ライフサイエンスコーパス: unwind

1 and nucleic acid that forms as duplexes are unwound.

2 as the double helix melts, and before it is unwound.

3 hile hydrolyzing approximately 5 ATPs per bp unwound.

4 telomeric duplexes that are otherwise poorly unwound.

5 probe-plasmid interactions once the site is unwound.

6 h initiation factors to locate promoter DNA, unwind 12-14 base pairs of the DNA duplex and load the t

7 in maintaining the split trajectories of the unwound 5' and 3' strands.

8 ing, whereby the AdnA nuclease processes the unwound 5' strand to liberate a short oligonucleotide pr

9 wild-type T antigen was able to specifically unwind a 31-bp DNA containing only site II in an ATPase-

10 mer to locate the lesion, orient the DNA and unwind a 5' flap for subsequent incision.

11 d sequence bias allows NPH-II to efficiently unwind a DNA x RNA hybrid containing a purine-rich DNA t

12 ed DNA tail of 15 nucleotides to efficiently unwind a simple duplex DNA substrate.

13 f anti-CS20 antibodies the force required to unwind a single fimbria was increased several-fold and t

14 ver, replication defective mutants failed to unwind a small origin containing circular DNA whereas re

15 UvrD has been shown to unwind a variety of substrates including partial duplex

16 All four proteins unwound a 10 bp helix in vitro in the presence of ATP; h

17 y base pairs it has unwound, and once it has unwound a critical length, it reverses the unwinding rea

18 FANCJ and BLM synergistically unwound a DNA duplex substrate with sugar phosphate back

19 However, Pif1 working with pol delta readily unwound a full-length Okazaki fragment initiated by a fo

20 blocking Rac1 interactions until irradiation unwound a helix linking LOV to Rac1.

21 isoforms and similar cleavage efficiency of unwound alpha1(I) and alpha2(I) chains suggested increas

22 icases, such as BLM and WRN, can efficiently unwind alternate/secondary structures during telomere re

23 along DNA at up to 250 bp per second and can unwind an average of 14,000 bp, with some complexes capa

24 is in which short 'invader' oligonucleotides unwind an RNA duplex through a toehold/branch migration

25 Moreover, hnRNP A1 can effectively unwind an RNA hairpin upon binding, displacing a bound p

26 which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ab

27 case and nuclease domains of Cas3 proceed to unwind and degrade the entire DNA target in a unidirecti

28 These enzyme complexes unwind and digest the DNA duplex from the broken end unt

29 on of a single ATP molecule is sufficient to unwind and displace an 8 base pair rRNA strand annealed

30 ic forces are applied via electrospinning to unwind and orient the molecular chains of a non-graphiti

31 amines the ability of WRN, BLM, and RecQ5 to unwind and POT1 to bind telomeric D-loops containing 8-o

32 nits, with a unique biomechanical ability to unwind and rewind.

33 city by inhibiting their natural capacity to unwind and rewind.

34 richia coli RNAP uses binding free energy to unwind and separate 13 base pairs of lambdaP(R) promoter

35 to-ISVP* conversion, neighboring mu1 trimers unwind and separate.

36 hyrin bound, the pi helix is not extended or unwound and is in the "substrate-bound" conformation.

37 ent stalling, G-quadruplexes are efficiently unwound and replicated.

38 ery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins.

39 e further showed that blunt dsRNA is locally unwound and threaded through the helicase domain in an a

40 After splicing, U2/U6 is unwound and U6 annealed to U4 to reassemble the tri-snRN

41 For initial nicking of the DNA, a locally unwound and unpaired DNA duplex forms a zipper via alter

42 BLM can 'measure' how many base pairs it has unwound, and once it has unwound a critical length, it r

43 stalled forks are actively dechromatinized, unwound, and repressed by an ATR-dependent checkpoint pa

44 and can be pre-programmed to either wind or unwind, as encoded in their geometry.

45 rce spectroscopy, we found that CS2 fimbriae unwind at a constant force of 10 pN and have a corner ve

46 nctional forms of RecQ can be assembled that unwind at rates tailored to the diverse biological funct

47 te in heterotrimeric collagen I is partially unwound at equilibrium.

48 uitment and suggests that downstream mRNA is unwound at least in part by being "pulled" through the 4

49 covalently modify the 5' or 3' end of RNA or unwind base-paired regions.

