ライフサイエンスコーパス: unrelated

1 DOAC exposure likely, possible, unlikely, or unrelated.

2 on of the causative genes that are otherwise unrelated.

3 emia, who received a HSCT at any age from an unrelated 10/10 HLA-matched donor, with a myeloablative

4 sortium and the 1000 Genomes Project data in unrelated 2812 vitiligo cases and 37 079 controls genoty

5 and HOOK3, representing three subfamilies of unrelated adaptors, interact with the same amphipathic h

6 henome-wide association study involving 9438 unrelated adult Europeans that CRY1Delta11 was associate

7 paternal rather than maternal relatives, and unrelated adult males often traveled together.

8 dentified a disorder that connects seemingly unrelated adult-onset inflammatory syndromes.

9 st, groups formed through the aggregation of unrelated adults are smaller and lack specialization.

10 Following the whole-exome sequencing of 19 unrelated affected individuals, we identified a subject

11 8alpha-gamma deficiency was examined in four unrelated African Americans.

12 sed mt-tRNA(Phe) , in subjects compared with unrelated age- and sex-matched controls.

13 cit IgE and stimulate bystander responses to unrelated allergens.

14 Ds) are encoded by a wide range of seemingly unrelated amino acid sequences, making it difficult to r

15 neric aggregation-related epitopes formed by unrelated amyloid sequences.

16 her as a pregnancy-associated etiology or an unrelated and coincidental liver injury.

17 ferative GN cases and 6442 controls who were unrelated and of European ancestry.

18 ease in donation was driven predominantly by unrelated and paired white donors.

19 ry may explain why we cooperate readily with unrelated and unfamiliar individuals, and why humans' un

20 identical, and one single-antigen mismatched unrelated) and proceeded to alloBMT.

21 family, assuming (contrary to fact) they are unrelated, and (2) improving its accuracy by correcting

22 nnectivity that resembles glycoproteins from unrelated animal-infecting viruses, suggesting a common

23 Tdap induces immunotolerance to unrelated antigens, which is partially restored by concu

24 ther concordant (T2D related) or discordant (unrelated), as a way of understanding the burden of dise

25 Alignment of DNA sequences from an unrelated Ashkenazi individual to Ash1 identified ~ 1 mi

26 gineered tyrosine donor-acceptor pair in the unrelated bacterial maltose-binding protein (MBP), which

27 sker responsiveness to both pneumococcus and unrelated bacterial pathogens.

28 they repurpose drugs with additional cancer-unrelated benefits.

29 transferases in Toxoplasma and Pythium by an unrelated bifunctional enzyme that assembles a distinct

30 nteracting (i.e., face-to-face), relative to unrelated bodies, and more accurately represent single b

31 e responses and functions of other seemingly unrelated body regions.

32 nical SARS-CoV-2 infection concomitant to an unrelated cardiomyopathy that led to euthanasia.

33 Here we report on two unrelated cases diagnosed with both COS and alternating

34 to a large set of UDS samples obtained from unrelated cases infected with hepatitis C virus (HCV) an

35 n polygenic load for cutaneous melanoma than unrelated cases or melanoma-free healthy controls (Bonfe

36 ged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance

37 s in two replication samples including 6,004 unrelated Caucasian and 38,292 unrelated Caucasian.

38 patients with unexplained dystonia yielded 2 unrelated Caucasian patients with an identical heterozyg

39 tudy (GWAS) of lean mass index (LMI) in 2207 unrelated Caucasian subjects and replicated major findin

40 cluding 6,004 unrelated Caucasian and 38,292 unrelated Caucasian.

41 9 and four patients who died from a COVID-19-unrelated cause.

42 ervention group: 9; control group: 4) due to unrelated causes, and there was no evidence of a differe

43 often informed by data sourced from multiple unrelated cell types (mosaic data) or from purified enzy

44 ll isolation procedures also co-purify other unrelated cell types that may interact with MPS cells in

45 ting the risks of using mosaic datasets from unrelated cell types.

