ライフサイエンスコーパス: untransformed

1 with lower bone mineral density, whereas an untransformed 25(OH)D concentration <20 ng/mL was not.

2 We explore the driving of LEDs by untransformed AC.

3 Oncogenic activation of KRAS in normal, untransformed acinar cells in the pancreatic tissues of

4 Detachment of most untransformed adherent cells from the extracellular matr

5 sing a simplified version of the model, with untransformed AFP values, a cut-off value of 2 was ident

6 to regulate ERK and Smad signaling in human untransformed and cancer cell lines, we showed that the

7 ate the method, we compare the filtration of untransformed and HRas(V12)-transformed murine ovary cel

8 t per capita participation variables in both untransformed and in difference models, further corrobor

9 cs to whole blood total mercury levels (TBM; untransformed and log-transformed) based on R2 values.

10 n of KIF2C and, to a lesser extent, KIF2A in untransformed and mutant K-Ras-transformed cells is regu

11 trated that a MiDAS mechanism also exists in untransformed and primary human cells, which is RAD52 in

12 ncrease RhoA-guanosine triphosphate (GTP) in untransformed and transformed cell lines and determine t

13 The differential sensitivities of untransformed and transformed cells to induction of apop

14 of two cancer-related genes in a variety of untransformed and transformed human cell lines.

15 R-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial

16 ling further potentiates this effect in both untransformed and transformed human prostate epithelial

17 nce but with much reduced expression, remain untransformed, and grow continuously.

18 RCA1 and a slight improvement compared with untransformed Arabidopsis plants.

19 inactivation of p53 is insufficient to allow untransformed B cells and B-cell lymphomas to survive wi

20 microM in each case, but it had no effect on untransformed Ba/F3 cells growing in IL-3 or on Ba/F3 ce

21 leen resulted in a transient accumulation of untransformed Ba/F3 cells, but not Ba/F3.

22 tus in wrestlers, but it is advisable to use untransformed BIA measurements rather than to convert re

23 For example, nuclear extracts from two human untransformed breast epithelial cell lines expressed onl

24 In contrast, untransformed breast epithelial cells arrest in G1, rema

25 In transient transfection analysis in untransformed breast epithelial cells, c-Rel-p52 or -p50

26 of Hsp72 in certain cancer cells, but not in untransformed breast epithelial cells, triggers senescen

27 duction increased markedly in anti-sense and untransformed, but not overexpressor, roots with KCN tre

28 labile fraction, py-OM added to SOM largely untransformed by soil microbes.

29 ere visually green in color when compared to untransformed carrot cells, and this offered a visual se

30 es to spread can be investigated in primary, untransformed CD4(+) cells.

31 Untransformed CD4(+) Th1 cells stimulated with Ag and AP

32 nduced by serum deprivation or confluency in untransformed CEF.

33 We therefore tested primary untransformed cell cultures that lack CCR5 and CXCR4, in

34 absent or substantially reduced compared to untransformed cell lines or leukemia cells lacking BCR/A

35 Untransformed cell lines were resistant to both ERBB4 an

36 Transfection of both E1A-transformed and untransformed cell lines with a series of mutant promote

37 high activities of src kinases as well as in untransformed cell lines.

38 er cells but not in the membranes of several untransformed cell lines.

39 n nine immortal human cell lines than in six untransformed cell strains.

40 This interaction enables an untransformed cell to respond to stress-induced, p53-dep

41 rence by vFosAP-1 compared with AP-1 from an untransformed cell.

42 tates from BCR/ABL-transformed, but not from untransformed, cell lines contained PI3K lipid kinase ac

43 screen based on competition between isogenic untransformed cells and BCR-Abl-transformed cells and id

44 is dispensable for FA pathway activation in untransformed cells and the Rad18 and FA pathways are se

45 In addition, untransformed cells appear to possess one or more active

46 y in all three transformed lines compared to untransformed cells by VP16 treatment, while slight acti

47 rform a proteogenomic analysis of tumors and untransformed cells containing somatic copy number alter

48 atmospheric oxygen levels, proliferation of untransformed cells continues for extended periods of ti

49 tinuously exposed to microtubule inhibitors, untransformed cells eventually slip out of mitosis after

50 the apoptotic response that is triggered in untransformed cells following inappropriate cell-cycling

51 Notably, cytosolic replication in untransformed cells from both species was less pronounce

52 ht of beta-Ala betaine and Gly betaine) than untransformed cells grown in liquid medium containing 10

53 cultures, but genetic manipulation of these untransformed cells has been technically challenging.