50 e triple helical structure has to be locally unwound before hydrolysis, but this process is not well

51 Its ability to unwind both DNA and RNA, as well as aberrant, noncanonic

52 charomyces pombe showed that it can bind and unwind both DNA and RNA, but the S. pombe protein is not

53 rminated with 3'-ssDNA; however, such DNA is unwound by RecQ to create ssDNA for RecJ exonuclease.

54 s were functional RNAs (ribozymes) that were unwound by the helicase, and the first synthesised prote

55 an half of the mitochondrial genome could be unwound by Twinkle during a single DNA-binding event.

56 g by trapping the non-template strand in the unwound conformation.

57 it is typically assembled, and an extended, unwound conformation.

58 e site of VKOR that alters between wound and unwound conformations.

59 However, the structure of a pre-unwound D1D2:dsRNA complex remains elusive, and thus, th

60 a, including structures of apo-D1D2 and post-unwound D1D2:single-stranded RNA complex, and the struct

61 Helicases are ubiquitous proteins that unwind DNA and participate in DNA metabolism including r

62 Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and transl

63 s in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase enc

64 The ability of UvsW to unwind DNA duplexes is likely to be mechanistically link

65 tion as efficient RNA helicase, and does not unwind DNA duplexes.

66 singly, we find that RecBCD can processively unwind DNA for at least 80bp beyond the reverse polarity

67 ighly conserved helicase-nuclease complex to unwind DNA from a broken end and cut it at specific DNA

68 DNA, and both HMGB proteins destabilize and unwind DNA from the H2A-H2B dimers.

69 and remodel abandoned DNA replication forks, unwind DNA in the 3'-to-5' direction, and facilitate the

70 rk, we have examined the ability of FANCJ to unwind DNA molecules with specific base damage that can

71 recombination enzymes can cleave, pair, and unwind DNA molecules, and collaborate with regulatory pr

72 ine abolishes the ability of the helicase to unwind DNA or allow T7 polymerase to mediate strand-disp

73 hydrolysis to produce the force required to unwind DNA or destabilize protein bound to DNA is requir

74 ded DNA (ssDNA) translocase but is unable to unwind DNA processively in vitro.

75 ed DNA, whereas two monomers are required to unwind DNA to a detectable degree.

76 UvrD303 mutation may enable the helicase to unwind DNA via a "strand displacement" mechanism, which

77 ntenance (SsoMCM) helicase has been shown to unwind DNA via a SEW mode to enhance unwinding efficienc

78 nt (kcat), consequently the combined enzymes unwind DNA with kinetic parameters resembling enzymes tr

79 enzymes are from different superfamilies and unwind DNA with opposite polarities.

80 on of CHK1i re-activates the DNA helicase to unwind DNA, but in the absence of dNTPs, this leads to e

81 d of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis.

82 igins, load the replicative helicase on DNA, unwind DNA, synthesize new DNA strands, and reassemble c

83 compassing a broad distribution of rates, to unwind DNA.

84 haped, hexameric helicases that encircle and unwind DNA.

85 hexameric motor domains are loaded onto and unwind DNA.

86 helicases are ATP-driven motor proteins that unwind DNA.

87 equences at the hairpin loop and stem and to unwind DNA.

88 lates with the ability of these complexes to unwind DNA.

89 haped motor proteins that translocate on and unwind DNA.

90 sDNA overhangs; helicases such as BLM, which unwind DNA; and other proteins such as BRCA1 and CtIP wh

91 Although any individual RecBCD molecule unwound DNA at a constant rate for an average of approxi

92 g H. pylori addA(NUC)B or addAB(NUC) mutants unwound DNA but had approximately half of the exonucleas

93 s(-1) and a dissociation step from partially unwound DNA of k(off) = 1.9 s(-1).

94 , MTERF1 binds a significantly distorted and unwound DNA structure, exhibiting a protein conformation

95 pin, slipped strand, triplex, quadruplex, or unwound DNA structures.

96 The DnaB-DnaC complex binds to the unwound DNA within the Escherichia coli replication orig

97 transiently in mRNA and in single-stranded, unwound DNA.

