ライフサイエンスコーパス: untreatable

1 degenerative retinal diseases, which remain untreatable.

2 mostly considered difficult to treat or even untreatable.

3 manifestations, neuropathology still remains untreatable.

4 n perception that many of these symptoms are untreatable.

5 atients who were previously considered to be untreatable.

6 isorders, which had hitherto been considered untreatable.

7 of human cancers that are largely presently untreatable.

8 ses that were formerly considered relatively untreatable.

9 ccept their debility as either inevitable or untreatable.

10 e pathophysiology is not well understood, is untreatable.

11 itating dysfunction is currently unknown and untreatable.

12 line that is poorly understood and currently untreatable.

13 ons, including those previously deemed to be untreatable.

14 ectious diseases were rife because they were untreatable.

15 ns occurring posttransplantation are usually untreatable.

16 a on the cell cytoskeletal system and may be untreatable.

17 er that is progressive, fatal, and currently untreatable.

18 endering infection by some strains virtually untreatable.

19 stage is common in most solid tumors and is untreatable.

20 cers, including malignancies once considered untreatable.

21 that is insufficiently studied and currently untreatable.

22 llion people worldwide and currently remains untreatable.

23 involve neurodegeneration, which to date is untreatable.

24 ial respiratory chain are common, severe and untreatable.

25 ues into adulthood and has historically been untreatable.

26 before cancer develops or before it becomes untreatable.

27 eatments for genetic diseases that were once untreatable.

28 ocular diseases, many of which are currently untreatable.

29 uromuscular disease which until recently was untreatable.

30 raises the concern that gonorrhea may become untreatable.

31 atments for PXE, a disease that has remained untreatable.

32 nomenon remains unexplained and is currently untreatable.

33 disorder, which was often doubted and deemed untreatable.

34 ssible cures for CVD conditions once thought untreatable.

35 nce debilitating fatigue, which is currently untreatable.

36 lateral sclerosis (ALS), which is currently untreatable.

37 rited retinal dystrophy previously medically untreatable.

38 hereditary blindness worldwide, are largely untreatable.

39 e of disability in patients and is currently untreatable.

40 " in which many bacterial infections will be untreatable.

41 an neurological diseases which are currently untreatable.

42 th advanced disease and renders them largely untreatable.

43 mitochondrial diseases, which remain largely untreatable.

44 of phenotypes that remains for the most part untreatable.

45 )-producing Escherichia coli (STEC), remains untreatable.

46 ns caused by these pathogens being virtually untreatable.

47 Geographic atrophy (GA), an untreatable advanced form of age-related macular degener

48 This condition is currently untreatable and carries a significant risk of melanoma w

49 hondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial

50 on morbidity and mortality, necrosis remains untreatable and has long been viewed as a chaotic, unavo

51 ears ago, this disorder is still regarded as untreatable and its pathogenesis is poorly understood de

52 ms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss

53 hology or as a consequence of living with an untreatable and lethal disease.

54 Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease that is increas

55 Several teeth were deemed untreatable and removed at the time of consultation and

56 g insult, i.e. treatable/self-limited versus untreatable and sustained.

57 Once considered an untreatable and unpredictable condition, research advanc

58 patients with TTC7A deficiency is severe and untreatable, and it recurs despite resection or allogene

59 omal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunct

60 Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow co

61 The tooth was deemed untreatable, and was extracted.

62 tance (mcr) genes, raises the possibility of untreatable bacterial infections and motivates the devel

63 Untreatable bacterial infections constitute a dark but v

64 The growing threat of untreatable bacterial infections has refocused efforts t

65 sence of creatine in the brain, is currently untreatable because CRT is required for creatine entry i

66 ng off future treatment of cases that may be untreatable because of high resistance levels.

67 gene supplementation therapy for a currently untreatable blinding condition-BCD.

68 n misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retini

69 Many untreatable blinding diseases involve degeneration of re

70 e retinal pigmented epithelium (RPE), causes untreatable blindness in millions worldwide.

71 photoreceptor cells is the leading cause of untreatable blindness in the developed world, with inher

72 generation (AMD) is the most common cause of untreatable blindness in the developed world.

73 congenital amaurosis, are a leading cause of untreatable blindness with substantive impact on the qua

74 retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmento

75 al degenerative diseases are major causes of untreatable blindness, and novel approaches to treatment

76 e eye diseases are the most common causes of untreatable blindness.

