1 There is an
urgent need to accelerate the academic development of sc
2 There is an
urgent need to accurately model how environmental change
3 The second concerns the
urgent need to address ethical issues when evaluating th
4 s, analysis of future scenarios suggests the
urgent need to address lingering geographical inequaliti
5 There is an
urgent need to address manpower and infrastructural defi
6 study in the scientific community due to the
urgent need to address many of the most important questi
7 lobal health policy, we aim to highlight the
urgent need to address oral diseases among other NCDs as
8 There is an
urgent need to address the broader challenge of adapting
9 bate, on both sides, continues to hamper the
urgent need to address the diverse and pressing challeng
10 The
urgent need to address the high-cost issue of proton-exc
11 This loss of bird abundance signals an
urgent need to address threats to avert future avifaunal
12 The results support an
urgent need to address vaccine hesitancy in policy dialo
13 Therefore, there is an
urgent need to assess the MRI characteristics of PML in
14 Hence, there is an
urgent need to be prepared with vaccines and therapeutic
15 There is an
urgent need to better define the natural history of FPIE
16 ronment to the leukemic cells, indicating an
urgent need to better understand the factors that promot
17 There is, therefore, an
urgent need to better understand the mechanisms driving
18 Thus, there is an
urgent need to better understand the neurobiological and
19 There is an
urgent need to better understand the pathophysiology of
20 There is an
urgent need to better understand these diseases in the c
21 A broader theme that emerged was the
urgent need to bring the glycosciences back into the mai
22 most burdened by the AMR crisis, there is an
urgent need to build effective, evidence-based policies
23 There is an
urgent need to build mitigation capacity where amphibian
24 Therefore, there is
urgent need to characterize dysregulated TK signaling ax
25 e, sequencing of tumor samples is driving an
urgent need to classify whether or not mutations seen in
26 eries, and dental implantations, there is an
urgent need to combat implant-associated infection.
27 There is an
urgent need to complement this traditional approach with
28 There is an
urgent need to confirm whether the use of tocilizumab pr
29 Given our
urgent need to conserve both wildlife and the food secur
30 Therefore, there is an
urgent need to continue researching in order to discover
31 There is an
urgent need to create novel models using human disease-r
32 Clearly, there is an
urgent need to define common standards for data analysis
33 This challenge shows the
urgent need to define novel strategies to provide long-t
34 xt of little clinical evidence, indicates an
urgent need to define the appropriate use of these medic
35 ng trends in maternal mortality, there is an
urgent need to derive a greater understanding of the mec
36 nza viruses have been developed, there is an
urgent need to design new strategies to develop influenz
37 Findings also indicate an
urgent need to destigmatize DUD and educate the public,
38 Nonetheless, there remains
urgent need to determine the basis for sepsis-related co
39 serious at higher temperatures, there is an
urgent need to determine the mortality projection of spe
40 Therefore, there is an
urgent need to develop a high-throughput and efficient s
41 There is thus an
urgent need to develop a representative animal model to
42 Therefore, there is an
urgent need to develop alternative technologies.
43 Thus, there is an
urgent need to develop alternative, egg-independent vacc
44 break of Ebola virus disease highlighted the
urgent need to develop an effective Ebola vaccine.
45 There is an
urgent need to develop an efficacious and affordable vac
46 gineered nanomaterials increase, there is an
urgent need to develop analytical techniques that are su
47 Indeed, there is
urgent need to develop and deploy robust diagnostic meth
48 There is an
urgent need to develop antifibrotic therapies for chroni
49 ousands of people worldwide, highlighting an
urgent need to develop antiviral therapies.
50 There is an
urgent need to develop antivirals that can effectively r
51 Clearly, there is an
urgent need to develop better tolerated and more effecti
52 There is an
urgent need to develop bioinformatics tools as to gain i
53 There is an
urgent need to develop biomarkers that predict patient p
54 pressure of diseases and pests, there is an
urgent need to develop crop varieties that can tolerate
55 ally approved to treat ZIKV, and there is an
urgent need to develop effective anti-ZIKV agents.
56 There is an
urgent need to develop effective therapies for COVID-19.
