ライフサイエンスコーパス: unsolved

1 nism is necessary for this asymmetry remains unsolved.

2 the fine mechanisms that participate remain unsolved.

3 hanisms involved in their development remain unsolved.

4 (quaternary) derivatives remains essentially unsolved.

5 tion of candidate cancer genes (CCG) remains unsolved.

6 ported V2 variant (MCDR1), while five remain unsolved.

7 low confidence, while the remaining four are unsolved.

8 d its connection to CD3zeta signaling remain unsolved.

9 as a causal relationship to allodynia remain unsolved.

10 alized protein folding and design problem is unsolved.

11 musculature, but its evolutionary origin is unsolved.

12 rmines a specific cellular targeting remains unsolved.

13 m between TRIM24 and histone modification is unsolved.

14 unctional integration into the tissue remain unsolved.

15 lementation of skilled movement has remained unsolved.

16 roscience, many theoretical questions remain unsolved.

17 rst two issues, but the last is still mostly unsolved.

18 ding, about half of our exome cases remained unsolved.

19 out the molecular mechanisms involved remain unsolved.

20 inal step of circularizing sequences remains unsolved.

21 he details of the enzymatic mechanism remain unsolved.

22 y influential spreaders, the problem remains unsolved.

23 ides before the emergence of enzymes remains unsolved.

24 and function within the visual cycle remain unsolved.

25 enes have been implicated, many cases remain unsolved.

26 ns and their mechanistic interactions remain unsolved.

27 ts ligand nerve growth factor (NGF) is still unsolved.

28 of the keratinocyte mild-cold sensor remains unsolved.

29 GC pairs function in this role, has remained unsolved.

30 would deter misuse, yet is still considered unsolved.

31 quence for Ca(2+) release remained, however, unsolved.

32 pathogenesis of neonatal septicemia is still unsolved.

33 underlying SOX9 transcription remain largely unsolved.

34 s an effect on PAH biodegradation was so far unsolved.

35 d electron transfer (PCET) mechanism remains unsolved.

36 inhibition to the plasticity, have remained unsolved.

37 re at the surface of the chromosomes remains unsolved.

38 ving tumor growth and ACTH secretion remains unsolved.

39 n of patients at risk of early sepsis remain unsolved.

40 their internal organization remains largely unsolved.

41 nd upon crossing the species barrier remains unsolved.

42 15 to 40 kDa, seven of which were previously unsolved.

43 ertakings, many technical limitations remain unsolved.

44 y recapitulate in vivo embryogenesis remains unsolved.

45 ome sequencing, the majority of cases remain unsolved.

46 der), the problem of identification is still unsolved.

47 emporal stability of several objects remains unsolved.

48 update on the current challenges that remain unsolved.

49 vity and translational control have remained unsolved.

50 nsory basis of facial proprioception remains unsolved.

51 ; however, its true etiopathogenesis remains unsolved.

52 tality, but the underlying mechanisms remain unsolved.

53 ontrol organ or organism size remain largely unsolved.

54 hear properties in this simple system remain unsolved.

55 ion, immunity, and pathogen evolution remain unsolved.

56 ents of practical applications still remains unsolved.

57 h, many basic epidemiologic questions remain unsolved.

58 nt Robinow syndrome cases remain molecularly unsolved.

59 -Lam amination, overcoming long-standing and unsolved amine and organoboron limitations of this valua

60 e when it crystallizes out of solution is an unsolved and fundamental problem in materials synthesis,

61 ing Multituberculata and Haramiyida, remains unsolved and has generated contentious views on the orig

62 orts in the past decade, the problem remains unsolved and therefore still attracts a lot of attention

63 or neoadjuvant use of targeted agents remain unsolved and vary among clinical trial protocols.

64 neural recordings and manipulations remains unsolved, and developing approaches to addressing this c

65 s bound to their effectors or regulators are unsolved, and it is unknown precisely how Ras proteins a

66 We proof the strength of EnPEn for three yet unsolved architectures: (a) selective Na over Ca transpo

67 have been solved and providing an outlook on unsolved avenues.

68 to engineer biochemical pathways to address unsolved biomedical problems.

