ライフサイエンスコーパス: unstructured

1 ome previous suggestions that this region is unstructured.

2 he 'middle domain', previously thought to be unstructured.

3 n a DISC1 section previously predicted to be unstructured.

4 xible linker, whereas the N-terminus remains unstructured.

5 N-terminal region of CYP144A1-FLV is largely unstructured.

6 ereas the C-terminal of the molecule remains unstructured.

7 ith previous suggestions that this region is unstructured.

8 second conserved tryptophan and is primarily unstructured.

9 P27A is an unstructured 104mer synthetic peptide from Plasmodium fa

10 parallelizability, low numerical dispersion, unstructured 3D gridding, and discrete fraction modeling

11 mRNAs with strong closed-loop potential and unstructured 5' UTRs, exactly the opposite features asso

12 uciferase mRNAs with stem-loop structured or unstructured 5'-UTR.

13 Unexpectedly, an unstructured A-rich element in 5' UTRs destabilizes mRNA

14 f Orai1 channels in puncta was substantially unstructured, a portion of channels were spaced at appro

15 Abeta42 monomers and its mature fibrils into unstructured Abeta aggregates with some beta-sheet struc

16 fied 4F-Abeta(M1-42) heteromers comprised of unstructured Abeta(M1-42) and helical 4F.

17 l unstructured tail of H3 and the C-terminal unstructured acidic tail of HMGB1, which are presumably

18 minutes of walking (P = 0.01) and free-time (unstructured) activity (P < 0.01).

19 lly located D'D3 domain through a relatively unstructured amino acid sequence, called here the N-term

20 actory cortex (piriform) is distributive and unstructured and can only be afforded behavioral signifi

21 TR activation domains (AADs) that are mostly unstructured and have minimal sequence similarity.

22 ated data in particular are often completely unstructured and highly context dependent, posing essent

23 s the C-terminal segment (residues 13-17) is unstructured and highly flexible.

24 ce motif is found in regions predicted to be unstructured and is present in a number of zDHHC17 subst

25 The N-terminal chain is unstructured and leads the permeation process for the LF

26 present time, the majority of EHR content is unstructured and locked into proprietary systems that po

27 s structured for RNA binding and one that is unstructured and low complexity that has no known functi

28 y and that the isolated subunit is partially unstructured and marginally stable.

29 ns or protein families and can process long, unstructured and multi-domain proteins thousands of resi

30 ntal results obtained with both conventional unstructured and nanostructured gold film SPRI sensor ch

31 A relatively unstructured and negatively charged RAM binds to a posit

32 we have measured the absorbance of both the unstructured and structured nucleic acids to accurately

33 no terminus, whereas the carboxy terminus is unstructured and therefore may better tolerate fluoresce

34 tes initiated by hydrophobic collapse for an unstructured and two globular proteins while directly me

35 ratio by risk of readmission, and extracted unstructured and unconventional structured data from the

36 mentorship programs, and most are informal, unstructured, and do not involve all of the key stakehol

37 dative metabolism and that this requires the unstructured anionic C-terminal tail peptides found on b

38 a C-terminal kinase domain interposed by an unstructured approximately 80-residue interdomain linker

39 Average mRNAs tend to be unstructured around the ribosome binding site.

40 x experts also provided a diagnosis based on unstructured assessment of the 80-scan subset.

41 tn to be alpha-helical at the N-terminus and unstructured at the C-terminus were matched by similar d

42 The partially unfolded species possess an unstructured beta-domain and C-helix with the rest of th

43 , we report here that the conformation of an unstructured bimetallic Zn(II) complex can be controlled

44 for rare diseases summarize phenotypes with unstructured binary or quantitative variables.

45 g the release of cell clusters from a thick, unstructured biofilm.

46 sidues 80-88, 108-110, and 129-131 represent unstructured breaks between the helices.

47 eptide (pHLIP) binds to a membrane at pH 7.4 unstructured but folds across the bilayer as a transmemb

48 s) are generally thought to be intrinsically unstructured, but capable of adopting limited secondary

49 Furthermore, the unstructured C terminus is able to facilitate contacts b

50 sequence complexity of the RNA polymerase II unstructured C-terminal domain in animal viability, deve

51 e comprising N-terminal, globular, and long, unstructured C-terminal domains.

