ライフサイエンスコーパス: uric

1 eruricemia was defined as a concentration of uric acid >=7.0 mg/dL in men and >=5.7 mg/dL in women.

2 natriuretic peptide (482 +/- 337 pg/mL) and uric acid (8.2 +/- 2.6 mg/dL), decreased left ventricula

3 correlated to BMI, whereas higher levels of uric acid (beta=0.164; P<0.001), proadrenomedullin (beta

4 tioxidant molecules [taurine (m/z 124.0068), uric acid (m/z 167.0210), ascorbic acid (m/z 175.0241),

5 95% CI: -0.71, -0.02; SUCRAglucose: 74%) and uric acid (MD: -23.77 umol/L; 95% CI: -44.21, -3.32 umol

6 We found that uric acid (monosodium urate [MSU]) crystals induce a pro

7 5% CI 1.06, 1.76; p = 0.015), elevated serum uric acid (OR 3.55; 95% CI 1.03, 12.27; p = 0.045), elev

8 rotein (OR, 0.99; 95% CI, 0.98-0.99); higher uric acid (OR, 1.13; 95% CI, 1.04-1.22); working in inst

9 In multivariate analysis, serum uric acid (P = 0.001), estimated glomerular filtration r

10 Higher plasma uric acid (PUA) levels are associated with lower glomeru

11 gger inflammation, published data on soluble uric acid (sUA) in this context are discrepant.

12 Soluble uric acid (sUA) is found in high concentrations in the s

13 Increased serum uric acid (SUA) levels cause gout and are associated wit

14 apable of non-invasively monitoring salivary uric acid (SUA) levels.

15 Elevated levels of serum uric acid (SUA) were considered to be risk factors for c

16 electrochemical detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) on three dimension

17 low-density lipoprotein cholesterol (LDL-C), uric acid (UA) and diabetes-related traits such as fasti

18 ve interferences such as ascorbic acid (AA), uric acid (UA) and dopamine (DA).

19 The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke

20 ration solutions and found that solubilizing uric acid (UA) by prewarming created erroneous results b

21 gen peroxide is the oxidative end product of uric acid (UA) by uricase, an efficient and sensitive ap

22 Uric acid (UA) can scavenge the peroxynitrite to avoid t

23 The roles of asymptomatic hyperuricemia or uric acid (UA) crystals in CKD progression are unknown.

24 Excessive production of uric acid (UA) in blood may lead to gout, hyperuricaemia

25 reductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribu

26 Recent data suggested a causative role of uric acid (UA) in the development of renal disease, in w

27 pression of xanthine oxidase and thereby the uric acid (UA) pathway of purine catabolism in macrophag

28 Elevated levels of uric acid (UA) were detected in mice undergoing sensitiz

29 d excellent photo-catalytic activity towards uric acid (UA) which served as the base for the Electroc

30 trochemical detection of ascorbic acid (AA), uric acid (UA), and dopamine (DA).

31 ection of ascorbic acid (AA), dopamine (DA), uric acid (UA), and serotonin (5-HT) in 0.1 M PBS (pH =

32 i-interference properties in the presence of uric acid (UA), ascorbic acid (AA) and glucose.

33 e common interferents ascorbic acid (AA) and uric acid (UA).

34 , Ascorbic Acid (AA), Acetaminophen (Ac) and Uric Acid (UA).

35 159.4 ng/mL; P = 0.028), and increased serum uric acid (WA: 341.4 mumol/L; CB: 330 mumol/L; P = 0.020

36 vity C-reactive protein) 2.8 (1.3-6.1) mg/L, uric acid 7.2 (5.8-8.7) mg/dL, and urine protein-creatin

37 While uric acid alone was unable to trigger a chloride secreto

38 Uric acid also amplified the effects of elevated glucose

39 Uric acid also proved superior to placebo in reducing in

40 Improvement Amendments (CLIA) criterion for uric acid analysis (+/-17%).

41 MDA, uric acid and ALT levels also increased, whereas GSH and

42 matography (HPLC), were compared to quantify uric acid and antioxidant reducing agents in 36 milk sam

43 l for electrochemical detection of dopamine, uric acid and ascorbic acid.

44 ly interfering physiological species such as uric acid and ascorbic acid.

45 positive genetic correlations between serum uric acid and BMI z score (rhoG = 0.45, P = 0.002), perc

46 laboratory analysis for the readily detected uric acid and for the clozapine which is present at 100-

47 erence observed in the presence of dopamine, uric acid and fructose.

48 blood was taken for the measurement of serum uric acid and glycosylated haemoglobin (HbA1C).

49 exclusion of the main interfering substances uric acid and hydrogen peroxide.

50 inflammation, where there is large amount of uric acid and inflammatory peroxidases.