57 Therefore, there exists an
urgent need to develop effective treatment strategies sp
58 There is an
urgent need to develop fertility-related information ada
59 There is an
urgent need to develop guidelines for the expansion of o
60 Hence there is an
urgent need to develop improved drug delivery systems wh
61 he advent of precision oncology, there is an
urgent need to develop improved methods for rapidly dete
62 There is an
urgent need to develop innovative methodologies and tool
63 There is an
urgent need to develop long-lasting alternative insectic
64 There is an
urgent need to develop means of ex situ biobanking and b
65 associated with CCHFV infection, there is an
urgent need to develop medical countermeasures for disea
66 Therefore, there is an
urgent need to develop methods to identify the populatio
67 There is an
urgent need to develop more effective approaches to prot
68 There is an
urgent need to develop more effective vaccines that can
69 for smaller scale variants, and there is an
urgent need to develop more efficient tools that scale t
70 There is an
urgent need to develop nanocarriers for the treatment of
71 There is
urgent need to develop new acceleration techniques capab
72 l drugs such as chloroquine, demonstrates an
urgent need to develop new and alternative approaches to
73 While there is an
urgent need to develop new and effective drugs for treat
74 There is now an
urgent need to develop new and effective treatments.
75 and tumorigenic diseases has resulted in an
urgent need to develop new and improved intervention str
76 Consequently, there is an
urgent need to develop new antimicrobials to treat A. ba
77 Thus, there is an
urgent need to develop new approaches and dialysis modal
78 r this deadly disease; therefore there is an
urgent need to develop new diagnostics to accurately det
79 There is an
urgent need to develop new drugs against tuberculosis.
80 It is an
urgent need to develop new drugs for Mycobacterium tuber
81 stance to available antibiotics, there is an
urgent need to develop new drugs.
82 There is an
urgent need to develop new efficacious antimalarials to
83 There is an
urgent need to develop new methods for male contraceptio
84 There is an
urgent need to develop new pathogenic R5 simian/human im
85 There is an
urgent need to develop new pathophysiology-oriented ther
86 Therefore, there is an
urgent need to develop new sources of insulin-producing
87 eading cause of death worldwide, there is an
urgent need to develop new strategies to prevent lipopro
88 Hence, we address an
urgent need to develop new targets in cancer.
89 ival with current therapies, emphasizing the
urgent need to develop new therapeutic approaches.
90 There is an
urgent need to develop new therapeutics for this disease
91 ation suffering from AMD and DR, there is an
urgent need to develop new therapeutics targeting the mi
92 usually die within one year, emphasizing an
urgent need to develop new treatment strategies for this
93 However, there remains an
urgent need to develop new vaccines for HIV/AIDS, malari
94 There is thus an
urgent need to develop novel analytical methods for arse
95 of cruzain inhibitors has been driven by the
urgent need to develop novel and more effective drugs fo
96 Consequently, there is an
urgent need to develop novel and safe anxiolytics.
97 istant strains of P. aeruginosa, there is an
urgent need to develop novel antibiotic and anti-virulen
98 There is therefore an
urgent need to develop novel antibiotics with improved e
99 There is an
urgent need to develop novel antimicrobial therapies to
100 ehydration and supporting care suggesting an
urgent need to develop novel approaches to improve stand
101 Thus, there is an
urgent need to develop novel space-hardy formulations fo
102 Thus, there is an
urgent need to develop novel therapeutic interventions t
103 ss the blood-brain barrier, underscoring the
urgent need to develop novel therapeutic strategies.
104 There is an
urgent need to develop novel therapeutics for suppressin
105 Thus, there is an
urgent need to develop novel therapeutics for this disea
106 new antibiotics virtually empty, there is an
urgent need to develop novel therapeutics.