98 s been observed to use dTTP, but not ATP, to unwind double-stranded (ds)DNA as it translocates from 5

99 DNA helicases are motor proteins that unwind double-stranded DNA (dsDNA) to reveal single-stra

100 Helicases are ubiquitous enzymes that unwind double-stranded DNA (dsDNA) to reveal single-stra

101 UvrD couples ATP binding and hydrolysis to unwind double-stranded DNA and translocate along ssDNA w

102 iae and Pfh1 from Schizosaccharomyces pombe, unwind double-stranded DNA by a branched mechanism with

103 wer concentrations of Aq793 were required to unwind double-stranded DNA that had a 3'-poly(dT) overha

104 ases utilize the energy of ATP hydrolysis to unwind double-stranded DNA while translocating on the DN

105 drolysis of ATP/NTP to translocate along and unwind double-stranded nucleic acids.

106 along single-stranded (ss) nucleic acid, and unwind double-stranded nucleic acids.

107 Helicases are proteins that unwind double-stranded nucleic acids.

108 ession of RhlE or RNase R, both of which can unwind double-stranded RNA.

109 monomer of Saccharomyces cerevisiae Pif1 can unwind dsDNA (double-stranded DNA).

110 We found that T7 helicase does in fact unwind dsDNA in the presence of ATP and that the unwindi

111 limits and controls the enzyme's capacity to unwind dsDNA.

112 DHX36 unwound dsDNA poorly compared with G4s of comparable int

113 ules are bound to each fork of the partially unwound dsDNA, and interact with the 5' arm and 3' ss/ds

114 EAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and me

115 Replicative helicases generally unwind duplex DNA an order of magnitude slower compared

116 plicative hexameric helicases are thought to unwind duplex DNA by steric exclusion (SE) where one DNA

117 DNA helicase preferentially utilizes dTTP to unwind duplex DNA in vitro but also hydrolyzes other nuc

118 To unwind duplex DNA in vitro, UvrD needs to be activated e

119 picomolar concentrations and can efficiently unwind duplex DNA molecules as long as 23,000 base pairs

120 These results indicate that RecBCD can unwind duplex DNA processively in the absence of ssDNA t

121 a 3' single-stranded DNA region to load and unwind duplex DNA structures.

122 istic DNA-dependent NTPase activity, and can unwind duplex DNA substrates independently of the N-term

123 ong a DNA strand in a 3' to 5' direction and unwind duplex DNA utilizing a DNA-dependent ATPase activ

124 g, allowing it to refold, or going beyond to unwind duplex DNA, Pif1 repeatedly unwinds G4 DNA, keepi

125 operate on the complementary DNA strands to unwind duplex DNA.

126 m2-7/GINS (CMG) complex that is competent to unwind duplex DNA.

127 ns of the DExH/D family are ATPases that can unwind duplex RNA in vitro.

128 eins are ATPase enzymes that destabilize and unwind duplex RNA.

129 vities that can operate on each strand of an unwound duplex DNA.

130 Extension of the 5'-tail of the unwound duplex induces a large conformational change in

131 ited to accommodate one or two strands of an unwound duplex.

132 translocation along single strand DNA and to unwind duplexes en route.

133 plication requires helicases to processively unwind duplexes.

134 DNA turn, consistent with the length of DNA unwound during transcription initiation.

135 m loop (U6 ISL), a stable helix that must be unwound during U4/U6 assembly.

136 for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule.

137 on with PCNA allows the helicase activity to unwind fork-blocking CAG/CTG hairpin structures to preve

138 many genetic observations, the detection of unwound fork structures in vivo and the identification o

139 y, we show that HEL308 appears to target and unwind from the junction between single-stranded to doub

140 equilibria, in which filaments progressively unwind from their native twist with increasing surface i

141 This strand is then unwound from its complement and transferred in the 5'-to

142 c stability are thus shown to be more easily unwound from one side than the other, in a quantifiable

143 the budding yeast Pif1 known to efficiently unwind G-quadruplex rescues all the telomeric defects of

144 ChlR1 unwound G-quadruplex (G4) DNA with a strong preference f

145 CJ helicase is among those helicases able to unwind G4 DNA in vitro, and FANCJ mutations are associat

146 amily members have been shown to bind to and unwind G4 structures.

147 36 uses a local, non-processive mechanism to unwind G4 substrates, reminiscent of that of eukaryotic

148 FANCJ unwound G4 DNA substrates in an ATPase-dependent manner.

149 o both the mitochondria and nucleus that can unwind G4s in vitro and prevent fork stalling at G4 form

150 metastructure is composed of bound water and unwound gelatin polypeptides.