54 ession imparted malignant characteristics to untransformed cells if p53 was compromised, promoting an

55 and the utility of studying transformed and untransformed cells in parallel.

56 lular matrix substrate arrests the growth of untransformed cells in the G1 phase.

57 Hence, FANCD2-driven MiDAS in untransformed cells is built to protect CFS stability, w

58 er, suppression of this apoptotic pathway in untransformed cells is not mediated only by adhesion to

59 s, and stably expressing oncogenic RasV12 in untransformed cells is sufficient to decrease pHlys.

60 Ectopic CK2 expression in untransformed cells led to increased IKK-i/IKKepsilon mR

61 Inhibition of RNAP II in untransformed cells like Rat-1 or human AG1522 fibroblas

62 Untransformed cells or those containing the parent const

63 RNA-Seq analysis in untransformed cells showed that they can regulate both d

64 Importantly, upon Ras expression, untransformed cells started responding to knockdown of H

65 ow rate of expression and activity levels in untransformed cells such as MCF10A.

66 The assembly does not kill untransformed cells that the aptamer does not bind.

67 ch hydrogen peroxide (H(2)O(2)) was added to untransformed cells to mimic the increase in ROS induced

68 w that induction of KRAS(G12V) expression in untransformed cells triggers H3K27me3 and HP1-associated

69 Whereas untransformed cells were sensitive to apoptotic death in

70 Also, while untransformed cells were sessile for long periods, BCR/A

71 Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increas

72 Pretreatment of untransformed cells with low doses of arsenic induced co

73 In untransformed cells with normal p53, the preferred mode

74 regulation of ODC in RIE-1 cells, comparing untransformed cells with those transformed by an activat

75 totoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to efficie

76 erent tissue origins have a lower pHlys than untransformed cells, and stably expressing oncogenic Ras

77 We find that in untransformed cells, HER3 is not phosphorylated by MET i

78 transcriptionally upregulated these miRNA in untransformed cells, indicating that this Myc-induced mi

79 Unlike untransformed cells, most cancer cells demonstrate reduc

80 BRG1 could not initiate tumor development in untransformed cells, our results indicate that transform

81 eta was phosphorylated at Ser 226/Ser 255 in untransformed cells, phosphorylation was absent in leuke

82 ur previous work has shown that, in cultured untransformed cells, preventing elimination of oxidized

83 transformed breast epithelial cells than in untransformed cells, suggesting a degree of tumor select

84 eta interacted weakly with the apoptosome in untransformed cells.

85 window between KRAS mutant cells and normal, untransformed cells.

86 itive to many signals that inhibit growth of untransformed cells.

87 eported NT ES cells derived from transfer of untransformed cells.

88 group of approximately 25 mRNAs compared to untransformed cells.

89 romotes and sustains cell-matrix adhesion of untransformed cells.

90 xygen species (ROS) compared with quiescent, untransformed cells.

91 protease phenotypes in both transformed and untransformed cells.

92 of inducing apoptosis of transformed but not untransformed cells.

93 was approximately 10-fold below the level of untransformed cells.

94 tivates caspases when added to extracts from untransformed cells.

95 are normally observed only during S-phase in untransformed cells.

96 h inhibitor selectively in cancer but not in untransformed cells.

97 and 8-fold less, respectively, than those in untransformed cells.

98 urfaces to function when FANCD2 is absent in untransformed cells.

99 ifferent cancer cell lines and compare it to untransformed cells.

100 t transcription while reducing toxicities to untransformed cells.

101 formed cell lines have longer telomeres than untransformed chicken lymphoid cells and have high level

102 O cells expressing human CAR, in contrast to untransformed CHO cells, all specifically bound the sCAR

103 increase in genomic complexity compared with untransformed CLL, but it presented clear differences in

104 es were significantly lower than those of an untransformed colonic epithelial cell line.

