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1 lkylamine functionality, however, remains an unsolved problem.
2 rization of phosphorylation sites remains an unsolved problem.
3 alidity of psychiatric diagnoses is still an unsolved problem.
4 six-membered ring to form ring D remains an unsolved problem.
5 of investigation, remains a challenging and unsolved problem.
6 members of a receptor family, is largely an unsolved problem.
7 ineers for over 100 years, yet it remains an unsolved problem.
8 esponsible for this behavior present a major unsolved problem.
9 domains represents a highly interesting and unsolved problem.
10 s based on EEG and MEG data alone remains an unsolved problem.
11 to electron-deficient derivatives remains an unsolved problem.
12 nt in preparation and measurement is a major unsolved problem.
13 d carbon and energy source, is an important, unsolved problem.
14 ondary neutrons in proton therapy is another unsolved problem.
15 ter inference is an inherently difficult and unsolved problem.
16 ermining optimal combinations of bnAbs is an unsolved problem.
17 nce (AI) that aligns with human values is an unsolved problem.
18 these imaging data sets is a long-standing, unsolved problem.
19 out homology to known complexes is a largely unsolved problem.
20 ite for life, but how they evolve remains an unsolved problem.
21 plex 2 (PRC2) is regulated by RNA remains an unsolved problem.
22 long genomic distances remains an important unsolved problem.
23 ile aromatic functionalities remains a major unsolved problem.
24 lf-organize to form structured tissues is an unsolved problem.
25 ver, how phenology should evolve is still an unsolved problem.
26 ion therapeutics maintains a challenging and unsolved problem.
27 e-associated mutations remains a significant unsolved problem.
28 ges in molecular diagnostics, and remains an unsolved problem.
29 dy motion data from these animals remains an unsolved problem.
30 y and specificity for any given ligand is an unsolved problem.
31 ving cells remains a significant and largely unsolved problem.
32 ploration in support of learning is still an unsolved problem.
33 Yet, the driving interactions remain an unsolved problem.
34 ting expression to specific cell types is an unsolved problem.
35 the transcription of genes is an important, unsolved problem.
36 ds with chiral phosphorus centers remains an unsolved problem.
37 s levels of torsional stress is an important unsolved problem.
38 f [2,3]- and [1,2]-rearrangements remains an unsolved problem.
39 rdinates is an extensively studied but still unsolved problem.
40 rocess; however, their synthesis is still an unsolved problem.
41 ostly low-quality models, is still a largely unsolved problem.
42 tive reactions of natural proteins remain an unsolved problem.
43 but the nature of this signal remains a key unsolved problem.
44 of more oxidizable functionality) remains an unsolved problem.
45 the resulting models has largely remained an unsolved problem.
46 terial strains or viruses, remains a largely unsolved problem.
47 y of these transformations is also a largely unsolved problem.
48 ations in a typical tumor is a difficult and unsolved problem.
49 e arose from the 'prebiotic soup' remains an unsolved problem.
50 protein-small-molecule interfaces remains an unsolved problem.
51 ds) from the measured time series is a major unsolved problem.
52 s a major diagnostically and therapeutically unsolved problem.
53 defense upon effector perception remains an unsolved problem.
54 ge of protein folding remains an interesting unsolved problem.
55 ulate transcriptional specificity remains an unsolved problem.
56 sents the correct structure, has remained an unsolved problem.
57 distantly related proteins remains a largely unsolved problem.
58 gene models from genome sequence remains an unsolved problem.
59 for coordinating these activities remains an unsolved problem.
60 which this lesion is repaired in vivo remain unsolved problems.
61 , discuss their complementarity, and outline unsolved problems.
62 These represent unsolved problems.
63 gagement by small-molecule inhibitors remain unsolved problems.
64 detection and assay design remain important unsolved problems.
