ライフサイエンスコーパス: unrestrained

1 of intermediate neural progenitors (INPs) is unrestrained.

2 mice that are conscious, unanesthetized, and unrestrained.

3 all trial-to-trial variability despite being unrestrained.

4 and the rest of the ensemble are essentially unrestrained.

5 es in the AV3V and were tested conscious and unrestrained.

6 efore proinflammatory effects of mCRP remain unrestrained.

7 lick during the first day after a permitted, unrestrained 4.3 m(3) oil release conducted on the North

8 The unrestrained accumulation of Tfh cells in the absence of

9 important regulators of the cell cycle, and unrestrained activation of E2F-dependent transcription i

10 pivotal oncogenic mechanism responsible for unrestrained activation of ERK and AKT pathways in human

11 on Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcripti

12 Unrestrained activation of oncogenic kinases together wi

13 rapid repair at primary nuclei while causing unrestrained activity at ruptured micronuclei, with cata

14 The resulting unrestrained activity of Ang II in brainstem regions neg

15 ody response to an organ transplant--despite unrestrained acute T cell-mediated allograft rejection.

16 and factor-cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers

17 r lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the l

18 resents a vicious feedback loop that elicits unrestrained AKT signaling.

19 IP2 SAM-SAM domain heterodimer complex using unrestrained all-atom molecular-dynamics simulations.

20 rm of insulin degrading enzyme (IDE) through unrestrained, all-atom MD simulations have been investig

21 We report unrestrained, all-atom molecular dynamics simulations of

22 brain imaging with cellular resolution in an unrestrained and behaving animal.

23 Conversely, radiotelemetry systems allow unrestrained and continuous monitoring of blood pressure

24 er, when examining difference scores between unrestrained and restrained conditions, knockout mice ex

25 Ninety-five participants (unrestrained and restrained males and females) were test

26 nd GABA in rats under two conditions: awake, unrestrained and under chloral hydrate anesthesia.

27 terminal G.A pair; instead, G1 appears quite unrestrained, and A16 stacks on both C15 and G2.

28 10 transgenic mice, parasite replication was unrestrained, and except for antimony responsiveness, me

29 Their heads were unrestrained, and head position was tracked.

30 ied after overnight food deprivation, awake, unrestrained, and unstressed; all ICV infusion of L-NMMA

31 days and measured ventilation in conscious, unrestrained animals before and after microinjecting glu

32 il now, no technology compatible with use in unrestrained animals has combined high spatiotemporal re

33 nimals but was much less effective in awake, unrestrained animals in terms of both the number of sens

34 odulating the activity of defined neurons in unrestrained animals is a powerful approach in investiga

35 recordings of neuronal activity in awake and unrestrained animals is needed to provide new insights i

36 Neural imaging in unrestrained animals shows that URX and RMG encode O2 co

37 togenetic stimulation of neural functions in unrestrained animals.

38 a seizure on unanesthetized freely behaving unrestrained animals.

39 tification of these cells in unanesthetized, unrestrained animals.

40 latency of response to a thermal stimulus in unrestrained animals.

41 have not been adequately explored in awake, unrestrained animals.

42 through active sampling movements with their unrestrained antennae.

43 simple forms of learning was carried out in unrestrained Aplysia in which the amplitude as well as t

44 loss of insulin response is associated with unrestrained apoC-III production and impaired triglyceri

45 Arg3.50(139) ionic bond would break, and the unrestrained Arg would be prevented from orienting itsel

46 Here we describe a simple, unrestrained associative place-conditioning paradigm.

47 Using unrestrained atomistic molecular dynamics simulations, w

48 This resulted in unrestrained autophagy in cardiomyocytes, which contribu

49 In unrestrained awake rats, unilateral injection of the glu

50 inant IFNgamma was sufficient to reverse the unrestrained bacterial growth and ultimately the lethal

51 In an unrestrained balance task in cats, we demonstrate that a

52 d to induce growth cone steering, but not at unrestrained bead binding sites.

