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1 he BCL6 promoter interacts with this distant upstream region.
2 x compete for a target sequence in the Epha4 upstream region.
3 m-a induced KRT3 expression by targeting its upstream region.
4 reas around exons, most frequently in the 5' upstream region.
5 lement(s) within the approximately 1.4-kb 5'-upstream region.
6 ssion by isolating and characterizing its 5' upstream region.
7 ms (-2022C/T and -1592G/C) within the repeat upstream region.
8 in mice from which we deleted this conserved upstream region.
9 rather than by regulatory elements in the 5' upstream region.
10 ontaining a 1.5 kb fragment of the mGSTA3 5'-upstream region.
11 t-specific suppressor activity in the distal upstream region.
12 nd one sigma(28) site were found in the flgM upstream region.
13 located at position -116 within the proximal upstream region.
14 y SigB activity and repressor binding to the upstream region.
15 abrogated binding of OmpR:6xHis to the tviA upstream region.
16 ene and one such target site in the act gene upstream region.
17 by binding an inverted repeat element in its upstream region.
18 possible DNA bending, particularly at operon-upstream regions.
19 ween the RepR binding sites in tcdR and repR upstream regions.
20 were also present in the Arabidopsis CBF1-3 upstream regions.
21 5'-UTRs, introns, coding exons, 3'-UTRs, and upstream regions.
22 l layers of medial entorhinal cortex and its upstream regions.
23 does not require an alignment of orthologous upstream regions.
24 f heptad TTTTGAT repeats in their respective upstream regions.
25 lower in the transcribed regions than in the upstream regions.
26 in addition to inheriting activity from the upstream regions.
27 (particularly Alu elements) present in these upstream regions.
28 cific parts of the basal promoter or further upstream regions.
29 nd RPGR (including ORF15) genes and their 5' upstream regions.
30 ring revealed 78 genes in which the promoter/upstream region (-10 kb to +0.5 kb) was recognized by ST
31 previously demonstrated that the human BEST1 upstream region -154 to +38 bp is sufficient to direct e
32 ns of DNA proximal to the ilvIH promoter, an upstream region (-260 to -190) and a downstream region (
33 n coding sequences, 37 in introns, and 12 in upstream regions; 3 of 4 rare novel coding SNPs were non
35 merase molecules at the fis promoter and the upstream region acts as a topological device regulating
36 ain a highly conserved hexanucleotide in the upstream region and a far less conserved U/GU-rich seque
38 e that integration host factor binds to this upstream region and increases in vivo expression of Pfnr
39 tions occurred within the hTERT promoter and upstream region and the fifth integration occurred in in
40 oriD; second, the PcrA is recruited to this upstream region and thirdly upon ATP-binding PcrA reloca
43 at pH 7 was able to interact with the bba66 upstream region and was specific as bba64 and ospC promo
44 hese extended 3'-end regions than within PAS-upstream regions and indeed are substantially more folde
45 num CBF1 upstream regions over the other CBF upstream regions and that CBF4 has retained the capacity
46 marks at the Peg13 and Slc38a4 DMRs, Cdkn1c upstream region, and Inpp5f_v2 DMR and paternal allele-s
47 x10 was also found to be associated with the upstream region, and its binding was required for Egr2-m
48 compared the sequence organization of their upstream regions, and examined their allelic methylation
49 ical tandem repeats (49-61 bp) in the hRFC-A upstream region are involved in regulating promoter acti
50 lthough the clustered AUUUA pentamers in the upstream region are required for stimulus sensitivity, m
52 h degrees of variability of their respective upstream regions are preferentially involved in environm
54 on near the phosphorylation site but not the upstream region around Cys(595), away from F-actin, thus
55 that encompassed the SUC2 gene promoter and upstream region but was devoid of other transcriptionall
56 on of PhyC, but frequent interruption of the upstream regions by the insertion of retroelements and o
57 rucial for basal transcription, and that two upstream regions can act as positive or negative regulat
58 ging this haplotype, located in the ZNRD1 5' upstream region, caused a loss of nuclear factor binding
59 th the pseudo-SNP allele frequency and GSTM1 upstream region CNV show population-specific patterns be
60 ences in CRT/DRE copy numbers in CAS30/CAS31 upstream regions combined with differences in gene copy
61 sequences and pools of coding and non-coding upstream regions, compare the observed symmetry levels t
64 er approach, in which a portion of the dHAND upstream region containing an enhancer that directs dHAN
65 ns a helix-turn-helix motif, while the ORF16 upstream region contains attributes of a theta-replicati
67 hat although the ATTARA sequence in the Psag upstream region contains thymine residues important for
68 ocampus receives gamma frequency inputs from upstream regions (cornu ammonis area 3 and medial entorh
69 methylated) cells in a previously unexplored upstream region, correlating with a 2.7-fold difference
70 ed histone levels increased, particularly at upstream regions, correlating with a 2-fold increase in
71 Similarly, deletion analyses of the recA upstream region defined sequences required for gene vari
73 '- and 3'-untranslated region, and immediate upstream region did not reveal the underlying mutation.