66 tinguishes hot spots from cold regions is an unsolved problem, although transcription factors determi
67 of complex, chiral cyclobutanes is a largely unsolved problem and there is a need for general and mod
68 y of Sciences, "Frontiers in Bioinformatics: Unsolved Problems and Challenges," organized by David Ei
69 their key features, applications and various unsolved problems and close this review with prospects a
70 rgetic changes and conclude by commenting on unsolved problems and opportunities for future basic and
72 xpression in different cell types is a major unsolved problem, and critical downstream applications i
73 evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) se
74 heoretical contributions to this classic but unsolved problem are presented here: a method to determi
75 nearly identical structures is a challenging unsolved problem because it requires the accurate design
76 ughput RNA-seq data is a challenging and yet unsolved problem because of the non-contiguous transcrip
77 passes HF is highly desirable but remains an unsolved problem because of the prohibitive insolubility
78 reparable heart valve dysfunction remains an unsolved problem because there are no heart valve implan
79 pecific proteinogenic amino acids remains an unsolved problem, but a non-enzymatic synthesis that rec
81 her, their key applications, and the various unsolved problems, closing with a perspective on the pro
82 olecules in high molar activity is mostly an unsolved problem, despite the indispensability of the di
83 ctions with electron-rich anilines remain an unsolved problem due to catalyst deactivation and delete
84 ction of distant genetic variants remains an unsolved problem due to the short-read length of common
85 on of the shape skeleton remains a notorious unsolved problem; existing approaches are extremely sens
89 coupled with tumor relapse, continue to pose unsolved problems for precision healthcare, as exemplifi
90 ination of the precise dopant location is an unsolved problem in applications from channel doping in
105 ecules having many molecular skeletons is an unsolved problem in diversity-oriented synthesis (DOS).
111 d fluctuation of artemisinin has remained an unsolved problem in meeting the global demand for ACT.
113 tive contributions of these properties is an unsolved problem in molecular evolution with broad impli
118 , to aldehydes and ketones remains a largely unsolved problem in organic synthesis, despite the wide
120 e of Mott insulators continues to be a major unsolved problem in physics despite more than 50 years o
122 olumetric imaging data remains a serious and unsolved problem in quantitative studies of embryogenesi
130 lkenes with nitrogen nucleophiles remains an unsolved problem in synthetic chemistry; this transforma
134 in generating novel asymmetric solutions to unsolved problems in asymmetric synthesis, particularly
139 ese ideas have been proposed for significant unsolved problems in condensed-matter physics, such as n
140 e are hidden intermediates are the two major unsolved problems in defining the folding pathway of bar
141 self-renewal and differentiation are central unsolved problems in developmental biology with potentia
143 e, it is widely recognized as one of the key unsolved problems in modern physics, representing a para
144 n in the form of results, chemical tools, or unsolved problems in return for valuable insights and id
145 turies, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoreti
151 hod of controlling tumor growth, but a major unsolved problem is the rapidity that injected drugs exi
154 theoretical background, one of the important unsolved problems is a direct experimental determination
155 ly has proved difficult, and one of the main unsolved problems is finding what determines the tempera
156 lowing antigen stimulation, remains a mostly unsolved problem, largely due to the lack of large data
157 contribution we underscore some of the main unsolved problems, mostly focusing on pathogenetic aspec
158 ong the approximately 43 superfamilies, with unsolved problems now yielding to much larger data sets
164 py-induced alopecia - one of the fundamental unsolved problems of clinical oncology - is driven in pa
168 rovides a practical solution to the hitherto unsolved problems of observing negative OKAN, but also,
169 n of planetary rings is one of the prominent unsolved problems of planetary sciences, with direct imp
171 of HCN and chromophores are two of the major unsolved problems of the atmospheric chemistry of Jupite
173 l for generating insight into a diversity of unsolved problems, ranging from genome structure to cell
174 ity of the chemiresistors is still a largely unsolved problem, reducing sensor accuracy and causing c
176 er of homologs of a gene is a very important unsolved problem that has broad implications for researc
178 hese immunologically important, historically unsolved problems to propose a new model for how antibod
179 ynamics in vitro and in vivo has remained an unsolved problem until now owing to the lack of a high-p
181 rough sustained antibiotic release have some unsolved problems which include short life-span, narrowe
182 multiple DCs at each position, a heretofore unsolved problem, while adhering to a constraint on the
184 nces, including nitric oxide, CDH remains an unsolved problem with a mortality rate of 35% to 50%.
185 ature compensation of circadian clocks is an unsolved problem with relevance to the general phenomeno
186 basis of translocation is the most important unsolved problem with respect to ribosome function.
187 real-time with wearable devices is a crucial unsolved problem with serious negative consequences for