69 ive in natural environments, remains a major unsolved biosafety problem.

70 The CFTR structure is unsolved but homology models of the CFTR closed and open

71 tion (HCAI) in hospitals mainly results from unsolved but well-identified causes such as hand hygiene

72 oles overcome this Coulomb trapping is still unsolved, but increasing evidence points to the critical

73 nting 360 years ago that to this day remains unsolved, but still mystifies and intrigues.

74 iology in subjects from 20 families remained unsolved by WES.

75 ectron-phonon coupling, is a fascinating but unsolved case after decades of research.

76 In genetically unsolved cases (16 with elevated, 35 with normal, 7 with

77 iants associated with known diseases but the unsolved cases remain a conundrum.

78 The remaining samples were from unsolved cases that were biased toward more phenotypical

79 For the unsolved cases, our assay resulted in a molecular geneti

80 lic predicted protein-truncating variants in unsolved cases.

81 re being increasingly used to diagnose these unsolved cases.

82 which explain the disease in several so far unsolved cases; and an intralocus OPA1 modifier, which e

83 g data from families affected by genetically unsolved CDGs and identified four individuals with diffe

84 offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent

85 low-abundance proteins from blood remains an unsolved challenge due to the extraordinary dynamic rang

86 logical and synthetic transformations and an unsolved challenge for synthetic chemists.

87 specific binding to nucleic acids remains an unsolved challenge in computational biophysics.

88 variation among bacterial genomes remains an unsolved challenge in evolutionary biology, despite long

89 hiles in cross-coupling reactions remains an unsolved challenge in organic chemistry.

90 ated, hindered halides persists as a largely unsolved challenge in organic synthesis.

91 y upon sequence mutation is an important but unsolved challenge in protein engineering.

92 A major unsolved challenge in the design of enantioselective cat

93 al microLEDs with large aspect ratios, a yet unsolved challenge in three-dimensional gallium nitride

94 aining useful life of Li-ion batteries is an unsolved challenge that limits technologies such as cons

95 kind of data it is still a major and largely unsolved challenge to infer the topology and interaction

96 An unsolved challenge, however, is to quantify varying leve

97 probe with proteins in a proteome remains an unsolved challenge.

98 es into wild mosquito populations remains an unsolved challenge.

99 sphates in our bodies is critical and yet an unsolved challenge.

100 mations at a single-cell level is to date an unsolved challenge.

101 y and high electrical performance remains an unsolved challenge.

102 ol over size and cluster geometry remains an unsolved challenge.

103 the pinnacle of asymmetric synthesis and an unsolved challenge.

104 y evolving network topology remains to be an unsolved challenge.

105 e from spurious de novo mutations remains an unsolved challenge.

106 rammed by shape and composition, is still an unsolved challenge.

107 stochastic cellular fluctuations remains an unsolved challenge.

108 viscosity patterns in plants has remained an unsolved challenge.

109 f cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease.

110 ons about QMC developments, limitations, and unsolved challenges are discussed as well.

111 Finally, the remaining unsolved challenges are examined, and the potential dire

112 tems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and

113 omagnetic fields represents one of the major unsolved challenges in sensory biology.

114 ensors are also examined, and some remaining unsolved challenges in the area of chemosensors are disc

115 ming to identify clear technology trends and unsolved challenges in this exciting field of research.

116 ays and interventions and highlight some key unsolved challenges that remain.

117 their production often suffers from multiple unsolved challenges.

118 rystal microbalance (QCM) sensors remains an unsolved challenging task.

119 on angioplasty and stenting (BAS) remains an unsolved clinical dilemma for patients with coronary art

120 However, restenosis remains an unsolved clinical problem after vascular interventions.

121 ludarabine refractoriness (FR) represents an unsolved clinical problem of chronic lymphocytic leukemi

122 therapies targeting refractory NB remains an unsolved clinical problem.

123 Screening additional families and querying unsolved CMT2 exomes, we identified the p.R252W mutation

124 on and datasets for comparison to active and unsolved cold case searches.

125 de inaccurate peptide-binding prediction and unsolved complexities of the HLA-II pathway.

126 This new structure represents one of the key unsolved conformational states of SERCA and provides a s

127 rgent roles in transcriptional regulation of unsolved consequence.

