ライフサイエンスコーパス: unsuitable

1 recombinant proteins may be unaffordable or unsuitable.

2 an optimal donor/recipient matching is often unsuitable.

3 Only 8 patients were deemed technically unsuitable.

4 other CE morphologic imaging modalities are unsuitable.

5 addition to making some anti-codon sequences unsuitable.

6 ot have (18)F-FDG avidity or are technically unsuitable.

7 n methods such as RFID tags and QR codes are unsuitable.

8 rmeate through the capsule shell and is thus unsuitable.

9 e interaction geometries become increasingly unsuitable.

10 peratures where this calibration approach is unsuitable.

11 misclassified patients, 128 became medically unsuitable, 35 died, and 26 became too sick to transplan

12 th removal codes of "too sick" or "medically unsuitable." A total of 44 388 patients were included; 4

13 raditional sequence alignment methods become unsuitable and infeasible.

14 the literature method for their preparation unsuitable and present an alternative synthesis.

15 conditions typically considered suitable to unsuitable and using vocal cues presented during two tim

16 t the assay used to reach this conclusion is unsuitable, and that promoter-bound, active Gal4 is inde

17 ding the presence of records in climatically unsuitable areas as a result of repeated introduction.

18 ing better discrimination of suitable versus unsuitable areas for AGM.

19 at sample heterogeneity makes RNASeq on PBMC unsuitable as a first-step method for screening biomarke

20 This test is unsuitable as a screening tool for gonorrhea.

21 at models, (11)C-JNJ-42491293 was considered unsuitable as a specific PET ligand for in vivo imaging

22 essure, hippocampal apoptosis), rendering it unsuitable as a therapeutic approach to chronic spinal i

23 Although unsuitable as a therapeutic due to M(2) receptor cross-r

24 thine decarboxylase activity was found to be unsuitable as an alternative to PCR identification, disp

25 Although unsuitable as biological probes due to widespread reacti

26 nearly all have properties that render them unsuitable as drug candidates.

27 viral antigenicity, which made these mutants unsuitable as vaccine candidates.

28 containing immunochemotherapy was considered unsuitable because of coexisting cardiac disease.

29 testing, two potential LRKD were considered unsuitable because of the detection of stage I ("simple"

30 We show that pyridine boronic acids are unsuitable, but they can be halogen-modified at the 2-po

31 This makes them unsuitable candidates for existing 3D-QSAR methods and h

32 d reduced graft function who were considered unsuitable candidates for PRB (4.2% of all renal transpl

33 when TTI is found to be low, would eliminate unsuitable class 1b drugs prior to next stage in vivo wo

34 have been in response to the strong flow and unsuitable conditions.

35 used host ants to be replaced by similar but unsuitable congeners, explaining the extinction of Europ

36 paranasal sinuses may be due to selection of unsuitable CT windows.

37 heir conclusions are overstatements based on unsuitable data and inappropriate analyses.

38 ues such as toxicity, variable efficacy, and unsuitable dosing options.

39 .1% unassessed, 30.4% medically unfit, 16.9% unsuitable due to age, 3.1% psychologically unfit and 1.

40 Women were more likely to be reported as unsuitable due to age, medically unfit and declined, and

41 ases procured for transplantation are deemed unsuitable due to concerns about graft quality and the a

42 However, such approach proved to be unsuitable due to the complexity of the obtained composi

43 to platforms that were previously considered unsuitable due to their large losses.

44 .g. CYTB gene, for species quantification is unsuitable, due to a fivefold inter-tissue variation in

45 These include ineffective pathways of care, unsuitable environments, inadequate resources and staffi

46 MRI) contrast agents (CAs) are suboptimal or unsuitable, especially at higher magnetic fields (>1.5 T

47 Unsuitable FOBT testing led to further unnecessary inves

48 Three patients were deemed medically unsuitable following surgical inspection, 56 patients di

49 ver, this method of analysis would likely be unsuitable for a high-throughput clinical microbiology l

50 ge coils (at least a centimeter in diameter) unsuitable for a microimplant.

51 dequate water quality can mean that water is unsuitable for a variety of human uses, thus exacerbatin

52 but who harbor potentially aggressive tumors unsuitable for active surveillance.