151 mutants, harboring substitutions within the unwound GMG loop and substrate binding pocket that mimic

152 lizes exclusively adenosine triphosphates to unwind helices, oligomerizes to function as efficient RN

153 viously shown to bind to hormone as a partly unwound helix, forms a complete alpha-helix that displac

154 s, MutS and MutL, may utilize its ability to unwind Holliday junctions directly in the prevention of

155 and reinforced when the protein was shown to unwind Holliday junctions.

156 is reactions until about four base pairs are unwound in a burst.

157 FANCJ efficiently unwound in a kinetic and ATPase-dependent manner entropi

158 Short RNA helices are unwound in a single ATPase cycle, but the ATP requiremen

159 The number of base pairs unwound in a single binding event for Dda is increased f

160 r experiments, which show that SNAREs can be unwound in a single encounter with NSF.

161 blished an RNA substrate for NS3 that can be unwound in a single sub-step.

162 U4 and U6 are then unwound in order for U6 to pair with U2 to form the spli

163 at 4-5 nt of downstream gap-proximal DNA are unwound in the binary complex.

164 eir complex with a bubble DNA having one arm unwound in the crystal.

165 amp opening allows DNA to be loaded into and unwound in the RNAP active-center cleft, that DNA loadin

166 mulated with a mechanism in which the DNA is unwound in two kinetic steps with rate constant of k(unw

167 als single strands soon after they have been unwound in vitro.

168 positions a nucleosome, evidently partially unwound, in a structure that facilitates Gal4 binding to

169 Strikingly, BLM unwound individual DNA molecules in a repetitive manner,

170 nitiation factor eIF4B, which is critical to unwind its structured 5' untranslated region (5'UTR).

171 s manner while the second copies the already unwound lagging-strand template in a discontinuous manne

172 Consistently, WRN efficiently unwound large (CTG)(n) hairpins and promoted DNA polymer

173 to the central channel of the N-tier and the unwound leading single-strand DNA traverses the channel

174 structures were composed of chains that were unwound like a yarn ball.

175 cessivity; yet, it is unable to processively unwind linear dsDNA, even 60 base-pairs long.

176 structures, and forked duplexes but fails to unwind linear duplex DNA.

177 by Prp8, wild type Delta247-Brr2 is able to unwind long stable duplexes in vitro, and even the RP mu

178 ding protein POT1 stimulates WRN helicase to unwind longer telomeric duplexes that are otherwise poor

179 While xDNA2 acts on ssDNA unwound mainly by the Xenopus Werner syndrome protein (x

180 age N4 gp2 protein, Drc likely binds locally unwound middle promoters and recruits the phage RNA poly

181 orce studied, nucleosomes containing H4-R45H unwind more rapidly and rewind more slowly than nucleoso

182 substrate containing a Holliday junction is unwound most efficiently.

183 hydrolysis-coupled conformational changes to unwind mRNA secondary structures during translation init

184 the activity of translocation factor EF-G to unwind mRNA secondary structures using high-resolution o

185 ases, uses two distinct active mechanisms to unwind mRNA structure: it destabilizes the helical junct

186 o form a block to SMARCAL1 or by reannealing unwound nascent strands to their parental template.

187 helicases are dependent on their ability to unwind nucleic acid duplexes in an ATP-dependent fashion

188 Helicases are biomolecular motors that unwind nucleic acids, and their regulation is essential

189 m ATP hydrolysis to translocate along and/or unwind nucleic acids.

190 Although the existence of different unwound nucleosome states has been hypothesized, there h

191 the existence of two distinct states of the unwound nucleosome, which are accessible at physiologica

192 e an unblocked 5' single-stranded DNA end to unwind or cleave DNA.

193 x small interfering RNAs, but were unable to unwind or eject the passenger strand and form functional

194 imulated ATPases that translocate on RNA and unwind or remodel structured RNA in an ATP-dependent fas

195 The beta-hairpin is not required to unwind or to overcome the bottleneck but is essential fo

196 transmembrane segment 5 (TM5i) in either an unwound or a helical conformation.

197 regulated during formation of complexes that unwind origin DNA and load replicative helicase.