105 malate, succinate, and acetate compared with untransformed control alfalfa plants.

106 Compared with untransformed control cells, malignant transformants car

107 BRI1-silenced cells as compared to levels in untransformed control cells.

108 n that observed following ATR suppression in untransformed control cells.

109 nd 23.1 and 35.2 mug per aphid for BGL-1 and untransformed control exudates, respectively, confirm th

110 cumulation of TGA5 transcripts compared with untransformed control plants, while the TGA5-sense lines

111 her salt tolerance as compared to equivalent untransformed control plants.

112 inase inhibitor that was not detected in the untransformed control plants.

113 ly, compared with FBP7:GhPRF1-RNAi lines and untransformed control seeds.

114 erived from c-myc : Cf-9 tobacco compared to untransformed control.

115 btained from BnCysP1 male-sterile plants and untransformed controls showed 1:1 (tolerant:sensitive) r

116 We found that in GSCs, but not untransformed controls, PHF5A facilitates recognition of

117 d vitamin C levels were compared to those in untransformed controls.

118 nsformed plants were more resistant than the untransformed controls.

119 in an oxalic acid solution when compared to untransformed controls.

120 3.2 kb mRNA species that was not present in untransformed controls.

121 0-fold increase in the H/G ratio relative to untransformed controls.

122 The t-test on untransformed costs ignores the skewness in cost data, t

123 on untransformed costs, the Wilcoxon test on untransformed costs, and the Student t-test on log-trans

124 ds were commonly used: the Student t-test on untransformed costs, the Wilcoxon test on untransformed

125 In articles that used t-tests on untransformed costs, two statistically significant resul

126 total of 23 Wilcoxon tests and 24 t-tests on untransformed costs.

127 ts the same fatal outcomes in animals as its untransformed counterpart and, importantly, maintains th

128 of extracellular matrix (ECM) synthesized by untransformed, cultured human corneal fibroblasts in lon

129 d concentrations in the sorbent: 50% for the untransformed data and a factor of 1.6 after log transfo

130 dicate that conventional kinetic analysis of untransformed data is less sensitive to mean zero noise

131 Compared with compartmental analysis of untransformed data, the graphic method enables derivatio

132 For the available raw, untransformed data, the mean ratio of CL and CPS was 10.

133 ere detected in the reduced than in the full untransformed dataset.

134 rove valuable for the generation of primary, untransformed DCs in which candidate genes have been ove

135 port the derivation of long-term cultures of untransformed DCs, uniformly expressing a defined mutant

136 lls and was not prevented by the presence of untransformed DCs.

137 difficult to study on a genome-wide level in untransformed differentiated metazoan cells.

138 hrough the use of high-throughput screens in untransformed diploid epithelial cells.

139 omes were particularly good in patients with untransformed disease and related donors, whereas patien

140 Whereas untransformed early passage fibroblasts undergo cell cyc

141 d chromosome instability in tumor cells, how untransformed ECs respond to excess centrosomes is poorl

142 d death domain protein (FADD) in a number of untransformed epithelial cell lines.

143 esion markedly reduces the migfilin level in untransformed epithelial cells and concomitantly induces

144 nducible resistance to ionizing radiation in untransformed epithelial cells pre-exposed to low-dose i

145 Depletion of CAF1 in untransformed epithelial cells using siRNA was sufficien

146 rictive link between anchorage and growth in untransformed epithelial cells was observed and disrupte

147 d to be more active in KLF5 degradation than untransformed epithelial cells, yet their proteasome act

148 beta-mediated up-regulation of these CKIs in untransformed epithelial cells.

149 acellular signal-regulated kinase (ERK) 1 in untransformed epithelial cells.

150 Using untransformed ex situ human intestinal enteroids and tra

151 ith PIR2 compared to seedlings infected with untransformed F. oxysporum or that transformed with vect

152 rations that did not affect the viability of untransformed FA cells.

153 transmitted via pollen when out-crossed with untransformed female plants.