53 ignment for single-end reads, which makes it unsuitable for alignment of longer reads where indels ma

54 xercise performance, but current systems are unsuitable for ambulatory use.

55 ates were cleaved by cathepsins, making them unsuitable for analysis of complex cellular systems, the

56 ties of porphyrins, many of these assays are unsuitable for analysis of the catalytic properties of C

57 , making them susceptible to degradation and unsuitable for applications requiring cleavage at elevat

58 re changes in the few kPa range, making them unsuitable for applications such as heart-rate monitorin

59 6 (37%) of the arterial sections examined as unsuitable for AVF creation compared with 61 of 236 (26%

60 the FVB strain, suggesting the background as unsuitable for behavioral analysis.

61 ythm's presence, not spectrally specific, or unsuitable for bidirectional modulation.

62 bility and are compute intensive making them unsuitable for big data and high-throughput environments

63 ontent of free fatty acids (FFAs), otherwise unsuitable for biodiesel production.

64 n 62 cases (4.9%): more complex CHD that was unsuitable for biventricular repair, leading to unplanne

65 degrees and 2 degrees alkylnitrene complexes unsuitable for C-H amination.

66 ring therapeutic enhancement of this process unsuitable for cancer treatment.

67 Though found to be unsuitable for cation determinations, the SCGD-RIC instr

68 However, such inorganic photodetectors are unsuitable for certain applications because of their hig

69 ive; no symptomatic brain metastases; deemed unsuitable for chemotherapy because of poor (>/=2) Easte

70 Patients with NSCLC who are deemed unsuitable for chemotherapy could be given erlotinib.

71 and sanitation, with the available vaccines unsuitable for children and primarily used by travelers.

72 compound-specific isotope analysis (CSIA) is unsuitable for chlorinated compounds such as trichloroet

73 Unfortunately, dantrolene is hepatotoxic and unsuitable for chronic long-term administration.

74 For a variety of reasons, many are unsuitable for clinical practice.

75 molecular level, and potentially render them unsuitable for clinical use in multiple recipients.

76 extracted DNA is of poor quality and may be unsuitable for CN assessment, thus representing a missed

77 changes that are large enough to render them unsuitable for coffee farming, in the absence of signifi

78 Multiple-day diet records can be unsuitable for cohort studies because of high administra

79 approach is time consuming, error prone and unsuitable for combining datasets from many sources.

80 hydrocarbon formation renders this approach unsuitable for commercialization.

81 hanged after 3 days of storage making the CW unsuitable for consumption.

82 children who are spectacle noncompliant and unsuitable for contact lens wear.

83 ty of some algal strains to thrive in waters unsuitable for conventional crop irrigation such as sali

84 w in a viscous bicelle suspension, making it unsuitable for conventional X-ray crystallography.

85 -income areas and marginal habitats that are unsuitable for crop production.

86 ad biopsy-proven oesophageal cancer that was unsuitable for curative treatment, symptomatic dysphagia

87 virus showed that many diagnostic tests were unsuitable for detecting the novel virus isolates.

88 narrow-spectrum agents are typically deemed unsuitable for development because of intrinsic limitati

89 hibitor of acetylcholine esterase (AChE) and unsuitable for development.

90 drates, but its high glycemic index makes it unsuitable for diabetics.

91 population-averaged interactions; therefore unsuitable for direct assessment of many-body interactio

92 n database dependent algorithms and are thus unsuitable for discovery-driven analyses of glycoproteom

93 c and immunological techniques, are at times unsuitable for discriminating closely related species.

94 lood-brain barrier permeability and thus are unsuitable for diseases of the brain.

95 of wHTH domains, resulting in a conformation unsuitable for DNA binding.

96 , and had previously either received or were unsuitable for docetaxel.

97 tories from closed-cleft receptor structures unsuitable for docking.

98 their improved performance, they are however unsuitable for early detection of cancer biomarkers or t

99 These inpatient algorithms are unsuitable for estimating stroke incidence because of lo

100 ul, these are often costly, nonspecific, and unsuitable for evaluating programmatic interventions.

101 Bs), whereas low-affinity binders (LABs) are unsuitable for evaluation.

102 e absence of any significant changes make it unsuitable for examining response to treatment in this s

103 include recognized uropathogens, and may be unsuitable for excluding UTI in patients with LUTS.

