ライフサイエンスコーパス: unresolved (issue|problem|question)(|s)

1 silver ions (Ag(+)) in vivo has remained an unresolved issue.

2 minant of conformation is a long-running and unresolved issue.

3 out of alloimmunity has been a longstanding unresolved issue.

4 CENP-A (CID in Drosophila) is a fundamental, unresolved issue.

5 s exact role in this process has remained an unresolved issue.

6 nduction into damaged sites has long been an unresolved issue.

7 ays to spatial vision is a long-standing and unresolved issue.

8 ith aortic arch involvement (AAI) remains an unresolved issue.

9 en spacing and size of such structures is an unresolved issue.

10 continents, to elucidate this long-standing unresolved issue.

11 established during development is a largely unresolved issue.

12 nteractions respond to mechanical cues is an unresolved issue.

13 (BCP) method, which addresses some of these unresolved issues.

14 of the normalization model, there are three unresolved issues.

15 broad range of findings and raises important unresolved issues.

16 eck squamous cell carcinoma, and to describe unresolved issues.

17 a unique opportunity to shed light on these unresolved issues.

18 in homeostasis and cancer development remain unresolved issues.

19 g of tree physiology and scaling, indicating unresolved issues.

20 data that throws light on several previously unresolved issues.

21 of these membranes to large-areas remains an unresolved problem.

22 tion of the toxic effects of OTA is still an unresolved problem.

23 ting them from microscopy images in 3D is an unresolved problem.

24 ggested, it remains a challenging and as yet unresolved problem.

25 ents, whose organization in the Z-ring is an unresolved problem.

26 atforms with the potential to face currently unresolved problems.

27 unterclockwise torque at high ATP is a major unresolved question.

28 ction in admixed populations is currently an unresolved question.

29 cessfully attached to the spindle remains an unresolved question.

30 n homothallic fungal species in nature is an unresolved question.

31 chnique in diabetic patients is an important unresolved question.

32 ndent of stress response abnormalities is an unresolved question.

33 tains adipose tissue inflammation remains an unresolved question.

34 is and thereby impact neuronal loss is a key unresolved question.

35 D8 T cell of the same specificity remains an unresolved question.

36 wound signals into regenerative growth is an unresolved question.

37 ry, how memory persists is a fundamental and unresolved question.

38 ction of the fetal primate brain is still an unresolved question.

39 rately through the receptor into cells is an unresolved question.

40 ion of GIP to promote weight loss remains an unresolved question.

41 stem beyond Anderson localization remains an unresolved question.

42 lls inactivate Hippo signaling remains a key unresolved question.

43 ently regulate their locomotion system is an unresolved question.

44 through mitotic cell divisions remains a key unresolved question.

45 estation of such behaviors evolve remains an unresolved question.

46 time of arrival of people in Australia is an unresolved question.

47 t-7 (AR-V7) in prostate cancer biology is an unresolved question.

48 where those have been examined, and outline unresolved questions.

49 his capacity is implemented in the brain are unresolved questions.

50 lective permeability and how this occurs are unresolved questions.

51 hing collaborative working groups to address unresolved questions.

52 work remains to be done, and there are many unresolved questions.

53 behavior and disease, and highlight critical unresolved questions.

54 o optimize transplant for MDS and identifies unresolved questions.

55 understanding of these events and highlight unresolved questions.

56 e required for any normal brain function are unresolved questions.

57 recent mechanistic insights and highlighting unresolved questions.

58 tial advantages but also safety concerns and unresolved questions.

59 ant antioxidative systems gives rise to many unresolved questions.

60 An unresolved issue about many neurodegenerative diseases i

61 y perspectives has contributed to addressing unresolved problems about the role of polyploidy.

