ライフサイエンスコーパス: uremic toxin

1 n, stiff vessels, coronary heart disease, or uremic toxins).

2 ototypical microbiome-derived metabolite and uremic toxin.

3 volving amino acids, lipids, bile acids, and uremic toxins.

4 thelial damage, dysbiosis, and generation of uremic toxins.

5 ling molecules, nutrients, antioxidants, and uremic toxins.

6 hanism of tubulotoxicity of tryptophan-based uremic toxins.

7 doxyl sulfate (IS) is one of the most potent uremic toxins.

8 excreted by the kidneys, which are potential uremic toxins.

9 d is being elucidated through the effects of uremic toxins.

10 relatively wide molecular weight spectrum of uremic toxins.

11 ts stresses exerted by as yet poorly defined uremic toxins.

12 sm of fatty acids, essential amino acids and uremic toxins.

13 ng altered excretion of indole compounds and uremic toxins.

14 ucts, antioxidants, choline derivatives, and uremic toxins.

15 gut microbiome products, uremic solutes, and uremic toxins.

16 Major metabolites such as uremic toxins (2,3-dihydroxy-5-methylthio-4-pentenoic ac

17 on, we found that DNMT3A was associated with uremic toxin, 8-hydroxy-2-deoxyguanosine, a biomarker of

18 acid, gut microbiome products, and so-called uremic toxins accumulating in chronic kidney disease.

19 fy the metabolism of indoxyl sulfate (IS), a uremic toxin and Apixaban.

20 These records described 32 previously known uremic toxins and 56 newly reported solutes.

21 Age modified the relationship between uremic toxins and CMH burden, with creatinine, TMAO and

22 ialysis, offers only suboptimal clearance of uremic toxins and fluid removal.

23 The correlation between uremic toxins and muscle dysfunction suggests that targe

24 CKD) is characterized by the accumulation of uremic toxins and renal tubular damage.

25 kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cres

26 OAT1 and/or OAT3 in the handling of over 35 uremic toxins and solutes, including those derived from

27 A causal link between uremic toxins and the development of mitochondrial abnor

28 tes numerous beneficial metabolites but also uremic toxins and their precursors, which are transporte

29 Both targeted (uremic toxins) and nontargeted metabolomics in plasma we

30 s (including tryptophan-derivatives that are uremic toxins), and lipids.

31 The latter are uremic toxins, and H(2)S has diverse physiological funct

32 ve capacity of the nephrons, accumulation of uremic toxins, and hypoxia- and arterial blood pressure-

33 P) are now recognized as a distinct class of uremic toxins, and numerous compounds in this category h

34 Recent work has demonstrated that uremic toxins are associated with limb amputation in PAD

35 Uraemic toxins (also called uremic toxins) are often considered to be the main cause

36 t understanding of the mechanisms concerning uremic toxins, arterial stiffening, and impaired cardiac

37 is placed on translational studies examining uremic toxin-associated pathogenic processes, including

38 Finally, circulating concentrations of the uremic toxin asymmetric dimethylarginine (ADMA) were ele

39 om human serum albumin, a protein that these uremic toxins bind to in the body.

40 ciated cognitive impairment with emphasis on uremic toxins; brain injury mechanisms; overlap between

41 rogram suggested that increased clearance of uremic toxins by intensified hemodialysis improves pregn

42 Increased levels of uremic toxins cause thrombogenicity by increasing tissue

43 emodialysis, although beneficial in terms of uremic toxin clearance, also contributes to cognitive de

44 composition can be utilized to predict serum uremic toxin concentrations, and based on this, we ident

45 Uremic toxins could modify the expression and/or activit

46 hanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the

47 Despite removing uremic toxins, dialysis may further accelerate immunosen

48 ic solutes and uraemic toxins (also known as uremic toxins), dysfunction of multiple organs and dysbi

49 th significant correlations observed between uremic toxins (eg, kynurenine and indoxyl sulfate) and b

50 d review of the existing knowledge regarding uremic toxins facilitates the design of experimental stu

51 date, assessment of the biologic activity of uremic toxins has focused primarily on in vitro effects,

52 bacterial endotoxins, or adsorb gut-derived uremic toxins have been developed.

53 We also found that relatively few uremic toxins have been examined for direct effects on p

54 Uremic toxin hippuric acid drives loss of mitochondrial

55 In CKD, uremic toxins, hyperparathyroidism and Klotho deficiency

56 egard, several pathogenic factors, including uremic toxins (i.e., uric acid, phosphates, endothelin-1

57 To characterize involvement of uremic toxins in cerebral and neurobehavioral abnormalit

58 rom the gut microbiome and are implicated as uremic toxins in chronic kidney disease.

59 in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (

60 sed further associations of IL-16 with other uremic toxins in this cohort.

