ライフサイエンスコーパス: upstream activator

1 ilarity, it demonstrates selectivity for the upstream activator.

2 losteric relief of autoinhibition by diverse upstream activators.

3 een questioned and little is known about its upstream activators.

4 ved to connect the IKK signalsome complex to upstream activators.

5 rion forms are inducible by their respective upstream activators.

6 the latter for activation via enhancer-bound upstream activators.

7 ein synthesis and reduced activity of mTORC1 upstream activators.

8 its metabolites would stimulate eNOS and its upstream activators Akt and phosphatidylinositol 3-kinas

9 e, consisting of Ypt1 and autophagy-specific upstream activator and downstream effector, regulates th

10 Because c-Src is known to be both an upstream activator and downstream mediator of epidermal

11 orms this function by functioning as both an upstream activator and downstream target for Cdc42.

12 hermore, the activation of HPK1, a known JNK upstream activator and HIP-55-interacting protein, was a

13 al mechanism of repressing both the opposing upstream activator and its downstream targets provides a

14 Here we investigated the upstream activators and downstream effectors of signalin

15 Here we identify upstream activators and downstream effectors of TET1 in

16 SCs and support the therapeutic targeting of upstream activators and downstream effectors of the AADR

17 enzymes are positioned in proximity to their upstream activators and downstream substrates.

18 s achieved through complexes containing both upstream activators and downstream targets of Rho.

19 scription and acts as a mediator between the upstream activators and general transcription machinery.

20 ue to the ability of the mutant to sequester upstream activators and its inability to activate downst

21 Ypt/Rab GTPases, are stimulated by specific upstream activators and, when activated, recruit specifi

22 orms selective interactions with substrates, upstream activators, and phosphatases.

23 paBbeta complexes are regulated by different upstream activators, and that NF-kappaB plays a key role

24 o cytoplasm where it associates with the JNK upstream activator, apoptosis signal-regulating kinase 1

25 moter complex as well as a contact point for upstream activators, appears similar to the dual roles t

26 ntimately linked to cancer as several of its upstream activators are frequently mutated in human dise

27 n silencing induction by depolarization, but upstream activators are unknown.

28 lasts since deletion of p53 or its requisite upstream activator ARF abrogates the growth-promoting ef

29 ctive activation of phospholipase D1 and its upstream activator Arf1.

30 at Ser259 regulates the coupling of Raf-1 to upstream activators as well as to its downstream substra

31 t has been shown that caspase-1, but not its upstream activator, ASC, contributes to oviduct patholog

32 en made from efforts that characterize their upstream activators, assembly of signaling complexes, an

33 letion reduced the activity of CDC25 and its upstream activators, Aurora A and Plk1.

34 ts of Ras, PI3K, or Akt, or treated with the upstream activator BDNF.

35 n of a dominant negative form of MKK4, a JNK upstream activator, blocked Netrin-1-induced JNK1 activa

36 egulates expression of CaMKIV and one of its upstream activators, CaMKK1 (calmodulin-dependent protei

37 Although their upstream activator, CASP1, and its amplifier, CASP11, ar

38 a cytosolic location that prevents access by upstream activators (caspase-8, -9, and -10).

39 inhibiting the binding between MLK3 and its upstream activator, Cdc42.

40 on, beta-arrestins scaffold cofilin with its upstream activator CIN, to facilitate the localized gene

41 The upstream activator Concertina, in its GTP but not GDP bo

42 oth an Etk downstream target gene and an Etk upstream activator, constituting a reciprocal Etk-VEGF a

43 nd DAF-8 that is independent of their normal upstream activator, DAF-7.

