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1 stream and a predicted antiterminator (licT) upstream.
2 ent downstream, additional H2A.Z accumulates upstream.
4 n sites (ESs) where VSG genes are flanked by upstream 70 bp repeats and downstream telomeric repeats.
6 the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targ
8 or 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain of function signif
9 en made from efforts that characterize their upstream activators, assembly of signaling complexes, an
10 notably amplified by virtual emissions from upstream activities that contribute 33-68% to their tota
14 to longer duration of disconnection between upstream and downstream habitats, a consequence of incre
16 itous discoveries of translated ORFs encoded upstream and downstream of annotated ORFs, from alternat
17 cluding increased sense-strand transcription upstream and downstream of genes, increased antisense tr
19 cement, at 11 sites along the Colorado River upstream and downstream of the WWTP and analyzed for in
21 progress has been made in understanding the upstream and downstream regulators of canonical PINK1/pa
24 TCRbeta loci contain 30 Vbeta gene segments upstream and in the same transcriptional orientation as
25 esults demonstrate significant fragmentation upstream and inside the TIMS tunnel that corresponds to
26 mmonly utilized leak detection method in the upstream and midstream sectors of the U.S. natural gas i
28 lowed by wild salmon captured upstream (wild-upstream) and wild-salmon captured downstream (wild-down
30 DNA binding; both half sites can be extended upstream, and these are typically not of equal strength
33 agating, hyperpolarizing signal that dilates upstream arterioles to rapidly increase local blood flow
34 e vessels, functioning at the mercy of their upstream arterioles, into independent contractile units
35 temperate-region effluent-dominated stream (upstream, at, and progressively downstream from effluent
38 ery, wherein receptor-mediated clustering of upstream autophagy factors drives continued autophagosom
41 hes are developed and assessed in this work: upstream-based permitting (i.e., environmental outcomes
43 ol I and the architectural chromatin protein Upstream Binding Transcription Factor (UBF) reveals a ra
45 ons received afferent inputs from a range of upstream brain regions as well as hypothalamic nuclei.
46 n of exonic stem-loop structures immediately upstream (but not downstream) of the introns regulate al
47 s experiments in P. putida, we uncovered an 'upstream' cascade of three consecutive transcription fac
48 a recombination centre-based J(H), RAG scans upstream chromatin via loop extrusion, potentially media
54 ts support a model in which integrins are an upstream component of the mechanosensory cellular appara
55 on of RhoA and the coordination of different upstream components in its regulation have not been well
57 .e., environmental outcomes as a function of upstream conditions) and means-based permitting (i.e., p
66 luidic channel and is easily integrated with upstream electronic, hydrodynamic, or other focusing uni
68 al emissions (volatile chemical products and upstream emissions) are emerging as important sources of
69 ol biosynthesis, only inhibition of the most upstream enzyme, EBP, led to cancer cell death via deple
70 rs or calculations before surgery (so-called upstream errors) were the second most common cause of su
72 ne deformation and facilitate ILV formation: Upstream ESCRT-driven budding does not require ATP consu
73 ells with a mathematical model, we show that upstream ESCRT-induced alteration of the Gaussian bendin
74 ished function in ILV formation, the role of upstream ESCRTs (0 to II) in membrane shape remodeling i
77 metal depletion and human toxicity caused by upstream extraction and manufacturing linked to technolo
78 by raising the intravascular pressure in the upstream feeding arteriole and promoting its rupture at
79 we show that RNA decay mechanisms involving upstream frameshift 1 (UPF1), including nonsense-mediate
83 mbrane integration of a transmembrane domain upstream from the ribosomal slip site generates a force
87 arcoma, driving growth and survival when the upstream Hippo tumor suppressor pathway is silenced, but
89 y professionals will need to be more engaged upstream in the technology design process and provide le
92 virus infection results in reduced levels of upstream intermediaries (called IKKs) that are needed fo
95 genes pho1, pho84 and tgp1 are repressed by upstream lncRNAs and are sensitive to changes in lncRNA
96 in phosphate-rich medium by transcription of upstream lncRNAs that interferes with activation of the
97 t KO mice accumulated high concentrations of upstream lysine metabolites including Delta1-piperideine
98 Ks) MPK3 and MPK6 by wounding depends on the upstream MAPK kinases MKK4 and MKK5 but is independent o
102 or the first time how rapid (100-450 m/year) upstream migration of 5-to-30 m high knickpoints can con
105 lation efficiency checkpoint that integrates upstream mRNA signals to activate anaerobic metabolism.
107 iring, tripeptide motifs, positively charged upstream nascent chain residues, and cognate tRNA concen
109 results suggest a novel role for RAB23 as an upstream negative regulator of both FGFR and canonical H
110 nt states are maintained in the brain, which upstream networks drive state transitions and how state-
111 olling tick salivary glands (SGs) are direct upstream neural signaling pathways arising from the tick
113 ve consistent expression levels by buffering upstream noise through a separation of transcription fac
114 vum) and wheat (Triticum aestivum), was just upstream of a minimal promoter and that none of these fo
115 our variants (but none of them individually) upstream of a reporter induced a decrease in reporter si
116 pendent manner, arguing that Nodal acts both upstream of and in parallel with PCP during gastrulation
117 s with unimpaired cognition on chromosome 18 upstream of ATP8B1 (index single nucleotide polymorphism
118 We outline the role of ROS in signalling upstream of autophagy initiation, by increased gene expr
119 matic amino acid biosynthesis (SA) pathways (upstream of BNA2), which produce tryptophan (the Bna2p s
120 our results suggest that BRCA1 may function upstream of BRCA2 in the stalled fork repair pathway.