154 letion of the Cdt1 inhibitor, geminin, in an untransformed fibroblast cell line is undetectable by st

155 compared genetically related transformed and untransformed fibroblast cells in vitro for proliferatio

156 e, transient stimulation of ERK signaling in untransformed fibroblasts by adhesion on fibronectin or

157 a comparison of the HeLa cancer cell line to untransformed fibroblasts suggests that HeLa cells produ

158 PML also regulates MHC expression in untransformed fibroblasts.

159 ad histology consistent with HT, and 154 had untransformed FL (median time to recurrence, 9.6 v 22.8

160 coding and noncoding mutation landscapes of untransformed FL, transformed FL, and de novo DLBCL.

161 fferences in the basal metabolic activity of untransformed from malignant breast cells (P < 0.05) and

162 -vine ripening and prolonged shelf life over untransformed fruits.

163 cts and inhibits cell proliferation, whereas untransformed glia cells are unaffected by similar IMPDH

164 roid binding activity of the immunopurified, untransformed GR.hsp90 complex in a manner that is preve

165 ents was 37 months versus 163 months for the untransformed group (P = .0029).

166 nstrated by chromatin immunoprecipitation in untransformed hepatocytes, but was markedly reduced in p

167 to these genes as "Suz12 repressed" genes in untransformed hepatocytes.

168 o interact with a 56-kDa cellular protein in untransformed, herpesvirus saimiri-transformed, and Jurk

169 mammary epithelial (HME) and Ras transfected untransformed HME (MCF-10A1 neo N) cells were less susce

170 familial platelet disorder (FPD), or normal untransformed HPCs.

171 CDC14A phosphatase activity (hCDC14A(PD)) in untransformed hTERT-RPE1 and colorectal cancer (HCT116)

172 -type (WT) or mutant IDH1 into immortalized, untransformed human astrocytes, then monitored transform

173 30% cytochalasin-induced cleavage failure in untransformed human cell cultures did not establish cent

174 We show that in untransformed human cells, timing of replication is high

175 of replication initiation and termination in untransformed human cells.

176 in amounts at least 200-fold greater than in untransformed human cells.

177 Here, we report that FANCD2-driven MiDAS in untransformed human cells: 1) requires a prerequisite st

178 Stable depletion of PTEN in untransformed human fibroblasts and epithelial cells als

179 NA) synthesis led to premature senescence of untransformed human fibroblasts, whose features include

180 mal escape from X chromosome inactivation in untransformed human fibroblasts.

181 pendent on caspase-4 in both transformed and untransformed human IECs.

182 rtalized cells, while PAK4 overexpression in untransformed human mammary epithelial cells abrogates H

183 type III receptor (RIII) when compared with untransformed human mammary epithelial cells.

184 Upon expression of HER2, untransformed human mammary epithelial MCF-10A cells und

185 Immortalized, untransformed human mesenchymal stem cells (HMSC), a put

186 ased actin dynamics in the immune synapse of untransformed human T cells under reducing conditions.

187 ate was also detected at Ser(380) in PTEN in untransformed human T cells.

188 otein levels sensitizes transformed, but not untransformed, human cells to therapeutic doses of the a

189 culture has enabled long-term propagation of untransformed IECs from multiple species, including mous

190 as also applied to comparable regions on the untransformed image datasets.

191 carcinoma cell lines tested as compared with untransformed immortal mammary epithelial cell lines, su

192 Meanwhile, HBZ is expressed in both untransformed infected cells and ATLL cells and is invol

193 ously demonstrated that growth inhibition of untransformed intestinal epithelial cells by transformin

194 Here, we addressed the role of p27 in untransformed intestinal epithelial cells in vivo and th

195 RP-8/14 complex was detected only in primary untransformed keratinocytes and not in the HPV-infected

196 hed in transgenic mosquitoes relative to the untransformed laboratory strain.

197 Genomic analysis of untransformed Landsberg erecta plants demonstrated that

198 Sensitivity analyses were performed using untransformed LAP and CMI to assess the robustness of th

199 ciations and dose-response relationships for untransformed LAP and CMI.

200 Untransformed last-sighting date frequency distributions

201 ls of damage greater than those observed for untransformed leaves.