46 rther, the shared structural feature between unrelated channels suggests the possibility of a unified

47 We now report three unrelated children with severe neurodegenerative disease

48 Unrelated chorioretinal diseases were diagnosed in the a

49 In particular, cross-resistance to unrelated classes may occur by co-selection of resistant

50 al architecture over time, and appearance of unrelated clones.

51 Examination of chromosome structure at unrelated clusters in maize, rice, and tomato indicates

52 vels (in plasma and PBMCs) were validated in unrelated cohorts (including long-term nonprogressors),

53 esistance on cells by extruding structurally unrelated compounds from the cellular interior.

54 Controls, usually 2 per case, with unrelated conditions who were at the same hospital at th

55 We here report four patients from two unrelated, consanguineous families with a childhood/adol

56 ected siblings, 2 unaffected parents, and 15 unrelated control PWDs.

57 nized infants, and greater IgG compared with unrelated cord blood (P = .005).

58 sequencing data derived from a cohort of 17 unrelated COS cases, we also examined ATP1A3 and all of

59 ationship of a crop to native plants because unrelated crops accrue fewer herbivores and pathogens.

60 Here we used 100 unrelated datasets from the Human Connectome Project to

61 al of consent, investigator decision, and an unrelated death from a motor vehicle accident.

62 ared genetic components underlying seemingly unrelated diseases and may offer novel insights into can

63 nofsky score of at least 60, and received an unrelated donor (fully matched or one-locus mismatched a

64 term outcome in matched (MUD) and mismatched unrelated donor (mMUD) setting is not well defined.

65 a haploidentical relative or HLA-mismatched unrelated donor and patients age 13 years or older with

66 ve case-series of 482 patients who underwent unrelated donor HCT (2005-2013) with T/S-based GvHD prop

67 igh risk of nonrelapse mortality (NRM) after unrelated donor hematopoietic cell transplant (HCT).

68 aimed at externally validating this model in unrelated donor hematopoietic cell transplantation.

69 D in the setting of HLA-identical sibling or unrelated donor transplantation in adult patients with h

70 dard GVHD prophylaxis in patients undergoing unrelated donor transplantation, including decreases in

71 ith haematological malignancies selected for unrelated donor transplantation.

72 age 12 years or younger with an HLA-matched unrelated donor were at intermediate risk (3-year EFS, 8

73 ts age 13 years or older with an HLA-matched unrelated donor were high risk (3-year EFS, 57%; score,

74 -HSCT, and with an HLA-compatible related or unrelated donor were randomly assigned to myeloablative

75 d received a kidney transplant from a living-unrelated donor.

76 ograft came from a matched sibling versus an unrelated donor.

77 with a 12/12 human leukocyte antigen-matched unrelated donor.

78 Among unrelated donors <35, 35-49, and >=50, white donors incr

79 rs were matched family donors (MFDs; n = 6), unrelated donors (UDs; n = 12), and haploidentical donor

80 ty reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in vitro assa

81 ages within complex malaria infections to be unrelated due to parasite inoculations from different mo

82 Replication on an independent set of 8145 unrelated European ancestry participants showed consiste

83 le size available within UK Biobank (375,736 unrelated European participants, including 16,430 with T

84 association tests were performed using 1832 unrelated European patients with PAH and 7509 non-Finnis

85 tability induced by depleting five different unrelated factors.

86 ct NFKB1 variants in 157 individuals from 68 unrelated families as pathogenic.

87 oblasts from affected individuals from seven unrelated families indicates that disease variants resul

88 We undertook exome sequencing in three unrelated families of Caucasian, Turkish and French-Cana

89 We report four unrelated families presenting with initial learning diff

90 Eighteen affected individuals from nine unrelated families showed a consistent phenotype charact

91 Four men from 2 unrelated families were admitted to the ICUs of 4 hospit

92 report, we describe 12 individuals from nine unrelated families with 10 different bi-allelic PIGK var

93 in 4 (RRP4), were recently identified in two unrelated families with a novel syndrome known as Short

94 ain binding protein 11 (WBP11) gene in seven unrelated families with a variety of overlapping congeni

95 ze a unique cohort of 25 individuals from 21 unrelated families with autosomal recessive nanophthalmo

96 in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifesta

97 dentified heterozygous KIF3B variants in two unrelated families with hallmark ciliopathy phenotypes.