53 Unrestrained bead propulsion matched or exceeded rates o

54 bjects are scanned awake and their heads are unrestrained, because the NHPs move their heads faster a

55 developed methods for chronic recordings in unrestrained, behaving bats reveal two consistent bouts

56 nstrumental to monitor neural signals during unrestrained behavior and their open-source versions hav

57 However, the problem of understanding unrestrained behavior in the context of neural recording

58 velop and leverage measures of naturalistic, unrestrained behavior, which will enable us to more effe

59 y and smoothly released for recording during unrestrained behavior.

60 activity of small subsets of neurons during unrestrained behavior.

61 o multi-region circuit investigations during unrestrained behavior.

62 l of pRb from the beta-cell should result in unrestrained beta-cell replication, increased beta-cell

63 pression, tethers formed from undulations of unrestrained bilayer area.

64 responses to the same stimulus in the awake, unrestrained bird.

65 xBakBid triple-knockout [TKO] mice) leads to unrestrained bone marrow necroptosis driven by increased

66 This report shows that wild, unrestrained bottlenose dolphins use their learned whist

67 a tight control of LytB activity to prevent unrestrained breakdown of the cell wall.

68 s exhibit high rates of proteolysis that are unrestrained by physiologic increases in insulin, intrav

69 diminish potentially deleterious effects of unrestrained calcineurin activity in cardiac and skeleta

70 estraints are lower than models generated in unrestrained calculations and (ii) the low-energy struct

71 or genome integrity and cell survival but if unrestrained can result in undesired chromosomal rearran

72 "motor" compartment of the RE in the awake, unrestrained cat during simple locomotion on a flat surf

73 ent in both pRb and p130, beta-cells undergo unrestrained cell cycle reentry and activation of apopto

74 te activation of Shh target genes results in unrestrained cell division and eventually medulloblastom

75 enhancing cell growth to levels required for unrestrained cell division.

76 driven by oncogenic lesions that facilitate unrestrained cell expansion and resistance to antiprolif

77 tiating cells (CICs) are responsible for the unrestrained cell growth and chemoresistance of malignan

78 feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking

79 Zinc deficiency alone induced unrestrained cellular proliferation in the esophagus and

80 clin/Cdk function, loss of p27 may result in unrestrained cellular proliferation.

81 ical measures can be obtained for physically unrestrained cetaceans.

82 nto the rat lateral cerebral ventricle under unrestrained condition.

83 e (GLU), and dopamine (DA) in rats in awake, unrestrained conditions and during chloral hydrate anest

84 s were tested under head-restrained and head-unrestrained conditions.

85 st and after pharmacological manipulation in unrestrained conscious mice using electrocardiogram (ECG

86 major determinant of nuclear shape and that unrestrained contractility causes nuclear dysmorphia, nu

87 ransmitters in spinal dialysates from awake, unrestrained control and diabetic rats under resting con

88 evalent forms of the disease is complex, but unrestrained de-novo lipogenesis driven by hyperinsulina

89 rway basal stem cells are lost through their unrestrained differentiation, resulting in the simplific

90 This leads to unrestrained DNA excision by Exo1, which causes increase

91 Unrestrained DNA supercoiling and the number of topologi

92 enuated BRCA1-A functions at DSBs and led to unrestrained DSB end resection and hyperactive DNA repai

93 Because unrestrained E2F activity in the absence of Rb function

94 was not significantly different from 100% in unrestrained eaters (99 +/- 6.8%) but was lower in restr

95 +/- SEM) and weighing 63.8 +/- 1.7 kg and 34 unrestrained eaters aged 59.4 +/- 0.6 y and weighing 64.

96 ence in 100 x rEI:TEE between restrained and unrestrained eaters by any of the dietary assessment met

97 d 18-60 y, with BMI 20.0-30.0 kg/m2 who were unrestrained eaters participated in a double-blind, rand

98 a second study consisting of restrained and unrestrained eaters.

99 an antagonizes blockade of CTLA-4, promoting unrestrained effector function and proliferation, and an

100 known, hampering our capacity to control its unrestrained effects.