44 Rho-family GTPases (Rac, Rho, Cdc42), their upstream activators (Dbl-family guanine nucleotide excha

45 omplex, whereas enforced induction of p38 by upstream activators (e.g. MKK3 and MKK6) enhanced both C

46 Inhibiting the KRAS effector MEK and its upstream activators EGFR and MET demonstrates that inter

47 hymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1), within ectoderma

48 on of activated mutant MAPK kinase 6b(E), an upstream activator for p38(MAPK), increased cell migrati

49 Rho GTPase and its upstream activator, guanine nucleotide exchange factor 2

50 o/Rac/Cdc42 superfamily of GTPases and their upstream activators, guanine nucleotide exchange factors

51 ce of the interaction of Rac with its direct upstream activators, guanine nucleotide exchange factors

52 up-regulated whereas those of miR-7 and its upstream activator HoxD10 are progressively down-regulat

53 PIKfyve-catalyzed synthesis and requires the upstream activator hVac14 (called herein ArPIKfyve) that

54 kappaB, or by dominant-negative forms of the upstream activator IkappaB kinase (IKK).

55 ssion of a constitutively active form of the upstream activator IkappaB kinase beta (IKKbeta).

56 in nuclear factor kappaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encode

57 ve colon cancer behavior and functions as an upstream activator in the Jagged1/Notch signaling pathwa

58 vity are key drivers of human tumors, as are upstream activators including RAS and receptor tyrosine

59 In addition, several JNK upstream activators, including the phorbol ester TPA, an

60 machinery, this motif does not mimic natural upstream activators: instead of mimicking an activated s

61 o caused constitutive hyperactivation of its upstream activator, IRE1alpha, which could degrade a sub

62 hich recognises RFXV/I motifs present in its upstream activator [isoforms of the With-No-lysine (K) k

63 Mitochondrially localized JNKs but not upstream activators, like mixed-lineage kinases (MLKs) o

64 lly, the identification of the p38-dependent upstream activator MAP kinase kinase 6 as a member of th

65 nases transduce signals emanating from their upstream activators MAP kinase kinases (MEKs).

66 n-activated protein kinases (MAPKs) by their upstream activators, MAPK/ERK kinases (MEKs), is crucial

67 e dialyzed with recombinant p38alpha and its upstream activator, MEK-6, which substantially inhibited

68 member of the MAPK family, and its specific upstream activator MEK5 were activated in response to in

69 rpin or a dominant-negative form of the ERK5 upstream activator, MEK5, in T cells led to downregulati

70 -Jun N-terminal kinase (JNK), along with its upstream activator MEKK-1, is typically thought of as a

71 pproach to achieve targeted expression of an upstream activator, mitogen-activated protein kinase kin

72 using inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kin

73 by mediating interaction between Akt and its upstream activator MK2.

74 ression of dominant negative p38alpha or its upstream activator, MKK3, inhibited EGF receptor phospho

75 inase c-Jun N-terminal kinase (JNK)2 and its upstream activator MKK4 were phosphorylated in platelets

76 reover, we demonstrate that p38alpha and its upstream activator, MKK6, phosphorylate STAT4 on serine

77 n of the constitutively active mutant of the upstream activator, MKK6b (GST-MKK6b S207E T211E), in th

78 ed mitogen-activated protein kinase, p38, by upstream activator MKK6bE led to significant induction o

79 p38 MAPK was constitutively turned on by an upstream activator (MKK6bE).

80 s the affinity of the Arp2/3 complex for its upstream activators N-WASP and ActA.

81 nally truncated isoforms associated with the upstream activator NIK (NF-kappaB-inducing kinase).

82 ide 3-kinase/PI3K functioned as an essential upstream activator of Akt and ERK1/2 in glutamate-treate

83 tivity of phosphatidylinositol 3-kinase (the upstream activator of Akt) in insulin signaling.

84 Phosphoinositide 3 kinase (PI3K) is a direct upstream activator of AKT, and plays a critical role in

85 the activity of mTOR complex 2 (mTORC2), an upstream activator of Akt, and this occurs independent o

86 ositol 3-kinase (LY294002), thought to be an upstream activator of Akt, exacerbated cortical apoptosi

87 Oncogenic Ras, an upstream activator of Akt, requires NF-kappaB to initiat

88 and LY294002, inhibitors of PI3-kinase, the upstream activator of Akt.