202 larval weights as compared to larvae fed on untransformed leaves.

203 eta(3) induction of TGFbeta(1) expression in untransformed lung and intestinal epithelial cells.

204 were found to contain higher PIC levels than untransformed lung epithelial cells.

205 decrease in IRGM expression (P < 10(-12)) in untransformed lymphocytes from CD patients.

206 f centrosomal proteins leads to G1 arrest in untransformed mammalian cells has been a mystery.

207 Therefore, previously untransformed mammary cells may establish residence in t

208 his p53 modification and its consequences in untransformed mammary epithelial cells and tissues.

209 we show that when detached from the matrix, untransformed mammary epithelial cells undergo metabolic

210 ctopic coexpression of c-Rel and CK2alpha in untransformed mammary epithelial cells was sufficient to

211 IKKalpha induced p52, RelB, and cyclin D1 in untransformed mammary epithelial cells.

212 M-2 with a membrane-localization signal into untransformed MCF-10-2A cells not susceptible to PNC-27

213 n 7 of 9 breast tumor lines when compared to untransformed MCF-10A cells.

214 IKKepsilon and kinase activity compared with untransformed MCF-10F breast epithelial cells.

215 of IKKalpha, IKKbeta, and CK2 activity than untransformed MCF-10F mammary epithelial cells.

216 High levels of RANK in untransformed MCF10A cells induce changes associated wit

217 Stable overexpression of Bcl-2 in the untransformed MCF10A cells was able to recapitulate the

218 Expression of Her2 in untransformed MCF10A mammary epithelial cells caused tra

219 we found that ATF3 enhances apoptosis in the untransformed MCF10A mammary epithelial cells, but prote

220 -carcinogenic cell fates by interaction with untransformed MECs during regenerative growth.

221 Importantly, untransformed melanocytes are minimally affected by TDG

222 melanoma cells and certain albino mutants in untransformed melanocytes are targeted to proteolytic de

223 2 cells containing these mutants have a flat untransformed morphological phenotype and do not express

224 rtance of different inflammatory caspases in untransformed mouse and human IECs and transformed human

225 agen in alpha mouse liver 12 hepatocytes (an untransformed mouse cell line) that had undergone EMT af

226 While nontoxic to untransformed mouse cells, FTI triggers a massive RhoB-d

227 In transformed and untransformed mouse fibroblasts, the most prominent cell

228 We report that untransformed mouse mammary cells that have been enginee

229 ng nuclear extracts from E1A-transformed and untransformed murine keratinocytes using radiolabeled po

230 >500-fold more resistant to hygromycin than untransformed mycelia.

231 ecovered from mice immunized in vivo with an untransformed myoblastoid cell line.

232 t also by independent sarcoma cell lines and untransformed myoblastoid cell lines.

233 By two weeks postinoculation with TBSV, all untransformed N. benthamiana plants and transformed nega

234 required for GSC expansion, as compared with untransformed neural stem cells (NSCs) and fibroblasts.

235 creased in ras-transformed cells relative to untransformed NIH 3T3 cells and only slightly reduced as

236 ese protease phenotypes can be duplicated in untransformed NIH 3T3 cells that express platelet-derive

237 n K-ras-transformed NIH 3T3 cells but not in untransformed NIH 3T3 cells.

238 In untransformed NIH3T3 cells, retroviral-mediated transduc

239 at normally are down-regulated in quiescent, untransformed NIH3T3 cells.

240 Here, TGF-beta1 treatment of untransformed NMuMG mammary epithelial and MDA-MB-231 br

241 ely with transformed KNRK cells and not with untransformed NRK cells.

242 d spread out) morphology resembling those of untransformed NRK cells.

243 PHF5A knockdown in GSCs, but not untransformed NSCs, astrocytes, or fibroblasts, inhibite

244 scoring transformed forecasts as opposed to untransformed ones.

245 Through dye-labeling experiments in untransformed onion epidermal and tobacco culture cells

246 rend in the risk of incident hypertension by untransformed or log-transformed continuous values of 25

247 tially in transformed cell lines, but not in untransformed or primary cells.