52 Surprisingly, the largely unstructured C-terminal half of CHT7 with predicted prot

53 In yeast and humans, the unstructured C-terminal region of alpha7 contains an aci

54 segment having a role of membrane anchor, an unstructured C-terminal region that is weakly associated

55 sts of a pentameric N-terminal domain and an unstructured C-terminal tail.

56 ethering the two G domains together at their unstructured C-terminal tails.

57 te that these individuals represent a single unstructured Central/Northern European population.

58 The unstructured character of the N-terminus, coupled with i

59 tral belt that contacts and encapsulates the unstructured client protein in the center of the decamer

60 tivity is 30-fold larger with respect to the unstructured complex.

61 ne blue (MB)-modified probe assumes a linear unstructured conformation in the absence of the target;

62 M binds to the membrane surface in a largely unstructured conformation, while in acidic conditions it

63 ndergoing transitions between structured and unstructured conformations.

64 kle fold, whereas the human sequence remains unstructured, consistent with the mutation of one of the

65 ated measures with a random intercept and an unstructured covariance matrix.Short-term changes in ene

66 by a random intercept per individual and an unstructured covariance R matrix was used as correlation

67 In contrast, unstructured Ctn[15-34] replicated the activity of paren

68 By translating unstructured data (i.e., images) into structured data (i

69 ive digital phenotyping using structured and unstructured data abstraction from the electronic health

70 The ability of SCR to utilize unstructured data and produce spatially explicit maps th

71 able cohort definitions that can incorporate unstructured data from clinical notes and management of

72 More automated means of leveraging unstructured data from daily clinical practice is crucia

73 m triangulating insights from structured and unstructured data holds potential for accelerating the g

74 bles superior classifier design using small, unstructured data sets.

75 chine-learning approach using structured and unstructured data.

76 tion of GroES and ATP, the more expanded and unstructured denatured cyclophilin A is not encapsulated

77 te transition involving the native state and unstructured denatured species.

78 tructure leading to a random distribution of unstructured, denatured forms, the results provide evide

79 of the transition state (TS), structured or unstructured, determines the binding mechanism.

80 serine/threonine residues at the N-terminal unstructured domain of ORF57 prevents its digestion by c

81 e this intrinsic timescale at the N-terminal unstructured domain of the prion protein.

82 We show that the TubZ C-terminal tail is an unstructured domain that fulfills multiple functions con

83 intrinsically disordered regions, uncovering unstructured domains as prevalent partners in protein-RN

84 The long unstructured domains of unassembled ribosomal proteins a

85 dy by computer simulation the dynamics of an unstructured droplet of chiral active fluid in three dim

86 comprises a kirigami sheet embedded into an unstructured elastomeric membrane.

87 lation with clinical outcomes extracted from unstructured electronic health record (EHR) provider not

88 clinical concepts (complaints) captured from unstructured electronic health record clinical notes.

89 loped for detecting SSI using structured and unstructured electronic health record data was tested to

90 ligent systems will autonomously navigate in unstructured environments and closely collaborate with h

91 h natural communities existing in physically unstructured environments are rare, the role of environm

92 handling of fragile objects and adapting to unstructured environments.

93 Thus, distinct DPF-based codes within the unstructured Eps15/R C terminus direct the assembly of t

94 Conserved residues map to the unstructured ERS, loops on the face opposite the ERS, an

95 e-edited cells, we described the role of the unstructured Fcho linker in stable AP-2 membrane deposit

96 Observers documented activities using unstructured field notes.

97 Here, we make use of unstructured financial and corporate reporting data in J

98 edom better (Cliff's Delta = 0.49) than the "unstructured" format, but neither eliminated all researc

99 animal screening data are only accessible in unstructured free-text format, which hinders computation

100 hain-reconfiguration motions expected for an unstructured, fully unfolded chain.

101 ure that are composed of a rigid core and an unstructured fuzzy coat.