98 uanine nucleotide exchange factor 1) in four unrelated families with individuals affected by sporadic

99 ype data for 21 affected individuals from 20 unrelated families with predicted deleterious variants i

100 Exome sequencing was performed in 2 unrelated families with progressive myoclonus epilepsy.

101 allelic variants in the formin DAAM2 in four unrelated families with steroid-resistant NS.

102 as a cause of peripheral nerve disease in 2 unrelated families with the hereditary axonal neuropathy

103 we present six affected individuals from six unrelated families, carrying bi-allelic GAD1 variants, p

104 Here we present five individuals from four unrelated families, individuals who share similar phenot

105 single-strand binding protein 1 (SSBP1) in 5 unrelated families, leading to the R38Q and R107Q amino

106 in seven CRSD-affected individuals from four unrelated families.

107 etic syndrome; the individuals are from four unrelated families.

108 tual disability; the individuals are from 17 unrelated families.

109 nts in HS2ST1 in four individuals from three unrelated families.

110 metabolism caused by TKFC deficiency in two unrelated families.

111 ternal to a building, numerous and seemingly unrelated features, with mz and rt differences up to hun

112 uninformed about the shapes and attended an unrelated foreground task (inattentional blind), (B) wer

113 ential autophagy regulator with no autophagy-unrelated functions, in the mechanism of EC inflammation

114 in family also mediate a number of apoptosis-unrelated functions.

115 ncluding the TDP-43 gene coding (TARDBP) and unrelated genes (eg, C9orf72).

116 ghts into function, and here we screened 193 unrelated genes encoded by 13 different mycobacteriophag

117 nd 894 clinical diagnoses measured in 58,838 unrelated genotyped individuals.

118 , most previous studies have either compared unrelated genotypes or delved into molecular mechanisms.

119 her can be categorized into two evolutionary unrelated groups of BMN proteins respectively defined by

120 The success of unrelated haemopoietic cell transplantation (HCT) is lim

121 Results There were 1731 unrelated HCM patients who underwent genetic testing for

122 der informs GVHD risk after HLA-B-mismatched unrelated HCT and differentiates high-risk HLA-B mismatc

123 ort study of 33 982 patients who received an unrelated HCT done in Australia, Europe, Japan, North Am

124 er dimorphism in GVHD after HLA-B-mismatched unrelated HCT.

125 We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PR

126 However, the gut microbiomes of multiple unrelated healthy individuals as well as diverse human g

127 samples from 183 previously uncharacterized, unrelated HHT and suspected HHT cases using the ThromboG

128 issense CASR variants were identified in two unrelated hypocalcemic individuals.

129 terozygous ASPRV1 missense mutations in four unrelated ichthyosis kindreds segregate with disease and

130 6 other nonfamilial cases identified another unrelated IMD patient with the same mutation.

131 he transcriptional responses elicited by two unrelated individual drugs are correlated.

132 Both Mendelian randomization estimates using unrelated individuals and within family methods reproduc

133 ates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled

134 Three unrelated individuals enrolled in the registry had a syn

135 Utilizing unrelated individuals from the Genomic Origins and Admix

136 ciated with cardiovascular events in 357 882 unrelated individuals from UK Biobank.

137 examine the CNV genomic landscape of 100,028 unrelated individuals of European ancestry, using SNP an

138 and phenotype data from a population of 268 unrelated individuals of P. deltoides The discovery of l

139 en and women were investigated among 317 509 unrelated individuals of the European ancestry.

140 We report seven unrelated individuals presenting with a multiple congeni

141 lian randomization estimates from samples of unrelated individuals suggested that taller height and l

142 iPSCs were generated from 9 unrelated individuals with autism without macrocephaly a

143 Here we describe six unrelated individuals with de novo missense variants aff

144 We identified three unrelated individuals with de novo missense variants in

145 Here, we describe the identification of nine unrelated individuals with heterozygous de novo missense

146 in ADARB1, the gene encoding ADAR2, in four unrelated individuals with microcephaly, intellectual di

147 g protein catalytic alpha subunit 1) in four unrelated individuals with profound neurodevelopmental d

148 data from the Framingham Heart Study (1,626 unrelated individuals) and the Jackson Heart Study (2,04

149 ividuals) and the Jackson Heart Study (2,046 unrelated individuals), and we compare them to LD-based,

150 ts and 12 different missense variants) in 38 unrelated individuals, 21 of whom were hypercalcemic.