128 ell form is a result of optimization remains unsolved despite previous attempts.

129 importance of reanalysis of individuals with unsolved diagnoses in conjunction with sequencing extend

130 Clinically, yet unsolved diagnostic issues in the 2017 WHO classificatio

131 One unsolved difficulty with non-enzymatic RNA replication i

132 However, liposomes still present some unsolved drawbacks, such as poor colloidal stability, sh

133 exact and analytic broadband pulses remains unsolved due to the nonlinearity and complexity of the u

134 positional cloning, the causative genes for unsolved dystroglycanopathy cases have escaped discovery

135 ion at legacy nuclear sites is a serious and unsolved environmental issue.

136 Rbeta ligand-binding domain remains the last unsolved ERR structure and also one of only a few unknow

137 This mismatch is an unsolved evolutionary paradox.

138 we provide evidence that a large fraction of unsolved exome cases have underlying structural mutation

139 The presence of unsolved families after highly parallel sequencing strat

140 r demonstrate that Mp1p-LBD1, the previously unsolved first lipid binding domain of Mp1p, is also a s

141 Three families remain unsolved following WES and WGS.

142 problem in visual neuroscience has remained unsolved for 50 years.

143 bing complex reaction networks have remained unsolved for over 70 years.

144 the structure of the recently obtained, but unsolved, Form III of this drug despite there being only

145 ons in complex flow environments still poses unsolved fundamental questions that preclude predictive

146 the absence of therapy remain important but unsolved goals of HIV-1 cure research.

147 ductal adenocarcinoma (PDAC) remains a major unsolved health problem.

148 However, it remains unsolved how the interplay between TFs and chromatin env

149 verse problem, however, has remained largely unsolved: How to reconstruct the underlying reactions de

150 ion, the problem for large networks is still unsolved in general.

151 t 50%, leaving the genetic basis for disease unsolved in many individuals.

152 ease in a substantial share of families with unsolved inherited optic neuropathies.

153 he etiology of seizures in R6/2 mice remains unsolved, involvement of the hippocampus is suggested by

154 of the most important problems that remains unsolved is sampling high-dimensional free-energy landsc

155 An unsolved issue is the role of the TRKA transmembrane dom

156 y, data also definitively settle a currently unsolved issue on the capacity of human neutrophils to p

157 erify such an accuracy remains a crucial but unsolved issue until now.

158 eported to occur in food products is a major unsolved issue.

159 -like transcriptional responses is a central unsolved issue.

160 To reach this goal, a number of unsolved issues have to be addressed and consensually ac

161 Unsolved issues include whether the increased atheroscle

162 of posttransplant MN, as well as to address unsolved issues specific to transplantation, including t

163 of post-transplant MN, as well as to address unsolved issues specific to transplantation, including t

164 ffects of PM in rural and suburban areas are unsolved issues.

165 Genome sequencing (GS) is promising for unsolved leukodystrophies, but its efficacy has not been

166 individuals with MAE, accounting for ~4% of unsolved MAE cases.

167 and produced a nearly complete model for an unsolved map containing a 660-residue heterodimeric prot

168 althcare concern, obesity remains largely an unsolved medical problem.

169 les in 1,929 human exomes from families with unsolved Mendelian disease.

170 importance of SVs as a genomic mechanism in unsolved Mendelian diseases.

171 This issue remains one of biology's great unsolved mysteries and has significant clinical relevanc

172 We also describe unsolved mysteries and new technologies that could help

173 fundamental bosons which may explain several unsolved mysteries in physics.

174 e sought in this essay to formulate a set of unsolved mysteries in the field, sort out established da

175 le progression are coordinated is one of the unsolved mysteries of cell biology.

176 eveloping human brain remains one of the few unsolved mysteries of science.

177 An unsolved mystery in cell biology is how unusually large

178 ctive and sterile castes, represents a major unsolved mystery in evolution.

179 metal distribution that to date have been an unsolved mystery in magnesium biology.

180 type 2 diabetes mellitus, cancer) remains an unsolved mystery of current biology and medicine.

181 nalgesia, amnesia, and immobility) remain an unsolved mystery.