62 ugh information to unequivocally answer many unresolved questions about cause and effect of polyploid

63 c studies have the potential to address many unresolved questions about microbial pathogens by facili

64 Unresolved questions about pre-implantation human develo

65 The authors investigated the following three unresolved questions about premorbid cognitive deficits:

66 lly, the report discusses limitations of and unresolved questions about SQUIRE; ancillary supporting

67 Key unresolved questions about the gp120-gp41 interface incl

68 However, there are unresolved questions about the ideal pharmacokinetic cha

69 Our results settle unresolved questions about the lattice dynamics and ther

70 However, these studies have left many unresolved questions about underlying causality and orde

71 erature supporting its use and summarize the unresolved issues affecting broader application of this

72 An unresolved problem affecting the clinical use of PIs is

73 Unresolved issues and directions for future study are pr

74 In the process, we highlight some key unresolved issues and discuss how they might be addresse

75 d post-procedural evaluation and management, unresolved issues and future perspectives.

76 We conclude by articulating unresolved issues and offer a future agenda for the scie

77 We also discuss some of the unresolved issues and potential future directions.

78 We conclude by exploring unresolved questions and future directions for inquiry r

79 We also discuss some key unresolved questions and future prospects.

80 hat animate current scholarship and identify unresolved questions and new opportunities for research.

81 e-molecule studies, highlighting some of the unresolved questions and ongoing debates.

82 nd summarizes subsequent progress, promises, unresolved issues, and challenges of the field.

83 ndings and some of the unanswered questions, unresolved issues, and controversies that remain.

84 Important unresolved issues are addressed, including the mechanism

85 Unresolved issues are also examined to shed light on new

86 A number of unresolved issues are outlined and discussed, including

87 These unresolved issues are risk prediction models to identify

88 Several unresolved questions are discussed in the context of ast

89 we contend that issues including continuing unresolved questions around mechanism; opportunities aff

90 purposes, further progress has been mired by unresolved questions around the definition and the mecha

91 pair, discussing recent findings and raising unresolved questions around this intriguing immune cell.

92 ure, discuss recent progress, and raise some unresolved questions awaiting the field.

93 We also provide our perspective on unresolved issues, both conceptual and technical, that w

94 Here, we addressed these unresolved questions by investigating BBA recorded using

95 Here, we show that these unresolved issues can be explained through analysis of t

96 evels, and to discuss current controversies, unresolved issues, challenges, and future directions.

97 element for energy transduction and a major unresolved question common for all motor proteins is the

98 nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrate

99 A major unresolved question concerning the synthesis of starch i

100 intends to stimulate new studies on the many unresolved questions concerning the chemical ecology of

101 Two unresolved issues could better illuminate the mechanisti

102 the development of socioemotional skills are unresolved issues destined to attract future research.

103 m these field synopses and discuss remaining unresolved issues -- especially in the light of evidence

104 elation to the martensitic phase is still an unresolved issue, even though it is critical to the unde

105 detection of tumorous tissue is an important unresolved issue for cancer surgery.

106 tion of nitroaromatic explosives has been an unresolved issue for over a decade.

107 s alleviated by a hearing device is a major, unresolved issue for rehabilitation.

108 cipitation interactions represent important, unresolved questions for biological and atmospheric scie

109 ADHF patients and identifies challenges and unresolved questions for each approach.

110 face contamination has long been a critical, unresolved issue, given graphene's two-dimensionality.

111 i is the prototype of such pathways, several unresolved issues have accumulated over the years.

112 An unresolved issue in chronic lymphocytic leukemia (CLL) i

113 A key unresolved issue in cuprates is the relationship between

114 e committing resources to reproduction is an unresolved issue in developmental biology.

115 neous natural environments remains a largely unresolved issue in ecology.

116 A central unresolved issue in evolutionary biology is how metaboli

117 herbivore dietary specialization has been an unresolved issue in evolutionary ecology.

118 Poor flow patency is an unresolved issue in grafts, particularly those with diam

119 One unresolved issue in immune tolerance is what prevents se

120 An important unresolved issue in microbial secondary metabolite produ

121 es an enduring yet dynamic memory remains an unresolved issue in studies of memory.

122 lfur clusters as they exist in vivo, a major unresolved issue in studies of Wbl proteins.

