ライフサイエンスコーパス: upstream promoter

1 ne H3 within a 968-bp region 5' of the ABCB1 upstream promoter.

2 a transcriptional fusion between lacZ and an upstream promoter.

3 repeat and transcribed from an unmethylated upstream promoter.

4 ter activity can rescue loss of an essential upstream promoter.

5 depending on the property of the neighboring upstream promoter.

6 ere transcription originates from a separate upstream promoter.

7 epends strongly on the distal segment of its upstream promoter.

8 specific sequence within the distal tRNACAla upstream promoter.

9 roblasts, which transcribe the gene from the upstream promoter.

10 polycistronic pre-snoRNA transcript from an upstream promoter.

11 structs containing different portions of the upstream promoter.

12 arger p18(L) transcript is expressed from an upstream promoter.

13 analogous to a weak core linked to a strong upstream promoter.

14 polycistronic pre-snoRNA transcript from an upstream promoter.

15 ter was not occluded by transcripts from the upstream promoter.

16 s in operons are cotranscribed from a single upstream promoter.

17 er located between -5 and -6 kb in the hiNOS upstream promoter.

18 esting that P4 somehow communicates with the upstream promoters.

19 iation, (iii) readthrough transcription from upstream promoters.

20 The upstream (promoter 1) regulates the msrA1 transcript tha

21 romoter (B) is 10 times more active than the upstream promoter (A) in insulin-secreting cells (INS-1)

22 The repression of upstream promoter activity prior to Tcrb assembly correl

23 quence was transcribed after formation of an upstream promoter, although such cases were rare compare

24 predict transcriptional coupling between an upstream promoter and a promoter-less reporter gene carr

25 The KARP-1 gene utilizes an upstream promoter and additional exons which results in

26 he Core Factor (CF) complex to recognize the upstream promoter and assemble into a Pre-Initiation Com

27 The alphaCTD-sigma(70) interaction spans the upstream promoter and core promoter, thereby linking rec

28 By cloning the 5' upstream promoter and creating promoter-deletion reporte

29 We show that the VGLUT1 upstream promoter and first intron each support glutamat

30 transcription of tco1(+) from an alternate, upstream promoter and inhibits expression of the normoxi

31 The arrangement of the upstream promoter and regulatory sequences required for

32 his VGLUT1 promoter contains both the VGLUT1 upstream promoter and the VGLUT1 first intron.

33 The replicon consisted of an upstream promoter and three contiguous genes (repM400, o

34 f mRNA transcription and p65/RelA binding to upstream promoters and appear to be due to altered forma

35 several kilobase-pair regions containing the upstream, promoter and/or coding regions of 25 genes.

36 is under the control of a previously unknown upstream promoter, and exon 12 are located approximately

37 LTF/ARE), the STAT3 binding site on the MT-I upstream promoter, and the glucocorticoid responsive ele

38 -the golli products, generated from the most upstream promoter, and the MBPs, produced from the two d

39 e prototype AAV2, AAV5 RNAs transcribed from upstream promoters at map units 7 (P7) and 19 (P19), whi

40 ity of the intron is higher than that of the upstream promoter by 12-fold in SK-N-MC cells and by 5.5

41 scription of hREN occurs from an alternative upstream promoter, causing translation to initiate withi

42 cetylation states of histones present on the upstream, promoter, coding or intronic regions of 88 tob

43 ance of D1A transcripts originating from the upstream promoter compared with those transcribed from t

44 ynthesis of 8 nt or 9 nt of RNA, whereas the upstream promoter contacts persists up to synthesis of 1

45 that has been implicated in RNA binding and upstream promoter contacts, support the hypothesis that,

46 t microRNA-302 (miR-302) is controlled by an upstream promoter containing Oct4-Sox2-Nanog-binding sit

47 lyses reveal that miR-21 is controlled by an upstream promoter containing Stat-3 binding site(s), whi

