ライフサイエンスコーパス: unsuccessful

1 large), and reinforcing outcomes (successful/unsuccessful).

2 general practitioner (GP) practice have been unsuccessful.

3 targeting the KRAS protein has thus far been unsuccessful.

4 ron carbene intermediates have thus far been unsuccessful.

5 uals with functional roles have been largely unsuccessful.

6 tivation in oligodendrocytes in MS have been unsuccessful.

7 the full capacity using additives have been unsuccessful.

8 a (201 copies/mL); sequence confirmation was unsuccessful.

9 he membrane current of intact GUVs have been unsuccessful.

10 degeneration (FTLD) tau inclusions has been unsuccessful.

11 tion underlying depression have largely been unsuccessful.

12 ed dimension of such defects has been so far unsuccessful.

13 approach based on a late-stage oxidation was unsuccessful.

14 ers was performed as a comparison and deemed unsuccessful.

15 uman BCO2 expressed in Escherichia coli were unsuccessful.

16 th prior attempts at direct inhibition being unsuccessful.

17 of the threatened red-crowned crane has been unsuccessful.

18 linically useful inhibitors has been largely unsuccessful.

19 rystallization of the full-length enzyme was unsuccessful.

20 r patients has been inconsistent and largely unsuccessful.

21 ispose tumors to metastasis have been mostly unsuccessful.

22 ately, targeted therapies thus far have been unsuccessful.

23 efforts to transmit GSS to rodents have been unsuccessful.

24 ioral therapy for insomnia (CBT-I) alone was unsuccessful.

25 eutic interventions has been disappointingly unsuccessful.

26 del-Crafts cyclization as the last step, was unsuccessful.

27 95%CI, 3-10) patients fundus photography was unsuccessful.

28 rosine phosphatases (PTPs), nearly all of it unsuccessful.

29 ctic processing was ultimately successful or unsuccessful.

30 to pharmacologically inhibit YAP1 have been unsuccessful.

31 r mitigate its neurotoxicity has so far been unsuccessful.

32 y years, yet these efforts have been largely unsuccessful.

33 ashion via nickel catalysis has been largely unsuccessful.

34 o therapeutic benefit have also been largely unsuccessful.

35 resolution approaches is often difficult and unsuccessful.

36 and trifluoromethylamino diazonium ions were unsuccessful.

37 dues of the amphipathic helical address were unsuccessful.

38 copy protein kinase C-encoding gene, proved unsuccessful.

39 cobacter pylori (H. pylori) are increasingly unsuccessful.

40 ared with communities where the invasion was unsuccessful.

41 s human trials of subunit vaccines have been unsuccessful.

42 nto proteins using the TM have thus far been unsuccessful.

43 PG from pathogenic Chlamydiae have remained unsuccessful.

44 ies to increase survival have proved largely unsuccessful.

45 while those that do not breed continue to be unsuccessful.

46 ects in non-human primates were surprisingly unsuccessful.

47 etion onto protoplanets have hitherto proven unsuccessful.

48 Previous treatment attempts have been unsuccessful.

49 tive 3CR using a chiral phosphoric acid were unsuccessful.

50 esigned to target CD8+ T cell responses were unsuccessful.

51 as its complete removal from the genome was unsuccessful.

52 these products were in the majority of cases unsuccessful.

53 at closure of the seven-membered D ring were unsuccessful.

54 omen with urgency UI if bladder training was unsuccessful.

55 ardizing ZAP-70 expression analysis has been unsuccessful.

56 ts in whom conventional treatments have been unsuccessful.

57 macrocycle from these conjoined subunits was unsuccessful.

58 is is unclear and antiallergic therapy often unsuccessful.

59 th solid tumors, however, have thus far been unsuccessful.

60 dTV horizontally through microinjection were unsuccessful.

61 ti-inflammatory therapies have proven mostly unsuccessful.

62 s based on these approaches have so far been unsuccessful.

63 early asymptomatic beta-cell defect remains unsuccessful.

64 y patients for cetuximab treatment have been unsuccessful.