104 her familiar nor coherently ordered and thus unsuitable for facilitating memory in this sense.

105 owth is very slow and highly variable and so unsuitable for fast high throughput anti-aggregation dru

106 , current methods have limitations: sampling unsuitable for field conditions, high cost and the inher

107 ing, tedious, expensive, less sensitive, and unsuitable for field situations.

108 hat enable bacteria to colonise environments unsuitable for free-living bacteria.

109 ctively to kringle domains and are therefore unsuitable for functional characterization of specific k

110 t or metastatic esthesioneuroblastoma deemed unsuitable for further conventional therapies.

111 perhexiline analogues 6a-j were found to be unsuitable for further development, as they retained a p

112 derate oral bioavailability made this series unsuitable for further development.

113 P-glycoprotein liability makes this scaffold unsuitable for further development.

114 nsense-mediated mRNA decay (NMD) making them unsuitable for gene targeting applications.

115 licitly and with ad hoc methods, making them unsuitable for general motif searches.

116 le of a large watershed, it was judged to be unsuitable for global scale simulations due to the high

117 eous in both space and time and is generally unsuitable for global trend analysis.

118 However, the current methods are unsuitable for growing single crystals of these oftentim

119 d on a symmetric noise assumption and can be unsuitable for heterogeneous data or asymmetric noise di

120 Because the soft agar assay is unsuitable for high throughput screens (HTS), we develop

121 latively high lasing thresholds, making them unsuitable for high-speed optical communication and comp

122 ively large volumes of solvents, making them unsuitable for high-throughput analysis.

123 mputed tomography (muCT) has been considered unsuitable for histologic analysis of unstained formalin

124 erwhelmingly used laboratory grade materials unsuitable for human clinical use - representing a furth

125 In contrast, we found it unsuitable for immunofluorescence applications in brain.

126 therapy is insufficient, or patients who are unsuitable for immunotherapy.

127 oxide hydrolase (sEH) stable replacement but unsuitable for in vivo applications due to limited oral

128 ameras and high powered microscopes which is unsuitable for in vivo imaging and diagnosis.

129 , in many situations not cost-beneficial and unsuitable for industrial grade scale-up, this study acc

130 e RAW 264.7 macrophage model of infection is unsuitable for inferring human-relevant differences in n

131 rs or older with acute myeloid leukaemia but unsuitable for intensive chemotherapy (or <60 years if u

132 in these elderly patients with AML who were unsuitable for intensive chemotherapy was manageable and

133 for intensive chemotherapy (or <60 years if unsuitable for intensive chemotherapy with an anthracycl

134 IOV-121 were >or= 65 years of age and deemed unsuitable for intensive chemotherapy.

135 This makes existing tools unsuitable for interactive data query or as part of geno

136 und-state geometries, which are increasingly unsuitable for intermolecular interactions as the carbon

137 an EW SPT response <2 mm at entry) and were unsuitable for intervention.

138 nd PS at low calcium concentration, they are unsuitable for intracellular use.

139 s) are useful for analyzing samples that are unsuitable for isotopic labeling but are less accurate.

140 , and the current network-based framework is unsuitable for it.

141 ure or cut from a whole corneal graft button unsuitable for keratoplasty.

142 1E2 antigen is the reliance on GNA, which is unsuitable for large scale-up and global vaccine deliver

143 However, this method is currently unsuitable for large-scale deployment and focus has inst

144 xisting protocols for purification of Sr are unsuitable for lipid matrix.

145 limited to photon wavelengths below 900 nm, unsuitable for long distance communication, and suffered

146 matically unstable and thus considered to be unsuitable for long-term use in patients with obesity.

147 g a marker based on 8bp deletion in BADH2 as unsuitable for MAS in rice cultivars under study.

148 drug capable of eliminating hypnozoites, is unsuitable for mass administration, an alternative drug

149 omised animals, rendered these murine models unsuitable for meaningful assessment of antibody-mediate

150 ns but suggest that self-rated health may be unsuitable for monitoring changes in population health o

151 d and colored in red areas they deemed to be unsuitable for mortgage lending on account of their Blac

152 ls with a few interacting components, and is unsuitable for multi-dimensional systems consisting of a

153 been successful extending access to patients unsuitable for myeloablation.