89 ciated with an enhanced activity of PDK1, an upstream activator of Akt1.

90 lin-dependent protein kinase kinase beta, an upstream activator of AMPK, and by the mTORC1 inhibitor

91 Inhibition of Ras, which represents an upstream activator of AP-1, also significantly inhibited

92 phosphatidylinositol-3-phosphate kinase, an upstream activator of Arf6, also had no effect on the in

93 a signaling pathway whereby Abeta acts as an upstream activator of astroglial nuclear factor kappa B

94 Nbs1 contributes to the DDR by acting as an upstream activator of ATM in response to double-strand D

95 We propose here that CARD9 is an upstream activator of BCL10 and NF-kappaB signaling.

96 clusion: In conclusion, Nqo1 functions as an upstream activator of both the PI3K/Akt and MAPK/ERK pat

97 ermal growth factor receptor (EGFR), a known upstream activator of both the prosurvival phosphoinosit

98 rget gene, MKK7D, a constitutively activated upstream activator of c-Jun N-terminal kinases (JNK).

99 d protein kinase kinase kinase 1 (Mekk1), an upstream activator of c-Jun, enhances the interaction of

100 n-1, rather than toll-like receptors, is the upstream activator of calcineurin.

101 Furthermore, inhibition of the upstream activator of CaM-KI, CaM-KK, using siRNA also r

102 Rs; APV) or CaM-kinase kinase (STO-609), the upstream activator of CaM-kinase I (CaMKI), as well as b

103 of neurons expressing dnCaMI or dnCaMKK, the upstream activator of CaMKI, exhibit collapsed morpholog

104 inhibition of CaM-kinase kinase (CaMKK), the upstream activator of CaMKI.

105 hibition (STO-609) of CaM kinase kinase, the upstream activator of CaMKI.

106 y 10-fold, and the amount of CaMK kinase (an upstream activator of CaMKIV) protein and mRNA was signi

107 ghly expressed CAM-kinase-kinase (CAMKK), an upstream activator of CaMKIV, suggesting a role for CaMK

108 rine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine m

109 or of host immunity and functions as a high, upstream activator of cells within the innate and the ad

110 ition, this study implicates ATR as a direct upstream activator of Chk1 in human cells.

111 In addition to serving as an upstream activator of Dpp and Wg, Ci acts combinatoriall

112 The upstream activator of EGF receptor transactivation, c-Sr

113 Moreover, we identify IGF-1R as a novel upstream activator of endogenous Abl kinases, and demons

114 Using p16ink4a, an upstream activator of endogenous RB, or a constitutively

115 the phosphorylation state of Raf1 kinase, an upstream activator of ERK signaling.

116 togen-activated protein/ERK kinase (MEK, the upstream activator of ERK), and ERK.

117 te that two different inhibitors of MEK, the upstream activator of ERK, block catecholamine- and beta

118 tors or a dominant-negative form of MEK, the upstream activator of ERK, reduced the survival of patie

119 and primary neurons, inhibition of MEK-1, an upstream activator of ERK-1/2 protects against MG132-ind

120 ctivation was blocked by inhibiting MEK, the upstream activator of ERK.

121 PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2,

122 post-ischemic phosphorylation of MEK1/2, the upstream activator of ERK1/2, was unaffected by precondi

123 nhibitors were also shown to affect MEK5, an upstream activator of ERK5, another class of MAPK with h

124 that encodes constitutively active MEK1, the upstream activator of ERKs, also protected cells against

125 of a constitutively active Mek1, a specific upstream activator of ERKs, maintained myoblast viabilit

126 -regulated kinase (ERK) kinase-1 (MEK1), the upstream activator of ERKs.

127 t upon the kinesin-1 light chain KLC2 and an upstream activator of HDAC6, aurora A kinase.

128 The upstream activator of Hh signaling, the Hh ligand, origi

129 tutively active Smoothened protein (Smo), an upstream activator of Hh signaling.