61 Emerging evidence suggests that uremic toxins, in particular indoxyl sulfate (IS) and p-

62 is modulated by sex and age, and gut-derived uremic toxins including TMAO and IS may contribute to va

63 In vitro studies showed that several uremic toxins increased cellular TF levels in monocytic

64 We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand

65 icrobiome and demonstrate that levels of the uremic toxin indoxyl sulfate can be modulated in vivo by

66 The highly protein-bound uremic toxin indoxyl sulfate has emerged as a potent tox

67 The putative uremic toxin indoxyl sulfate induces oxidative stress an

68 Protein-bound uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate

69 Tryptophan-derived uremic toxins [indoxyl sulfate (IS) and kynurenine (Kyn)

70 adsorbent AST-120 were able to mitigate the uremic toxin-induced mitochondrial changes and improve b

71 Accumulation of uremic toxins is a hallmark of renal excretory dysfuncti

72 he interactions between an adsorbent and the uremic toxins is critical for designing effective materi

73 n that reuse could decrease the clearance of uremic toxins, leading to a decrease in the delivered do

74 AhR activation by indoxyl sulfate, a uremic toxin, leads to blood-brain barrier disruption as

75 ondrial function in the setting of increased uremic toxin levels.

76 Some uremic toxins, like indoxyl sulfate, are agonists of the

77 This dysfunction has been ascribed to uremic toxins, malnutrition, and dialysis.

78 levels of phosphorus and/or other potential uremic toxins may play an important role by transforming

79 is review, we demonstrate that protein-bound uremic toxins may play an important role in progression

80 uggest that indoxyl sulfate, a protein-bound uremic toxin, may induce vascular dysfunction and thromb

81 plicated pathways and features, particularly uremic toxins, may be important regulators of firefighte

82 hropogenic contaminants, 20 mycotoxins and 5 uremic toxins notably.

83 Uremic toxins often accumulate in patients with compromi

84 dialysis and hence varying concentrations of uremic toxins on CYP3A4 activity using the 14C-erythromy

85 The direct effects of uremic toxins on platelet function have been described,

86 erature search for the effects of individual uremic toxins on platelet function.

87 However, the impact of these uremic toxins on the crosstalk between endothelium and l

88 mic inflammation through the accumulation of uremic toxins, oxidative stress, and dysregulated immune

89 Targeting uremic toxins, oxygen-free radical production and the mi

90 P and history of cardiovascular disease; and uremic toxins p-cresyl sulfate and indoxyl sulfate.

91 ein, we study the adsorption behavior of the uremic toxins, p-cresyl sulfate, indoxyl sulfate, and hi

92 Protein-bound uremic toxins (PBUTs) are difficult to remove by convent

93 Protein-bound uremic toxins (PBUTs) are poorly removed during hemodial

94 ed analysis of cardiac cellular responses to uremic toxins pointed toward endothelin-1 and methylglyo

95 This reduced uremic toxin-producing activity and ameliorated progress

96 dequacy, the roles of urea and creatinine as uremic toxins remain controversial.

97 principles for potential MOFs candidates for uremic toxin removal.

98 enylalanine and tryptophan to cardiovascular uremic toxins, resulting in lower plasma levels of these

99 ions, treatment of cultured osteoblasts with uremic toxins revealed increased mitolysosome number and

100 high glucose or cardiomyocytes treated with uremic toxins, stimulated secretion of SIRPalpha in cult

101 SGLT2i reduced microbiome formation of uremic toxins such as p-cresol sulfate and thereby their

102 iltration rate and increased serum levels of uremic toxins, such as indoxyl sulfate.

103 Altogether, these results suggest that uremic toxins, such as IS, through effects on drug trans

104 , interventional approaches directed against uremic toxins, such as TNFalpha, hold promise to amelior

105 However, eight of the 12 uremic toxins tested in animal models mostly induced pro

106 Oxalate, a uremic toxin that accumulates in dialysis patients, is a

107 nce of I3S lies in the fact that it is a key uremic toxin that accumulates to high micromolar concent

108 d is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from tyrosine metabolism by

109 Specific uremic toxins that are removed by protein-leaking membra

110 ion of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are

111 nic acid and indole-3-acetic acid; the known uremic toxins trimethylamine n-oxide and hippuric acid;

112 elevation of numerous previously identified uremic toxins, we identified several additional markers

113 Creatinine and uremic toxins were elevated in both young and aged CKD m

114 To determine if uremic toxins were potentially responsible for these obs

115 ired mitophagy machinery, and the effects of uremic toxins were reversible by rapamycin.

116 of resistin, a proinflammatory cytokine and uremic toxin, were significantly elevated during both fo

117 cess of protein leads to the accumulation of uremic toxins, whereas a diet insufficient in protein co

118 on of a myriad of solutes termed uraemic (or uremic) toxins, which inflict damage to several organs,

119 Uremic toxins with potent effects have been identified.