65 all attempts to develop a vaccine have been unsuccessful.

66 and chicken cell lines for both viruses were unsuccessful.

67 ncer (NSCLC), in whom crizotinib therapy was unsuccessful.

68 fungal vaccine over the last 2 decades were unsuccessful.

69 CCR2 and CCR5 clinical candidates have been unsuccessful.

70 approaches to reduce exacerbations have been unsuccessful.

71 s to combat the underlying obesity are often unsuccessful.

72 bixin as separation of the two compounds was unsuccessful.

73 rapeutic STAT3 inhibitors have thus far been unsuccessful.

74 y testing examples of one successful and one unsuccessful 2D combination experimentally.

75 One placement was unsuccessful (abdominal wall not breached), two patients

76 entation for mapping and ablation because of unsuccessful ablation from the coronary venous system an

77 tion is associated with better outcomes than unsuccessful ablation.

78 However, ACT against large tumor burdens was unsuccessful, accompanied by CTL deletion and functional

79 Across outcomes (ie, successful and unsuccessful) activity in the right habenula decreased i

80 onships between CMV, immune dysfunction, and unsuccessful aging during chronic HIV infection is warra

81 ods of dendrite suppression have been mainly unsuccessful and have significant implications for pract

82 ivacy attacks are theoretically possible but unsuccessful and unconvincing in real settings.

83 edical weight loss strategies are frequently unsuccessful and unsustainable.

84 Extensive workup was unsuccessful, and a genetic cause was suspected.

85 re for topologies where design was initially unsuccessful, and revealed subtle contributions to stabi

86 eft kidney by flushing on the backtable were unsuccessful, and the kidney was thought to be unsuitabl

87 developed solution is highlighted by several unsuccessful approaches and unexpected rearrangements.

88 ations, and the delineation of several other unsuccessful approaches highlight its unique elements.

89 d with mitochondrially-targeted lipoate were unsuccessful at correcting the deficiency.

90 f mPV IgG into wild-type (WT) mice have been unsuccessful at inducing disease.

91 ches into thermally stable photoisomers were unsuccessful at photogenerating macroscopic shapes that

92 mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology o

93 However, if these processes are unsuccessful at resolving ER stress, a terminal UPR prog

94 of a 2-deoxy-2-fluoro-substrate, and several unsuccessful attempts at confirmation of a simpler mecha

95 Our unsuccessful attempts at intramolecular carboacylation o

96 h mortality and significant morbidity due to unsuccessful attempts at rehabilitation that necessitate

97 pmental defects, perhaps explaining previous unsuccessful attempts at their stable transformation.

98 Numerous unsuccessful attempts have been made to identify specifi

99 The unsuccessful attempts often result in dissociation of BL

100 xic treatments, fertility concerns, previous unsuccessful attempts to conceive, and sexual dysfunctio

101 Following unsuccessful attempts to express functional myosin 15-S1

102 After numerous unsuccessful attempts to prepare these compounds by ther

103 teins are associated with many diseases, but unsuccessful attempts to target the small GTPases direct

104 Therapy was judged unsuccessful because of the continuous growth of the NV

105 to target this pathway therapeutically were unsuccessful because of toxicity, lack of efficacy, or b

106 erapies to induce a hypoestrogenic state are unsuccessful because of undesirable side effects, reprod

107 rmediates using a 1,1-difluoro-substrate was unsuccessful because the probe was too deactivated to be

108 So far, drug discovery strategies have been unsuccessful, because of a lack of suitable screening me

109 Predictors for unsuccessful bidirectional mitral isthmus blockade were

110 oupling with naphthoquinone fragments proved unsuccessful, both amidation and C-N bond formation tact

111 (RT-PCR) identification of known viruses was unsuccessful, but a next-generation sequencing (NGS) app

112 owed greater activation than the rIFC during Unsuccessful, but not Successful, Stop trials, and multi

113 Effective vaccine development has been unsuccessful, but surveillance data suggest that outer m

114 These kindreds had earlier unsuccessful candidate gene testing and five probands we

115 ded the majority of those who died following unsuccessful cardiopulmonary resuscitation attempts or b

116 arge and extreme horizontal aorta in 2 and 1 unsuccessful cases, respectively).