182 left the identity of the feedback signal an unsolved mystery.

183 to tumorigenesis has remained a decades-long unsolved mystery.

184 ons to brain function and behavior remain an unsolved mystery.

185 ative conditions.SIGNIFICANCE STATEMENT Many unsolved neurodegenerative conditions result from defect

186 ith histologically confirmed but genetically unsolved NM.

187 There exist unsolved, open statistical questions about the inaccurat

188 ecruited to specific targets remains largely unsolved, particularly in plants.

189 ly with respect to Hexapoda remain the major unsolved phylogenetic problems.

190 ughput RNA-seq data is a challenging and yet unsolved problem because of the non-contiguous transcrip

191 ctions with electron-rich anilines remain an unsolved problem due to catalyst deactivation and delete

192 ction of distant genetic variants remains an unsolved problem due to the short-read length of common

193 enting the material explored-is an important unsolved problem for disordered materials.

194 ty make asymmetric C-H oxidation a generally unsolved problem for nonenzymatic systems.

195 ination of the precise dopant location is an unsolved problem in applications from channel doping in

196 Continual learning remains an unsolved problem in artificial neural networks.

197 Protein aggregation is a major unsolved problem in biochemistry with implications for s

198 However, it remains an unsolved problem in catalysis, as typically it involves

199 d hair loss (alopecia) (CIA) remains a major unsolved problem in clinical oncology.

200 lelic asymmetry is generated remains a major unsolved problem in epigenetics.

201 d fluctuation of artemisinin has remained an unsolved problem in meeting the global demand for ACT.

202 tive contributions of these properties is an unsolved problem in molecular evolution with broad impli

203 to behavioural action selection, remains an unsolved problem in neuroscience.

204 lkenes with simple dialkyl amines remains an unsolved problem in organic synthesis.

205 strong Bronsted acids to alkenes remains an unsolved problem in synthetic chemistry.

206 or of thermodynamic response functions is an unsolved problem in the physics of water.

207 An unsolved problem in this context is how to systematicall

208 l trial designs, alternative targets and the unsolved problem of bilateral lesional treatment.

209 A solution to the classic unsolved problem of olefin hydromethylation is presented

210 tinguishes hot spots from cold regions is an unsolved problem, although transcription factors determi

211 multiple DCs at each position, a heretofore unsolved problem, while adhering to a constraint on the

212 the transcription of genes is an important, unsolved problem.

213 ds with chiral phosphorus centers remains an unsolved problem.

214 s levels of torsional stress is an important unsolved problem.

215 f [2,3]- and [1,2]-rearrangements remains an unsolved problem.

216 rdinates is an extensively studied but still unsolved problem.

217 rocess; however, their synthesis is still an unsolved problem.

218 ostly low-quality models, is still a largely unsolved problem.

219 tive reactions of natural proteins remain an unsolved problem.

220 but the nature of this signal remains a key unsolved problem.

221 of more oxidizable functionality) remains an unsolved problem.

222 the resulting models has largely remained an unsolved problem.

223 terial strains or viruses, remains a largely unsolved problem.

224 y of these transformations is also a largely unsolved problem.

225 ations in a typical tumor is a difficult and unsolved problem.

226 e arose from the 'prebiotic soup' remains an unsolved problem.

227 protein-small-molecule interfaces remains an unsolved problem.

228 ds) from the measured time series is a major unsolved problem.

229 s a major diagnostically and therapeutically unsolved problem.

230 defense upon effector perception remains an unsolved problem.

231 ge of protein folding remains an interesting unsolved problem.

232 ulate transcriptional specificity remains an unsolved problem.

233 lkylamine functionality, however, remains an unsolved problem.

234 to electron-deficient derivatives remains an unsolved problem.

235 these imaging data sets is a long-standing, unsolved problem.

236 ile aromatic functionalities remains a major unsolved problem.

237 e-associated mutations remains a significant unsolved problem.

238 y and specificity for any given ligand is an unsolved problem.

239 ting expression to specific cell types is an unsolved problem.

240 their key features, applications and various unsolved problems and close this review with prospects a

241 We discuss major unsolved problems and suggest areas that may be particul

242 tructure prediction remains one of the major unsolved problems in computational biology.