101 This, in turn, may contribute to unrestrained epithelial cell proliferation and carcinoge

102 This causes unrestrained ESCRT-III accumulation, which drives extens

103 ccRCC cells, JARID1C inactivation led to the unrestrained expression of heterochromatic noncoding RNA

104 to TLR activation and produce TNFalpha in an unrestrained fashion.

105 s this inactivation mechanism and results in unrestrained FGFR1 ubiquitylation in cells.

106 acute infarct size but were associated with unrestrained fibroblast proliferation, impaired scar rem

107 ectious pathogens, chronic inflammation, and unrestrained fibroproliferation are likely to be part of

108 tations affecting fork reversal also induced unrestrained fork progression and chromosomal breakage,

109 to analyze the muscle patterns of intact and unrestrained frogs during kicking, a natural defensive b

110 and 0.5 degrees for bond angles based on an unrestrained full-matrix least-squares refinement.

111 Twenty-five 10 ns unrestrained fully solvated molecular dynamics simulatio

112 stimate the coupling term as a biophysically unrestrained function of the presynaptic inter-spike int

113 d or acquired ADAMTS13 deficiency allows the unrestrained growth of microthrombi that are composed of

114 al problems with mixed cultures on scale are unrestrained growth of one bacterium, which leads to sub

115 The unrestrained growth of tumor cells is generally attribut

116 rates detrimental long-term consequences for unrestrained growth.

117 perinsulinemia and insulin resistance due to unrestrained hepatic gluconeogenesis, without alteration

118 etion, their lymphadenopathy may result from unrestrained homeostatic proliferation.

119 ctivity must be tightly regulated in vivo as unrestrained HR can cause genomic instability.

120 e state, with membrane-anchored farnesyl and unrestrained HVR, the catalytic domain fluctuates reinle

121 -17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopa

122 kines, is essential to prevent initiation of unrestrained immune activation.

123 s IDO-dependent mechanism to limit otherwise unrestrained immune responses, inhibition of this counte

124 basalis, and infection by Listeria remained unrestrained in its absence.

125 Thereafter, infection was unrestrained in mice lacking iNOS but was fully controll

126 in the United States involve a child riding unrestrained in the same vehicle with a drinking driver.

127 the spread of new technologies is relatively unrestrained in the United States, many of these technol

128 teraction with like types, whereas it is the unrestrained individuals that must face the negative lon

129 ion of BACH2 and its phosphorylation enabled unrestrained induction of TCR-driven effector programs.

130 as mediating pathways that lead to further, unrestrained inflammation and depression.

131 mmatory phenotype, establishing a pattern of unrestrained inflammation associated with nonhealing wou

132 rotecting tissues from injury and infection, unrestrained inflammation can cause chronic inflammatory

133 However, brains from ASC(-/-) mice displayed unrestrained inflammation, including elevated levels of

134 erminate immune responses as a check against unrestrained inflammation.

135 This unrestrained inflammatory response may cause tissue dama

136 ematopoietic phenotypes seem to be driven by unrestrained inflammatory signaling that leads to the ex

137 cyclitolic ceramide analog designed to avoid unrestrained iNKT cell activation.

138 ystal conformation exhibits low conductance; unrestrained it increases the channel radius upon applic

139 When inactive, unrestrained kinesin movement generates flows that wash

140 Unrestrained Kit signalling leads to the transformation

141 Unrestrained KO mice exhibited significantly lower c-Fos

142 long-term 2-photon intravital microscopy of unrestrained large arteries in live CX3CR1-GFP (green fl

143 or clinical decay, chronic stabilization, or unrestrained lethal growth of the pathogen; the response

144 red adipose tissue insulin action results in unrestrained lipolysis and lipotoxicity, which are hallm

145 amic insulin action, which may contribute to unrestrained lipolysis seen in human obesity and type 2

146 n contrast, systemic disease, in the form of unrestrained lymphoproliferation, continued unabated.

147 ithout lipid/heparin were performed in alert unrestrained male rats.

148 Here, we show that in conscious, unrestrained male Sprague Dawley rats the infusion of in

149 ay be driving a speciation event, by a live, unrestrained male.