123 A major unresolved issue in the cloning of mammals by somatic ce

124 for their expression have long been a major unresolved issue in the field of epigenetics.

125 heparin-induced thrombocytopenia remains an unresolved issue in the ICU leading to the unjustified s

126 's disease (PD) is the single most important unresolved issue in the management of this disorder.

127 ons perturbed by TorsinA[DeltaE] are a major unresolved issue in understanding the pathophysiology of

128 There are many unresolved issues in adults and children with PN depende

129 There are a number of unresolved issues in EoE, including phenotypes, optimal

130 slands' can improve our understanding of two unresolved issues in evolutionary genetics: the likely l

131 erism of ligands and receptors is one of the unresolved issues in structure-based prediction of bindi

132 Unresolved issues in the field are outlined.

133 Key unresolved issues in the field of emotional memory inclu

134 nderstanding of STING and highlight the many unresolved issues in the field.

135 We conclude with a discussion of several unresolved issues in the field.

136 t results and discuss some controversies and unresolved issues in this field.

137 ve rise to functional innovations is a major unresolved problem in biology.

138 clinically relevant fluid volumes remains an unresolved problem in biomedicine and diagnosis.

139 Ischemia/reperfusion injury (IRI) remains unresolved problem in clinical organ transplantation.

140 reakdown in pipe transition is a century-old unresolved problem in fluid mechanics.

141 the genome are inherited-is still mostly an unresolved problem in genomics.

142 ificity during positive selection remains an unresolved problem in immunology.

143 A key unresolved problem in neuroscience is to determine the r

144 his energy conversion occurs remains a major unresolved problem in plasma physics.

145 electron tomography to address long-standing unresolved problems in the physical sciences.

146 One unresolved question in ApoE biology is whether ApoE is n

147 their characteristic shape is a fundamental unresolved question in biology.

148 a million-fold excess of undamaged DNA is an unresolved question in biology.

149 size with growth and development is a major, unresolved question in cell biology.

150 ans reach their final shape is a central yet unresolved question in developmental biology.

151 A central and largely unresolved question in drug discovery, which is especial

152 An unresolved question in ecology concerns why the ecologic

153 y species is maintained is a fundamental and unresolved question in ecology.

154 The root of the eukaryotic tree is a major unresolved question in evolutionary biology.

155 es into biochemical signals is a crucial yet unresolved question in mechanobiology.

156 However, an unresolved question in molecular evolution is how often

157 An unresolved question in neuroscience relates to the exten

158 An unresolved question in our understanding of the medial t

159 tinct brain regions still are a fundamental, unresolved question in prion research.

160 An important unresolved question in skeletal muscle plasticity is whe

161 One major unresolved question in the field of pancreas biology is

162 tion, measured in single cells, to answer an unresolved question in the field-whether receptor endocy

163 lomorpha in the tree of life remains a major unresolved question in the study of deep animal relation

164 A major unresolved question in understanding visually guided loc

165 An unresolved question in vasculogenesis is how mammalian e

166 continued promise for unlocking many of the unresolved questions in evolutionary biology and biogeog

167 Finally, we review unresolved questions in gene regulation as it pertains t

168 ch it causes Ca(2+) entry remain fundamental unresolved questions in human reproduction.

169 One of the major unresolved questions in influenza A virus (IAV) ecology

170 RT is demonstrated for shedding new light on unresolved questions in intracellular transport.

171 We also put forward two major unresolved questions in the field and propose future ave

172 One of the unresolved questions in the field of cell division is ho

173 th increasing risk, this study addressed two unresolved questions in the field of decision-making: Fi

174 as regulators of cardiac form and function, unresolved questions in the field, and issues for the fu

175 ar protein quality control, and identify the unresolved questions in the field.

176 ecades of research and formulate the central unresolved questions in the field.

177 tiple surprises, seeming contradictions, and unresolved questions in the long-term record of ecosyste

178 e also discuss future aspirations to address unresolved questions in this exciting area of research.