77 nal neovascularization is the major cause of untreatable blindness.

78 The condition was previously regarded as untreatable, but progress in understanding and managemen

79 s suffering from devastating tissue deficits untreatable by conventional treatment options.

80 iffuse coronary artery disease is frequently untreatable by coronary artery bypass or angioplasty.

81 tastrophic life-long injuries and is largely untreatable by current antivenoms.

82 growing threat of strains of M. tuberculosis untreatable by modern antibiotic regimens only exacerbat

83 ible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-app

84 ry of novel drug therapies for the otherwise untreatable C. parvum.

85 ear survival rates of less than 10%, into an untreatable cancer class.

86 By contrast, untreatable cancer mortality was not significantly linke

87 y prove to be a breakthrough in an otherwise untreatable cancer.

88 ld vaccine will change the way we approached untreatable cancers, but more importantly, will allow a

89 effective treatments for several previously untreatable cancers.

90 eatments for cerebral amyloid angiopathy, an untreatable cause of haemorrhagic stroke and vascular co

91 arker in trials of candidate agents for this untreatable cause of hemorrhagic stroke.

92 l-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contr

93 erception of light (NPL) in individuals with untreatable causes of visual loss.

94 netic screening has reduced the incidence of untreatable childhood genetic diseases and improved the

95 al pathogen to show pronounced and sometimes untreatable clinical drug resistance to all known antifu

96 eutic strategies to better address currently untreatable CNS disorders.

97 crease their quality of life and lead to yet untreatable comorbidities.

98 ts with Crohn's disease (CD) is a common and untreatable comorbidity that is notoriously difficult to

99 ponatinib's effectiveness against currently untreatable compound mutants at clinically achievable co

100 thyosis-deafness (KID) syndrome is a severe, untreatable condition characterized by ocular, auditory,

101 ing nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd)

102 diseases is reactive Muller cell gliosis, an untreatable condition that leads to tissue scarring and

103 successful, improving outcome in a hitherto untreatable condition.

104 utic approach for the management of this yet untreatable condition.

105 or therapeutic development in this currently untreatable condition.

106 Ischemic acute kidney injury is a serious untreatable condition.

107 the diagnosis and prediction of rare, often untreatable conditions, to the prediction of common, oft

108 ising therapeutic target for these currently untreatable conditions.

109 on may be an effective therapy for diffuse, "untreatable" coronary disease by supplying a robust infl

110 from treatable androgen-dependent disease to untreatable CRPC.

111 ntial new therapeutics against the virtually untreatable cryptosporidial infection in immunocompromis

112 utations can cause Hajdu-Cheney syndrome, an untreatable disease characterized by osteoporosis and fr

113 dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid cognitive dec

114 eserved ejection fraction (HFpEF) remains an untreatable disease currently representing 65% of new he

115 field, transforming a rare, devastating, and untreatable disease into a more common disease with seve

116 How the inflammasome is activated in this untreatable disease is largely unknown.

117 ncer treatment, which make a once previously untreatable disease now amenable to a potential cure.

118 preventing the development of this otherwise untreatable disease process.

119 anide with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alt

120 y effective form of therapy for a previously untreatable disease.

121 lly be used to treat patients with currently untreatable disease.

122 aps identify a novel target for an otherwise untreatable disease.

123 responses as a therapeutic modality for this untreatable disease.

124 ment plan, may be the answer to a heretofore untreatable disease.

125 r research and interventions for this as yet untreatable disease.

126 ools to test potential therapeutics for this untreatable disease.

127 novel therapeutic targets for this currently untreatable disease.

128 As currently untreatable diseases come within the reach of oligonucle

129 agents, 4R-tauopathies are still severe and untreatable diseases for which no validated biomarkers e

130 RTANCE Prion disorders are invariably fatal, untreatable diseases typically associated with long incu

131 ntially curative medicine for many currently untreatable diseases, and recombinant adeno-associated v

132 the iPSC technology into novel therapies for untreatable diseases.

133 ing the course of these invariably fatal and untreatable diseases.

134 ative intervention for a range of previously untreatable diseases.

135 ons and life-saving therapies for previously untreatable diseases.

136 or prevention of a large number of hitherto untreatable diseases.

137 rmative treatments for a range of previously untreatable diseases.

138 ad to curative therapies for many previously untreatable diseases.

139 on OCT is macular telangiectasia type 2, an untreatable disorder for which a clinical trial is in pr

140 has been transformed from a rare and largely untreatable disorder to a common genetic disease with ma

141 d be effective treatments for this currently untreatable disorder.