150 Arg80 and that loss of HAI-2 in IECs led to unrestrained matriptase activity and efficient cleavage

151 Unrestrained MD calculations indicate that DAOTA-M2 disp

152 a modern force field, we performed a 200 mus unrestrained MD simulation of the acid-unfolded state of

153 ocking these structures to B-DNA followed by unrestrained MD simulations led to a stable complex in w

154 Unrestrained MD simulations suggest that the conversion

155 but that it is not yet reasonable to expect unrestrained MD simulations to do the same.

156 Dynamics in unrestrained MD trajectories were in poor agreement with

157 valuated luciferase bioimaging in conscious, unrestrained mice after neonatal intracranial or intrava

158 ) and heart rate were measured in conscious, unrestrained mice after they were instrumented with intr

159 We monitored breathing patterns of unrestrained mice during wake-sleep states and while alt

160 ) injection of human REN (hREN) in conscious unrestrained mice elicited a pressor response, which was

161 weights to lightly anesthetized, completely unrestrained mice established a paradigm that simulates

162 imate-like selective attention rigorously in unrestrained mice opens a rich avenue for research into

163 sleep, we use deep-brain calcium imaging in unrestrained mice to map the activity of hypothalamic me

164 mps were performed on 5-h-fasted, conscious, unrestrained mice using an arterial catheter for samplin

165 dings from cerebellum and cerebral cortex in unrestrained mice, demonstrate its optogenetic stimulati

166 eely controllable virtual reality system for unrestrained mice.

167 ctroacupuncture in conscious, freely moving, unrestrained mice.

168 mechanism at atomic resolution, revealed by unrestrained microsecond equilibrium molecular dynamics

169 We validated the unrestrained Mitf expression downstream of p38 in Fanca-

170 Taken together, our data demonstrate that unrestrained MK growth and proliferation results in rapi

171 tensive NMR data set and performed the first unrestrained molecular dynamics (MD) simulation in water

172 and-protein complex we report 10 ns of fully unrestrained molecular dynamics (MD) simulations with ex

173 Unrestrained molecular dynamics calculations showed that

174 a closed-pore conformation that results from unrestrained molecular dynamics equilibration of the str

175 With a total of more than 43 mus of unrestrained molecular dynamics simulation, this study i

176 Extensive unrestrained molecular dynamics simulations (accumulativ

177 The model was refined in light of unrestrained molecular dynamics simulations conducted in

178 We performed unrestrained molecular dynamics simulations for several

179 eport on the results of five independent and unrestrained molecular dynamics simulations of an RNA te

180 e carried out molecular modeling and 1.25 ns unrestrained molecular dynamics simulations of the adduc

181 Unrestrained molecular dynamics simulations of the dimer

182 Here we present unrestrained molecular dynamics simulations of the DNA a

183 Unrestrained molecular dynamics simulations of unfolding

184 Unrestrained molecular dynamics simulations predicted th

185 We have carried out fully unrestrained molecular dynamics simulations starting fro

186 In the present study, restrained and unrestrained molecular dynamics simulations, carried out

187 In this work, we generate several unrestrained molecular dynamics trajectories of its isol

188 Using unrestrained molecular dynamics, it was shown that for t

189 in then relaxed the complex by a 100-ns long unrestrained molecular dynamics.

190 old and refine structures, as well as to run unrestrained molecular-dynamics simulations.

191 - dorsolateral prefrontal cortex (dlPFC) of unrestrained monkey.

192 gating goal-directed whole-body movements of unrestrained monkeys.

193 ts in a configurable 3D spatial setting with unrestrained monkeys.

194 perinsulinaemic conditions in the conscious, unrestrained mouse.

195 studies on discrete object manipulation and unrestrained movements.

196 modeled androgen receptor was refined using unrestrained multiple molecular dynamics simulations in

197 cal data and TIRF microscopy show that NEDD4 unrestrained mutant constitutively downregulates the IKS

198 trophysiological activity of NAcc neurons in unrestrained, naive Sprague-Dawley rats.

