ライフサイエンスコーパス: urea transporter

1 KCC2), Wnk1, Stk39 (SPAK), and Slc14a2 (UT-A urea transporter).

2 inity, small molecule inhibitors of the UT-B urea transporter.

3 an antibody to the rat vasopressin-regulated urea transporter.

4 odium channel (ENaC), aquaporin-2 (AQP2) and urea transporters.

5 ithout the inverted repeat of mammalian-type urea transporters.

6 concentration by stimulating aquaporin-2 and urea transporters.

7 t there are at least four different rat UT-A urea transporters.

8 cted with a reporter construct driven by the urea transporter-A promoter, in which the nitric oxide d

9 onor S-nitroso-N-acetylpenicillamine reduces urea transporter-A reporter activity under isotonic and

10 g the inner medullary collecting duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-

11 Urea transport, mediated by the urea transporter A1 (UT-A1) and/or UT-A3, is important f

12 ease in inner medulla aquaporin-2 (AQP2) and urea transporter A1 (UT-A1) in GD rats as compared with

13 G treatment significantly up-regulated renal urea transporter A1 and promoted its trafficking to apic

14 f TonEBP/NFAT5 target genes ClC-K1, Barttin, urea transporter-A1, and aquaporin 2 that are required f

15 ncomitantly, expressions of ClC-K1, Barttin, urea transporter-A1, and aquaporin 2 were significantly

16 oride channel 1 and its subunit Barttin, the urea transporter-A1, and the water channel aquaporin 2,

17 duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-A3) have very low levels of urea

18 after prolonged fasting in late winter, when urea transporter abundance in gut tissue and urease gene

19 ys also had decreased expression of the UT-A urea transporter and collectrin, which is involved in ap

20 tein expression of renal sodium chloride and urea transporters and aquaporins in hypothyroid rats (HT

21 ions by analyzing experimental structures of urea transporters and proteins crystallized in the prese

22 TonEBP target genes, including aquaporin-2, urea transporter, and aldose reductase.

23 olecular evidence for facilitated and active urea transporters, and integrative studies of their acut

24 ne-concentrating ability is reduced; and (c) urea transporters are expressed in non-renal tissues, an

25 the effect of adrenal steroids on the UT-A1 urea transporter because it is involved in the urine-con

26 discovers phospholipids associating with the urea transporters by combining structural observations,

27 isition of unique adaptive traits, such as a urea transporter, Ca(2+) :H(+) antiporter, mannosyl-3-ph

28 rea transporters, UT-A and UT-B, and several urea transporter cDNA isoforms have been cloned from hum

29 ransporters, UT-A and UT-B, encoding several urea transporter cDNA isoforms in humans, rodents, and s

30 We report here the cloning of a novel urea transporter, designated UT1, from the rat inner med

31 echanism of dietary salt excretion relies on urea transporter-driven urea recycling by the kidneys an

32 e expression of solute carriers, such as the urea transporters encoded by Slc14a2, as well as aquapor

33 Four isoforms of the UT-A urea transporter family have been cloned to date.

34 ut whether it is mediated by the kidney UT-A urea transporter family is unknown.

35 present the 2.3 A structure of a functional urea transporter from the bacterium Desulfovibrio vulgar

36 These insights improve our understanding of urea transporter function at a molecular level and provi

37 In addition to the facilitated urea transporters, functional evidence exists for active

38 The UT3 class of urea transporters functioned as efficient water channels

39 ating mechanism, we deleted 3 kb of the UT-A urea transporter gene containing a single 140-bp exon (e

40 rs, the molecular biology of the facilitated urea transporter gene families and cDNAs, and integrativ

41 the H. pylori urease cluster, including the urea transporter gene ureI.

42 Urea transporters have been cloned from kidney medulla (

43 Recently, three types of urea transporters have been cloned, UT1 and UT2 from rat

44 owing to its high polarity, and specialized urea transporters have evolved to achieve rapid and sele

45 otide variation in the kidney-specific human urea transporter, HUT2, is associated with variation in

46 orter UT-B has been proposed to be the major urea transporter in erythrocytes and kidney-descending v

47 and expression of the vasopressin-regulated urea transporter in rat terminal IMCD.