130 These studies position mTOR as an upstream activator of HIF-1 function in cancer cells and

131 osis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascade

132 ptosis signal-regulating kinase-1 (ASK1), an upstream activator of JNK and p38.

133 bited in cells deficient in MEK kinase 1, an upstream activator of JNK in reovirus-infected cells.

134 nstitutively active mutant Rac-1 (Val12), an upstream activator of JNK, abrogated Deltap85-induced lu

135 a dominant negative mutant form of SEK1, an upstream activator of JNK, likewise suppressed JNK activ

136 dominant-negative forms of JNK1 and MKK4, an upstream activator of JNK, results in loss of TGF-beta-s

137 y, versus control, 40.5%), whereas MEKK1, an upstream activator of JNK, sharply reduced apoptosis in

138 MAPK kinase-4, an upstream activator of JNK, was also significantly activa

139 -negative form of Src, implicating Src as an upstream activator of JNK.

140 A specific upstream activator of JNKs is the mitogen-activated prot

141 of Myc, whereas inhibition of Rho kinase, an upstream activator of LIMK1, stimulates Myc expression.

142 activated kinase kinase (MEK1), an immediate upstream activator of MAPK in estrogen receptor positive

143 owth factor-beta-associated kinase-1 (TAK1), upstream activator of MAPK, but not p38 MAPK restored ce

144 Inhibition of the specific upstream activator of MAPK, MAPK kinase (MEK), blocked f

145 t or constitutively active MAPK kinase-1, an upstream activator of MAPK, partially blocked IGFBP-3-in

146 studies demonstrate that p38alpha is a major upstream activator of MAPKAP kinase 2 and a key componen

147 diate these effects by deactivating Raf, the upstream activator of MEK.

148 was even greater upon cotransfection with an upstream activator of mitogen-activated protein kinases

149 MIF is an upstream activator of monocytes/macrophages, and it is c

150 at mechanical stimuli utilize PA as a direct upstream activator of mTOR signaling.

151 8) in AKT, a known substrate of CaMKK and an upstream activator of mTOR-dependent translation, was pr

152 Rheb, a Ras-related small GTPase, is a key upstream activator of mTOR.

153 ely active form of the small GTPase Rheb, an upstream activator of mTor.

154 tor (M-CSF) was implicated as a contributing upstream activator of mTORC2 in a pathway that involved

155 or 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain of function signif

156 Thus, Pitx2 is the first demonstrated upstream activator of myogenesis in the extraocular musc

157 E2A acts as an upstream activator of neural lineage genes, including So

158 tic weakness and that oxidative stress is an upstream activator of nuclear factor-kappaB.

159 tively active MAP kinase kinase 6 (MKK6), an upstream activator of p38 MAP kinases.

160 ely active mutant of MAPK kinase 6 (MKK6, an upstream activator of p38 MAPK) but not constitutive act

161 Constitutively active MKK6, an immediate upstream activator of p38 MAPK, induced selectin ligand

162 duced MyD88-dependent activation of MKK4, an upstream activator of p38 MAPK.

163 Mice deficient for MKK3, an upstream activator of p38 mitogen-activated protein (MAP

164 n of an activated form of MKK6 (an immediate upstream activator of p38) rescues the ability of Cdo(-/

165 h MKK6b(E), a constitutively active specific upstream activator of p38, led to a potent inhibition of

166 ctive form of MAPK kinase 3 (Ad-CA-MKK3), an upstream activator of p38.

167 n, suggesting a possible role for Pyk2 as an upstream activator of p38.

168 noprecipitated with the MAPK kinase MKK3, an upstream activator of p38.

169 a constitutively active mutant of MKK6, the upstream activator of p38.