199 When uninduced, unrestrained negative supercoiling was organized into 32

200 protect T cells from adverse consequences of unrestrained NF-kappaB activation, such as cellular sene

201 Striatal [GABA](ecf) was determined in unrestrained, non-hibernating ground squirrels (T(b) ran

202 10 mm Hg from day to day and hour to hour in unrestrained nonhuman primates, which indicates that sna

203 trained front target occupant in front of an unrestrained occupant compared with a restrained front t

204 a restrained rear target occupant behind an unrestrained occupant compared with a restrained rear ta

205 ined side target occupant sitting next to an unrestrained occupant compared with a restrained side ta

206 s were randomized into two groups--awake and unrestrained or treated with intensive care medicine the

207 At the cellular level, unrestrained p38 MAPK activity diminished cardiac contra

208 cts, combined disruption of Dusp1/4 promoted unrestrained p38 MAPK activity in both mouse embryonic f

209 ring becomes severe and unacceptable despite unrestrained palliative efforts; some of these patients

210 Tracheally intubated, awake, and unrestrained patients (group 1, n = 54; mean age, 113 +/

211 Unrestrained phosphorylation by JNK, as obtained by a ce

212 Unrestrained PKA activity is pathological, and an enduri

213 ut (KO) mice (i) initial liver infection was unrestrained, plateaued, and then declined somewhat by w

214 assessed by using invasive tracheostomy and unrestrained plethysmography.

215 The consequent unrestrained proliferation allows the glycolytic phenoty

216 enetic and epigenetic alterations that allow unrestrained proliferation and increased survival.

217 n self-renewing multiple myeloma cells begin unrestrained proliferation by unknown mechanisms.

218 athway overcomes cellular protection against unrestrained proliferation in cancer.

219 The mechanism for intermittent, unrestrained proliferation of myeloma cells is unknown,

220 To determine the factors responsible for the unrestrained proliferation of PEL, we have studied the g

221 However, the risk of triggering unrestrained proliferation of permanently engineered T c

222 The growth factors responsible for the unrestrained proliferation of these lymphomas have not y

223 fe mechanism for the cell to protect against unrestrained proliferation.

224 Concomitant loss of p53, which causes unrestrained propagation of tetraploids into aneuploid c

225 he earliest stages of development in living, unrestrained pups.

226 tenin to cell/cell contacts, indicating that unrestrained Rap activity underlies the alterations in c

227 p66(Shc) in normal epithelial cells leads to unrestrained Ras activation, preventing anoikis through

228 matosensory cortex of the unanesthetized and unrestrained rat.

229 rgic agonist, were administered to conscious unrestrained rats 24 hr later to elicit the cardiac resp

230 d mean arterial blood pressure in conscious, unrestrained rats [peak elevations vs. baseline: PrRP-20

231 all relevant muscles in both head-fixed and unrestrained rats and two-dimensional imaging to monitor

232 d with fluorescent microspheres in conscious unrestrained rats before and 2, 4, and 6 hours after lip

233 Unrestrained rats chronically implanted with electrodes

234 rt-1 and Hcrt-2 given i.c.v. into conscious, unrestrained rats stimulated significant elevations in m

235 activity (SP-LI) in spinal CSF of conscious, unrestrained rats using microdialysis techniques followi

236 excitations induced by bicuculline in awake, unrestrained rats, suggest that modulation of GABA inhib

237 We demonstrate, in unrestrained rats, that the discharge activity of a homo

238 ssure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the

239 ses to subsequent hypoglycemia in conscious, unrestrained rats.

240 le neurons in the lateral striatum of awake, unrestrained rats.

241 he medial preoptic area (mPOA) of conscious, unrestrained rats.

242 s combined with microiontophoresis in awake, unrestrained rats.

243 ng was combined with iontophoresis in awake, unrestrained rats.

244 easurement of renal tissue oxygen tension in unrestrained rats.

245 spatial and temporal characteristics of free unrestrained reaching movements of the arm were examined

246 Unrestrained recombination causes undesired endpoints (t

247 Unrestrained reconsolidation may have the opposite effec

248 refineD outperforms unrestrained relaxation strategy or relaxation that is r

249 By contrast, in an HLTF-HIRAN mutant, unrestrained replication relies on the TLS protein REV1.

250 he primase-polymerase PRIMPOL for repriming, unrestrained replication, and S phase progression upon l

251 t to limit clonal expansion and to terminate unrestrained responses.