102 More flexible methods like the use of unstructured grids can significantly increase the comput

103 ation of meteorological data, and the use of unstructured-grids to better resolve nearshore features.

104 XTEN is a class of unstructured hydrophilic, biodegradable protein polymers

105 The peptide was unstructured in aqueous buffer and dimyristoylphosphatid

106 We also found that PEP87 is unstructured in isolation but tends to form a helix as e

107 peptide corresponding to the C terminus was unstructured in solution and only folded into an alpha-h

108 s, we demonstrate that the NTD is completely unstructured in solution but undergoes an important diso

109 lthough almost half of the capsid protein is unstructured in solution, this unstructured region folds

110 at the unbound form of PopZ(Delta134-177) is unstructured in solution, with the exception of a small

111 zetacyt is unstructured in solution.

112 in loops because natural sequences are often unstructured in solution.

113 d (25/76 amino acid residues) and inherently unstructured in solution.

114 The C-terminal domain is relatively unstructured in the monomeric state but forms an alpha-h

115 n of the protein is predicted to be natively unstructured, in reconstituted systems PopZ can self-ass

116 ion of Se-Te on isolated Au islands using an unstructured, incoherent beam of light produces growth o

117 Diagnostic radiologists generally produce unstructured information in the form of images and narra

118 faster than the reduced monomer because the unstructured intermediate of oxidized ClyA is less stabl

119 Unstructured interviews and field observations were cond

120 %) provided informal SEE, which consisted of unstructured intraoperative directives and isolated lect

121 e able to show that despite the region being unstructured, it nevertheless is resistant to general pr

122 ed "sensory" layer and a randomly connected, unstructured layer.

123 onfiguration of these colloidal particles by unstructured light, which resembles the driving of atoms

124 equences were homogeneous and geographically unstructured, likely reflecting a recent population bott

125 located in a putative "hinge" adjacent to an unstructured linker connecting domains TNT1 and TNT2.

126 stally and dynamically because of a natively unstructured linker connecting the dimerization domain a

127 We discovered a role for the unstructured linker region connecting the N-terminal oli

128 ent upon the presence of the matrix-exposed, unstructured linker region of Cox15 needed for Cox15 oli

129 he N-terminal microtubule-binding domain and unstructured linker region, and indirectly, through an a

130 It is positionally analogous to an unstructured linker that becomes helical and membrane-fa

131 rate KIN and CPD domains are connected by an unstructured linker.

132 nconserved region thought to function as an "unstructured" linker also abrogated polymerase activity

133 y 3-5) of a small domain, CcmM(S), joined by unstructured linkers.

134 onsisting of a four-helix bundle with a long unstructured loop between helices 1 and 2.

135 t is unchanged by aPKC phosphorylation of an unstructured loop in its second beta-propeller, ruling o

136 structural homology was used to identify an unstructured loop of approximately 20 residues in the Ex

137 h a high proline content, consistent with an unstructured loop present in the portion of the molecule

138 ad-associated (FHA) interaction motifs in an unstructured loop region of Cdc45, which is phosphorylat

139 ts intermembrane space (IMS)-exposed charged unstructured loop region.

140 hat the N-terminal region and the C-terminal unstructured loop undergo conformational changes when as

141 We identified mutations in an unstructured loop within the MSP that uncoupled VAPB-reg

142 ed by a short alpha-helical segment, a large unstructured loop, and finally, the membrane-associated

143 and, induces structural perturbations on two unstructured loops that are distally located beyond the

144 tion of protein folds with multiple flexible unstructured loops, such as the TIM-barrel fold.

145 ucture, where it folds into alpha helices or unstructured loops.

146 , from Pro-405 to Phe-431, and is flanked by unstructured loops.

147 Unstructured low complexity domains (LCDs) in proteins a

148 odel the covariance of the residuals with an unstructured matrix.

149 complex and induces refolding of the short, unstructured MDM2 N-terminal region to achieve its high

150 gation: a slow, structured mode, and a fast, unstructured mode sustained by wind-fire coupling.

151 points) warn of impending transitions to the unstructured mode.