151 ed to infer the local ancestries in a set of unrelated individuals, a few of them have been extended

152 /27), with 6 alleles recurring in apparently unrelated individuals, the most common of which was c.42

153 nd lead to protection against mortality from unrelated infections (trained immunity).

154 ccines can also have non-specific effects on unrelated infections and diseases, with important implic

155 a reduced HIV set point virus load and fewer unrelated infections in HIV/TB coinfected patients sugge

156 Sorangicin A (Sor) is an unrelated inhibitor that binds in the Rif-binding pocket

157 quite distinct and generally scientifically-unrelated intellectual territory.

158 ons and policies across these four seemingly unrelated issues, and a fifth, using nuclear weapons aga

159 ollowed by Trump tweeting increasingly about unrelated issues.

160 The low sequence homology among unrelated kinases with bulky DFG-1 residues provides a n

161 We report 12 patients from 8 unrelated kindreds with AD-HIES due to DN IL6ST mutation

162 clade that also facilitated lichenization in unrelated lineages of LFF.

163 on territorial conflicts we show that while unrelated males cooperate, kin-selected benefits are ult

164 ere, we describe two sibling pairs and three unrelated males who presented in infancy with intractabl

165 ing opportunities to related partners versus unrelated males.

166 without known high-penetrance mutations with unrelated melanoma cases and melanoma-free controls.

167 oding meiosis 1 associated protein, in three unrelated men.

168 We performed a range of analyses in 367,703 unrelated middle-aged participants of European ancestry

169 re circadian clock gene cryptochrome 1 in 15 unrelated multigenerational families with combined ADHD

170 also revealed connections between apparently unrelated mumps outbreaks.

171 where statistical models for a drug include unrelated mutations known to be causing resistance to ot

172 aracteristics that can be distinguished from unrelated nutrition deficit characteristics.

173 ver, we found strong HIV-1 inhibition in one unrelated oceanic sample closely matching to HIV-1-inhib

174 e of surgery for colorectal cancer during an unrelated pandemic.

175 Additional analysis of 699 unrelated Parkinson's disease probands with autosomal-do

176 ed vaccine vector for expression of genes of unrelated pathogens, is safe, immunogenic, and can incor

177 ontaining vaccines on the immune response to unrelated pathogens.

178 edisposes the host to severe infections with unrelated pathogens.

179 long-term repression of T-cell reactivity to unrelated pathogens.

180 N633S, and KCNH2-R685P were generated from 3 unrelated patients diagnosed with severe LQT2 (rate-corr

181 , we performed whole-exome sequencing of 314 unrelated patients of Chinese Han origin and verified ou

182 Fifty-six eyes of 28 unrelated patients were included.

183 thousands of blood cells obtained from three unrelated patients who had A3243G-associated mitochondri

184 We studied 2 unrelated patients with immune thrombocytopenia and auto

185 EIF2AK2 sequencing in 191 unrelated patients with unexplained dystonia yielded 2 u

186 t-generation sequencing has identified three unrelated pediatric subjects, each with a clinical diagn

187 We identified two unrelated pedigrees in which there was autosomal dominan

188 in products, CSA and CSB, while structurally unrelated, play roles in DNA repair and other aspects of

189 gher resolution to discriminate related from unrelated polyclonal infections than biallelic SNP barco

190 ng of neural representations, even into task-unrelated primary sensory processing regions.

191 Two-hundred five unrelated probands with various forms of cardiomyopathy

192 s, each containing 2 DN damaging variants in unrelated probands: CHD8 and SCUBE1.

193 introducing a phase-separation motif from an unrelated protein.

194 sing only examples of structural motifs from unrelated proteins.

195 ted against private (not shared) targets and unrelated quantitatively or qualitatively to the patient

196 shown to stimulate human B cell responses to unrelated recall antigens in vitro.