107 There is an
urgent need to develop novel therapies for controlling c
108 There is an
urgent need to develop novel therapies for controlling r
109 Given the
urgent need to develop novel, potent antibiotics, the re
110 Therefore, there is an
urgent need to develop novel, specific amyloidophilic ra
111 Our study provides an early warning of the
urgent need to develop policies that manage nitrogen emi
112 These include an
urgent need to develop pretest education for all pregnan
113 ral therapy approved for humans, there is an
urgent need to develop prophylactic and therapeutic opti
114 There is an
urgent need to develop protective vaccines and host-dire
115 eum and other fossil fuels, has motivated an
urgent need to develop renewable, carbon-neutral, econom
116 Thus, there is an
urgent need to develop second-generation M2 inhibitors t
117 There is an
urgent need to develop simple and fast antimicrobial sus
118 There is, therefore, an
urgent need to develop single-dose and long-lasting rabi
119 However, there is an
urgent need to develop substitutes for pure Pt catalysts
120 Consequently, there is an
urgent need to develop targeted therapies capable of eli
121 There is an
urgent need to develop technologies that use renewable e
122 There is an
urgent need to develop the next-generation vectors for g
123 existing immunity to SARS-CoV-2, there is an
urgent need to develop therapeutic agents and vaccines t
124 There is an
urgent need to develop therapies that slow down the prog
125 As such, there is an
urgent need to develop viable alternatives to overcome t
126 The first was the
urgent need to differentiate between tumor cell and tumo
127 Therefore, there is an
urgent need to discover effective therapeutic agents for
128 There is therefore an
urgent need to discover more effective targets for PEL m
129 There is an
urgent need to discover new anti-tubercular agents with
130 We highlight the
urgent need to dissect the mechanistic underpinnings of
131 Our results highlight the
urgent need to document and understand Neotropical salam
132 The NESARC-III data indicate an
urgent need to educate the public and policy makers abou
133 There is an
urgent need to either significantly expand the R55/R56 m
134 There is an
urgent need to elicit and validate highly efficacious ta
135 There has been an
urgent need to eliminate toxic lead from the prevailing
136 nd chronic visceral pain states points to an
urgent need to elucidate the development of such imbalan
137 There is an
urgent need to elucidate the genetic architecture of the
138 ted risk of colorectal cancer reinforces the
urgent need to elucidate the underlying mechanisms contr
139 the widespread plight of coral reefs and the
urgent need to enact conservation measures.
140 To meet this demand, there is an
urgent need to enhance the accessibility and reach of su
141 There is an
urgent need to ensure the robustness of fractional-dose
142 There is an
urgent need to establish national risk assessment system
143 There is an
urgent need to establish protocols specifically designed
144 There is an
urgent need to establish standardized BPD case definitio
145 There is an
urgent need to establish sustainable technologies for in
146 This change indicates the
urgent need to evaluate and document ophthalmic manifest
147 Raquel Gonzalez and colleagues highlight an
urgent need to evaluate antimalarials that can be safely
148 ctor for VL treatment success, suggesting an
urgent need to evaluate the recently proposed optimal al
149 t possible, but analytical approaches are of
urgent need to evaluate the similarity between different
150 ise in antimicrobial resistance, there is an
urgent need to examine market mechanisms that are approp
151 There is an
urgent need to expand basic science approaches for negle
152 There is an
urgent need to expand the surgical care delivery system
153 Therefore, there is an
urgent need to explore genetic factors involved in this
154 Thus, there is an
urgent need to explore new approaches for modulating the
155 There is thus an
urgent need to explore new control solutions, one of whi
156 Together, this synthesis underscores an
urgent need to explore the interactions among multiple g
157 Thus, there is still an
urgent need to explore these areas to develop effective
158 of emerging infectious diseases, there is an
urgent need to facilitate multidisciplinary research in
159 tructure-structure alignment algorithm is in
urgent need to facilitate the comparative study.
160 gainst disseminated disease, and there is an
urgent need to fill this gap.
161 India and poor uptake worldwide, there is an
urgent need to find alternative models of CR that are in
162 s and drug resistant mutants, highlights the
urgent need to find antivirals with novel mechanisms of
163 Consequently, there is an
urgent need to find better mechanisms of inhibiting myel
164 Despite the
urgent need to find effective therapeutics, research on
165 Therefore there is an
urgent need to find new therapeutic strategies to treat
166 Therefore, there is an
urgent need to find novel antivirals for the treatment o
167 There is an
urgent need to focus on implementing existing cost-effec
168 In particular, there is an
urgent need to focus our efforts on effective therapeuti
169 due to increasing cover of PAC, there is an
urgent need to further investigate competitive interacti
170 nce factors that we discover underscores the
urgent need to halt the advance of pathogenic chytrids a
171 There is an
urgent need to help people with serious mental illness t
172 Thus, there is an
urgent need to identify and characterize aberrantly expr
173 Therefore, there is an
urgent need to identify and target signaling molecules w
174 To overcome this shortcoming, there is an
urgent need to identify appropriate surrogate endpoints.
175 million OA cases worldwide, and there is an
urgent need to identify biomarkers for early detection,
176 There is an
urgent need to identify biomarkers for hepatocellular ca
177 ce with this therapeutic class highlights an
urgent need to identify biomarkers of HAP sensitivity, i
178 l cannabis use and availability, there is an
urgent need to identify cognitive impairments related to
179 tion to patients and clinicians, there is an
urgent need to identify consensus statements on head and
180 There is an
urgent need to identify correlates of both vaccine prote
181 There is an
urgent need to identify electrocardiographic characteris
182 There is an
urgent need to identify environmental risk and protectiv
183 arily to metastatic spread, highlighting the
urgent need to identify factors involved in this progres
184 adjunctive treatments for CM, so there is an
urgent need to identify new targets for therapy.