170 ate apoptosis signal-regulating kinase 1, an upstream activator of p38/JNK in the MAPK signaling casc

171 A constitutively active form of MEK6, an upstream activator of p38delta, can also produce cell de

172 Inhibition of the upstream activator of p44/42 MAPK, mitogen-activated pro

173 either was indirect, perhaps mediated by an upstream activator of p53, or was due to oxidation of on

174 RF tumor suppressor is widely regarded as an upstream activator of p53-dependent growth arrest and ap

175 As mammalian target of rapamycin (mTOR), an upstream activator of p70 S6Kinase is, in part, regulate

176 n receptor substrate-2 (IRS2) expression, an upstream activator of PI3K, we therefore anticipated tha

177 mosome segments containing PIK3CA, ERBB2 (an upstream activator of PIK3CA), and CCNE1 (a target of FB

178 sized that a G(s)-coupled P2Y receptor is an upstream activator of PKA mediating LTCC potentiation du

179 s, providing genetic evidence that PDK1 (the upstream activator of PKB) is required for the phosphory

180 Insulin, an upstream activator of PKCzeta, increased both OAT3-media

181 C was previously identified as the immediate upstream activator of PKD, PKD vs PKC selectivity was es

182 C activation, PKC acts more proximally as an upstream activator of PKD.

183 el in which PHS, rather than simply being an upstream activator of Pkh1, also activates kinases that

184 The GTPase Rho2, an upstream activator of Pmk1, also co-localized with PI(4,

185 h a linear pathway, in which RhoG acts as an upstream activator of Rac1, indicating that increased su

186 tein directly activated by cAMP) is a likely upstream activator of Rap1, since Epac is present in the

187 ) mice, suggesting that Flt3 is an important upstream activator of Ras in early B cell progenitors.

188 breast cancer cells driven by Her-2/neu, an upstream activator of Ras.

189 king site for either mTOR itself or a common upstream activator of S6K1 and 4E-BP1.

190 ogether, these findings identify dHAND as an upstream activator of Shh expression and important trans

191 site-secreted diacylglycerol kinase as a key upstream activator of signaling for 'programmed' egress

192 und that alphavbeta6 integrin acted as a key upstream activator of TGF-beta in evolving pancreatic ca

193 protein kinase, is a hematopoietic-specific upstream activator of the c-Jun N-terminal kinase.

194 eonine kinase that has been identified as an upstream activator of the c-Jun NH(2)-terminal kinase (J

195 was attenuated by the inhibition of PKA, the upstream activator of the CREB pathway.

196 We further showed that ATF4 was an upstream activator of the critical transcription factor

197 ATF3 promoter can be activated by MEKK1, an upstream activator of the ERK and JNK kinase pathway, bu

198 NGF treatment and cotransfection with an upstream activator of the extracellular signal-regulated

199 ciated with a down-regulation of c-Raf-1, an upstream activator of the extracellular signal-regulated

200 hage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates

201 hBVR is an upstream activator of the insulin/IGF-1/MAPK/PI3K signal

202 hreonine protein kinase that functions as an upstream activator of the JNK pathway.

203 Rho1 forms a complex with Slipper (Slpr), an upstream activator of the JNK pathway.

204 on of mice that are deficient for a specific upstream activator of the kinase, MAP kinase kinase 3, r

205 The Ras-like small GTPase Rheb is an upstream activator of the mammalian target of rapamycin

206 ssion of a dominant negative form of Ras, an upstream activator of the MAPK pathway, also inhibited s

207 gnals that negatively regulate MKK4/SEK1, an upstream activator of the MAPKs JNK and p38/HOG1.

208 sfection of constitutively active MEKK-1, an upstream activator of the mitogen-activated protein (MAP

209 We report here that Rheb GTPase, the upstream activator of the mTOR complex 1 (mTORC1) is amp

210 her suggest that focal adhesion kinase is an upstream activator of the RACK1/ERK pathway.

211 titutively active form of RalA (RalA23V), an upstream activator of the RalBP1 signaling pathway, incr

212 the inhibition of the small GTPase RAC1, an upstream activator of the WRC.

213 The PI4P5-kinase, Mss4p, is an upstream activator of this pool of Slt2p.

214 ain (Rheb) small GTPase is known to be a key upstream activator of TORC1, although the mechanism of R

215 ffector kinase PKA is a conserved and direct upstream activator of Wnd/DLK.