51 At the bedside in the last 5 years, uric acid and nerinetide are the only compounds tested f

52 Any interference of uric acid and other electroactive AAs was noticed.

53 levels of various small molecules, including uric acid and p-hydroxybenzoic acid among their structur

54 Uric acid and the GRS were both associated with cardiova

55 acetyl-D-hexosamine and fumaric acid (2 mo); uric acid and tyrosine (6 mo).

56 , respiration rate and low concentrations of uric acid and tyrosine, analytes associated with disease

57 Elevated concentrations of serum uric acid are associated with increased risk of gout and

58 eptor 4 (TLR-4), interleukin-18 (IL-18), and uric acid as markers of the inflammatory host response i

59 dehydrogenase, resulting in the formation of uric acid as well as ROS.

60 (SERS) approach for the routine analysis of uric acid at clinically relevant levels in urine patient

61 been utilized in the nanomolar detection of uric acid at physiological pH in water.

62 from anionic analytes like ascorbic acid and uric acid at physiological pH.

63 The prepared LRSPR based uric acid bio-sensor gives good response characteristics

64 The genetic score raised uric acid by 17 micromol/L (95% CI 15, 18) per SD increa

65 droperoxide is a product of the oxidation of uric acid by inflammatory heme peroxidases.

66 ower autophagic activity in cells exposed to uric acid compared with control conditions.

67 Human serum uric acid concentration (SUA) is a complex trait.

68 ated a weighted genetic risk score (GRS) for uric acid concentration based on eight uric acid-regulat

69 ect, we found that a 59.48 micromol/L higher uric acid concentration did not have a causal effect on

70 te that our CaT-SMelor directly measured the uric acid concentration in clinical human blood samples,

71 ch 1-mg/dl increase in genetically predicted uric acid concentration were significant for cardiovascu

72 ood linearity over a wide range of 0-700 muM uric acid concentration with a limit of detection (LOD)

73 between the EC-SERS signal intensity and the uric acid concentration.

74 QDs fluorescence, which was proportional to uric acid concentration.

75 .9 +/- 3.1 mg/dL, P < 0.0001), and 24-h mean uric acid concentrations (0%: -0.13 +/- 0.07; 10%: 0.15

76 investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk.

77 Insulin resistance and uric acid concentrations were beneficially affected by r

78 variation in SLC2A9 is associated with serum uric acid concentrations, an important biomarker of rena

79 rain samples was determined by measuring the uric acid content of their aqueous extracts.

80 icted versus reference values of protein and uric acid content were found to be fitting with R(2) of

81 idated with reference methods of protein and uric acid content.

82 The potential mechanisms by which uric acid could cause vasoconstriction and a progressive

83 , the authors believe that TLR-4, IL-18, and uric acid could have a role in the inflammatory patholog

84 Clec12A detects uric acid crystals and limits proinflammatory pathways b

85 ng EPEC and STEC infections, we noticed that uric acid crystals became enmeshed in the neutrophilic e

86 While trying to visualize uric acid crystals formed during EPEC and STEC infection

87 Uric acid crystals were formed in vivo in the lumen of t

88 activated by stimuli that include nigericin, uric acid crystals, amyloid-beta fibrils and extracellul

89 well as other sterile particulates, such as uric acid crystals, induces DCs to produce IL-2 followin

90 sitivity, selectivity, and stability towards uric acid detection in human saliva, covering the concen

91 ient samples have been used for quantitative uric acid detection using a simple, rapid colloidal SERS

92 ase, an efficient and sensitive approach for uric acid determination was also established.

93 Peroxynitrite scavenger uric acid did not affect the first phase but ameliorated

94 ), allows for the absolute quantification of uric acid directly in a complex matrix such as that from

95 We find that uric acid directly inhibits uridine monophosphate syntha

96 Uric acid dose-dependently stimulated aldose reductase e

97 ve dietary sodium intake and increased serum uric acid during follow-up despite pharmacological contr

98 0 years before diagnosis and lower levels of uric acid during the 20 years before diagnosis, compared

99 identified parameters, including fractional uric acid excretion and plasma copeptin concentration, m

100 glycosuria, increased urinary phosphate, and uric acid excretion.

101 om healthy volunteers were first primed with uric acid for 24 h and then subjected to stimulation wit

102 The mean level of serum uric acid for both the groups was within normal range an

103 Quantitative detection of uric acid for rapid and routine diagnosis of early preec

104 Although blocking uric acid formation by allopurinol did not affect outcom

105 We wondered, however, if uric acid generated by XO also had biological effects in

106 These results suggest that uric acid generated during fructose metabolism may act a

107 gical and experimental evidence suggest that uric acid has a role in the etiology of type 2 diabetes

108 Because uric acid has been implicated as a mediator of adjuvant

109 Uric acid has been linked to the progression of native k

110 ng of epithelial absorption and secretion of uric acid has recently emerged, aided in particular by t

111 etic and regulatory networks with effects on uric acid homeostasis have also emerged.

112 scopy and used for quantitative detection of uric acid in 0.1 M NaF and synthetic urine at clinically

113 ng process and used to measure pyocyanin and uric acid in a wound fluid simulant at 37 degrees C.