179 Unresolved issues include optimal patient selection crit

180 Unresolved issues include psychology's neglect of levels

181 However, unresolved issues include the astonishing complexity of

182 The many unresolved issues include the role of the amino-terminal

183 Unresolved issues include to what degree, when, and how

184 Crucial unresolved questions include the expression of multiple

185 An unresolved issue is how ASMase residing within lysosomes

186 One unresolved issue is how infection or vaccination with se

187 A key unresolved issue is how ions gain access to the pore, be

188 An important and unresolved issue is how T cells discriminate between pot

189 A central unresolved issue is how the Cdc45-MCM-GINS helicase is l

190 A key unresolved issue is how the highly complex adaptor-clath

191 However, a major unresolved issue is how the individual component traits

192 A major unresolved issue is how these different populations of T

193 A major unresolved issue is how transcription factors find their

194 One unresolved issue is the duration and significance of the

195 An important unresolved issue is the extent to which incompatibility

196 A major unresolved issue is the role of Cdc20 autoubiquitination

197 The most important unresolved issue is understanding the evolutionary cause

198 A key unresolved issue is whether astrocyte [Ca(2+)](i) elevat

199 An unresolved issue is whether power-law scaling on differe

200 An important but unresolved issue is why this occurs.

201 ted with activities of neuronal networks, an unresolved problem is how the brain assembles these acti

202 An interesting unresolved question is how additional copies of FliM mig

203 A major unresolved question is how bacteria living in complex co

204 An important but unresolved question is how direction selectivity is impl

205 An outstanding unresolved question is how does the mitotic spindle util

206 An important unresolved question is how four different EBNAs (EBNA2,

207 An unresolved question is how HIV-1 achieves efficient repl

208 A central unresolved question is how its many substrates bind and

209 An unresolved question is how neural systems for reinforcem

210 A fundamental and still largely unresolved question is how neurons achieve rapid deliver

211 An important and unresolved question is how orientation tuning emerges du

212 An important unresolved question is how populations of coldwater-depe

213 One unresolved question is how RLRs interact with each other

214 of intense interest in neuroscience, but an unresolved question is how sensory information from hear

215 An open and unresolved question is how STRF maturation affects stimu

216 An unresolved question is how the brain allocates attention

217 An unresolved question is how the brain solves this binding

218 A major, unresolved question is how the disruption of specific ac

219 An important and unresolved question is how the human brain processes spe

220 A significant unresolved question is how vitamin A deprivation causes,

221 A major unresolved question is the extent of functional specific

222 An unresolved question is the involvement of chromatin mark

223 A major unresolved question is the mechanism in which the intera

224 One unresolved question is the origin of the tight correlati

225 An unresolved question is to what extent such age-related a

226 A key unresolved question is understanding which physiological

227 An unresolved question is whether clamp loaders capture cla

228 An unresolved question is whether each SV protein is sorted

229 An unresolved question is whether En plays intrinsic roles

230 A critical unresolved question is whether generation of protrusions

231 Moreover, an important but unresolved question is whether hippocampal mismatch sign

232 An unresolved question is whether NK1.1(+) CD8(+) cells are

233 An unresolved question is whether PKA is sufficient to init

234 Another unresolved question is whether predictive processes are

235 A fundamental unresolved question is whether terminally differentiated

236 However, one major unresolved question is whether the neonatal mouse heart

237 A hitherto unresolved question is whether the structure of the land

238 The major unresolved question is why some cell lines fail to restr

239 Among the many unresolved questions is the difference between GR regula

240 One of the major unresolved questions is the location, morphology, and ne

241 e results hold the promise of answering many unresolved questions linking structural diversity of vir

242 er or not bacterial species exist remains an unresolved issue of paramount theoretical as well as pra

243 offer significant advantages for addressing unresolved issues of neuronal development.