124 tion of a ferroptosis-inducing signal occurs upstream of cell rupture and involves the spreading of a
125 , NEUROD1) emerged as key regulators, acting upstream of core components of the fly's molecular machi
126 therefore suggest that UBP12 and UBP13 work upstream of DA1, DAR1 and DAR2 to restrict their proteas
127 ng factor-bound elements (CBEs) within IGCR1 upstream of Ds impede RAG scanning(3-5); however, their
128 autocrine FGF21 expressed by adipocytes and upstream of endocrine FGF21 expressed by hepatocytes.
129 les map to a set of sensory neurons that act upstream of fat regulation as well as of central sleep-c
130 1 is a regulator of Fe homeostasis that acts upstream of FIT in concert with ILR3 and its closest hom
131 BAP2L is an essential SG nucleator that acts upstream of G3BP1 and 2 and facilitates G3BP1 core forma
132 x TF GAGA1 contributes to stamen development upstream of GhCYC3 Our data demonstrate how interactions
134 dentify the PIP5K family as novel regulators upstream of Hippo signaling, and uncover the importance
135 R interference screen, we identified factors upstream of HRI: OMA1, a mitochondrial stress-activated
137 emature termination of host gene transcripts upstream of iCGIs is closely correlated with the level o
139 In a metaanalysis, we found that a variant upstream of IL12A (rs17753641) is strongly associated wi
140 emonstrate that spindle checkpoint genes act upstream of Isc1, and their deletion phenocopies that of
141 rs45471499, P(combined) = 1.15 x 10(-9)) and upstream of LRP2BP (rs4317244, P(combined) = 4.17 x 10(-
143 o populations of inhibitory neurons that lie upstream of neurons in the periaqueductal gray (PAG) tha
146 RNA Shine-Dalgarno (SD) sequences positioned upstream of open reading frames facilitate translation i
148 s by activating a calcium-mitochondrial axis upstream of PGC-1alpha transcriptional upregulation, rec
149 eam of the RGF1-RGI ligand-receptor pair and upstream of PLT1/PLT2 to modulate the stem cell populati
150 id backbone and sterol biosynthesis pathways upstream of pregnenolone synthesis was coordinately down
151 ignals and their reciprocal interaction were upstream of proximal tubule YAP activation in diabetic k
154 , we provide genetic evidence that NPVF acts upstream of serotonin in the RN to maintain normal sleep
156 ng pregnancy, with the lead SNP located 15kB upstream of SLC5A2, a target of antidiabetic drugs.
157 r, these findings place Rho-actin and NAD(+) upstream of spheroid formation and may suggest that othe
159 ors are closely clustered in genomic regions upstream of target genes, defining cis-regulatory module
160 vealed that LM11A-31 likely acts principally upstream of tau phosphorylation, and has effects prevent
161 ker-specific REs were identified up to 1 Mbp upstream of TBX3 in a region close to MED13L harboring v
165 ry similar sequence, located ~60 nucleotides upstream of the atpI initiation codon, was also found in
170 sion, specifically interacting with a region upstream of the DDIT4L gene and changing the chromatin a
171 tion through inhibition of DHTKD1, an enzyme upstream of the defective glutaryl-CoA dehydrogenase, ha
174 on as a repressor of photoperiodic flowering upstream of the floral activators OsMADS14 and Hd3a, thr
175 ific variability of sequences from the U5 to upstream of the gag gene start codon of diverse HIV-1 st
176 rs present in photosystem I subunits, acting upstream of the high-chlorophyll fluorescence 101 (HCF10
177 e-a receptor, anaplastic lymphoma kinase, is upstream of the HLH regulatory protein, Id2a, and of the
180 essential meiotic transcription factor Ndt80 upstream of the integration site, thereby tightly linkin
181 e, HIV-1 infection activates LTR12C elements upstream of the interferon-inducible genes GBP2 and GBP5
183 control via energy balance sensing, which is upstream of the known genetic networks for branching and
184 cell growth and intracellular stress signals upstream of the mammalian target of rapamycin complex 1
188 point 6955C->T mutation in the Notch2 locus upstream of the PEST domain, and we termed this model No
190 r that these CREs, located at -44 and -35 kb upstream of the promoter, have strong cell-type-selectiv
192 is often modulated by enhancer-like elements upstream of the SD, sRNA-mediated enhancer silencing cou
193 ere we report that promoter sequence changes upstream of the site of transcription initiation similar
194 at DRT111 controls splicing of ABI3 and acts upstream of the splicing factor SUPPRESSOR OF ABI3-ABI5.
