensing.

111 nd fine-scale haplotypic structure (which is unprecedented in resolution for a prehistoric population

112 The recognition mode is unprecedented in that the targeted domain of CEP250 is a

113 This paper therefore presents an unprecedented in-depth analysis of the polymer and eleme

114 the noncovalent recognition of fullerenes is unprecedented, in part because archetypal PDIs are also

115 he recent pandemic in the Americas led to an unprecedented increase of newborn babies with developmen

116 tribute to novel morphogenetic behaviors and unprecedented increases in the complexities of tissue me

117 three-dimensional compositional data reveal unprecedented information on the distribution of individ

118 Investigators are employing unprecedented innovation in the design of clinical trial

119 hnologies in ethology and ecology, providing unprecedented insight into animal behaviour.

120 Our studies provide an unprecedented insight into bicomponent leukocidin-host r

121 gle-molecule methods that we discuss provide unprecedented insight into chemical and structural behav

122 high-throughput technologies, have given us unprecedented insight into circulating biomarkers of T2D

123 with unbiased computational analysis provide unprecedented insight into how different DNA sequences s

124 ly parallel phenotyping assays have provided unprecedented insight into how multiple mutations combin

125 These data provide unprecedented insight into some of the processes by whic

126 Cryo-electron tomography (cryo-ET) can give unprecedented insight into these complexes in the contex

127 These structurally annotated CDRs provide unprecedented insights into both the structural predeter

128 ntal and imaging techniques have allowed for unprecedented insights into the dynamical processes with

129 year-old amber from northern Myanmar provide unprecedented insights into the soft tissue and skeletal

130 or transfer them between hosts have allowed unprecedented insights into their impact.

131 SARS-CoV-2 presents an unprecedented international challenge, but it will not b

132 It remains unclear how these unprecedented interventions, including travel restrictio

133 Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million

134 The unprecedented introgression signatures within both domes

135 n, and clinical research; and 3) provided an unprecedented investigational tool to conduct longitudin

136 than existing tools but also performs at an unprecedented level of accuracy by achieving a 12 percen

137 This affords an unprecedented level of control over the device propertie

138 creation of architecture and devices with an unprecedented level of functional integration.

139 This approach reveals an unprecedented level of fundamental genomic novelties in

140 equencing analysis of 207 donors revealed an unprecedented level of heterogeneity of SLC5A2 expressio

141 and the resultant laminar atlas provides an unprecedented level of precision and detail.

142 This unprecedented level of stress relaxation in the glassy s

143 ncreases the practical security of QKD to an unprecedented level.

144 trast, cross-evolutionary profiling revealed unprecedented levels of ac(4)C across hundreds of residu

145 Tropical forest ecosystems are facing unprecedented levels of degradation, severely compromisi

146 lm of novel electrolyte systems has grown to unprecedented levels.

147 ly evolved and changed our way of life in an unprecedented manner.

148 y to exploit light-matter interactions in an unprecedented manner.

149 Unprecedented metal-free synthesis of a variety of amine

150 This catalytic amination follows an unprecedented metalloradical activation mechanism.

151 We describe an unprecedented methodology for the synthesis of heteromet

152 rthermore, a dual-diode CQD detector into an unprecedented mid-wave infrared two-channel polarization

153 rapidly expanding area, which experienced an unprecedented momentum thanks to the rapid development o

154 These findings were also applied in unprecedented mono- and di-N-arylation of amino acid der

155 current COVID-19 pandemic is associated with unprecedented morbidity and mortality.

156 nce of Akalin et al. and Pereira et al. with unprecedented mortality (18-28%) in transplant recipient

157 r creating new classes of LM composites with unprecedented multifunctionality.

158 his mechanism further supports efficient and unprecedented myristoylation of an N-terminal lysine sid

159 ratios (>50%), these systems offer not only unprecedented negative and positive biaxial CTE (i.e., -

160 here we analyzed functional MRI data from an unprecedented number (n = 424) of monozygotic (MZ) and d

161 eomic landscapes have now been mapped for an unprecedented number of bulk samples from patients with

162 ough the latest Earth system models offer an unprecedented number of features, fundamental uncertaint

163 VID-19 pandemic, despite the availability of unprecedented numbers of SARS-CoV-2 genomes.

164 The United States is in the midst of an unprecedented opioid crisis with increasing injection dr

165 This information provides unprecedented opportunities for novel interventions to c

166 spectrometry (MS)-based proteomics provides unprecedented opportunities for understanding the struct

167 Online social networks provide users with unprecedented opportunities to engage with diverse opini

168 high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the

169 rimental discovery of Weyl semimetals offers unprecedented opportunities to study Weyl physics in con

170 ugh this easy to design system has presented unprecedented opportunities to treat inherited disorders

171 the advent of the Genomics Era, there is an unprecedented opportunity to address the evolution of eu

172 This structure provides an unprecedented opportunity to assess various signaling mo

173 n DNA sequencing have offered researchers an unprecedented opportunity to better study the variety of

174 irect-acting antiviral agents (DAA) offer an unprecedented opportunity to cure HCV.