48 yses reveal that miR-10b is controlled by an upstream promoter containing the Twist binding site(s),

49 gion containing two tandem chicken ovalbumin upstream promoter (COUP) sites, which is also the cis-el

50 Upstream promoter deletion analysis showed that a 200- a

51 is achieved through the use of an alternate upstream promoter, designated Pro1, that is active only

52 operative binding of the cI repressor to the upstream promoter DNA did not preclude efficient diffusi

53 ure reveals that RNAP and BmrR recognize the upstream promoter DNA from opposite faces and induce fou

54 initiation RNAP remains associated with the upstream promoter DNA via sequence-specific interactions

55 , we examine effects of removal of alphaCTD, upstream promoter DNA, or both on the rate of open-compl

56 res contact between the Spx/RNAP complex and upstream promoter DNA, which allows Spx-induced engageme

57 Pol II protrusion where it may interact with upstream promoter DNA.

58 ynthesis supported by templates bearing this upstream promoter domain but not by templates lacking it

59 2(I) collagen (COL1A2) gene by binding to an upstream promoter element (TbRE).

60 g binding of an Sp1-containing complex to an upstream promoter element (TGFbeta responsive element or

61 DR1 transcription, and they do so through an upstream promoter element (the alternative p63/p73 eleme

62 A regulatory sequence with similarity to an upstream promoter element (UP) was identified upstream o

63 of the two upstream activating elements, the upstream promoter element (UPE) and the inverted CAAT bo

64 nsitive region, between a GAL80-specific far upstream promoter element and the more gene-proximal pro

65 We show that DDB2 binds to an upstream promoter element in the HIF1Alpha gene and prom

66 e Elements, and octamer sequences, which are upstream promoter element motifs indicative of Class 3 R

67 vector containing the bb0729-cdr operon and upstream promoter element was used to complement the cdr

68 scription factors, yet which functions as an upstream promoter element.

69 ation consisting of an initiator and a novel upstream promoter element.

70 ds on the integrity of previously identified upstream promoter elements and on the presence of other

71 ription augments recent findings identifying upstream promoter elements and provides further insights

72 IL-4 induced binding of CREB and AP-1 to the upstream promoter elements and resulted in increased CR2

73 00 and CBP in promoting interactions between upstream promoter elements and the basal transcription a

74 neurons when juxtaposed with additional far-upstream promoter elements of the gene.

75 studies show that the SUP gene has discrete upstream promoter elements required for expression in st

76 cular and functional studies of the LDH/C 5' upstream promoter elements were undertaken to elucidate

77 pe 2 (HIV-2) gene expression is regulated by upstream promoter elements, including the peri-Ets (pets

78 romoters lie in the same region as essential upstream promoter elements.

79 of the open reading frame (ORF) and putative upstream promoter elements.

80 ispensable for enhanced NER in both the MFA2 upstream promoter, except in the TATA box region, and fo

81 of nuclear orphan receptor chicken ovalbumin upstream promoter-factor II (COUP-TFII, or Nr2f2) persis

82 nslated sequence and a potential alternative upstream promoter for mouse Dio3.

83 An insertion mutation near the upstream promoter for Parp-e disrupts all Parp expressio

84 A 1500 bp upstream promoter fragment was fused to the chlorampheni

85 ent with this hypothesis, apolipoprotein A-1 upstream promoter fragments active in normal and c-Jun e

86 Because the upstream promoter has the same sequence as the 3' end of

87 gn with a vector encoding tat but lacking an upstream promoter in a cell line in which drug resistanc

88 decrease in transcriptional activity of the upstream promoter in two D1A-expressing neuroblastoma ce

89 pable of enhancing the activation of distant upstream promoters in vitro.

90 lysis and primer extension indicate that the upstream promoter is 'TATA-less' with multiple transcrip

91 site were abundant, indicating that only the upstream promoter is active during erythropoiesis.