244 A central, unresolved problem of DNA microarray technology is the i

245 sh by discussing current models to the still unresolved question of how piRNA precursors are selected

246 pproach to gain insight into the fundamental unresolved question of what makes the Tm coiled coil an

247 ts provide a positive answer to the hitherto unresolved question of whether neurodegeneration (e.g.,

248 cell hypothesis has the potential to explain unresolved questions of tumorigenesis, tumor heterogenei

249 ific deletion of SCL and CXCL12, we focus on unresolved issues on HSC niches, framed around some very

250 With regard to earlier unresolved issues on the macaque evolution, the topology

251 gene-targeted mice can be used to elucidate unresolved questions on the occurrence, distribution and

252 to the interchain hopping energy remains an unresolved issue, one that is central to many organic an

253 To discuss unresolved issues pertaining to aetiology and diagnosis

254 till unknown, in this study we address other unresolved questions pertaining to the molecular mechani

255 affects microvascular obstruction in SCD, an unresolved issue pivotal to understanding its clinical e

256 The last section summarizes some critical unresolved issues, possible challenges/obstacles and als

257 nd mesenteric vein thrombosis, but there are unresolved issues regarding monitoring with both the ant

258 One of the key unresolved issues regarding proton pumping in cytochrome

259 Here, we address the unresolved question regarding a possible zebrafish homol

260 A central, yet unresolved question regarding the function of integrins

261 There are unresolved questions regarding the association between p

262 Unresolved questions regarding the mechanism of ER-phagy

263 Key unresolved questions regarding the role of aspirin in pr

264 in this field and discuss several important, unresolved questions regarding the roles and mechanisms

265 That uncertainty relates to unresolved questions regarding the supramolecular nature

266 conclude by exploring overarching themes and unresolved questions regarding unconventional interactio

267 will be placed in the context of previously unresolved issues related to BDNF biology, as well as ho

268 Three unresolved issues related to cortical activity in subjec

269 ned studies are necessary to address several unresolved issues related to PFO stroke and PFO migraine

270 However, unresolved issues related to the spatial, spectral, and

271 We will also highlight unresolved questions related to B cell activation and to

272 a timely and invaluable resource to explore unresolved questions related to stem/progenitor origin o

273 important insights and highlight significant unresolved questions related to ZIKV and other emerging

274 A critical unresolved question relates to how these gradients can b

275 A major unresolved issue relating to internal climate dynamics i

276 Allergens induce type-2 immunity, but unresolved questions remain about initiation of this res

277 Important unresolved questions remain in these areas, promising ex

278 (E1) is known to interact with SOST, several unresolved questions remain, such as the reason why SOST

279 Moreover, some of the unresolved issues revolving around the suboptimal positi

280 stent embodied energy calculation, there are unresolved issues, such as an overdependence on price da

281 An unresolved issue surrounding self-antigens as immunother

282 There are a number of unresolved issues surrounding this illness, which are th

283 briefly review the evidence and some of the unresolved questions surrounding a causative role for ac

284 The traceability of olive oil is an unresolved issue that remains a challenge.

285 Here, we define the previously unresolved issues that are now better understood for the

286 controls pluripotent identity and highlight unresolved issues that arise from these studies.

287 igin-free (CD-AOF) media and supplements are unresolved issues that hamper the clinical applicability

288 in the immune system, as well as some of the unresolved issues that remain on the road to eventually

289 We conclude by presenting some unresolved problems that require the attention of biophy

290 tal unit in visual search, we point out some unresolved problems that their account will have to solv

291 n polyamide binding in live cells remains an unresolved question that impedes their deployment in viv

292 work on APS has revolved around a series of unresolved questions: the actual incidence of conversion

293 Here we addressed these unresolved issues using simultaneous recordings from mul

294 on current understanding and a discussion of unresolved issues, we propose a molecular model for init

295 orm of the dimer remains a controversial and unresolved question, we addressed this matter by enginee

296 However, it remains an unresolved issue whether beat-to-beat alternations in in

297 However, it remained an unresolved issue whether differences in Aux/IAA turnover

298 rrent sensor technologies still exhibit some unresolved issues which hampers their direct application

299 To address unresolved issues with respect to the evolutionary relat

300 s here on work that strives to address these unresolved questions, with emphasis on fate mapping and