74 vivo, the ankyrin erythroid promoter and its upstream region direct position-independent, uniform exp
75 the DRR into two segments, a 376 nucleotide upstream region (DRR(-2473/-2100)) and a 147 nucleotide
77 chip data indicate that FLP/MYB88 target the upstream regions especially of cell cycle genes, includi
81 cC protects about 25 nucleotides of the P(F) upstream region from DNase I digestion, and RNA polymera
83 informative pedigrees, and sequencing SHARP1 upstream regions from normal and affected dogs will be n
84 we explored the function of the 3.7-kb Gata1 upstream region (GdC region) that harbors 3 core cis-ele
85 valuated a 5' distal weak enhancer (IGF-1 5'-upstream region growth hormone response element; 5URGHRE
86 Furthermore, P(cap) contains an extensive upstream region harboring a weak SigA-dependent promoter
88 s of the wheat PhyC gene and of some 5 kb of upstream region has demonstrated a high level of conserv
89 cumbens integrates information from multiple upstream regions has been a central question for decades
90 generator is independent of activity in the upstream regions, highlighting that CA1 can produce its
91 is a large secreted glycoprotein composed of upstream regions I-II-III, followed by the approximately
92 ments and acetylation of expressed immediate upstream regions implicates involvement of epigenetic me
95 patients had abnormal imprinting of the more upstream regions in addition to the exon 1A imprinting d
96 med in telomere reverse transcriptase (TERT) upstream regions in several cancers, associated with ele
99 hat CA1 inherits a complex spatial code from upstream regions, including CA3, that have already compu
101 pletely abolishes TCR in both the coding and upstream regions, indicating that no other TCR subpathwa
103 tity in the photosystem II protein D1 (psbA) upstream region is 59% across all taxa; similar variatio
105 in configuration of Crabp1 promoter with its upstream region is maintained, but the 6-nucleosomes spa
107 we showed that a 54-bp fragment of the G564 upstream region is sufficient for suspensor transcriptio
109 ted with a portion of the NFAT1 gene and its upstream region, leading to the repression of NFAT1 expr
110 iation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibr
111 ed extended promoter regions with regulatory upstream regions more than 1,000 bp from the transcripti
112 hat the most conserved 8-mer sequence in the upstream region of 21U-RNAs, CTGTTTCA, is absolutely req
113 , BME3, had a T-DNA insertion site in the 5' upstream region of a GATA-type zinc finger transcription
114 information of multiple binding sites in the upstream region of a gene and that in the upstream regio
116 tion showed that the affinity of Lrp for the upstream region of all of these constructs was about the
117 detected in a fragment of 4,700 bp of the 5' upstream region of all self-compatible samples of the S
118 ve promoter site (amyP2), which overlaps the upstream region of amyP, were eliminated by mutagenesis
120 10(-15)), PRIC285 (P = 3.0 x 10(-10)) and an upstream region of CDKN1A (P = 2 x 10(-52)), suggesting
121 ion factor binding site (TFBS) motifs in the upstream region of coexpressed genes is therefore critic
127 cription factors are over-represented in the upstream region of genes regulated during consolidation
129 tion to show that Fur bound, in vivo, to the upstream region of hns in a metal-dependent fashion.