92 The upstream promoter is active in fibroblasts, but inactive

93 e time in the cell cycle when the single var upstream promoter is active.

94 However, the human FPGS upstream promoter is infrequently used, and transcripts

95 The upstream promoter is only partially repressed in chondro

96 When the upstream promoter is used for p63 expression, three majo

97 sition the initiation factor, TFIIIB, on the upstream promoter-less DNA.

98 sociated with radiographic response, and the upstream promoter of angiogenesis, hypoxia, determined s

99 epressor that constrains autoimmunity, as an upstream promoter of GATA3 expression that is critical f

100 Together, these data suggest that 3-kb upstream promoter of human Robo4 contains information fo

101 ly associated domain that also contained the upstream promoter of LINC00632, permitting ectopic conta

102 at transcripts originating from the putative upstream promoter of MDR-1 are in fact aberrant transcri

103 identified a complex between TFIIIB and the upstream promoter of silkworm tRNA Ala genes that is det

104 h the cis-acting regulatory element 1 in the upstream promoter of this gene.

105 resence of androgen response elements in the upstream promoter of TPD52.

106 Furthermore, the upstream promoter of WsMYC2 presented several cis-regula

107 A search in the 5' upstream promoters of these genes identified a motif (SC

108 be generated by alternative splicing from an upstream promoter or by multiple transcriptional start s

109 Next, we fused either the VGLUT1 upstream promoter or the first intron to this basal prom

110 The VGLUT1 upstream promoter or the first intron, fused to the basa

111 In this hypothesis, an upstream promoter (P(0)) produces an unstable transcript

112 An upstream promoter, P (oah) , controls the constitutive t

113 constructs, we found that Ca2+ inhibited the upstream promoter P1 but activated the downstream promot

114 and by pyrimidine-mediated regulation at an upstream promoter, P1.

115 cleotide polymorphism (SNPs) in an alternate upstream promoter (P2) of HNF4A that were associated wit

116 n expression, whereas transcription from the upstream promoter (P2) was activated only weakly by the

117 Transcription of ccpC from the upstream promoter (P2) was repressed by glucose in a Ccp

118 r PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via trans

119 t and that RNA polymerases initiating at the upstream promoter proceed through the 3' LTR.

120 E1 gene is transcribed by two promoters: the upstream promoter produces erythroid band 3, whereas the

121 romoters control utrophin expression and the upstream promoter (promoter A) is synaptically regulated

122 tional analysis of deletion mutations of the upstream promoter (promoter III) identified an IFN-gamma

123 The upstream promoter, promoter A, is subject to tissue spec

124 be initiated from two distinct promoters: an upstream promoter (PU), upstream of exon 1, and a downst

125 was sufficient for weak transcription of the upstream promoter (Pv) by Esigma(A), transcription which

126 st, ca. 50% of the A-AAV RNAs generated from upstream promoters read through (pA)p, as seen for AAV2.

127 show that transcriptional activation at the upstream promoter reduces transcription from the downstr

128 fied a specific double E-box sequence in the upstream promoter region (-2.0 to -2.6 kb) that is respo

129 te from conserved sequence motifs within the upstream promoter region (termed betaGK).

130 e indicates that under those conditions, the upstream promoter region acts as a silencer of the downs

131 Mediator coactivators bind first to the far upstream promoter region and subsequently to a promoter

132 Examination of the proximal ZTA upstream promoter region by in vitro EMSA analysis revea

133 stance has been attributed to changes in the upstream promoter region has been cloned and was not suf

134 C/EBP alpha identified a densely methylated upstream promoter region in 51% of AML patients.

135 3' NF-kappaB consensus element in the COX-2 upstream promoter region in human vascular endothelial c

136 Within the upstream promoter region of Bcl-x, a potential NF-kappaB

137 pression of a long non-coding RNA within the upstream promoter region of COX-2.