154 Because Medicare DRGs are unsuitable for obstetrics, pediatrics, and neonatology,

155 tats identified by all models that were also unsuitable for oil palm - a major threat to tropical bio

156 artefacts, require a special hardware or are unsuitable for online application.

157 eceived previous docetaxel treatment or were unsuitable for or declined docetaxel; previous docetaxel

158 t of atrial fibrillation in patients who are unsuitable for or intolerant of drug approaches.

159 ot be offered to patients who are clinically unsuitable for or unwilling to accept further treatment.

160 og that can drive CFTR channel gating but is unsuitable for phosphotransfer by PKA, and CFTR mutants

161 ithography and inkjet printing are currently unsuitable for POC applications due to issues of cost an

162 m time-consuming, costly, less accurate, and unsuitable for point-of-care (POC) diagnostics.

163 However, they are unsuitable for point-of-care multistep reactions because

164 l, K-O(2) is often underestimated and deemed unsuitable for practical applications.

165 uble intercellular adhesion molecule 1) were unsuitable for predicting early complications after live

166 classification and enhancement but is often unsuitable for predictive modeling using features withou

167 d by this technological advancement, and are unsuitable for processing images acquired with rapidly i

168 using the SMD in combination with the SE are unsuitable for publication bias assessments and can lead

169 Dielectrics have long been considered as unsuitable for pure electrical switches; under weak elec

170 However, they are unsuitable for reactions that benefit from bimetallic pr

171 multiple reagents and washing steps and are unsuitable for real-time detection of analyte binding.

172 and that common cell culture media might be unsuitable for redox research.

173 uch that conditions have become increasingly unsuitable for regeneration.

174 rarily sampled data distributions, which are unsuitable for reliable mechanistic inferences.

175 erparameterized and therefore, in principle, unsuitable for representing any data--those models are c

176 onstant need of electricity which makes them unsuitable for resource-limited or POC settings.

177 banked seeds from those populations will be unsuitable for restoring them.

178 timal salvage strategy and identify patients unsuitable for retreatment with FCR, we examined the sur

179 ), 525 patients with critical limb ischaemia unsuitable for revascularisation were enrolled from 171

180 for irreversible chemistry and are typically unsuitable for reversible applications, theoretical proc

181 The lack of a bandgap makes bulk graphene unsuitable for room temperature transistors with a suffi

182 This renders LC x LC unsuitable for routine analysis.

183 or reproducibility and stability making them unsuitable for routine in vivo applications.

184 ng reads to a reference genome, and are thus unsuitable for samples with a partial or missing referen

185 For ECD kidneys unsuitable for single use, dual kidney transplants (DKT)

186 consistently yielded microcrystals that were unsuitable for single-crystal X-ray diffraction, but ide

187 mature brain, these approaches are generally unsuitable for soft, irregular, and heterogeneous tissue

188 rature habitat conditions in tributaries are unsuitable for some dispersing species, thus probably pr

189 ty, this method of fibronectin deposition is unsuitable for some types of research, including quartz

190 n lymphoma or in younger patients considered unsuitable for standard ABVD (ie, doxorubicin, bleomycin

191 der, or younger than 60 years but considered unsuitable for standard chemotherapy because of a cardia

192 trials of SBRT for patients with active HCC unsuitable for standard locoregional therapies were cond

193 ensive and prone to human error, making them unsuitable for standardized clinical diagnoses.

194 xpression, making standard phenotypic assays unsuitable for strain characterization.

195 Xenopus and explant assays in the chick are unsuitable for studying instructive signals in neural in

196 ng pathogenesis is minor, the model has been unsuitable for studying the impact of antibodies on path

197 disease that existing mouse models have been unsuitable for studying.IMPORTANCE The role of antibody

198 e patients (mean age 76.6+/-10 years) deemed unsuitable for surgery who underwent MitraClip treatment

199 ported favorable 1-year outcomes in patients unsuitable for surgery who underwent self-expanding tran

200 due to their location within the brain, are unsuitable for surgical resection and consequently have

201 NSCLC patients with brain metastases unsuitable for surgical resection or stereotactic radiot

202 after liver transplantation (LT) when HCC is unsuitable for surgical/locoregional treatments.

