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1 mbryo fibroblasts (MEFs), CRT null MEFs were unresponsive.
2 limitation and most tumors eventually become unresponsive.
3 e mice with CSP, and uPA-deficient mice were unresponsive.
4 ons to be visually responsive, and 42% to be unresponsive.
5 espectively), whereas GABAAR-null cells were unresponsive.
6 ise-based muscle rehabilitation programs are unresponsive.
7 mals dosed intranasally with LENK alone were unresponsive.
8 -CREB signaling, whereas the rat ortholog is unresponsive.
9 onded to a target stimulus until they became unresponsive.
10 e number of patients and cancer types remain unresponsive.
11 reas other, more advanced cases often remain unresponsive.
12 dependent on PD-1/PD-L1 signaling to remain unresponsive.
13 ed from the MSG-treated rats were completely unresponsive.
14 replication, human beta-cells are completely unresponsive.
17 5/8 signaling in C2C12 cells expressing BMP9-unresponsive ALK1 HHT mutants and in HHT patient blood o
18 ng comparing responsive and connected versus unresponsive and disconnected states of consciousness du
19 CD4(+)YFP(+)GFP(+) T cell-derived cells were unresponsive and failed to proliferate during the early
21 esponses significantly discriminated between unresponsive and minimally conscious states at the group
23 ia due to iron deficiency compared with iron-unresponsive anemia due to impaired iron absorption/redi
26 The changes observed are consistent with an unresponsive, anergy-like T cell phenotype of latently H
30 eptor (PPAR)-gamma, while rendered generally unresponsive by a non-permissive dimer partner, thyroid
31 robust connectivity in patients diagnosed as unresponsive by clinical consensus, but later rediagnose
33 ntact littermates, suggesting that the T1IFN-unresponsive cardiomyocytes may act as a safe haven for
35 Increasing alertness did not cause visually unresponsive CG neurons to become responsive and did not
37 ominant mutations in ABCC8 causing medically unresponsive CHI have been reported; however, the molecu
45 works at baseline were more likely to become unresponsive during sedation, despite registering simila
47 rity of these CD8 T cells remained IFN-gamma unresponsive even after TCR-dependent polyclonal stimula
49 cancers, but a multitude of patients remain unresponsive for various reasons, including poor homing
53 day of admission, the patient became acutely unresponsive, her condition deteriorated rapidly, and sh
54 tically, CD38 PRIT may benefit patients with unresponsive, high-risk disease because refractory disea
55 ons, mTregs were nonmigratory and relatively unresponsive; however, in inflamed skin from psoriasis p
56 lation results in NEAT1 becoming chronically unresponsive in independent in vivo rat model systems re
57 ted analysis revealed three layers that were unresponsive in quiescent flies but became responsive to
58 (EGFR/ERBB1) as a mediator of corticosteroid-unresponsive inflammation and bronchial hyperresponsiven
59 that FAK inhibition rendered the previously unresponsive KPC mouse model responsive to T cell immuno
60 cal protocol for Stage-IV PDAC suggests that unresponsive lesions may be growth-restrained when expos
63 alpha expression sensitized an intrinsically unresponsive MLL-rearranged leukemia cell to CCI-006, in
66 In comparison to the sensitive cells, the unresponsive MLL-rearranged leukemia cells were characte
67 Furthermore, silencing of CXCL12 in TGFbeta-unresponsive MSCs restored their ability to promote tumo
68 Testing the model predictions using a sugar-unresponsive mutant of Arabidopsis demonstrated that the
74 ed patients aged 18 years or older, with BCG-unresponsive non-muscle-invasive bladder cancer and an E
75 patients did not meet the definition of BCG-unresponsive non-muscle-invasive bladder cancer and were
80 patient, to determine whether the patient is unresponsive or perhaps minimally conscious(1), and to p
81 rm recoveries, the area 3b hand neurons were unresponsive or responded weakly to touch on the hand, w
82 ecoveries, the area 3b hand neurons remained unresponsive, or responded to touch on the hand or somat
84 e combination of autonomic failure, levodopa-unresponsive parkinsonism, cerebellar ataxia and pyramid
85 Notably, at the single-patient level, if an unresponsive patient had a sniff response, this assured
87 ediated major responses in 9 of 11 cidofovir-unresponsive patients and resulted in complete responses
89 sed indices of consciousness in behaviorally unresponsive patients represents a challenge due to the
91 e, independently validated stratification of unresponsive patients that has important physiopathologi
95 n (BCG) has failed, the type of failure (BCG unresponsive, refractory, relapsing, or intolerant) shou
100 in patients, ranging from those diagnosed as unresponsive, through those who have emerged from minima
101 reserved brain networks in patients who seem unresponsive, thus raising hope for more accurate diagno
102 loss of the tumor suppressor Pten is mainly unresponsive to a high-fat diet (HFD), but that coordina
103 re applied to achieve rapid recovery from an unresponsive to a responsive state, followed by immediat
104 teady-state stomatal conductance (g(s) ) was unresponsive to ABA in some studies, supporting this mod
106 ndent on longer-term photoperiod cues and is unresponsive to acute, short-term food availability.