138 For this stimulation the upstream promoter region of lonD was found to be essenti

139 ETA2 antisera showed that BETA2 occupies the upstream promoter region of the endogenous betaGK gene i

140 FruA-DBD-H(8) bound the upstream promoter region of the fdgA gene from nucleotid

141 We show that the upstream promoter region of the gene most abundantly exp

142 erized the structural organization of the 5' upstream promoter region of the human NET (hNET) gene.

143 block, with DNA containing the origin at the upstream promoter region of the MCM4 gene.

144 ilatory genes, bind to adjacent sites in the upstream promoter region of the nitrate reductase gene,

145 morphic pentanucleotide repeat within the 5' upstream promoter region of the NOS2A gene in samples of

146 conserved Nrl response element (NRE) in the upstream promoter region of the rhodopsin gene.

147 The ability of the 5' upstream promoter region of these two genes to drive luc

148 The upstream promoter region of VCAM-1 contains a thrombin r

149 B p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY2940

150 he two-tandem NF-kappaB binding sites in the upstream promoter region significantly reduced the lucif

151 ysis mapped the alphaCTD binding site to the upstream promoter region that includes the LexA binding

152 In the present study, the upstream promoter region was found to be necessary for t

153 A series of deletions of the bfpA upstream promoter region was prepared; with respect to t

154 4 TA dinucleotide repeat insertion in the 5'-upstream promoter region, a third has a 17-bp deletion n

155 poral control of mga expression requires its upstream promoter region, and the subsequent growth phas

156 nhanced association of FoxO3a with the Bnip3 upstream promoter region, increased levels of Bnip3 tran

157 specific recognition elements located in the upstream promoter region, we examined the activity of tr

158 well as oppA-IV and -V, each has a potential upstream promoter region.

159 closely spaced, CREB/AP-1 half-sites in the upstream promoter region.

160 g approximately 9.5 kilobase pairs of the 5' upstream promoter region.

161 shown to contain Gfi-1 binding sites in the upstream promoter region.

162 ins G-quadruplex DNA forming sequence in the upstream promoter region.

163 responsive element (TRE) existing in the 5'-upstream promoter regions (5'-UPR) of the genes respondi

164 and a Cas9 nuclease mutant directed to bind upstream promoter regions can achieve programmable trans

165 we report the structures of the genomic and upstream promoter regions of a mouse and human Mix-like

166 Global analysis of the upstream promoter regions of differentially expressed ge

167 ranscription factor binding site analysis on upstream promoter regions of genes that are enriched in

168 ssor activator protein 1) relocalizes to the upstream promoter regions of hundreds of new target gene

169 sed to identify over-represented TFBS in the upstream promoter regions of ischemia-induced genes comp

170 we report that DNA fragments containing the upstream promoter regions of the porin genes (ompF and o

171 rs for BORIS, and these proteins bind to the upstream promoter regions of two well-characterized proc

172 First, QFP is correlated with upstream promoter regions with low histone occupancy.

173 ind strong enrichment for these sequences in upstream promoter regions, as well as weaker but signifi

174 ity tail-to-tail NarL binding sites found in upstream promoter regions.

175 onstrated that Nrf2 binds the Gbe1 and Phka1 upstream promoter regions.

176 ed chromatin structures within both core and upstream promoter regions.

177 lex (G4) DNA structures located within their upstream promoter regions.

178 ated secondary H3 Lys 9 acetylation peaks on upstream promoters (regulated secondary upstream peaks [

179 ll transcription of the distal genes from an upstream promoter required RfaH and the 5' cls-acting op

180 Utilization of the upstream promoter results in expression of the TAp63 var

181 plasmids with various sizes of truncated 5' upstream promoter sequence (UPS) of the alphaI(I) collag

182 e was identified by this analysis within the upstream promoter sequence between the two Sp1 sites pro

183 ows that RNAP-bound Spx contacts a conserved upstream promoter sequence element when bound to RNAP.