130 ve promoters are localized within the 200-kb upstream region of human and mouse PEG3, which is well c
134 ealed that a 54-bp insertion mutation in the upstream region of miR-15a-16 displayed high allele freq
140 sults indicate that activator binding to the upstream region of P2 late promoters compensates in part
141 ranscription factors CREB and AP1 within the upstream region of P41 that are absent from the AAV2 cap
142 and point mutations were introduced into the upstream region of pnrfA demonstrated that an additional
143 oson-derived 24-nt RNAs target and cover the upstream region of retained genes preferentially when lo
146 nstrated that regulatory sequences in the 5' upstream region of Rpx are important for early expressio
147 bind two LIM protein-binding sites in the 5' upstream region of Rpx, which are required for Rpx promo
150 nscription factor NtcA binds to sites in the upstream region of sigE and that this binding is enhance
152 conserved noncoding sequences within the 5' upstream region of STM genes in both simple and compound
153 The presence of GATA-like motifs in the upstream region of the Acl1.4 gene (encoding for ACP4) a
154 leotide substitutions have been found in the upstream region of the ankyrin gene promoter that is act
156 e show that GATA-1 binds a highly restricted upstream region of the approximately 70-kb GATA-2 domain
159 We have carried out a mutational scan of the upstream region of the bacteriophage P2 FETUD late opero
161 umber of normally methylated CpGs in the far-upstream region of the boundary is decreased about 4-fol
162 In this study, we have characterized the upstream region of the CD1D1 gene and identified a minim
167 E-box repressor motif, not present in the 5'-upstream region of the CYP3A5 gene, that attenuates CYP3
170 nctional polymorphism (-1021C-->T) in the 5' upstream region of the DBH gene that accounted for 35%-5
171 ct and specific interaction of MisR with the upstream region of the dsbD promoter was demonstrated by
173 previously that GATA-1 replaces GATA-2 at an upstream region of the GATA-2 locus, and that this GATA
174 ake up the original risk haplotype in the 5' upstream region of the gene for their effects on mRNA ab
175 cribed from the same gene locus, the 2320 bp upstream region of the gene was functionally characteriz
176 to the cis-regulatory motif structure in the upstream region of the gene, multiple trans-acting facto
177 g sites and other regulatory elements in the upstream region of the genes, as contained in the Saccha
181 he lysine-sensitive factor that binds to the upstream region of the Klebsiella pneumoniae gdhA promot
183 to bind to a CRP binding site located in the upstream region of the lsr promoter and works with the L
184 siRNA loci were specifically enriched in the upstream region of the most highly expressed genes.
185 hrough deletion analysis of a -907/+70-bp 5' upstream region of the mouse COX-2 gene, we identified a
189 asmids that incorporate up to 2.86 kb of the upstream region of the rat follistatin gene are not indu
190 We hypothesize that DsrABb binds to the upstream region of the rpoS mRNA and stimulates translat
191 an essential requirement for binding to the upstream region of the rtxA1 operon and is the key featu
192 nally orthologous nucleotide variants in the upstream region of the same gene, WntA, are responsible
197 independent chromosomal rearrangement in the upstream region of the streptolysin O (slo) gene of Stre
198 Focusing on sigma(E), we discovered that the upstream region of the T2S operon possesses both the con
199 is facilitated by reannealing of DNA in the upstream region of the transcription bubble, as is also
204 case-control study design, we show that the upstream region of TNFSF4 contains a single risk haploty
205 commonly occurring sequence motifs in the 5' upstream region of transcripts for subset of down-regula
209 ys identified NF-kappaB binding sites in the upstream regions of 75% of the genes regulated by GSK-3.
212 tified an 18 bp inverted repeat motif in six upstream regions of all seven operons directly regulated
215 ulator MprA bound to conserved motifs in the upstream regions of both sigB and sigE in vitro and regu
216 identified as a common sequence motif in the upstream regions of calcineurin/ Crz1p-dependent genes.