142 ce therapeutic approaches for this currently untreatable disorder.

143 be a promising therapeutic strategy for this untreatable disorder.

144 rosopagnosia has largely been regarded as an untreatable disorder.

145 treatments for this debilitating, currently untreatable disorder.

146 amilial variants are progressive and largely untreatable disorders with poorly understood molecular m

147 asmy may be on the horizon for these largely untreatable disorders.

148 ars that many infectious diseases may become untreatable, disruptive innovations are in the process o

149 ycobacterium tuberculosis strains that cause untreatable drug-resistant disease are a threat worldwid

150 e cancer usually metastasizes to bone and is untreatable due to poor biodistribution of intravenously

151 Once regarded as largely untreatable, evidence-based decision making now guides c

152 lize visual acuity in a number of previously untreatable eye diseases, of which the main are age-rela

153 duration of complications due to previously untreatable flavivirus meningoencephalitis.

154 PE of human eyes with geographic atrophy, an untreatable form of age-related macular degeneration.

155 ed with geographic atrophy (GA), a currently untreatable form of age-related macular degeneration.

156 autosomal dominant retinitis pigmentosa, an untreatable form of blindness.

157 Uveal melanoma (UM) is a currently untreatable form of melanoma with a 50% mortality rate.

158 precision medicine approaches for otherwise untreatable gain-of-function inherited disorders.

159 c health; without new effective antibiotics, untreatable gonococcal infections loom as a real possibi

160 ptions, has raised concerns over a future of untreatable gonorrhea.

161 itional measures to respond to the threat of untreatable gonorrhea.

162 ectrum cephalosporins raises the prospect of untreatable gonorrhoea.

163 te concentrations in patients with otherwise untreatable gout is progressing.

164 ultimately lead to novel therapies for this untreatable group of disorders.

165 iminate tumour cells has cured patients with untreatable haematologic cancers.

166 ate nodules smaller than 2 cm did not become untreatable HCC with delayed HCC diagnosis of 6-12 month

167 cm at HCC diagnosis, and none progressed to untreatable HCC.

168 athway mediating neuronal death in currently untreatable human neurodegenerative disorders, including

169 eep anterior chamber (3 eyes in each group), untreatable hypotony in 1 eye in the PPV group (that led

170 tic melanoma, and the disease is essentially untreatable if not cured surgically.

171 children, but is generally considered to be untreatable in adults.

172 DDS is untreatable in reproductive medicine.

173 ses, many of which were viewed as relatively untreatable in the 1950s.

174 ation (AMD), a progressive condition that is untreatable in up to 90% of patients, is a leading cause

175 brosis and muscular dystrophies in currently untreatable individuals.

176 ccal antibiotic resistance and the threat of untreatable infection are focusing attention on strategi

177 Even in the worst-case scenario of untreatable infection emerging, the WHO target is achiev

178 ultifocal leukoencephalopathy is a currently untreatable infection of the brain.

179 E. coli but was more likely to result in an untreatable infection.

180 cterial drug discovery brings the spectre of untreatable infections.

181 lly, could be used to tackle these currently untreatable infections.

182 re community as the cause of a wide range of untreatable infections.

183 ing pattern of causes of death from formerly untreatable infectious diseases to chronic degenerative

184 Stargardt disease is a currently untreatable, inherited neurodegenerative disease that le

185 egulator (RPGR) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to p

186 s potentially could lead to the emergence of untreatable invasive K. pneumoniae infections; our data

187 complement 3 (C3) glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular c

188 splants, offers the potential for correcting untreatable large tissue defects.

189 , curing subsets of patients with previously untreatable, late-stage cancers.

190 course and prognosis in the degenerative and untreatable later phase of multiple sclerosis.

191 many cancer patients, chemotherapy produces untreatable life-long neurologic effects termed chemothe

192 chronic disease (111/117; 94.9%) than for an untreatable life-threatening illness (95/117; 81.2%) (p

193 -2-regulated apoptotic pathway in previously untreatable lymphoid malignancies.

194 effective targeted therapy for this commonly untreatable malignancy.

195 tive/therapeutic monotherapy options against untreatable MDR PA infections.

196 lass of immunotherapy for use in settings of untreatable metastatic disease.

197 se', where mankind faces its biggest threat, untreatable microbes.