184 Analysis of 1.6 kb of upstream promoter sequence of DSPG3 reveals three TATA b

185 The upstream promoter sequence of the mouse uroguanylin gene

186 nal start site of hNEIL1 was mapped, and the upstream promoter sequence was characterized via lucifer

187 agment of the Mullerian inhibiting substance upstream promoter sequence.

188 ructs containing at least 272 nucleotides of upstream promoter sequence.

189 We amplified 521 bp upstream promoter sequences containing alternative haplo

190 Our results identified upstream promoter sequences necessary for Agr system reg

191 De novo motif analysis was conducted on upstream promoter sequences of differentially expressed

192 gene that affects transcript regulation, the upstream promoter sequences of soybean SMT2 genes were c

193 fection was largely independent of these and upstream promoter sequences, and expression of viral imm

194 bacteria or yeast is largely independent of upstream promoter sequences.

195 thylated guanosine caps at their 5' ends and upstream promoters similar to those of telomerase RNA.

196 occurs when the act of transcription from an upstream promoter suppresses utilization of a co-oriente

197 transcription using RNA transcribed from an upstream promoter, termed read-in RNA transcripts, resul

198 polymerase III (Pol III) and has an external upstream promoter that consists of a TATA sequence recog

199 s (Tcrb) D segments, Dbeta1 is flanked by an upstream promoter that directs its transcription and rec

200 e first ATG) enhances transcription from the upstream promoter that is active in the brain.

201 omoter but maintained expression from P1, an upstream promoter that is not contained within the IGF2

202 otranscribed and coregulated from the common upstream promoter that precedes tbpB.

203 ays were used to show that chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds s

204 ct with all members of the chicken ovalbumin upstream promoter transcription factor (COUP-TF) subfami

205 We demonstrate that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a nucl

206 that the nuclear receptor, chicken ovalbumin upstream promoter transcription factor (COUP-TF), repres

207 he orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF)-I inter

208 Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interac

209 Previous studies using chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interac

210 Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interac

211 g the COL7A1 promoter from chicken ovalbumin upstream promoter transcription factor (COUP-TF)-mediate

212 racterized protein(s), and chicken ovalbumin upstream promoter transcription factor (COUP-TF).

213 nuclear hormone receptor [chicken ovalbumin upstream promoter transcription factor (COUP-TF)/erbA-re

214 other receptors, including chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1), hum

215 cyte nuclear factor [HNF]4/chicken ovalbumin upstream promoter transcription factor 1 and HNF3beta) a

216 ed through the function of chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII) at

217 The constitutive repressor chicken ovalbumin upstream promoter transcription factor competitively bin

218 he orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) play

219 nuclear factor 4 (HNF-4), chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), apo

220 Chicken ovalbumin upstream promoter transcription factor I, an orphan nucl

221 nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor I/II.

222 in A1 regulatory protein-1/chicken ovalbumin upstream promoter transcription factor II (ARP-1/COUP-TF

223 e nuclear hormone receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) in

224 he orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) in

225 We report that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is

226 y through up-regulation of chicken ovalbumin upstream promoter transcription factor II (COUP-TFII).

227 he orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII, al

228 ression, by competing with chicken ovalbumin upstream promoter transcription factor II for the DR1 si

229 embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffi

230 promoters are occupied by chicken ovalbumin upstream promoter transcription factor II, and transcrip

231 genitor cells that express chicken ovalbumin upstream promoter transcription factor II.

232 and implicate ERRalpha and chicken ovalbumin upstream promoter transcription factor in the control of

233 nly when the orphan receptor chick ovalbumin upstream promoter transcription factor was expressed, or

234 or neurons by the COUP-TF (chicken ovalbumin upstream promoter transcription factor) homolog, UNC-55.

235 ranscription factor CTIP2 (chicken ovalbumin upstream promoter transcription factor-interacting prote

236 d the transcription factor chicken ovalbumin upstream promoter transcription factor.