175 tigation climate simulations now provides an unprecedented opportunity to inform ecological impact as

176 based assays such as Hi-C provide us with an unprecedented opportunity to investigate the spatial org

177 ion factors (TFs) and cell lines provides an unprecedented opportunity to jointly analyze large-scale

178 uman pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types an

179 is universal microarray platform provides an unprecedented opportunity to resolve a broad range of is

180 multiplexed sequencing strategy, provides an unprecedented opportunity to study mechanisms of repeat

181 We are on the precipice of an unprecedented opportunity to track, predict, and prevent

182 iles in the same individual cells provide an unprecedented opportunity to understand cell fates.

183 n-site seismicity monitoring data provide an unprecedented opportunity.

184 The unprecedented organization of minicircles and gRNAs in T

185 ies compounding in the recent two decades is unprecedented over the quarter of a millennium, and this

186 (dscRNA-seq) data are being generated at an unprecedented pace, and the accurate estimation of gene-

187 rt to identify medical countermeasures at an unprecedented pace.

188 d a chemoenzymatic approach that provided an unprecedented panel of oligosaccharides composed of the

189 entration of H(2) O(2) and to proceed via an unprecedented pathway that avoids the production of elec

190 ture and a means of rationalising (sometimes unprecedented) patterns of reactivity.

191 n of single-ion conducting polymers leads to unprecedented percolated gyroidal ionic aggregate morpho

192 phoranes bearing ortho urea was achieved via unprecedented Ph(3)P-I(2) mediated ring-opening of 1,3-d

193 ar-IR spectroscopy and theory can provide an unprecedented picture of the structure of neutral biomol

194 ry syndrome coronavirus 2 (SARS-CoV-2), with unprecedented policies designed to slow the growth rate

195 Unprecedented polymerization rates were achieved with ex

196 mber of recombinant progeny should allow for unprecedented power and efficiency in the execution of a

197 electron microscopy (PEEM) has demonstrated unprecedented power in the characterization of surface p

198 manipulation of samples and reagents with an unprecedented precision and control, paving the way for

199 istribution of sandy-soil water content with unprecedented precision.

200 Single molecules can now be visualised with unprecedented precision.

201 the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, re

202 ociated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in

203 nations of properties and in some cases even unprecedented properties for covalent materials, such as

204 m of n protein-receptor pairs, we provide an unprecedented quantification of the mechanistic features

205 al shearing, and compressed sensing-enabling unprecedented quantitative imaging of rapid nonlinear li

206 This work provides an unprecedented quantitative landscape of the Parkin-modif

207 orldwide health emergency which calls for an unprecedented race for vaccines and treatment.

208 Biodiversity on the Earth is changing at an unprecedented rate due to a variety of global change fac

209 SARS-CoV-2 RNA genome and its proteins at an unprecedented rate during the COVID-19 pandemic.

210 collection and its analysis are moving at an unprecedented rate, we urge ecologists to thoughtfully c

211 nvironmental changes affect our planet at an unprecedented rate.

212 temporary climate change is proceeding at an unprecedented rate.

213 tivity is changing climatic conditions at an unprecedented rate.

214 on (STEMI) in particular is increasing at an unprecedented rate.

215 Humans alter the environment at unprecedented rates through habitat destruction, nutrien

216 Biodiversity is declining at unprecedented rates worldwide.

217 With opioid abuse-related deaths rising at unprecedented rates, understanding these mechanisms may

218 Digital data are accumulating at unprecedented rates.

219 of a Co(III) iodosylbenzene complex and the unprecedented reactivity of metal-iodosylarene adduct.

220 ed 1,4-B,N-anthracene 1 was found to display unprecedented reactivity, acting as a convenient and hig

221 Reduced temperature and sunlight could drive unprecedented reductions in agricultural production, end

222 ing transmission, and essential to achieving unprecedented reductions in malaria until 2015 (ref.

223 pportunity to interrogate this complexity at unprecedented resolution.

224 ble characterization of neuronal function at unprecedented resolution.

225 to dissect human disease pathophysiology at unprecedented resolutions(6), particularly in diseases l

226 ng the real-time nanostructure kinetics with unprecedented resolutions.

227 ensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-

228 This unprecedented result indicates that polyspermy can bypas

229 e checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological featur

230 nstrated its utility on frequently found and unprecedented ring systems, in agreement with literature

231 Altogether, this study unveils an unprecedented role for a transcription sigma factor in s

232 We further demonstrate an unprecedented role for AP-1B at the basal plasma membran

233 An unprecedented ruthenium (Ru)-catalyzed twofold unsymmetr

234 However, unprecedented satellite images showing long-lived short-

235 ave organized their healthcare systems at an unprecedented scale and pace to make their operations 'p

236 The unprecedented scale of parallel species responses to a c

237 necessitated conference cancellations on an unprecedented scale.

238 2 (SARS-CoV-2) led to a current pandemic of unprecedented scale.