198 ities but with a severely reduced ability to unwind origin DNA and to support SV40 DNA replication in

199 R to be highly processive: one molecule can unwind over 500 bp of a structured substrate.

200 ppears to be dictated by the geometry of the unwound part of the transmembrane (TM) helix 3, mostly a

201 The NMDGT motif on the partially unwound part of the transmembrane helix TM7 and the resi

202 s release to the cytoplasm provided that the unwound part of TM3 switches from a shielding to a yield

203 how that PcrA, in combination with RepD, can unwind plasmid lengths of DNA in a single run, and that

204 ase the processivity of PcrA, allowing it to unwind plasmid lengths of DNA.

205 trong effect on the initial concentration of unwound plasmids.

206 ites attention to the functional role of the unwound portion of TM helices (TM6 Trp-202-Glu-208 in Ad

207 athway between the sodium-binding sites, the unwound portion of transmembrane helix 1 and the substra

208 f residues in the opposing hairpin loops and unwound portions of adjacent helices.

209 branch migration by RecA, where a completely unwound product consisting of the paired nascent leading

210 d SSB; however, RuvAB generates a completely unwound product consisting of the paired nascent leading

211 rved pi helix was in the extended, partially unwound "product release" state.

212 ma factor uses the same strategy to bind and unwind promoter DNA as primary sigma factors.

213 ep, preventing the transition of a partially unwound promoter DNA intermediate to the fully opened DN

214 ated helicases in cancer cells are unable to unwind quadruplexes, which are impediments to transcript

215 he ability of BC200 to act as an acceptor of unwound quadruplexes via a cytosine-rich region near the

216 hybrids in human cells, and can efficiently unwind R-loops in vitro.

217 A shorter 12-bp substrate is unwound rapidly under single turnover conditions.

218 o acids 128-142 and 147-154) separated by an unwound region (amino acids 143-146).

219 xibility of a Gly-Met-Gly (GMG) motif in the unwound region of transmembrane segment 6 (TM6) is centr

220 RecQ helicases unwind remarkably diverse DNA structures as key componen

221 in a substantial reduction in the ability to unwind replication fork and Holliday junction structures

222 imulate group I and group II intron splicing unwind RNA duplexes by local strand separation and have

223 Viral RNA helicases of the NS3/NPH-II group unwind RNA duplexes by processive, directional transloca

224 Both mutants completely lost ability to unwind RNA duplexes with 5' overhangs.

225 odel for how DEAD-box proteins recognize and unwind RNA duplexes.

226 NS3 has been shown to unwind RNA in a discontinuous manner, pausing after long

227 s a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5'-untranslated re

228 H-box helicases, which use ATP hydrolysis to unwind RNA secondary structures.

229 of a very short 5' UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilita

230 onetheless, polyadenylation enables TRAMP to unwind RNA substrates that it otherwise cannot separate.

231 ure on every encounter, and is sufficient to unwind RNA-DNA heteroduplex but not duplex DNA.

232 two mechanisms by which RNA helicase enzymes unwind RNA: The nonprocessive DEAD group catalyzes local

233 RNA, thereby facilitating the release of the unwound rRNA mother strand and the recycling of DbpA for

234 ch syndrome, activities must also exist that unwind secondary structures to facilitate replication fi

235 omain (TM6a) that is separated by a central, unwound section from a cytoplasmically localized domain

236 evealed that closed-ring conformers bind and unwind several hundred base pairs of duplex DNA at an av

237 D-box proteins have been shown to use ATP to unwind short RNA helices, it is not known how they disru

238 AdnAB helicase under conditions in which the unwound single strands are coated by SSB and thereby pre

239 ing a synthetic sequence that mimics freshly unwound single-stranded DNA at replication fork showed t

240 lecular G4 DNA likely to form in transiently unwound single-stranded genomic regions.

241 ems primarily target transcripts, instead of unwound ssDNA in TECs, for immunity against double-stran

242 to defined DNA substrates and stabilizes the unwound ssDNA product, resulting in a ~5-fold stimulatio

243 nwinding and/or by POT1 loading on partially unwound ssDNA strands to prevent strand re-annealing.

244 vironment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in

245 in complex with a 23-base pair dsRNA at pre-unwound state, revealing that two DDXs recognize a 2-tur

246 eported strain in the catalytically relevant unwound state, suggesting that this state is distinct fr

247 A complex that is thought to represent a pre-unwound state.

248 r results demonstrate not only that multiple unwound states exist but that their accessibility can be

249 We anticipate that the two unwound states reported here will be the basis for futur

250 nealing of a complementary RNA by making the unwound strand more accessible.

251 randed (ss) DNA that is complementary to the unwound strand.