203 le pharmacokinetic properties that render it unsuitable for systemic administration.

204 ss here, the protocol employed by Markel was unsuitable for testing for associative learning.

205 ctron bunch, such an electron-driven wake is unsuitable for the acceleration and focusing of a positr

206 y on optimal starting DNA, and are therefore unsuitable for the analysis of formalin-fixed paraffin-e

207 However, this renders these tools unsuitable for the analysis of large cosmopolitan cohort

208 phosphoprotein characterisation are largely unsuitable for the analysis of non-canonical phosphoryla

209 have a shorter lifespan and NOD ES cells are unsuitable for the complex genetic engineering that is r

210 c A-ring substrate, however, was found to be unsuitable for the introduction of the requisite hydroxy

211 olymerization (DP) <50) species but appeared unsuitable for the largest polymers in the series due to

212 or the study of quantum systems and are also unsuitable for the low-temperature operation that is req

213 es suitable for quantum key distribution but unsuitable for the most general quantum key repeater pro

214 re approaches toward this heterocycle remain unsuitable for the practical synthesis of a library of t

215 intolerable; or treatment contraindicated or unsuitable for the preventive treatment of migraine for

216 protein kinases, but these technologies are unsuitable for the study of kinase behavior in large num

217 es and the volumes required make them highly unsuitable for the testing of mouse platelets.

218 s, the shake-flask method, is antiquated and unsuitable for the testing of valuable and scarce drug c

219 antification of melanoidins were found to be unsuitable for their analysis in bread.

220 ow amounts of moisture makes them, a priori, unsuitable for their direct use as light harvesters in a

221 that lose their identity over time could be unsuitable for therapeutic use.

222 owever, LMB is toxic in vivo, which makes it unsuitable for therapeutic use.

223 Perovskites, however, have so far proved unsuitable for thickness scaling and integration with mo

224 Neopentyl sulfate proved to be unsuitable for this purpose, since it was found to under

225 ceiving life-sustaining treatments are often unsuitable for transfer to home or community hospices.

226 from blood anticoagulated with citrate were unsuitable for transfusion because of platelet clumping.

227 of Canada classified as unsuitable or rather unsuitable for transmission.

228 usly refused for quality are not necessarily unsuitable for transplant and often show excellent outco

229 successful, and the kidney was thought to be unsuitable for transplant.

230 ytime within 72 hours; (III) Declined: lungs unsuitable for transplantation after EVLP.

231 ed after prolonged warm ischemia (WI) may be unsuitable for transplantation due to the risk of reperf

232 Sixteen human donor corneal tissues unsuitable for transplantation were used.

233 Nine human corneoscleral specimens unsuitable for transplantation were used.

234 ssue cubes (ALTCs) using normal liver tissue unsuitable for transplantation.

235 assess and rescue kidneys previously deemed unsuitable for transplantation.

236 ifty-four random human donor corneal tissues unsuitable for transplantation.

237 ys will be discarded because they are deemed unsuitable for transplantation.

238 assess and preserve high-risk kidneys deemed unsuitable for transplantation.

239 going hypothermic pulsatile perfusion deemed unsuitable for transplantation.

240 are available, many of which have been found unsuitable for treatment of neuropsychiatric disorders f

241 endering them difficult to process and often unsuitable for usage.

242 mide, a nonbiodegradable polymer that may be unsuitable for use as a cyanocide in open aquatic enviro

243 t, ES-62, which as an immunogenic protein is unsuitable for use as a drug.

244 are expensive and/or invasive and therefore unsuitable for use as screening tools, but a non-invasiv

245 oped in the 1940s and 1960s that were deemed unsuitable for use as therapeutic agents as a result of

246 xperimental compounds used preclinically are unsuitable for use in humans, due to associated toxicity

247 raditional diagnostic methods that make them unsuitable for use in resource-limited settings, from ex

248 a wide range of mutations, which makes them unsuitable for use in vaccination treatment.

249 r have rigid and bulky form factors that are unsuitable for use on the face or on other curvilinear b

250 ither positrons or gamma-rays and are, thus, unsuitable for use with current nuclear imaging modaliti

251 ily convert into an alternative conformation unsuitable for vaccine purposes.