239 ces are producing data from biosensors on an unprecedented scale.

240 ltifunctional substrate activation modes and unprecedented selectivity manifolds.

241 inactive BTK conformation, which affords it unprecedented selectivity.

242 Reactions are facilitated by an unprecedented selenourea-thiourea organocatalyst.

243 a low-cost electrochemical immunoarray with unprecedented sensitivity in the sub-zeptomole range wit

244 ptide N-acetylgalactosaminyltransferase with unprecedented sensitivity.

245 The melanoma field has seen an unprecedented set of clinical advances over the past dec

246 Unprecedented single-pass yields of 58 % are observed at

247 blue-light driven upconversion in water with unprecedented singlet-state energies approaching 4 eV.

248 ted to lead to models trained on datasets of unprecedented size, hence have a catalytic impact toward

249 elatively inexpensive access to libraries of unprecedented size, their production has been hampered b

250 drome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and economic consequences.

251 Using unprecedented spatial sensitivity and specificity, we we

252 ng and actuation of electrical activity with unprecedented spatiotemporal resolution and parallelism.

253 d the two cavity-based receptors leads to an unprecedented specificity for primary ammonium ions over

254 s, STAR3D has become a valuable tool for its unprecedented speed and accuracy.

255 Vaccines are being developed at an unprecedented speed and are already in clinical trials,

256 ate vast bodies of MHC-II binding data at an unprecedented speed and for the benefit of generating pe

257 and interrogate gene regulatory networks at unprecedented speed and scale, their implementation in p

258 D-19) has spread and ravaged the world at an unprecedented speed in modern history, rivaling the 1918

259 isease 2019 (COVID-19) is taking place at an unprecedented speed.

260 tuators will enable bio-inspired robots with unprecedented speeds of motion.

261 2 and resulting COVID-19 disease have had an unprecedented spread and continue to cause an increasing

262 ater uptake in the polymer films, OECTs with unprecedented steady-state performances in terms of [muC

263 This unprecedented stepwise control of dye assembly via hiera

264 and its dissemination globally has caused an unprecedented strain on public health.

265 This work offers unprecedented structural insights into the configuration

266 This unprecedented structural plasticity of helical repeats m

267 3) )(3) ; E=As, 2As; P, 2P), where 2As is an unprecedented structurally characterised arsonium-carben

268 The NOCAP aglycone has an unprecedented structure comprised of a substituted resor

269 lawless structures, such as dendrimers, with unprecedented structure-to-property capacity but with ty

270 tor (CB2R) ligands was developed based on an unprecedented structure.

271 Deep learning, due to its unprecedented success in tasks such as image classificat

272 Recently, deep learning has unlocked unprecedented success in various domains, especially usi

273 The COVID-19 pandemic has led to an unprecedented surge in unemployment in the United States

274 The unprecedented synthesis of 1-methyl naphthalenes proceed

275 is strategy was successfully applied for the unprecedented synthesis of quinazolines by the reaction

276 th molecular large-scale data sets to enable unprecedented systems-level computational modeling.

277 ecade due to the large data availability and unprecedented technology developments.

278 webserver, interferENZY, that allows (i) an unprecedented tight quality control of experimental data

279 ion of limited health care resources in this unprecedented time of health care crisis.

280 ction of AMV for the past ~3 millennia at an unprecedented time resolution, indicating North Atlantic

281 in IR pump - X-ray probe experiments with an unprecedented time resolution.

282 Overall, this unprecedented transformation, albeit at the proof of con

283 CAN and HClO(4) play essential roles in this unprecedented transformation, in which the comproportion

284 method, we quantify biomass generated by the unprecedented tree die-off that occurred in California f

285 cal cyclization could be recycled through an unprecedented triflation/fragmentation.

286 eptide self-assembles through an unusual and unprecedented two-step process as elucidated by solid-st

287 There is unprecedented urgency to understand who is most at risk

288 Notably, the formation of 3 represents the unprecedented utilization of carbene-stabilized disilico

289 V, the coercivity is reversibly tuned by an unprecedented value of ~1.3 T.

290 mics displayed by the clusters thus offer an unprecedented view into the molecular-level processes th

291 ng the structure-function roles, we offer an unprecedented view of the conformational mechanics of th

292 o process large, whole-body specimens for an unprecedented view of the natural abdominal SNS.

293 Mechanistic studies support that this unprecedented visible-light-induced reactivity is enable

294 nd Pacific Decadal Oscillation, and recently unprecedented warm ocean conditions from 2014 to 2016, r

295 Such unprecedented water-stability has been applied to promot

296 es) to study neurodegenerative disease in an unprecedented way.

297 hieved by this system is harnessed to create unprecedented wearable bioanalytical capabilities at bot

298 cent materials establish the existence of an unprecedented well-organization of the emitters into 2D

299 hades accessible with rhodoxanthin across an unprecedented wide range of (E/Z)-ratios by thermal (E/Z

300 e response to the COVID-19 pandemic has been unprecedented with government, academic, and private par