110 patients had high-risk cytogenetics, 17 were unresponsive to all previous treatments, and 32 were rec
112 BOK appears to be constitutively active and unresponsive to antagonistic effects of the antiapoptoti
114 demonstrates that a case of prolonged fever unresponsive to antibiotics and related to cholestatic j
115 le population with major depressive disorder unresponsive to antidepressant treatment, augmentation w
116 However, a third of anxiety patients remain unresponsive to anxiolytics highlighting the need for mo
117 rs who were diagnosed with nonpsychotic MDD, unresponsive to at least 1 antidepressant course meeting
118 f cats, the anterior auditory field (AAF) is unresponsive to auditory stimuli but can be activated by
120 dren presenting with status epilepticus were unresponsive to benzodiazepine treatment, and critically
121 that, unlike BRAF fusions, CRAF fusions are unresponsive to both generations of RAFi, vemurafenib an
122 tiviral short hairpin RNA rendered the cells unresponsive to C5a-induced adhesion, chemotaxis, and me
129 marmoset monkeys, we discovered that neurons unresponsive to CI stimulation were sharply tuned to fre
133 andomized 30 patients with chronic knee pain unresponsive to conservative treatments and showing radi
134 diagnosed with lumbar disk degeneration and unresponsive to conservative treatments into 2 groups.
135 oy with advanced anomalous lymphatic disease unresponsive to conventional sirolimus therapy and in an
137 acular fluid without fluorescein leakage and unresponsive to conventional treatment may suggest an un
141 However, these late embryonic B cells were unresponsive to CXCL13 (although responsive to CXCL12) a
142 These anti-inflammatory macrophages are unresponsive to dendritic cell induction factors, effect
143 From July 2012 to November 2013, 10 patients unresponsive to DES with IVIg + Rituximab were treated w
144 n studied in 10 patients, who were medically unresponsive to diazoxide (DZX), and nine of whom requir
145 ent of hyperinsulinemic hypoglycemia that is unresponsive to diazoxide is subtotal pancreatectomy.
146 a gut microbial community structure that is unresponsive to dietary changes, studies manipulating di
147 assays, FAs in arrestin-deficient cells were unresponsive to disassociation or regrowth of microtubul
148 d low surface expression of ULBP2/5 and were unresponsive to DMF treatment, suggesting that the fumar
150 s also critical to adapt therapy in patients unresponsive to empiric treatment options, which occurs
151 s and render KRAS-mutated colorectal cancers unresponsive to epidermal growth factor receptor (EGFR)
152 s poorly understood, and 30% of patients are unresponsive to established treatments targeting tumor n
155 ied Irr-regulated genes that were relatively unresponsive to factors that promote Irr degradation.
157 blocked IL-2 secretion, and rendered T cells unresponsive to further downstream differentiation signa
158 n Miscanthus support that g(m) and g(bs) are unresponsive to growth temperature and that the CCM is a
159 -sensitive transcriptional regulation, being unresponsive to heme itself, and even down regulated whe
160 derate-to-severe CSU symptoms and angioedema unresponsive to high doses of antihistamine treatment.
162 improved viral oncolytics.IMPORTANCE TNBC is unresponsive to hormone therapies, leaving patients affl
168 rrested at an early pro-B-like stage that is unresponsive to IL-7 receptor signaling and unable to ef
170 gan transplant recipients, with CD20(+) PTLD unresponsive to immunosuppression reduction, were treate
175 d and VIP, V6 neurons are almost universally unresponsive to inertial motion in the absence of optic
176 ronchial, and allergic inflammation that was unresponsive to inhaled corticosteroids, but responsive
177 ation and continued chronic therapy in those unresponsive to initial empiric therapy is discouraged.