197 age registration using structured and plaque-unrelated reference ion images.

198 a broad panel of SSVs as well as a panel of unrelated S. islandicus rod-shaped viruses (SIRVs).

199 eries of dopaminergic neuron types, but with unrelated sister neurons.

200 Unrelated small-molecule natural products and synthetic

201 orresponding auditory stimulus or imagery of unrelated sounds.

202 ne by DHLPC and NGS in a large cohort of 531 unrelated Spanish probands and one Australian family wit

203 itory stimulus rather than mental imagery of unrelated, speech or non-speech, sounds.

204 Ex vivo leukocyte responses to unrelated stimuli and pathogens were assessed.

205 separate tasks or presented unexpected, task-unrelated stimuli during response inhibition tasks to re

206 o build in function from the ground up in an unrelated structure.

207 ase, we found common MoAs for compounds with unrelated structures, connectivity scores, and binding t

208 The most common unrelated symptoms included sleepiness and neck pain.

209 ich included LASV-specific and antigenically unrelated T cells.

210 shows an analogous preparatory response for unrelated tactile events.

211 on 0.0-1.0) associated with both related and unrelated taxa.

212 ling a common allosteric pathway among three unrelated TCRs.

213 ell differentiation with molecular functions unrelated to A-to-I RNA editing.

214 ts died during the study, from causes judged unrelated to active treatment; one patient assigned amil

215 The slr2103 protein sequence is unrelated to acyltransferases from bacteria (AtfA) or pl

216 The increased risk was unrelated to AF and inserted mechanical valves.

217 ERAP2 and leucine aminopeptidase, an enzyme unrelated to antigen processing, could trim this labile

218 Unconditioned responding was unrelated to anxiety and brain structure.

219 The unhealthy plant-based diet index was unrelated to any of the abdominal or liver fat parameter

220 saliva; otherwise, child cortisol output was unrelated to any other aspect of social disadvantage.

221 in the nasal group (P = .04), but these were unrelated to BCVA.

222 variation in dispersal probability that was unrelated to body size variation.

223 resumed infectious endophthalmitis, 74% were unrelated to cataract surgery.

224 sensor exhibited strong non-specific signal unrelated to cellular forces.

225 yngeal PCR negative or presented for reasons unrelated to COVID-19 and were not tested.

226 tted to the hospital for medical emergencies unrelated to COVID-19.

227 s AEs; most were cardiac disorders; all were unrelated to DEX treatment.

228 ciated only with diagnosis and 59 in modules unrelated to diagnosis or PRS.

229 FAs at 8 weeks of gestation were largely unrelated to DNA methylation.

230 ation occurs largely through changes at loci unrelated to domestication.

231 sophagus is an unpleasant/painful sensation, unrelated to dysphagia, occurring immediately after esop

232 prisingly, this exchange rate was relatively unrelated to each Nup's position, accessibility, or role

233 ational cc1157 strains, they were relatively unrelated to each other.

234 ithin-individual specialization or variation unrelated to growth.

235 associated with breeding habitat overlap and unrelated to habitat structure.

236 Male sterility was, in general, unrelated to homozygosity in any region of the Z, but th

237 sonal terms, and endorsed other social harms unrelated to immigration (e.g., the death penalty for co

238 underwent catheterization, surgery, or both, unrelated to infection.

239 the Htt(Q111) allele, likely via mechanisms unrelated to instability suppression.

240 ted with activation of T cells antigenically unrelated to Lassa virus and poor Lassa virus-specific e

241 pathways in nephropathic cystinosis that are unrelated to lysosomal cystine accumulation.

242 ompared to that of male patients, which were unrelated to microbiota composition.

243 In contrast, female age (experience) was unrelated to multiple paternity.

244 at these heme proteins play additional roles unrelated to nitrogen fixation.

245 Total circulating BCAAs were unrelated to obesity-related cancer incidence although a

246 These may reduce VA or cause VF defects unrelated to papilledema, emphasizing the importance of

247 gests the acral melanoma subtype is uniquely unrelated to pigmentation.

248 1) inverse agonists-which were topologically unrelated to previously explored chemotypes-that acted a

249 We also found changes unrelated to PSPH, PHGDH and CPS1 activity.

250 n criteria included severe retinal pathology unrelated to RD.