217 significant enrichment of Etv2 peaks in the upstream regions of cell cycle regulatory genes relative
218 of the cotH in Bacillus subtilis, as well as upstream regions of certain genes, such as the sucC gene
219 ay-based studies have successfully mined the upstream regions of co-expressed genes and discovered ov
221 ed transcription factor binding sites in the upstream regions of either single or grouped eukaryotic
222 rison of the CTnDOT tetQ leader regions with upstream regions of five tetQ genes found in other eleme
223 equence similarity metric operating on 10 kb upstream regions of gene pairs quantitatively predicts a
225 to identify cis-regulatory binding sites in upstream regions of genes co-regulated in embryonic stem
226 frequent occurrence of telobox motifs in the upstream regions of genes in this category, but it is no
228 ale gonads, while SOX9 bound to the proximal upstream regions of genes more frequently in male gonads
229 sequences using the PWM and map SNPs to the upstream regions of genes; (iii) examine the evolutionar
230 ed marked variations in H3K9Ac levels at the upstream regions of HLA-DRB1 and HLA-DQB1 within the ins
231 he upstream region of a gene and that in the upstream regions of its orthologues in related genomes.
234 se I footprint analysis was performed on the upstream regions of norB and nsrR, where NsrR was shown
238 rter strains containing gfp fusions with the upstream regions of sigB2, sigD, sigI, and sigJ did not
240 ix-His tag and documented its binding to the upstream regions of tcdR in C. difficile PaLoc and in re
241 with computer-based pattern searches of the upstream regions of the 26 other Sig1 regulon members, t
244 2 GC/GT-box elements (GC-f and GT-d) in the upstream regions of the CBS -1b promoter in CMK nuclear
245 nd transgenic mice were used to characterize upstream regions of the chicken betaB1-crystallin gene.
247 from the expanded GAA-TR in intron 1 to the upstream regions of the FXN gene, involving the FXN tran
250 ndromic sequence (5'-GGAA-N6-TTCC-3') in the upstream regions of the idhA, iolY, iolR, and iolC genes
251 fied a common sequence motif enriched in the upstream regions of the most consistently cytokinin up-r
252 5)GFI(217) anchors these potentially dynamic upstream regions of the protein to maintain protein inte
255 ucleosomes are enriched on the coding and/or upstream regions of these genes, suggesting that their i
256 for CREB were highly over-represented in the upstream regions of these genes, with 9 genes containing
261 andidate mechanism of neuroplasticity within upstream regions of this inhibitory network after chroni
262 position of endogenous Ty1 elements into the upstream regions of tRNA(Gly) genes was substantially de
264 Intriguingly, this region encompasses the upstream regions of two divergently transcribed genes an
266 constraints are placed upon the Solanum CBF1 upstream regions over the other CBF upstream regions and
267 vR bound to two extended regions of Psag, an upstream region overlapping the -35 and -10 promoter ele
268 ion and site-directed mutagenesis of the dCK upstream region (positions -464 to -27) confirmed the im
270 d spatial expression, we constructed a -5 kb upstream region rat DSP-PP promoter into the beta-galact
275 sitive sites at the TERT promoters and their upstream regions, revealing positions of potential regul
277 single allele (-13910( *)T, rs4988235) in an upstream region that acts as an enhancer to the expressi
278 sion under low-iron conditions, including an upstream region that appears to partially repress expres
279 and SOX10-we found several enhancers in this upstream region that contain open chromatin and direct r
280 tion to juxtaposition of HPFH enhancers, the upstream region that is absent in the beta-YAC construct
282 e structural viral Gag protein with an extra upstream region that provides a cytosolic domain and a p
283 error, rather than inherit it passively from upstream regions; that they combine multiple separate an
284 H2 (FR-H2) possessing CRT/DRE sites in their upstream regions, the most notable of which was CBF12.
285 EGF-D, in which incorporation is confined to upstream regions, the presence of exogenous H3 results i
286 box consensus sequence in the rabbit Aldh1a1 upstream region; these elements are prevalent in other h
287 d a strong candidate Fur-binding site in its upstream region, thus suggesting that omcA may be a dire
288 vity and showed the ability of GerB and GerF upstream regions to drive gfp expression in coleoptiles,
289 otide composition between coding regions and upstream regions to rank putative open reading frames ba
293 is of single nucleotide polymorphisms in the upstream region was used to determine the extent of the
295 dentify regulatory sites in the murine c-myb upstream region, we looked by chromatin immunoprecipitat
298 ifs shared between the Solanum CBF1 and CBF4 upstream regions were identified, portions of which were
299 motifs, the cognate CBF binding site in its upstream region whereas MtCAS31 lacked one CRT/DRE partn
300 edicted operators in the norB, aniA and nsrR upstream regions with a K(d) of 7, 19 and 35 nM respecti