243 ss transition still remains one of the great unsolved problems in condensed matter physics.

244 The glass transition is one of the few unsolved problems in condensed matter physics: agreement

245 e, it is widely recognized as one of the key unsolved problems in modern physics, representing a para

246 n in the form of results, chemical tools, or unsolved problems in return for valuable insights and id

247 turies, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoreti

248 theoretical background, one of the important unsolved problems is a direct experimental determination

249 ong the approximately 43 superfamilies, with unsolved problems now yielding to much larger data sets

250 ics researchers about the pressing needs and unsolved problems of computational virology.

251 rovides a practical solution to the hitherto unsolved problems of observing negative OKAN, but also,

252 ncy (C1-INH-HAE) represent one of the oldest unsolved problems of the disease.

253 rough sustained antibiotic release have some unsolved problems which include short life-span, narrowe

254 Moreover, novel trends and unsolved problems will be introduced.

255 evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) se

256 her, their key applications, and the various unsolved problems, closing with a perspective on the pro

257 contribution we underscore some of the main unsolved problems, mostly focusing on pathogenetic aspec

258 l for generating insight into a diversity of unsolved problems, ranging from genome structure to cell

259 gagement by small-molecule inhibitors remain unsolved problems.

260 detection and assay design remain important unsolved problems.

261 arrest (SCA) in the young remains a largely unsolved public health problem, and sports activity is a

262 It has been an old unsolved puzzle to evolutionary theorists on which mecha

263 s such as SQUIDs and qubits is still a major unsolved puzzle.

264 f this ancient enzymatic system are still an unsolved puzzle.

265 the lunar surface, represents a fundamental, unsolved puzzle.

266 nfluence is one of social science's greatest unsolved puzzles: Do people befriend others who are simi

267 rete surrounding matter is a fundamental yet unsolved question in astrophysics.

268 ion is well developed in human society is an unsolved question in biological and human sciences.

269 A key unsolved question regarding the developmental origin of

270 An essential unsolved question regarding this prebiotic set is whethe

271 These observations pose a general unsolved question that is relevant to all nervous system

272 e germline-soma distinction is a fundamental unsolved question.

273 of Hox proteins in vivo remains an important unsolved question.

274 of evolutionary patterns is an important and unsolved question.

275 us cell carcinoma, remains a fundamental yet unsolved question.

276 pulation of epithelial stem cells is a major unsolved question.

277 itors exist in the adult pancreas is a major unsolved question.

278 ne and then to the cell cytoplasm remains an unsolved question.

279 ersible defect accumulation is a fundamental unsolved question.

280 is of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demo

281 recent molecular advances and some remaining unsolved questions and discuss the possible implications

282 rated solutions remains one of the last deep unsolved questions in polymer physics.

283 erspectives on future experiments to address unsolved questions related to the EC.

284 omoting and anti-tumor effectors, as well as unsolved questions such as DAMP release from non-tumor c

285 merging or future research opportunities and unsolved questions.

286 Applying this database to unsolved recessive conditions in the GME population redu

287 tensive research, important questions remain unsolved regarding the molecular and cellular mechanisms

288 need for vascular imaging at the RHs remains unsolved, resulting in an important amount of futile tra

289 reviously generated exome sequencing data in unsolved retinal dystrophy cases identified a homozygous

290 with other methods, as well applications to unsolved RNAs, are also presented.

291 a large cohort of patients with genetically unsolved RP.

292 lular basis of the magnetic sense remains an unsolved scientific mystery.

293 reate Roger Sperry in 1968, and has remained unsolved since then.

294 as a special [4Fe-4S](2+) cluster with a yet unsolved structure.

295 tomography to generate models of previously unsolved structures in their cellular environment.

296 Nevertheless, major issues remain unsolved, such as the origin of a genetic code.

297 0 GPa, although recently conjectured, remain unsolved to date.

298 ave shown great promise against high-impact, unsolved vaccine targets ranging from bacterial and vira

299 However, it has remained unsolved whether the oligomers are a necessary step in t

300 A long-standing puzzle remains unsolved: why the Au surfaces with {100} sub-facets were