248 he TNF receptor family, induced apoptosis in untransformed or tumor-derived cells and the apoptotic f

249 ormally, suggesting that the morphologically untransformed parasites are biochemically mature ookinet

250 e parent, since use of a CHS mutant, tt4, as untransformed parent resulted in uniform green F1 plants

251 cells transformed by Bcr/Abl, but not in the untransformed parental cell lines in the absence of IL-3

252 Fas cell surface expression as compared with untransformed parental cell lines.

253 s not changed significantly from that of the untransformed parental cells, but the saturation density

254 bacterial communities was largely similar to untransformed plant roots with approximately 74% of the

255 ercury at approximately 10 times the rate of untransformed plantlets.

256 Membranes of untransformed plants and calli or those transformed with

257 ls are 2-fold higher in BGL-1 leaves than in untransformed plants but do not increase in other organs

258 In untransformed plants of the Landsberg ecotype, which con

259 Analyses of callus and untransformed plants regenerated from callus indicated t

260 Reciprocal backcrosses to untransformed plants showed unequal transmission of the

261 Treatment of untransformed plants with an apyrase inhibitor increased

262 hoots (up to 400 mug Cu. g(-1)), compared to untransformed plants, over the limits established for Cu

263 Compared with that of untransformed plants, the ATP sulfurylase activity was a

264 were morphologically indistinguishable from untransformed plants, when CTB was constitutively expres

265 four- to fivefold greater than extracts from untransformed plants, whereas no difference was observed

266 ht (1.5-fold), and leaf area (1.6-fold) than untransformed plants.

267 e fertile, flowered and set seeds similar to untransformed plants.

268 photosynthetic rates comparable to those of untransformed plants.

269 mature tobacco leaves of vector control and untransformed plants.

270 ass and removed more TNT from the media than untransformed plants.

271 ettuce expressing prM/E proteins, but not in untransformed plants.

272 ice but the role of PLKs in TLR signaling in untransformed primary immune cells has not been addresse

273 by systematic batch effects (over 98% of all untransformed probes were significantly different by ANO

274 Untransformed prostate cells appear less sensitive than

275 g organisms occur in unprotected, relatively untransformed rangelands and natural forests.

276 SSeCKS/Gravin protein was detected in untransformed rat and human prostate epithelial cell lin

277 In untransformed, resting cells, the ARE targets GM-CSF mRN

278 Untransformed results are potentially useful in evaluati

279 sion level of OsNAC121 during milky stage in untransformed rice, compared to 14-day old shoot tissue,

280 Incubation of untransformed RIE-1 cells in the presence of conditioned

281 While untransformed RLEs undergo growth arrest and apoptosis i

282 We used human untransformed RPE-1 cells depleted of KIF18A/kinesin-8 a

283 of Dkk-3 enhanced cell cycle progression in untransformed RWPE-1 prostate epithelial cells.

284 r the high-intensity blue light, compared to untransformed seedlings.

285 y a specialized metabolism that differs from untransformed somatic cells.

286 inaric acids, neither of which is present in untransformed soybean embryos.

287 ced up to 10 times more volatile Se than the untransformed strain when both were supplied with Se-Met

288 Furthermore, treatment of untransformed sunflower leaves with jasmonic acid, salic

289 her physiological parameters compared to the untransformed system grown without stress.

290 ligands normally induced by TCR signaling in untransformed T cells.

291 on in leukemic T lymphocytes than in normal, untransformed T lymphoblasts.

292 Notch1 expression was higher in untransformed thymocytes in the absence of ZFP36L1 and Z

293 arman correlation analyses were performed on untransformed time series and on transformed percentage

294 ependence on translation factors compared to untransformed tissue.

295 g ras at this moderately enhanced level were untransformed, transformation must follow either a nondo

296 sformed cells express a proneural signature, untransformed tumor-associated cells, including reactive

297 core (SL1), and the second, on the original, untransformed variables (SL2).

298 However, in untransformed WI-38 fibroblasts, RECQL4 was found to be

299 st, the chl1::Tag1 mutant was backcrossed to untransformed wild-type Arabidopsis plants to remove the