117 performed multiple short, high-speed, mostly unsuccessful chases to capture prey, while cheetahs (Aci

118 Unsuccessful choices are more likely to be abandoned but

119 ent and temporal structure information (with unsuccessful classification of image content or interval

120 experimentally adapted prions led to several unsuccessful clinical studies in patients with prion dis

121 The unsuccessful clinical trials of proteasome inhibitor PS-

122 thic pain have failed to translate following unsuccessful clinical trials suggesting the possibility

123 Despite unsuccessful clinical trials using anti-IL-1beta monothe

124 0 orthologue in Mycobacterium smegmatis were unsuccessful, consistent with previous studies indicatin

125 .4 versus 22.5+/-20.8, P<0.01) compared with unsuccessful CTO PCI.

126 Patients with unsuccessful CTO PCIs had significantly higher 2.5-year

127 roved survival compared with procedures with unsuccessful CTO, and higher-volume CTO operators are mo

128 bers (N = 15) who had direct experience with unsuccessful DCD and 5 focus groups with professionals i

129 bdominal transplants are not possible due to unsuccessful DCD organ donation.

130 experimental results for both successful and unsuccessful dechlorination, suggesting the model is a v

131 manipulation for nutrient acquisition and/or unsuccessful defence responses, such as kauralexin produ

132 g these activation patterns in LDVF and that unsuccessful defibrillation shocks may alter activation

133 All unsuccessful direct laryngoscopy patients were successfu

134 Were unsuccessful donations converted to successful donations

135 m withdrawal of support to patient death for unsuccessful donations was 33 hours, 37 minutes (range,

136 UPR attempts to restore proteostasis but if unsuccessful drives affected cells towards apoptosis.

137 tal tissues (including cementum) are largely unsuccessful due to a lack of full understanding about t

138 Earlier attempts to produce MH were unsuccessful due to diamond failure before the required

139 f the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges.

140 n peg formation, but cuticle penetration was unsuccessful due to reduced appressorial adhesion, which

141 cancers including colorectal cancer, but are unsuccessful due to severe adverse reactions.

142 maguchi macrolactonization reaction that was unsuccessful due to steric hindrance of the oxygen at th

143 of CA IX inhibitors so far has been largely unsuccessful due to technical difficulties regarding the

144 This attempt was unsuccessful due to the chemical instability of the bis-

145 programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood-brain

146 Although the oxidants tested were unsuccessful, electrophiles, particularly NBS, enabled t

147 entifies neural signatures of successful and unsuccessful emotional memory discrimination.

148 was greater during successful compared with unsuccessful encoding, and that this alignment was corre

149 controlled under antiarrhythmic drugs after unsuccessful endocardial/epicardial ablation.

150 Reasons for failed or limited ablation were unsuccessful epicardial access (6%), failure to identify

151 t placement indicated after a total of three unsuccessful EVD clamping attempts or need for CSF drain

152 Treatment of ventilated pneumonia is often unsuccessful, even when patients are treated according t

153 y probe transmembrane motion, and reversible unsuccessful excursions to the intermediate state occur.

154 rous theoretical investigations and hitherto unsuccessful experimental searches have followed Dirac's

155 ect on extinction when administered after an unsuccessful exposure session.

156 FAV but in only 16% of the 19 patients with unsuccessful FAV.

157 ose undergoing technically successful versus unsuccessful FCI (63.6% vs. 46.7%, respectively), althou

158 Therapies targeting these events have been unsuccessful; findings in experimental models suggest th

159 Of the unsuccessful first-time applications, 24 (15.9%) include

160 tates with spectroscopic tools are typically unsuccessful for such systems.

161 area index were significantly smaller in the unsuccessful group (P = 0.004 and 0.003, respectively).

162 n the successful group versus 2 (11%) in the unsuccessful group (P = 0.008).