252 vious palliative surgical procedures, may be unsuitable for ventricular assist device implantation.

253 Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin-K Antagonist Treatment (AVERROES)

254 me and/or mild NPQ responses and were, thus, unsuitable for WABI-based monitoring.

255 ke risk in atrial fibrillation (AF) patients unsuitable for warfarin by 63% but does not increase maj

256 what we conclude are microscopic aggregates unsuitable for x-ray crystallography.

257 -level framework were due to the adoption of unsuitable gene sets defined typically on the basis of t

258 rather than one reaction at a time, which is unsuitable given the size of genome-scale models.

259 st fragments), shade coffee, sun coffee, and unsuitable habitat.

260 ent of "most suitable", "less suitable" and "unsuitable" habitat was calculated for the baseline year

261 , and 327 (41.1%) had positive crossmatch or unsuitable human leukocyte antigens.

262 e-bnAb germline precursors and are therefore unsuitable immunogens to prime supersite-bnAb responses.

263 Communication headsets were found to be unsuitable in simulation.

264 e chlorinated compounds (VOCls) and are thus unsuitable in systems designed for studies of such compo

265 ould result in only the conversion of highly unsuitable land.

266 humans, because previous studies used either unsuitable methods or paradigms to address this question

267 ques for analyzing miRs; however, the use of unsuitable normalizers might bias the results.

268 nd expanded, certain definitions have become unsuitable or ambiguous.

269 is very low with all of Canada classified as unsuitable or rather unsuitable for transmission.

270 Eligible patients were unsuitable or refractory to trans-arterial chemoemboliza

271 nd leftover blood specimens that were either unsuitable or unavailable for culture or that failed to

272 nd leftover blood specimens that were either unsuitable or unavailable for culture, or that failed to

273 In situations where liver biopsy is unsuitable or unavailable the white cell and platelet co

274 ients subject to ICOD were finally medically unsuitable organ donors.ICOD contributed to 24% of the 4

275 e of the system, and Monte Carlo methods are unsuitable owing to the fermionic sign problem.

276 s with low canopy cover typically considered unsuitable, resulting in aggregations of warblers in are

277 retrospective correction for injections with unsuitable signal levels without the necessity to repeat

278 systems, a two-class classification is often unsuitable, since it does not consider the unpredictable

279 on and 10% of pancreatic cancer making it an unsuitable single marker for diagnosis.

280 renal biopsies, until recently considered an unsuitable source of mRNA for microarray analysis, to in

281 e initially identified 527 records and after unsuitable studies were removed, our search yielded 148

282 etimes substantial, making autorefraction an unsuitable substitute for trial frame refraction.

283 eding areas are separated from each other by unsuitable surroundings, and a stable population in a co

284 s are protected by a monolayer and thus seem unsuitable targets for coatomers.

285 ity degrader for a ligase-target pair deemed unsuitable: the von Hippel-Lindau (VHL) and BRD9, a brom

286 n obtained from CPE parameters, following an unsuitable theory for the case of microbial-electrochemi

287 tly, antimalarials that were once considered unsuitable therapeutic agents have been revisited to imp

288 t Agent in the United States, thus making it unsuitable to be used as a vaccine vector.

289 rotic drugs and any individuals deemed to be unsuitable to enter a research study (eg, known dementia

290 ponges can tolerate environments that appear unsuitable to many corals and with increased sedimentati

291 tis elegans and Drosophila melanogaster) are unsuitable to model CKDs.

292 stroke risk and atrial fibrillation who are unsuitable to oral anticoagulants (OACs) require other s

293 required a large amount of memory, making it unsuitable to process reads from large genomes with comm

294 tic-alignment at low temperatures makes them unsuitable to study heat-sensitive membrane proteins lik

295 found in refugia: patchy, marginal habitats unsuitable to their nonnative competitors.

296 ing, is sensitive to propionate making it an unsuitable tracer to assess hepatic glycolytic, gluconeo

297 As existing fluorescence probes are unsuitable, we have designed membrane-permeable HMRef-be

298 system as a measure of its diversity, being unsuitable when systems are composed of a large number o

299 females find some display sequences of males unsuitable, while others are accepted.

300 e great majority of stream segments would be unsuitable with high certainty, regardless of the climat