252 e, a serine and a main-chain carbonyl in the unwound stretch of trans-membrane helix 5 at the deepest

253 Helicases that unwind structured DNA molecules are emerging as an impor

254 eIF4A has been thought to unwind structures formed in the untranslated 5' region v

255 cassette of BRR2 is an active ATPase and can unwind substrate RNAs.

256 on, we tested the ability of the helicase to unwind substrates with site-specific oxidative DNA lesio

257 he RTEL1 helicase can transiently access and unwind t-loops to facilitate telomere replication.

258 demonstrate that WRN and BLM preferentially unwind telomeric D-loops containing 8-oxodG and that POT

259 at T antigen has a mechanism to specifically unwind the central palindrome.

260 ipolar torque activity may either tighten or unwind the cholesteric helix and if tuned, can power rot

261 a "skip residue," which is likely to locally unwind the coiled-coil and perhaps contributes to the bi

262 anslocate along one strand of the duplex and unwind the complementary strand.

263 translocate along one strand of the DNA and unwind the complementary strand.

264 aryotes, these factors include a helicase to unwind the DNA ahead of the replication fork, a single-s

265 beta at the origins of latent replication to unwind the DNA for replication.

266 t least one of the helicases will completely unwind the DNA prior to dissociation.

267 a hypothesis owing to its ability to locally unwind the double helix.

268 w Rep and PcrA proteins interact to nick and unwind the duplex is not fully understood.

269 t the predominant role of UvrD in vivo is to unwind the excised 13-mer from dsDNA and that mutation o

270 Fewer kinetic steps were required to unwind the fork compared to the ss/ds junction, suggesti

271 how two BaPif1 coordinate with each other to unwind the forked dsDNA.

272 rtiary contacts, and then CYT-19 uses ATP to unwind the helix, liberating the product strands.

273 imately 13 pN of force, barely sufficient to unwind the most stable structures in mRNAs, thus providi

274 ting was not the major reason they failed to unwind the origin because supplying an EP region as a mi

275 he N. gonorrhoeae RecQ helicase can bind and unwind the pilE G4 structure.

276 e enzyme's inability to efficiently bind and unwind the pilE G4 structure.

277 ere used to dissect pDC function in vivo and unwind the potential mechanisms involved.

278 chromosome replication requires DnaA-ATP to unwind the replication origin, oriC, and load DNA helica

279 ptor strand uses its long RNA-binding arm to unwind the RNA secondary structure.

280 d strand displacement [TMSD] ability, helped unwind the secondary structures of the RNA molecule and

281 Replicative helicases that unwind the template DNA for polymerases at the fork can

282 Brr2 is an RNA-dependent ATPase required to unwind the U4/U6 snRNA duplex during spliceosome assembl

283 ading sequence in U4 snRNA, enabling Brr2 to unwind the U4/U6 snRNA duplex to allow U6 snRNA to form

284 anded DNA-binding protein, FANCJ efficiently unwound the DNA substrate harboring the thymine glycol d

285 ated that if the terminator DNA is partially unwound, the resulting melted DNA could bind tightly to

286 HrP helix is gently curved and C-terminally "unwound." The receptor accommodates the altered binding

287 a Warsaw breakage syndrome patient failed to unwind these triplexes.

288 Unable to smoothly unwind, this conflict bends the helices until the helix

289 -tail and the length of the duplex DNA to be unwound, this activity is sufficiently strong to mask th

290 ty converts it into a superhelicase that can unwind thousands of base pairs processively, even agains

291 substrate binding by stabilizing the partly unwound TM1' helix.

292 ical barriers within the genome that must be unwound to ensure cellular genomic integrity.

293 e-stranded genome require protein modules to unwind, transcribe/replicate nucleic acid substrates, an

294 to prevent spurious recombination events and unwind trinucleotide sequences that are prone to hairpin

295 sed to destabilize protein-DNA complexes and unwind triple helix alternate DNA structures.

296 we test the ability of G4R1/RHAU to bind and unwind unimolecular G4-DNA.

297 We find that U4/U6 is efficiently unwound using DNA oligonucleotides by coupling unwinding

298 s frequent mode, longer stretches of DNA are unwound via a path that is separate from the one leading

299 gical substrate that a monomer of FacXPD can unwind with a processivity sufficient for expansion of t

300 Particularly, the GC-rich dsDNAs are unwound with lower amplitudes under single-turnover cond