152 coarse-grained MD of several structured and unstructured models that indicate that coupled folding a

153 ay in the presence of detergent, in which an unstructured, monomeric intermediate is transiently popu

154 eir 3' UTRs, suggesting a connection between unstructured mRNA noncoding sequences and optimal protei

155 Phosphorylation of UPF1 occurs in its unstructured N- and C-terminal regions at Serine/Threoni

156 at SutA comprises a central alpha-helix with unstructured N- and C-terminal tails, and binds to the b

157 domains: a globular C-terminal domain and an unstructured N-terminal domain.

158 Here we demonstrate that the unstructured N-terminal extension (NTE) of ClpS enters t

159 An unstructured N-terminal region of Tim10 is necessary and

160 This enables CH1 to bind actin aided by an unstructured N-terminal region that becomes alpha-helica

161 immunity depends on the presence of a basic unstructured N-terminal region that tethers SpaI to the

162 The unstructured N-terminal tail (NTT) of yeast eIF1A deploy

163 ate the mechanism by which the intrinsically unstructured N-terminal translocation domain (IUTD) of t

164 the resulting excited state ensemble was an unstructured N-terminus stabilized by non-native contact

165 nds and beta-strands formed in the initially unstructured N-terminus.

166 ains a nuclear localization signal within an unstructured, N-terminal region that is rich in serine a

167 nantly alpha-helical, in contrast to largely unstructured native omega, and then studied its assembly

168 to infection by Chrysomyxa rhododendri in an unstructured natural population of Norway spruce.

169 preferences from RNAcompete data due to the unstructured nature of the data, as noted by its develop

170 The transient, dynamic, and unstructured nature of this protein-protein interaction

171 urred more often than would be expected from unstructured network activity (e.g., by chance).

172 ces may emerge through learning from largely unstructured network architectures.

173 In our model, unstructured neural noise, after passing through the rec

174 lements; (4) machine-learning approach using unstructured notes; and (5) machine-learning approach us

175 channel of the NPC and depends critically on unstructured nuclear pore proteins, and is therefore not

176 ivator-3 (SRC-3 or AIB1), a large and mostly unstructured nuclear protein.

177 method that takes advantage of intrinsically unstructured nucleic acid sequences to achieve exception

178 Assembly of one bPNA strand with two unstructured oligo T/U strands enables facile insertion

179 beta(17-36) from a fibrillar aggregate to an unstructured oligomer.

180 In the absence of unstructured omega, the association of sigma-factors to

181 n-fold catalytic domain supplemented with an unstructured Omega-loop.

182 and internal loops are often represented as unstructured on secondary structure diagrams, but RNA 3D

183 Exploration of spatially unstructured options depends on the neocortex, striatum,

184 otein structural domain boundaries, natively unstructured or disordered regions in proteins, and prot

185 , worm, and fly genomes that have anomalous, unstructured, or high signal in next-generation sequenci

186 tured group psychoeducation versus optimised unstructured peer support for patients with remitted bip

187 this intervention are unclear compared with unstructured peer support matched for delivery and aim o

188 linically effective than similarly intensive unstructured peer support, but was more acceptable and i

189 tructured group psychoeducation or optimised unstructured peer support.

190 N- and C-terminal domains; insertions of an unstructured peptide between these domains and the trans

191 C-36 converts from an unstructured peptide to mature amyloid twisted-ribbon fi

192 Promoter B encodes a charged, unstructured peptide, whereas promoter C encodes an amph

193 Towards this goal, here we have combined unstructured peptide-insertion screening (UPS) with elec

194 We show that unstructured peptides containing alternating N--trifluor

195 Control HX-MS experiments using unstructured peptides labeled at pD 4.0 under crowded an

196 n and in a proof-of-concept experiment using unstructured peptides under slow-exchange conditions (pD

197 globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins.

198 rk demonstrates that digital phenotyping and unstructured phenotype data can be combined with structu

199 ore variability altogether or only model its unstructured Poisson-like aspects.

200 l findings by describing the chaperone as an unstructured polyelectrolyte.