216 ctivation of inositol-requiring enzyme 1, an upstream activator of XBP1, leading to phosphorylation o

217 The immediate upstream activators of Akt and STAT5 such as PI-3k and J

218 infection, Src and p110beta PI 3-kinase are upstream activators of Akt and the IL-8 promoter and tha

219 Although some of the immediate upstream activators of Akt have been defined, the roles

220 Fgf3 and Fgf8 are upstream activators of atoh1 genes during both phases, a

221 novel MAGUK family members that function as upstream activators of BCL10 and NF-kappaB signaling.

222 Importantly, loss of flbC or flbD encoding upstream activators of brlA in the absence of nsdD resul

223 s of calcium injury in neurons, calpains are upstream activators of Erk1,2 signaling and are likely t

224 Vac14 and Vac7 are both upstream activators of Fab1-catalysed PtdIns(3,5)P(2) sy

225 ed levels of phosphorylated MKK4 and MKK3/6, upstream activators of JNK and p38, respectively.

226 e phosphorylation of MKK7, MKK4, and MKK3/6, upstream activators of JNK and p38, was markedly reduced

227 ivation suggesting that G(i/o) proteins were upstream activators of JNK.

228 protein kinase kinase 7 (MKK7) are immediate upstream activators of JNK1.

229 horing mixed lineage kinase (MLK) 2 or MLK3, upstream activators of JNKs, to the receptor complex.

230 owever, no significant activation of several upstream activators of MEK, including Ras, Rap1, and Raf

231 ular signal-regulated kinase (ERK) 1/2 MAPK (upstream activators of MSK1) reduced MOR expression leve

232 However, upstream activators of MyD88 function in response to tra

233 ding the participation of these molecules as upstream activators of N-WASP in the initiation of actin

234 ings suggest that PYPAF1 and ASC function as upstream activators of NF-kappaB signaling.

235 e (SP) thymocyte development because loss of upstream activators of NF-kappaB, such as the IKK comple

236 ed tumorigenesis in vivo Genes encoding some upstream activators of NOTCH were highly enriched for H3

237 MAPK kinase-3 (MKK3), MKK6 (the immediately upstream activators of p38 kinase) and a MAP3K, i.e., TG

238 Upstream activators of p38 MAP kinases, MKK3 and MKK6, i

239 (MKK3), MKK4, and MKK6, are known to be the upstream activators of p38alpha.

240 m mass spectrometry approach that identifies upstream activators of PI3K both in vitro and in vivo.

241 However, possible upstream activators of PKD, and the time course and sign

242 s, likely through constitutive activation of upstream activators of Raf.

243 e show that light-gated translocation of the upstream activators of Rho-family GTPases, which control

244 ed upon FFA treatment, potentially acting as upstream activators of the EMT program.

245 Fibroblast growth factors (FGFs) are upstream activators of the mitogen-activated protein kin

246 rs that directly target mTORC1 or, possibly, upstream activators of the mTORC1 pathway.

247 bers of the focal adhesion kinase family are upstream activators of the SFKs after wounding.

248 4 signalling in brain endothelial cells, but upstream activators of this disease pathway have yet to

249 Our analysis uncovered KLHL9 deletions as upstream activators of two previously established master

250 mour suppressor protein kinase is the major "upstream" activator of the energy sensor AMP-activated p

251 -dependent kinase 1 (PDK1), a rate-limiting 'upstream' activator of AGC kinases.

252 ssors that must bind within 100 bp of either upstream activators or the core transcription complex to

253 ls, p50(Cool-1) suppresses Pak activation by upstream activators; p85(Cool-1) has a permissive effect

254 r LIMK1 activation by its membrane-localized upstream activator PAK.

255 ions, rare somatic mutations and loss of its upstream activator, PAX5.