163 R/S ratio of > 2 in V1 versus 5 (28%) in the unsuccessful group (P = 0.056).

164 ave in lead V1, as opposed to 6 (33%) in the unsuccessful group.

165 Crossover to half-dose PDT after previous unsuccessful HSML treatment for cCSC may lead to improve

166 or patients in whom it is contraindicated or unsuccessful, hydromorphone could be offered as an alter

167 d information on 'dark' reactions--failed or unsuccessful hydrothermal syntheses--collected from arch

168 patient was cured or completed treatment and unsuccessful if the patient died or defaulted from treat

169 as inducible at the end of the procedure and unsuccessful if VT remained inducible or if programmed s

170 image of one or both eyes was gradable, and "unsuccessful" if neither macula-centered image was grada

171 henomenon of hyperprogression in response to unsuccessful immunotherapy.

172 Regardless of group, 71.4% of the unsuccessful implants failed before the end of the first

173 Endoscopic resection was unsuccessful in 5 patients, but no surgical intervention

174 cefixime-resistant strains with cefixime was unsuccessful in 83% (95% CrI 53%-99%) of cases, represen

175 tiology but endoscopic intervention is often unsuccessful in achieving durable hemostasis with surger

176 s targeted toward these type 2 pathways were unsuccessful in all patients.

177 mechanisms of resistance have generally been unsuccessful in clinical practice.

178 ar, vaccines containing AMA1 alone have been unsuccessful in clinical trials.

179 mall, inconsistent in their formulations, or unsuccessful in controlling for total supplement calorie

180 MALDI MSI was unsuccessful in detecting all of the target compounds; t

181 WAS) of chronic periodontitis (CP) have been unsuccessful in discovering susceptibility factors.

182 Clinical trials to date have been largely unsuccessful in identifying effective treatments for HFp

183 dered in patients with obesity who have been unsuccessful in losing or maintaining weight loss with l

184 viruses implicated in myocarditis have been unsuccessful in more accessible samples such as peripher

185 anoma cells even in drug-sensitive tumors is unsuccessful in patients because a subset of cells can t

186 of HGF-targeting therapies have been largely unsuccessful in several different cancers (e.g., gastric

187 mechanistic insight as to why surgery may be unsuccessful in some patients.

188 require an HR defect for efficacy, have been unsuccessful in sporadic BLCs, unlike cisplatin, which e

189 This approach has often been unsuccessful in the long term, especially for solid tumo

190 Furthermore, those who are unsuccessful in their cessation attempt can safely re-es

191 rivatives which are commercially limited and unsuccessful in traditional condensation chemistry.

192 sis factor (TNF)inhibitors have been largely unsuccessful in treating AA and have been reported to in

193 IL-6 inhibition has been unsuccessful in treating psoriasis, despite high levels

194 r, many efforts toward ocean recovery remain unsuccessful, in part because marine ecosystems and the

195 und reaction in a synthetic system have been unsuccessful, in part because of the challenge in prepar

196 preclinical models, but have been clinically unsuccessful, in part due to side effects.

197 s related to alloimmune status kinetics were unsuccessful, indicating considerable complexity in indi

198 ut in only 6% initial fundus photography was unsuccessful, indicating its value in assessing retinopa

199 We quantified host behaviour, successful and unsuccessful infections, and each species' reaction norm

200 rescuing method for patients undergoing two unsuccessful initial attempts of NGI without a preinstal

201 otection was associated with reduced risk of unsuccessful intervention (odds ratio, 0.27; 95% credibl

202 ed to compare outcomes at 30 days, including unsuccessful intervention, periprocedural myocardial inf

203 When therapy is unsuccessful, it is likely due to resistance to clarithr

204 he uterine cavity and history of two to four unsuccessful IVF cycles.