201 ClpB3 specifically targets unstructured polypeptides and mediates the reactivation

202 relatively slow but eventually surpasses the unstructured population (hare) in average fitness.

203 a structured population only lags behind an unstructured population in average fitness (ultimately c

204 In an unstructured population, a lineage with selective access

205 At pH 6.4, for the major unstructured population, the peptide sinks deeper into t

206 recent changes in effective size compared to unstructured populations.

207 inform on the structural preferences of the unstructured portion using RDC-prediction tools and the

208 Unstructured protein or polymer chains pack loosely and

209 ify the search; these include the removal of unstructured protein regions, application of attraction

210 Numerous biomolecular interactions involve unstructured protein regions, but how to exploit such in

211 How can an unstructured protein sense the structure of the membrane

212 an alpha-synuclein (alpha-Syn) is a natively unstructured protein whose aggregation into amyloid fibr

213 cofactors that bind MET-2: LIN-65, a highly unstructured protein, and ARLE-14, a conserved GTPase ef

214 onformational change, generating a partially unstructured protein.

215 globule structures ( approximately 0.33) and unstructured proteins ( approximately 0.50).

216 nal distributions, many of the properties of unstructured proteins are difficult to describe with the

217 asis for relating the physical properties of unstructured proteins to folding and function.

218 rete coordination environment reminiscent of unstructured proteins, the micelles favor triplet format

219 losis ClpP1P2 to degrade larger peptides and unstructured proteins, this effect is weaker than for Cl

220 in, particularly for partially or completely unstructured proteins.

221 ve hydrogels are designed with intrinsically unstructured proteins.

222 he enthusiasm of using the massive amount of unstructured public data.

223 use/dependence (n = 2797) and (2) data from unstructured qualitative interviews with a subset of pat

224 unting for 44.3% of the total variance in an unstructured random-effects model.

225 ven though RNAcompete data is designed to be unstructured, RCK can still learn structural preferences

226 s substitutions at residues 95 and 96 in the unstructured region affected CWD propagation, their prot

227 component, and is instead determined by the unstructured region flanking AUG828.

228 id protein is unstructured in solution, this unstructured region folds in the virion into a single ex

229 eptide sequence of the exposed extracellular unstructured region linking the S5-S6 transmembrane segm

230 f specific sequence features in the normally unstructured region of PrP that influence the infectious

231 main and a conserved peptide motif within an unstructured region of the molecule, partly occludes the

232 ong single-stranded areas and a large A-rich unstructured region surrounding the initiation codon AUG

233 The Q-rich domain is part of the unstructured region, which becomes increasingly dynamic

234 LV] and S[AV]F[SA]FLN, within its C-terminal unstructured region, which interact with the C-terminal

235 ally from the Bcl-2 fold is an intrinsically unstructured region.

236 served throughout the protein, especially in unstructured regions and at the end of helices.

237 ind DNA, whereas weak nucleosome binders use unstructured regions and/or beta sheets.

238 Similar interactions occur with unstructured regions flanking the rod domain during olig

239 he Ypp1 C-terminal lobe, which also binds to unstructured regions in the Efr3 C terminus.

240 It is increasingly apparent that unstructured regions integrate the kinase catalytic chas

241 Moreover, docking peptides arise in unstructured regions of proteins that are probably alrea

242 COP subunits bind Wxn(1-6)[WF] motifs within unstructured regions of proteins that influence the life

243 n control over mineral microstructure, where unstructured regions of these proteins become more order

244 Recently, the surprising prevalence of unstructured regions or entirely disordered proteins und

245 signal and local conformational bias within unstructured regions raises a question: can phosphorylat

246 chondroitin attachment sites are located in unstructured regions.

247 Mcm4, a helicase subunit, possesses an unstructured regulatory domain that mediates control fro

248 ng pathways in a manner reminiscent of other unstructured regulatory elements commonly found in mamma

249 cal exchange rates are measured by use of an unstructured reporter peptide, YPI.

250 led to an overall increase in the amount of unstructured RNA in the 3'UTR.

251 s of a specific protein to more than 240 000 unstructured RNA probes in one experiment.