178 ent with refractory ventricular fibrillation unresponsive to initial standard advanced cardiac life s
188 7 +/- 9.9 mm Hg, and upper body hypertension unresponsive to medical treatment was present in all pat
189 with a long history of illness, or in those unresponsive to medical treatments, while are only anecd
190 for a medical visit about a persistent cough unresponsive to medication) are related to other self-ma
193 elated to the Arabidopsis CEP Receptor1, are unresponsive to MtCEP1 effects on lateral root and nodul
198 nonimmortalized) human urothelial cells were unresponsive to NMDAR agonists or antagonists, and no ex
200 nical presentation of chronic conjunctivitis unresponsive to normal treatment was noted within a Prim
206 t production of gonococcal TdfH and TdfJ are unresponsive to or upregulated under iron-replete condit
207 ted with severe ocular and cutaneous rosacea unresponsive to oral doxycycline, oral isotretinoin, and
208 -deficiency anemia who were intolerant of or unresponsive to oral iron, iron isomaltoside (now called
210 hese lesions can become locally invasive and unresponsive to pharmacologic intervention, leading to s
211 Sometimes, these behaviors are extreme and unresponsive to pharmacological and behavioral therapies
213 c for bilateral wrist and knee pain that was unresponsive to physiotherapy and intra-articular steroi
219 deetiolated bak1-3 and bak1-4 seedlings were unresponsive to PSK, and bak1-3 and bak1-4 protoplasts e
225 injury from a variety of causes and who were unresponsive to spoken commands, including some patients
227 tients with progressive infectious keratitis unresponsive to standard medical therapy underwent RB-PD
229 be among high-risk patients intolerant of or unresponsive to statins; however, this strategy should b
231 ndritic cells from P2X7R-deficient mice were unresponsive to stimulation with tumor cells, and chemot
233 Helminths did not control GVHD when T cells unresponsive to TGF-beta-mediated immune regulation were
235 f this helix showed that the F148A mutant is unresponsive to the compound, providing further evidence
239 e secondary mutations render EGFR completely unresponsive to the inhibitors, but contrary to this, we
242 lly manifested by cardiovascular instability unresponsive to the usual doses of inotropes or vasopres
246 2'-O-methyl-5'-AMP to select cells that were unresponsive to these signals and hence remained prolife
248 rticosteroids; however, many patients become unresponsive to this treatment over time, and there is n
250 er beginning therapy, whereas clonal B cells unresponsive to TLR9 stimulation persist for at least 24
255 ely treat the 30-50% of MDD patients who are unresponsive to traditional antidepressant medications.
256 TCC tumors are generally inoperable and unresponsive to traditional chemotherapy, indicating a n
257 cancer (TNBC) is a subtype of breast cancer unresponsive to traditional receptor-targeted treatments
258 m and platelet-derived growth factor BB, and unresponsive to transforming growth factor beta, a promi
259 nction mutations in THPO cause BMF, which is unresponsive to transplant due to a hematopoietic cell-e
264 we show that murine ex vivo splenic DCs are unresponsive to TSLP, as they fail to phosphorylate STAT
265 In contrast, electron-boson coupling is unresponsive to ultrafast excitations above the critical
267 nts with primary biliary cholangitis who are unresponsive to ursodeoxycholic acid; however, approxima
268 ne expression signatures for individual bees unresponsive to various salient social stimuli are signi
270 s versus 48+/-19 years; P<0.0001), were more unresponsive to vasodilator challenge (0/7 versus 140/10
271 Scale [RASS], on which scores range from -5 [unresponsive] to +4 [combative]) (sedation group) with d
272 and Sedation Scale (which is scored from -5 [unresponsive] to +4 [combative]) was -2 to +1 (lightly s
274 t, IL-17 is consistently upregulated in TLR5-unresponsive tumor-bearing mice but only accelerates mal
275 ingly, it is used during therapy to identify unresponsive tumors and predict pTR, using avidity of th
278 ptor tyrosine kinase is overexpressed in the unresponsive tumours, and Axl knockout resulted in slowe
280 uracil, consistent with the expression of an unresponsive variant of its cognate receptor, TAS2R38, i
282 Intriguingly, some patients in behaviourally unresponsive vegetative states who demonstrated evidence
283 nd allowed the identification of a number of unresponsive VS patients (9 of 43) with high values of P
284 for informing diagnosis and prognosis in the unresponsive wakeful syndrome and minimally conscious st
285 19 consecutive patients: 72 vegetative state/unresponsive wakefulness state (VS/UWS), 36 minimally-co
286 the minimally conscious state (MCS) and the unresponsive wakefulness syndrome (UWS) is a persistent
287 on between vegetative state (VS)-also coined unresponsive wakefulness syndrome (UWS)-and minimally co
288 consciousness (DoC) such as vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally
289 A cohort of 127 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS; n = 70) and m
291 conscious state compared to vegetative state/unresponsive wakefulness syndrome encompassed bilateral
292 tients diagnosed to be vigilant but unaware (Unresponsive Wakefulness Syndrome) and 17 patients revea
293 imally conscious state, one vegetative state/unresponsive wakefulness syndrome, one emerged from mini
294 nimally conscious state, 19 vegetative state/unresponsive wakefulness syndrome, six coma; 15 females;
295 quired from 18 patients (11 vegetative state/unresponsive wakefulness syndrome, VS/UWS, and 7 minimal
298 mally conscious state, five vegetative state/unresponsive wakefulness syndrome; New York: five minima
299 Over time, the patient became completely unresponsive with no further abnormal movements and ulti
300 A new study shows that subjects rendered unresponsive with sedatives do not exhibit a stereotypic