251 author than would be expected if gender were unrelated to referencing.

252 Age at death was unrelated to residual decline in episodic memory but was

253 common after errors, but their incidence was unrelated to response time (RT) adaptation.

254 ood and urinary DBP biomarkers examined were unrelated to SGA, LBW, or preterm birth.

255 ability was surprisingly improved, which was unrelated to spectral content.

256 The composite risk score was unrelated to SSF in children who selected smaller food p

257 microbiome is distinct from nearby sites and unrelated to stool microbiome with more Actinobacteria,

258 e networks do not predict a subjective state unrelated to stress, and a nonhippocampal network does n

259 were measured in cord blood from 50 mothers unrelated to study infants.

260 o-moderate in severity and 98.8% were deemed unrelated to study treatment.

261 Hypophosphataemia following FCM is common, unrelated to symptomatic adverse events, baseline intest

262 lated proteins that are otherwise completely unrelated to syntaxins.

263 These effects were unrelated to the alternative lengthening of telomeres pa

264 iological siblings of cases with GD (n = 17, unrelated to the current GD group) were compared with a

265 al impact in ~ 1300 additional Utah suicides unrelated to the discovery families.

266 he gastro intestinal tract that are commonly unrelated to the disease.

267 that bind methylated RNA and is structurally unrelated to the E. coli McrB DNA-binding domain.

268 y of Sec61beta, a membrane protein of the SR unrelated to the EC coupling process.

269 These are often unrelated to the immediate environment and have unique p

270 dverse events was similar in both groups and unrelated to the intervention (POPPIE group 6 versus sta

271 represent novel hMC1R agonists, structurally unrelated to the natural agonists.

272 which represented coincidental transmission unrelated to the outbreak.

273 accumulation of lipid species but is largely unrelated to the prevention of atrophy with oral l-carni

274 of breast cancer by noncanonical mechanisms unrelated to the previously cytotoxic properties attribu

275 196 patients before randomisation, which was unrelated to the procedure, device, or stimulation.

276 nder a new myeloid neoplasm that is clonally unrelated to the recipient's original AML.

277 ion selectivity of a postsynaptic neuron was unrelated to the selectivity of presynaptic neurons, but

278 Of the 16 serious adverse events unrelated to the study drugs, 4 (25%) occurred among 4 p

279 he protocol because of medical complications unrelated to the study procedures.

280 rse events were reported but were considered unrelated to the study treatment.

281 ts on neuropsychiatric illnesses that may be unrelated to their effects on sleep disorders.

282 ecisions, beliefs can provide other benefits unrelated to their epistemic truth value, such as group

283 but 2 deaths (7.4%) occurred that were felt unrelated to tocilizumab.

284 SCC incidence was unrelated to treatment with vitamin D compared with no v

285 Cataract events, all assessed as unrelated to treatment, and events of elevated intraocul

286 articipants experienced headache, all deemed unrelated to treatment.

287 All serious TEAEs were unrelated to treatment.

288 Two (0.8%) deaths were considered unrelated to treatment.

289 Two deaths were unrelated to trial procedures.

290 t COPI coatomer components may perform roles unrelated to vesicle formation, adding further complexit

291 ved target, the ergAB operon, with functions unrelated to virulence.

292 onstrate that TSWV titers in the vector were unrelated to virus titers in the leaf tissue from which

293 population-level genetic variation from 41K unrelated TOPMed samples.

294 rgeted sequencing of ASH1L in additional 524 unrelated TS samples and replicated the association (P v

295 juvenile Bengalese finches with the songs of unrelated tutors.

296 identified (two matched sibling, two matched unrelated, two haploidentical, and one single-antigen mi

297 Reciprocally, several unrelated viruses including cytomegalovirus, human immun

298 peptides have been shown to inhibit multiple unrelated viruses.

299 siblings, 4258 parents or offspring) of 2122 unrelated vitiligo probands.

300 l of 104 patients with AAAs and 112 healthy, unrelated volunteers were screened for the presence of T

301 Uveitis are unrelated with IBD activity and they even precede the on