48 eviously characterized vasopressin-regulated urea transporter in the apical membrane of the terminal

49 le of inner medullary collecting duct (IMCD) urea transporters in the renal concentrating mechanism,

50 creased urea and a corresponding increase in urea transporters in the renal medulla as the result of

51 The UT-A1 urea transporter is a glycoprotein with two different gl

52 lusions can be made: (1) The collecting duct urea transporter is present in at least two forms (97 an

53 s among aquaporin-2 (AQP2), aquaporin-4, and urea transporter isoforms A1 and A3.

54 hannel (aquaporin: Colton antigens), and the urea transporter (Kidd antigens).

55 dent pathway and activation of a specialized urea transporter located in the apical membrane.

56 This new urea transporter may be a sodium- urea antiporter.

57 The UT-A1 urea transporter mediates rapid transepithelial urea tra

58 e, and Northern analysis showed no change in urea transporter mRNA abundance in either inner medullar

59 hypothesis that the abundance of the apical urea transporter of the inner medullary collecting duct

60 wever, the influence of genetic variation in urea transporters on BP has not been examined.

61 These results establish that the urea transporter operates by a channel-like mechanism an

62 ng the concept that phloretin-sensitive IMCD urea transporters play a central role in medullary urea

63 The UT-A1 urea transporter plays an important role in the urinary

64 There was no change in vasopressin-regulated urea transporter protein in the inner medullary base, an

65 (2) The expression level of the 117-kD urea transporter protein is regulated and is inversely c

66 s, including studies of uremic rats in which urea transporter protein is upregulated in liver and hea

67 proaches to perform integrative studies into urea transporter protein regulation, both in normal anim

68 lies and cDNAs, and integrative studies into urea transporter protein regulation, both in the kidney

69 Vasopressin-regulated urea transporter protein was significantly increased in

70 ntibodies have been generated to many of the urea transporter proteins, and several novel findings ha

71 antibodies have been generated to the cloned urea transporter proteins, and the use of these antibodi

72 idney and red blood cells occurs by specific urea transporter proteins.

73 idney inner medulla was mediated by specific urea transporter proteins.

74 is transported by facilitated and by active urea transporter proteins.

75 bbit polyclonal antibodies against the renal urea transporter (RUT) gene product.

76 tified significantly increased levels of the urea transporter SLC14A1 in the OVT73 striatum, along wi

77 carrier family 14 member 1 gene, SLC14A1, a urea transporter that regulates cellular osmotic pressur

78 Thus, both new isoforms encode functional urea transporters that may be vasopressin-regulated.

79 for the existence of facilitated and active urea transporters, the molecular biology of the facilita

80 In addition to these facilitated urea transporters, three sodium-dependent, secondary act

81 The rat renal urea transporter UT-A includes four isoforms.

82 The rat renal urea transporter UT-A includes four mRNA isoforms: UT-A1

83 Abundant slc14a1 expression, encoding the urea transporter UT-A, suggests a significant role in th

84 onstrated a decrease in the abundance of the urea transporter UT-A3.

85 on coefficient in Xenopus oocytes expressing urea transporter UT-B (former name UT3), suggesting that

86 Urea transporter UT-B has been proposed to be the major

87 is study, we present the structures of human urea transporters UT-A and UT-B to characterize them at

88 The urea transporters UT-A1 and UT-A3 mediate rapid transepi

89 orter proteins and a marked reduction of the urea transporters UT-A1 and UT-A3.

90 Urea transporter (UT) inhibition increases the excretion

91 The vasopressin-regulated urea transporter (UT)-A1 is a transmembrane protein with

92 Two isoforms of the renal urea transporter (UT-A) have been cloned so far: UT-A1 a

93 The facilitated urea transporter (UT-A) in the terminal inner medullary

94 We show that the urea transporter (UT-B) can be used as a gene reporter,

95 The facilitated urea transporter (UT-B) in erythrocytes permits these ce

96 Urea transporters (UT) play an important role in the uri

97 Two gene families for facilitated urea transporters, UT-A and UT-B, and several urea trans

98 cloning of two gene families for facilitated urea transporters, UT-A and UT-B, encoding several urea

99 distinct from the previously reported kidney urea transporter UT2.

100 Protein abundance of renal AQP1 and urea transporters UTA(1) and UTA(2) did not differ signi

101 Urea transporters (UTs) facilitate urea permeation acros

102 A family of molecular urea transporters (UTs) has been identified whose member

103 n knockout mice indicate a critical role for urea transporters (UTs) in the urinary concentrating mec

104 m, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration b

105 ucidate the physiological role of the latter urea transporter, we have isolated the rat homologue (UT

106 Urea transporters, which include UT-B in kidney microves