198 The global crisis of untreatable microbial infections necessitates the design

199 al model for testing therapies for currently untreatable mitochondrial optic neuropathies such as Leb

200 ng drug resistance threatens to make malaria untreatable, necessitating both the discovery of new ant

201 in cases of deteriorating renal function or untreatable nephrotic syndrome.

202 interrupt mitochondrial fusion and cause the untreatable neurodegenerative condition Charcot-Marie-To

203 develop drugs for prion disease, a currently untreatable neurodegenerative disease.

204 ion of RdCVF is a promising therapy for this untreatable neurodegenerative disease.

205 pongiform encephalopathies (TSEs) are fatal, untreatable neurodegenerative diseases associated with t

206 Prion diseases are fatal, untreatable neurodegenerative diseases caused by the acc

207 ritical insights into the mechanism of these untreatable neurodegenerative diseases.

208 ial new therapeutic strategies for currently untreatable neurodegenerative diseases.

209 pathway; inactivation of ATP7A results in an untreatable neurodegenerative disorder, Menkes disease.

210 from pathogenic repeat sequences in multiple untreatable neurodegenerative disorders.

211 Familial dysautonomia (FD) is a currently untreatable, neurodegenerative disease caused by a splic

212 ne of the most common recessively inherited, untreatable, neurodegenerative diseases of humans, is ch

213 A1) and Huntington disease, are progressive, untreatable, neurodegenerative disorders.

214 e disease field, particularly for previously untreatable neurological conditions.

215 epetitive seizures can lead to endurable and untreatable neurological deficits.

216 Currently untreatable neurological diseases are especially attract

217 ation and NMD across the spectrum of largely untreatable neurological diseases.

218 Huntington's disease (HD) is an untreatable neurological disorder caused by selective an

219 untington disease is a dominantly inherited, untreatable neurological disorder featuring a progressiv

220 rom being a psychoanalytic colloquialism for untreatable neurotics to becoming a valid diagnosis with

221 therapeutic vulnerabilities in the currently untreatable NRAS-mutant melanoma subtype.

222 pneumoniae can persist to yield potentially untreatable, persistent infection.

223 Spinal muscular atrophy is an untreatable potentially fatal hereditary disorder caused

224 s provide new avenues to target MDS symptoms untreatable previously.

225 amilial frontotemporal dementia, a currently untreatable progressive neurodegenerative disease.

226 sclerosis (MS) contributes to the currently untreatable progressive phase of the disease.

227 ry for quickly distinguishing treatable from untreatable rapidly progressive dementias and for future

228 esent a valuable therapeutic alternative for untreatable rare diseases caused by nonsense variants.

229 inically significant therapies for currently untreatable retinal disease.

230 ation in X-linked retinoschisis, a currently untreatable retinopathy.

231 mplications, represent a large and currently untreatable roadblock to effective cancer management.

232 th tumors (MPNSTs) are aggressive, currently untreatable Schwann cell-derived neoplasms with hyperact

233 e in mental abilities, increased severity of untreatable seizures, blindness, loss of motor skills an

234 There exists a family of currently untreatable, serious human diseases that arise from the

235 eral neuropathy (CIPN) remains a lasting and untreatable side effect.

236 regarded as being on the way to becoming an untreatable superbug.

237 ay hypersecretion is a serious and presently untreatable symptom of chronic inflammatory airway disea

238 of drug-resistant M.tb. strains to initiate untreatable TB epidemics, as it is possible that loss or

239 advanced stage metastatic disease is mostly untreatable, thus warrants newer therapeutic strategies.

240 discuss the emerging problem of functionally untreatable tuberculosis, and the issues and challenges

241 ries, heralding the possibility of virtually untreatable tuberculosis.

242 omas are common, highly morbid and medically untreatable tumors that can arise in patients with germ

243 as led to remarkable responses in previously untreatable tumors.

244 d be effective therapeutically for these now untreatable tumors.

245 store damaged visual abilities for currently untreatable visual dysfunctions.

246 c levels in East Asia, is a leading cause of untreatable visual impairment.

247 The main cause of untreatable visual loss was glaucoma.

248 erial pathogens has rendered some infections untreatable with available antibiotics.

249 ervous system and renal cell carcinoma, both untreatable with conventional chemotherapies.

250 TNBC) is a highly aggressive subtype that is untreatable with hormonal or HER2-targeted therapies and

251 AR SV-dependent advanced PCs that are often untreatable with known hormone therapies are discussed.