252 ed of stably folded RNA domains connected by unstructured RNA regions.

253 For RNAPII, unstructured RNA, which favors slowed elongation, was as

254 Our model shows a transition from an unstructured salt-and-pepper organization to a pinwheel

255 andem pair of dsRBDs separated by a natively unstructured segment confers dsRNA binding activity.

256 branes in the absence of Ca(2+) and the long unstructured segment linking C2A to the vesicle membrane

257 RNase E cleavage in an unstructured segment located immediately upstream from t

258 cally contain higher-order RNA structure, an unstructured sequence of about 84 nucleotides (nt) immed

259 erall structure by fusing the 3' UTR with an unstructured sequence.

260 of a greater number of co-moving stars than unstructured space) and the field.

261 iven navigational locomotion in confined and unstructured space.

262 red by the nanopore can freely fold from the unstructured state without constraint and can be program

263 retches that become available because of the unstructured states of targeting-competent preproteins.

264 atically identifying the features present in unstructured stimuli based solely on neuronal responses.

265 te state for folding and aggregation with an unstructured strand A and a native-like core.

266 Basalins are predicted to be highly unstructured, suggesting they may act as 'hubs' facilita

267 ayer integrity as determined by conventional unstructured surface based SPRI.

268 orders of magnitude higher than that from an unstructured surface, and vortex beams with topological

269 Unstructured T-rich DNAs cooperatively fold with the tre

270 at the interaction is between the N-terminal unstructured tail of H3 and the C-terminal unstructured

271 from multiple phosphorylation events on the unstructured tail of its Hec1 subunit are additively int

272 of Abeta accommodated by the oligomers as an unstructured tail.

273 s an SH3 domain fold flanked by a C-terminal unstructured tail.

274 the dimer-dimer interface and the C-terminal unstructured tail.

275 ce or post-translational modification of the unstructured tails of tubulin result in substantial chan

276 acent to each other and can be bridged by an unstructured target loop of 1-15 nucleotides.

277 ibuted interactions mediated by the natively unstructured termini of Hfq.

278 of this information remains 'locked' in the unstructured text of biomedical publications.

279 is information is distributed throughout the unstructured text of over 23 million articles.

280 illion possible conceptual associations from unstructured text, and triangulation with insights from

281 However, much of the data contains unstructured text, presenting an obstacle to automated e

282 r utilization of both structured (coded) and unstructured (text) data.

283 d NVivo 11 to derive descriptive patterns of unstructured textual data.

284 ral pH both N17 and the polyQ become largely unstructured-thereby suggesting a mechanism for how N17

285 GORS extended to downstream differences from unstructured transcripts in expression of TNF-alpha, oth

286 ocess can proceed through both structured or unstructured TS's with similar probabilities.

287 ned with both pre-structured (adenosine) and unstructured (tyrosinamide) aptamers and with dyes of di

288 ivity in Xanthomonas XopD, contributed by an unstructured ubiquitin binding region.

289 Chains of rU bases are relatively unstructured under all conditions, while chains of rA ba

290 at the IL-23 alpha-subunit remains partially unstructured until assembly with its beta-subunit occurs

291 y functional sites of the 50S subunit remain unstructured until late stages of maturation, preventing

292 domain in dynamin, however, Drp1 contains an unstructured variable domain, whose function is not yet

293 roteins contain polypeptide domains that are unstructured when analyzed in cell lysates.

294 se that the amino-terminal portion of p33 is unstructured when VacA is in a monomeric form and that i

295 nal alpha6/alpha7/alpha8-helices are largely unstructured, whereas the apo-PhuS H212R variant showed

296 ever, in RNAcompete, most synthetic RNAs are unstructured, which makes machine learning methods not e

297 irm completeness; the "Standard" format was "unstructured" with minimal direct guidance to give resea

298 Unstructured XTEN polypeptides have hydrodynamic volumes

299 Chaperone-bound SH3 is largely unstructured yet distinct from the unfolded state in the

300 he CCCH-type TZF domain of MEX-5 contains an unstructured zinc finger that folds upon binding of its