205 sound of the uterine cavity and a history of unsuccessful IVF treatment cycles does not improve the l

206 We show that they are formed at unsuccessful leader branches, are as bright as the light

207 Pharmacological inhibition of KRAS has been unsuccessful, leading to a focus on downstream effectors

208 g the dopaminergic system have thus far been unsuccessful, leading to alternative strategies aimed at

209 eractive in major depressive disorder during unsuccessful loss-avoidance although the median raphe nu

210 in emergency departments, yet traumatic and unsuccessful lumbar punctures occur 30% to 50% of the ti

211 Dehydration may be a risk factor for unsuccessful lumbar punctures, but to our knowledge, no

212 r revealed signatures of both successful and unsuccessful maladaptive repair.

213 lity to extract useful information even from unsuccessful metadynamics runs.

214 roduce human speech sounds have largely been unsuccessful, most notably in extensive studies on great

215 s motor behavior is shaped by successful and unsuccessful movements.

216 and retinal vein occlusion the procedure was unsuccessful, necessitating pars plana vitrectomy, while

217 ing biomarkers for distinguishing successful/unsuccessful nerve repairs and potentially identify case

218 ion rates among trials of new successful and unsuccessful neurological drugs.

219 Six of 171 (3.5%) other patients received unsuccessful nonsurgical treatment with SAE.

220 Four patients underwent SAE after unsuccessful observation.

221 Since they are associated with unsuccessful ocriplasmin treatment, presence and topogra

222 atabase listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain

223 ts, and in the remaining 39 patients, it was unsuccessful or had to be abandoned because of anatomic

224 iological measure of idiopathic LVOT VAs was unsuccessful or had to be abandoned because of anatomic

225 ficult, and clonality analysis may be either unsuccessful or misleading.

226 If the ECV was unsuccessful or not performed, the women were offered ei

227 urgical coagulation and hemostatic clips are unsuccessful or predicted to be ineffective.

228 ) is recommended when a single medication is unsuccessful or produces side effects at higher dosages;

229 ail and ablation has been declined, has been unsuccessful, or has been deemed inappropriate.

230 PLWH were at increased risk of an unsuccessful outcome (adjusted hazard ratio, 4.8; 95% CI

231 MTBDRplus at 2 months was associated with an unsuccessful outcome (aOR 2.87; 95% CI, 1.11 to 7.42).

232 dently associated with outcome, with risk of unsuccessful outcome decreasing by 12% (95% CI, .81%-.95

233 (19%) were HIV positive, and 35 (6%) had an unsuccessful outcome.

234 had a successful outcome, and 222 (56.5%) an unsuccessful outcome: 39 (9.9%) died, 56 (14.3%) had fai

235 eals the actual ratio between successful and unsuccessful outcomes, allowing to learn from both to re

236 Intriguingly, in patients with unsuccessful outcomes, the proposed computational approa

237 oximately 39% of identified pregnancies were unsuccessful over the 15 years, and the average annual p

238 Extubation is often unsuccessful owing to lung disease or inadequate respira

239 Such observations have, to date, been unsuccessful owing to the difficulty in preparing cold,

240 outcomes of patients with successful versus unsuccessful PCI to a CTO.

241 These results demonstrate that the risk of unsuccessful periodontal treatment is associated with ta

242 damage of the vitreoretinal interface after unsuccessful pharmacologic vitreolysis compared to untre

243 ng recently been validated using data from 3 unsuccessful phase 3 trials.

244 een promising but are frequently followed by unsuccessful phase III studies, highlighting a disconnec

245 y assigned; one was not immunised because of unsuccessful phlebotomy.

246 Approaches using ancient DNA have also been unsuccessful, probably because of rapid DNA degradation

247 d was associated with a higher percentage of unsuccessful procedures compared to patients with unilat

248 Several unsuccessful recapturing attempts occurred once the doma

249 series correlations during successful versus unsuccessful recollection in three separate experiments,

250 to understand the dynamics of successful and unsuccessful reductive dechlorination of chlorinated eth

251 function, and age (all p < 0.001) along with unsuccessful reperfusion (p = 0.25) were independently p

252 t inevitably differ from the original study; Unsuccessful replication indicates that the reliability

253 % OPEN.Disease-free survival was impacted by unsuccessful resection (hazard ratio [HR] 1.87, 95% CI 1

254 le paralysis may be a contributing factor to unsuccessful respiratory support.