237 n ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II

238 orphan nuclear receptors, chicken ovalbumin upstream promoter transcription factors I and II, were i

239 similar to the vertebrate chicken ovalbumin upstream promoter transcription factors.

240 e orphan nuclear receptors chicken ovalbumin upstream promoter-transcription factor (COUP-TF) 2 and C

241 ression of orphan receptor chicken ovalbumin upstream promoter-transcription factor (COUP-TF) plays a

242 he orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor (COUP-TF) repress

243 Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfami

244 Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) was ide

245 upregulated mRNAs included chicken ovalbumin upstream promoter-transcription factor (COUP-TF1), retin

246 mone receptor superfamily, chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), pla

247 In addition, chicken ovalbumin upstream promoter-transcription factor 1 can interact wi

248 and on co-factors such as chicken ovalbumin upstream promoter-transcription factor 1.

249 ion factors, including the chicken ovalbumin upstream promoter-transcription factor COUP-TF, pregnane

250 squito Seven-up (AaSvp), a chicken ovalbumin upstream promoter-transcription factor homologue, is inv

251 Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI, or N

252 neage, relies on COUP-TFI (chicken ovalbumin upstream promoter-transcription factor I), a patterning

253 Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) ha

254 Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hy

255 ntially important role for Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) in

256 The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is

257 ment was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) pr

258 show that inactivation of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a

259 Here, we show that the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a

260 n orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII).

261 he orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; Nr

262 nuclear factor 4alpha, the chicken ovalbumin upstream promoter-transcription factor II, and the perox

263 COUP-TFII (NR2F2), chicken ovalbumin upstream promoter-transcription factor II, is an orphan

264 activating protein-2, and chicken ovalbumin upstream promoter-transcription factor transcription fac

265 mma isoforms as well as to chicken ovalbumin upstream promoter-transcription factor, a member of the

266 the transcription factor, chicken ovalbumin upstream promoter-transcription factor, and two coactiva

267 nd responsiveness, such as chicken ovalbumin upstream promoter-transcription factor, may modulate the

268 he orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor.

269 Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs), orph

270 h is a distant member of the chick ovalbumin upstream promoter-transcription factors of the orphan nu

271 h U1 snRNP favors productive elongation from upstream promoters, triggering downstream promoter activ

272 lin promoter, with or without its associated upstream promoter (UP) element, we demonstrate that UP e

273 ve 3'-splice site choice is coordinated with upstream promoter use across a long 5'-intron such that

274 r, at low levels in most tissues; and P1, an upstream promoter used extensively in liver and kidney.

275 Suppressed transcription from the upstream promoter using transgene-directed silencing red

276 changes the chromatin structure of the ABCB1 upstream promoter via acetylation of histone H3 initiati

277 approximately 150-base pair region 5' to the upstream promoter was identified that, when stimulated w

278 When transfected into RAW macrophages, the upstream promoter was induced 7-fold by 22(R)-hydroxycho

279 luciferase reporter assay revealed that the upstream promoter was used 2-10-fold less frequently tha

280 start sites into downstream gene bodies and upstream promoters was observed specifically in neuronal

281 ltransferase (CAT) activities directed by 5' upstream promoter were detected preferentially in perfor

282 Similar upstream promoters were detected in bovine oocytes.

283 r to AAV5, >99% of B-AAV RNAs generated from upstream promoters were polyadenylated at (pA)p and henc

284 ing that it cannot be driven by a single far-upstream promoter, which suggests that promoters could b

285 but would not be readily observed without an upstream promoter with controllable activity.

286 gnition of UP-elements and activators in the upstream promoter with recognition of the -35 element in

287 the MYC proto-oncogene initiates in the near upstream promoter, within which lies the nuclease hypers

288 that a strong core promoter linked to a weak upstream promoter would be functionally analogous to a w