185 There is an
urgent need to identify new therapeutic opportunities fo
186 There is an
urgent need to identify new treatments for tuberculosis
187 Therefore, there is an
urgent need to identify new, safe, and targeted therapeu
188 As such, there is an
urgent need to identify novel drugs to treat TB infectio
189 tion for blast resistance and emphasizes the
urgent need to identify novel non-2NS sources of blast r
190 al morbidity and mortality, highlighting the
urgent need to identify novel pathophysiological mechani
191 There is an
urgent need to identify novel risk factors and primary p
192 approved in the past 2 decades, there is an
urgent need to identify novel targets and therapeutic st
193 Thus, there is an
urgent need to identify potential underlying mechanisms
194 There is an
urgent need to identify relevant tumor markers showing h
195 There is an
urgent need to identify reliable biomarkers of amyotroph
196 ed with many human diseases, and there is an
urgent need to identify specific DUBs associated with th
197 Therefore, there is an
urgent need to identify specific targets and effective p
198 ariants in the clinical setting, there is an
urgent need to identify the best variant caller(s) from
199 the response to selection, highlighting the
urgent need to identify the contribution of each CNV to
200 There is an
urgent need to identify therapeutic targets for BLBC, be
201 have not been fully elucidated, there is an
urgent need to identify those at increased risk of devel
202 ing SCID patients early in life, there is an
urgent need to identify validated approaches through pro
203 We highlight the
urgent need to implement Bd monitoring and mitigation st
204 Our analyses underline the
urgent need to implement global strategies to measure se
205 imperative to reduce suffering, there is an
urgent need to implement scalable mental health interven
206 There is an
urgent need to improve clinical management of LD using p
207 heria diagnostics EQA alarmingly reflect the
urgent need to improve laboratory performance in diphthe
208 national quality-control study underline the
urgent need to improve methods used to monitor HDV virem
209 timal anticoagulation control, suggesting an
urgent need to improve oral anticoagulation care for mos
210 Consequently there is an
urgent need to improve our understanding of the mechanis
211 There is an
urgent need to improve outcomes and reduce costs for pat
212 y and chronic airway diseases, which face an
urgent need to improve the level of disease control, enh
213 of pancreatic cancer increases, there is an
urgent need to improve the training of surgeons and deve
214 ith low-access to HCV services emphasises an
urgent need to include resource-limited settings in the
215 The study emphasizes the
urgent need to incorporate climate change into the IUCN
216 The discrepancy highlights the
urgent need to incorporate paleoclimate information into
217 ent as previously expected and highlight the
urgent need to incorporate this mechanism into most IPCC
218 y affects N(2) O emission and highlights the
urgent need to incorporate this strong feedback into mos
219 There is therefore an
urgent need to increase multisectoral coverage of qualit
220 There is an
urgent need to increase the number of coinfected patient
221 We highlight the
urgent need to integrate a broader perspective into loca
222 ities of new therapeutic agents, there is an
urgent need to integrate human-relevant platforms/approa
223 Therefore, there is an
urgent need to integrate key controls into microbiome re
224 There is an
urgent need to investigate molecular pathways underlying
225 This prompts an
urgent need to investigate the molecular mechanisms unde
226 There is an
urgent need to know how to interpret the degree of diffe
227 These findings highlight an
urgent need to manage the sustainability of game hunting
228 To optimize their use, there has been an
urgent need to minimize both warm and cold ischemia, whi
229 The
urgent need to minimize the potential harm deriving from
230 The
urgent need to mitigate climate change invokes both oppo
231 ems resembling kidney characteristics are in
urgent need to model disease as well as to establish rel
232 This work demonstrates the
urgent need to monitor Lm strains at the global level an
233 primary productivity (NPP), emphasizing the
urgent need to monitor the impacts of climate change.
234 In sum, there is an
urgent need to more accurately define the syndrome of HF
235 ble-duty actions now identified, there is an
urgent need to move forward with double-duty actions to
236 r by adaptation or by migration, there is an
urgent need to obtain estimates of dispersal distance.