256 etal muscle FNDC5 (irisin precursor) and its upstream activator peroxisome proliferator-activated rec

257 itions of the mTOR signaling, as well as its upstream activators, phosphatidylinositol 3-kinase and A

258 R-associated factor 2 as well as PKB and its upstream activator phosphoinositide 3-kinase (PI3K).

259 ks the translocation of Akt/PKB, but not its upstream activator phosphoinositide-dependent kinase-1,

260 -gamma mutant neurons by inhibiting PKC, its upstream activator phospholipase C, or the gamma-Pcdh bi

261 phosphatidylinositol 3-kinase (PI3K) and its upstream activator PI3K enhancer PIKE, predicted targets

262 uction of the substrate required by both its upstream activator, PI3K, and its downstream target, PLC

263 9 are essentially identical to that of their upstream activator Plk1, suggesting that Nek6/7/9 functi

264 Nek6, as well as its upstream activators polo-like kinase 1 and Aurora-A, tar

265 equently, LEOPARD syndrome SHP2 mutants bind upstream activators preferentially and are hypersensitiv

266 n silenced chromatin inhibits the binding of upstream activator proteins or polymerase or (2) silenci

267 Whereas GABP operates as an essential upstream activator, PU.1 assists the flanking "TTTAAA" e

268 tial for growth or secretion when either the upstream activator rab, Sec4p, or the downstream SNARE-b

269 k 'fixes up' the interaction of Pak with its upstream activator, Rac.

270 ma invasion and metastasis 1 (Tiam1) and its upstream activator Ras in a phosphoinositide-3-kinase-in

271 minus may assist in its association with the upstream activators (Ras1 and Rap1) through a CRN-mediat

272 ly suppresses glial responses to injury, but upstream activators remain poorly defined.

273 he ROS sensitivity of these events and their upstream activators remain unclear.

274 ssion of TOR and RAPTOR, together with their upstream activator Rheb, was sufficient to provide TORC1

275 of the -35 element (GTGGGA; the rRNA operon upstream activator [RUA]) that is conserved in monocot a

276 ctivated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and conseq

277 e that inhibition of IKKalpha/IKKbeta or its upstream activators sensitizes cells to death by inducin

278 the control of multiple tandem copies of the upstream activator sequence (UAS) often show evidence of

279 of transcription, defined the 3' end of the upstream activator sequence (UAS) regulatory element, an

280 me sequence showed that the regulatory site, upstream activator sequence (UAS), the putative binding

281 At these operons, NifA binds to an upstream activator sequence (UAS), with the consensus TG

282 rap screen using GAL4 to drive expression of upstream activator sequence (UAS)-linked transgenes in e

283 cent protein (GFP) gene through a multicopy, upstream activator sequence (UAS).

284 es in yeast that contained the CRT/DRE as an upstream activator sequence.

285 ssion of other genes under the regulation of upstream activator sequences (UAS).

286 Single insertions containing four distinct upstream activator sequences were far less susceptible t

287 re likely to include previously unrecognized upstream activator sequences.

288 MAPK docking sites show specificity for the upstream activator similar to that reported for the full

289 Interactions between 4EBE and upstream activator sites are position, distance, and seq

290 influences transcriptional regulation by the upstream activator Sp1.

291 Activation of Vav1, but not its upstream activator, Syk, is suppressed by cell adhesion.

292 dependent recruitment of the MAPK cascade to upstream activators that are unique to one or the other

293 n disrupted the interaction of SHP2 with its upstream activator, the Grb2-associated binder 2 adaptor

294 the function in beta-selection of its known upstream activator, the serine/threonine kinase Pim1: ME

295 ta or the siRNA knockdown of IKKbeta or its "upstream" activator, the protein kinase TAK1.

296 not processed by hepsin, we investigated the upstream activators, urokinase-type plasminogen activato

297 GTPase Rac was constitutively active and its upstream activator Vav was constitutively phosphorylated

298 vation of temperature-sensitive Vps34 or its upstream activator, Vps15, blocks the Cvt and macroautop

299 n kinase kinase 7 (mutant D), a JNK-specific upstream activator, was expressed in myocytes by adenovi

300 ctivated receptor gamma (PPARgamma), and its upstream activator xanthine-oxidoreductase (XOR).