200 ental myelination by transiently controlling upstream OPC differentiation but not downstream oligoden
202 NLA1 promoter region was found to contain an upstream open reading frame that is required for Pi-resp
207 We find multiple microproteins encoded in upstream open reading frames, which form stable complexe
208 However, very little is known about the upstream or downstream factors that underlie YBX1's regu
209 Second, we find that over-expression of an upstream or downstream gene by a fusion-mediated reposit
210 of this study was to compare downstream and upstream oral P2Y(12) inhibitors administration strategi
211 of new open reading frames (ORFs), including upstream ORFs (uORFs) and internal ORFs (iORFs), generat
212 enhancing translation of specific mRNAs with upstream ORFs (uORFs) situated in their 5'-leader region
214 of the electrophysiological function of the upstream primary auditory receptors is warranted to unde
217 occurs when the act of transcription from an upstream promoter suppresses utilization of a co-oriente
219 xed Lineage Kinase Domain-Like (MLKL) by the upstream protein kinase RIPK3 is a hallmark of pathway a
220 of a specialised repair complex required for upstream proteolysis of TOP1ccs and their subsequent res
227 epigenome map, and a knockout of a predicted upstream regulator disrupts normal regeneration, validat
228 responsive to nutrient stress, including the upstream regulator KLF15, aminoacid catabolizing enzymes
229 f ATC and suggest that ASH1L, along with its upstream regulator miR-200b-3p and its downstream mediat
231 , we identify the ABL2 tyrosine kinase as an upstream regulator of HSF1 protein expression and show t
232 res a bidirectional promoter with MAP3K4, an upstream regulator of the MAPK signaling pathway, and re
233 updosing detected minimal changes to pathway/upstream regulator profiles despite 32.5% symptom reduct
234 overed cell-type heterogeneity and predicted upstream regulator proteins that mediate cell survival,
235 y, we used RT-qPCR, RNA sequencing, pathway, upstream regulator, and histological analyses to demonst
238 , NF-kappaB, complement, IL-6 signaling) and upstream regulators (INFgamma, IL-1beta, NF-kappaB, MYD8
241 retaining the pattern of gene expression and upstream regulators characteristic of each species.
249 Early transcriptomic changes and predicted upstream regulators that were found in all three procedu
250 tical role in modulating levels of KLF2, its upstream regulators, and its downstream target molecules
251 ences in the expression or function of their upstream regulators, providing insights into the genetic
254 ) was used to identify enriched pathways and upstream regulators.Measurements and Main Results: Respo
255 pression levels of microRNA-155 and PU.1 (as upstream regulatory axis of FcepsilonRI) and transcripti
257 estor of plants, fungi, and animals, but the upstream regulatory mechanisms and downstream effectors
260 ationship between transcriptional states and upstream regulatory programs determining different cell
262 sing on predicting and preventing modifiable upstream risk factors associated with stroke, but there
263 Together, these data uncover TDRD7's novel upstream role in elevation of stress-responsive chaperon
264 tions that force nonoptimal modifications to upstream sample preparation steps, limit the throughput
265 er, the specific cell death pathways and key upstream sensors activated in the context of Candida and
266 wever, some of these barriers should prevent upstream shifts for a considerable number of species, re
267 ing seems to be especially prevalent amongst upstream short ORFs located in the 5' mRNA leaders, and
269 ate publicly available databases to identify upstream signaling events and novel therapeutic targets.
272 en calcium/calmodulin-dependent pathways and upstream signaling of Ras in the ISO-specific context.
273 acity or phenoloxidase activation, or at the upstream signaling pathways that regulate these immune e
275 some hotspots were on arterial roads with an upstream signalized intersection and positive road grade
276 r, the precise mechanism of how NF2 mediates upstream signals to regulate the Hippo pathway is not cl
277 MKKs), MKK1/2/3/7/9 are required to transmit upstream signals to two MPKs, MPK3/4, to mediate compati
278 ne-replete conditions by transcription of an upstream SRG1 lncRNA that traverses the SER3 promoter an
279 e of this viral strategy: the acquisition of upstream start codons from host-derived sequences and su
280 stigated S838/T841 dual phosphorylation, its upstream stimulus, and downstream functional output.
282 the superiority of the downstream versus the upstream strategy on the combination of efficacy and saf
283 article presents a framework of a potential upstream stroke prevention program with evidence-based i
284 clinicians and health systems with effective upstream stroke prevention strategies that encourage sca
286 vide the identification and visualization of upstream TF binding motifs in InDel-containing enhancers
288 rganic C contents and storage decreased from upstream to downstream, likely due to primarily changes
289 nsive enhancers (RREs), including an element upstream to inhibin beta A (inhba), a known effector of
291 ichiometry of the SHR-SCR complex as well as upstream transcriptional regulation of SHR and SCR.
292 pre-mRNAs on the forward strand and promoter upstream transcripts (PROMPTs) on the reverse strand.
296 roduce mature alphabeta T cells that express upstream Vbeta peptides in surface TCRs and carry Trbv31
299 experience, followed by wild salmon captured upstream (wild-upstream) and wild-salmon captured downst
300 activity, and therefore predict response to upstream Wnt inhibitors in cancers without microsatellit