237 There is an
urgent need to offer targeted, age-appropriate routine H
238 These results reinforce the
urgent need to overcome barriers to scaling up pediatric
239 Collective efforts are in
urgent need to preserve the potency of these essential a
240 There is an
urgent need to proactively tailor strategies to contain
241 There is an
urgent need to quantify anthropogenic influence on fores
242 Analogously, there is an
urgent need to quantify the mechanics of emerging electr
243 h captive amphibian collections, there is an
urgent need to raise awareness of the importance of effe
244 ated for coronavirus infections, there is an
urgent need to rapidly identify potential therapeutics t
245 ected by rapid habitat loss which creates an
urgent need to re-assess the conservation status based o
246 These results support an
urgent need to re-evaluate current global guidelines for
247 rne viruses such as Zika has highlighted the
urgent need to re-evaluate mosquito-control standards.
248 urrent pedagogic models, and underscores the
urgent need to realign and synergize these models to ref
249 Climate change imposes an
urgent need to recognise and conserve the species likely
250 -resistant Enterobacteriaceae highlights the
urgent need to reduce carbapenem dependence.
251 Our results suggest an
urgent need to reform African governments' and foreign a
252 s and other soft tissue defects, there is an
urgent need to regenerate skin.
253 There is
urgent need to regularly monitor and improve the availab
254 There is an
urgent need to report the successes and failures of thes
255 There is an
urgent need to rethink policies and strategies to combat
256 There is an
urgent need to rethink the immunology of Mycobacterium t
257 Conclusions pointed out an
urgent need to review legislative limits in food matrice
258 There is therefore an
urgent need to revisit these methods and summarize their
259 However, there is an
urgent need to rigorously estimate actual mortality rate
260 These data suggest an
urgent need to scale up access to quality HIV prevention
261 There is therefore an
urgent need to scale up vector control and access to hea
262 There is thus an
urgent need to sort out the key points of preparing the
263 There is an
urgent need to standardize reporting of methods and defi
264 implications of optical imaging, there is an
urgent need to standardize surgical navigation tools and
265 is becoming known, we are presented with an
urgent need to study their effects on various forms of l
266 Consequently, there is an
urgent need to systematically assess the state-of-the-ar
267 This implies an
urgent need to systematically evaluate many aspects of t
268 Thus, there is an
urgent need to test novel therapeutic agents to countera
269 Hence our study emphasizes the
urgent need to test the inflammatory properties of trans
270 Consequently, there is an
urgent need to translate diagnostic strategies to establ
271 There is an
urgent need to translate these assays to the study of ce
272 This strongly suggests that there is an
urgent need to treat breast cancer with a personalized a
273 f the EGFR-PI3K/Akt pathway, underscores the
urgent need to understand alternative downstream pathway
274 ansplantation from older donors, there is an
urgent need to understand how brain death leads to kidne
275 ined in terms of observed cases, there is an
urgent need to understand how changes in detection delay
276 There is an
urgent need to understand how the paradigm that has guid
277 Given the
urgent need to understand how the thousands of loci that
278 alongside economic development, creating an
urgent need to understand how these changes can benefit
279 containing this water annually, creating an
urgent need to understand its effects on bird health.
280 These SSEs demonstrate the
urgent need to understand routes of transmission, while
281 There is an
urgent need to understand signaling cascades that promot
282 There is an
urgent need to understand the basis of resistance to opt
283 avirus-2 (SARS-CoV-2) infection presents the
urgent need to understand the complex pathogen-host inte
284 to urbanization and development there is an
urgent need to understand the dynamics of vector-borne d
285 There is an
urgent need to understand the effect of such disturbance
286 There is an
urgent need to understand the factors that contribute to
287 There is an
urgent need to understand the immune response to tubercu
288 ratures and decreasing rainfall, there is an
urgent need to understand the influence of climate chang
289 Therefore there is an
urgent need to understand the mechanisms by which glucoc
290 There is an
urgent need to understand the mechanisms by which the mu
291 treat RVFV infection, and thus, there is an
urgent need to understand the mechanisms by which the vi
292 Indeed, there is an
urgent need to understand the mechanisms linking unhealt
293 There is an
urgent need to understand the mechanisms of A. baumannii
294 stant (MDR) tuberculosis (TB) highlights the
urgent need to understand the mechanisms of resistance t
295 There is an
urgent need to understand the molecular signaling pathwa
296 There is an
urgent need to understand the pathogenesis of coronaviru
297 To mitigate or eliminate PWMI, there is an
urgent need to understand the pathological mechanism(s)
298 There is an
urgent need to understand the relationships between amyl
299 pplications continues to expand, there is an
urgent need to understand the underlying physics and est
300 hways, medicinal chemistry efforts remain an
urgent need to yield selective and efficacious AP-1 inhi