252 s-from several meters to up to 10 m-and that unrestrained, resting Ae. aegypti males leap off their p

253 hese observations, we also found patterns of unrestrained retrotransposons in p53-driven mouse and hu

254 al homeostasis is reflected in the fact that unrestrained signaling activity in mammals is associated

255 ich acts as a Rheb GAP, yields constitutive, unrestrained signaling from the cell growth machinery co

256 An unrestrained simulation also was performed.

257 tructure factors and those derived from this unrestrained simulation is 23% to 1.0 A resolution.

258 A 30 ns unrestrained simulation reveals dynamic partitioning of

259 Long unrestrained simulations allowed a new interpretation of

260 outine refinement of predicted structures by unrestrained simulations infeasible.

261 Comparisons with unrestrained simulations show that internal and global m

262 of these interactions using microsecond-long unrestrained simulations shows that urea-aromatic stacki

263 In unrestrained simulations, the cellulose diffuses into th

264 In another set of 10 unrestrained simulations, the dominant growth mode was d

265 Unlike the unrestrained simulations, the resulting sarcolipin struc

266 For both restrained and unrestrained simulations, the strongest water density pe

267 gy profile of the gating transition and from unrestrained simulations, we conclude that the pore of t

268 onsistent with the observed behaviors of the unrestrained simulations.

269 ndividual vocal signals during 30 minutes of unrestrained social interaction between a female and a s

270 Unrestrained spider dragline 'super-contracts' when it i

271 at another potential negative consequence of unrestrained spontaneous LIP is constriction of the tota

272 A total of 41 conscious unrestrained Sprague-Dawley rats were studied during 2-d

273 ular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflu

274 Three unrestrained stochastic dynamics simulations have been c

275 ing should be enhanced transiently until the unrestrained supercoiling is removed by diffusion or top

276 elated with their effects on either total or unrestrained supercoiling.

277 of an autoimmune syndrome consistent with an unrestrained T helper type 2 (Th2) immune response.

278 required to effectively eliminate pathogens, unrestrained T(H) activity also contributes to tissue in

279 om the miR-29ab1 genomic cluster, results in unrestrained T-bet expression and IFN-gamma production.

280 Among unrestrained target occupants, the adjusted RRs were, fo

281 Prior research indicates that unrestrained TGF-beta1 and/or type 2 cytokine-driven imm

282 Consequently, absence of T-bet leads to unrestrained Th17 cell differentiation and activation ch

283 s response must be tightly regulated because unrestrained TLR signaling generates a chronic inflammat

284 e (EA) on persistent inflammatory pain in an unrestrained, unsedated, and conscious rat model.

285 likelihood refinement with stereochemically unrestrained updating of the model, proved to be of cruc

286 Unrestrained use of blood cultures has serious implicati

287 verify that, unlike the corresponding parent unrestrained variant, the restrained molecule is not sub

288 ing of dentate granule neurons with a novel, unrestrained virtual reality system for rodents, we disc

289 ical microstimulation (ICMS) during hours of unrestrained volitional behavior.

290 methacholine was measured by use of a Buxco unrestrained whole-body plethysmograph.

291 Unrestrained whole-body plethysmography measurement of e

292 This was done by subjecting unrestrained wild-type, cryophilic, or thermophilic worm

293 tracking microscope records the motion of an unrestrained worm expressing channelrhodopsin-2 or halor

294 Because each cell in an unrestrained worm is a rapidly moving target, our system

295 re, by using fluorescent biosensors in live, unrestrained worms, we show that intestinal pH also osci

296 c molecules and drive redox chemistry, which unrestrained would be destructive.

297 er chronic inflammation is the key driver of unrestrained wound healing (i.e., the fibrotic response)

298 significantly lower c-Fos levels relative to unrestrained WT mice in 9 regions, including lateral sep

299 d potency observed with the conformationally unrestrained Xaa-boroPro class of inhibitors, the L-L di

300 alphaq-driven pathophysiologies that involve unrestrained YAP function.