255 infarct-related ventricular tachycardia had unsuccessful response to radiofrequency ablation at crit

256 -wide association studies, have been largely unsuccessful, resulting in limited knowledge as to the c

257 sults of tarsoaponeurectomy in patients with unsuccessful results after repetitive surgery or who dev

258 behaviorally and neurally: successful versus unsuccessful retrieval was associated with hippocampal a

259 that GBA patterns during successful (but not unsuccessful) retrieval of one sequence were more simila

260 This challenge was highlighted by the unsuccessful search for Malaysian Flight 370 (MH370) whi

261 tants in the presence of A4(1) or E5(1) were unsuccessful, showing that effective broad-spectrum anti

262 ents with novel mechanisms have been largely unsuccessful since the 1950's until the discovery of ket

263 at control virus load but disappointingly is unsuccessful so far in preventing infection, and attenti

264 gets in angiogenesis and metabolism has been unsuccessful so far in the breast cancer clinical settin

265 rately differentiated between Successful and Unsuccessful Stop trials.

266 ul strikes where the tongue hit the fly, and unsuccessful strikes where the fly turned and the tongue

267 to restore fusion with a reducing agent were unsuccessful, suggesting that the introduced disulfide b

268 mmune mechanisms that underlie successful vs unsuccessful Tac removal are unknown.

269 ect PG in any chlamydial species have proven unsuccessful (the 'chlamydial anomaly').

270 When the first ablation was unsuccessful, the second ablation was delivered on the o

271 If unsuccessful, the UPR initiates a proapoptotic program t

272 targeting EGFR in glioma has been relatively unsuccessful, this study suggests that IGFBP2 may be a n

273 from shore and within the water column were unsuccessful; this was identified as a key bottleneck to

274 id tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced im

275 romising, CCR2 antagonists have been largely unsuccessful to date.

276 anges associated with EF-G dissociation upon unsuccessful translocation attempts of the second slippa

277 al benefit of achieving an SVR compared with unsuccessful treatment in a range of populations infecte

278 y of HCV and inadequate drug exposure during unsuccessful treatment may lead to the accumulation of v

279 ear was not significantly associated with an unsuccessful treatment outcome (adjusted odds ratio [aOR

280 ICs of fluoroquinolones were correlated with unsuccessful treatment outcome in MDR-tuberculosis patie

281 -8.81) were independently associated with an unsuccessful treatment outcome.

282 >40 years were significantly associated with unsuccessful treatment outcome.

283 Reducing unsuccessful treatment trials could improve depression t

284 tiple sclerosis are traditionally used after unsuccessful treatment with first-line disease modifying

285 direct MTBDRplus at 2 months with subsequent unsuccessful tuberculosis treatment outcome (failure/dea

286 y HIV status, using quantile regression, and unsuccessful tuberculosis treatment outcome (treatment f

287 weight gain and HIV independently predicted unsuccessful tuberculosis treatment outcomes.

288 ve immune reconstitution have until now been unsuccessful, underscoring the need for better insight i

289 severe biventricular dysfunction predicting unsuccessful univentricular left heart support; and (3)

290 otent and durable B-cell responses have been unsuccessful until now.

291 tihyperglycemic therapies, however, has been unsuccessful until recently.

292 r second-generation ALK inhibitors have been unsuccessful warrants further studies.

293 nti-Abeta immunotherapy clinical trials were unsuccessful was due to this high percentage of VCID com

294 gnificant differences between successful and unsuccessful weans.

295 vironmental risks of exploration by reducing unsuccessful wells.

296 ium-mediated transformation of epicotyls was unsuccessful when a constitutive promoter (2x CaMV 35S)

297 In mammals complete regeneration is often unsuccessful, while most of the low phyla animals can re

298 ombination antiretroviral therapy (cART) was unsuccessful with viremia levels 50-1000 copies/mL, for

299 attempts were made into the sternum; 54 were unsuccessful, with an overall success rate of 76%.

300 to either the tibia or the humerus; 192 were unsuccessful, with an overall success rate of 91%.