114 g lipid/lipoprotein risk factors for CVD and uric acid in adults [age: 18-40 y; body mass index (in k

115 tocol is then employed for the estimation of uric acid in blood serum samples of healthy individuals.

116 etween RNFL and macular thickness with serum uric acid in both the groups.

117 This first GWAS of serum uric acid in continental Africans identified three assoc

118 Here, we performed the first GWAS for serum uric acid in continental Africans, with replication in A

119 Our results show that variation in serum uric acid in Hispanic children is under considerable gen

120 ited the expected pharmacodynamics to remove uric acid in hyperuricemic blood in vitro and multiple f

121 ricemic blood in vitro and multiple forms of uric acid in hyperuricemic geese.

122 d simple method for the reliable analysis of uric acid in milk.

123 wed significantly higher level of mean serum uric acid in no diabetic retinopathy group (p = 0.004 re

124 ed LRSPR sensor was also evaluated to detect uric acid in real serum samples.

125 Levels of uric acid in sweat were higher in patients with gout tha

126 n blood digestion, a massive accumulation of uric acid in the midgut posterior region, and a signific

127 The detection figures of merit for uric acid in the simulant at 37 degrees C were as follow

128 ayer (RNFL) and macular thickness with serum uric acid in type 2 diabetic patients.

129 High levels of uric acid in urine and serum can be indicative of hypert

130 quantum dots (QDs) for the determination of uric acid in urine sample is described.

131 Uric acid induced the phenotype transition of vascular e

132 filtering out signals from ascorbic acid and uric acid interferents.

133 pite its role in converting highly insoluble uric acid into 5-hydroxyisourate.

134 Uric acid is a damage-associated molecular pattern (DAMP

135 Uric acid is a final breakdown product of purine catabol

136 Uric acid is a potential important biomarker in urine an

137 d Mendelian randomization to examine whether uric acid is an independent and causal cardiovascular ri

138 These results suggest that high uric acid is causally related to adverse cardiovascular

139 Serum uric acid is determined by production and the net balanc

140 However, uric acid is not responsible for brain dysfunction, and

141 reanalysis of the URICO-ICTUS trial whether uric acid is superior to placebo in improving the functi

142 Serum uric acid is the end-product of purine metabolism and at

143 as to investigate whether variation in serum uric acid is under genetic influence and whether the ass

144 e (35.2 [33.0-38.0] vs 33.0 [30.0-35.5] cm), uric acid level (4.9 [4.0-5.8] vs 4.5 [3.7-5.5] mg/dL),

145 height, family history of ESRD, higher serum uric acid level, and lower measured GFR.

146 eys, reduced oxidative stress, lowered serum uric acid level, reduced glomerular hyperfiltration and

147 sma AST, salivary AST, and salivary ALT with uric acid level.

148 tricular ejection fraction </=40%, and serum uric acid levels >/=9.5 mg/dL to receive allopurinol (ta

149 difference = 1.7, 95% CI: -0.1, 3.4), plasma uric acid levels (for those born early preterm, differen

150 , whereas both serum magnesium (P<0.001) and uric acid levels (P=0.008) improved.

151 nd the allopurinol groups had baseline serum uric acid levels (SDs) of 8.7 (1.6) mg/dl and 8.3 (1.4)

152 osodium urate crystals in joints when plasma uric acid levels are chronically elevated beyond the sat

153 These results indicate that, although uric acid levels are elevated in the airways of NO2-expo

154 A modest rise in uric acid levels beginning early after donation, and a s

155 purinol effectively and safely lowered serum uric acid levels in adults with stage 3 CKD and asymptom

156 etween maternal serum fructose and placental uric acid levels in humans.

157 Moreover, plasma uric acid levels in mice fed the WD were decreased after

158 ed cell systems and in the intestine in vivo Uric acid levels in the gut lumen increased in response

159 and non-human primates and normalized serum uric acid levels in uricase-deficient mice.

160 Uric acid levels were significantly reduced with allopur

161 We evaluated whether lowering serum uric acid levels with allopurinol improves endothelial d

162 d hemoglobin, albuminuria, triglycerides and uric acid levels, and worse measured glomerular filtrati

163 dase inhibitor allopurinol reduced placental uric acid levels, prevented placental inefficiency, and

164 with reduced ejection fraction and elevated uric acid levels, xanthine oxidase inhibition with allop

165 vels significantly correlated with placental uric acid levels.

166 prevent glucose reabsorption and lower serum uric acid levels.

167 enal function plays a critical role in serum uric acid levels.

168 d renal inflammation phenotypes, reprogramed uric acid metabolism pathways, inhibited the activation

169 Next, we tested whether uric acid might mediate inflammasome activation in cells

170 The levels of uric acid obtained by CV compared well to those determin

171 s not support a causal effect of circulating uric acid on diabetes risk.

172 ascorbic acid, 1.3 mM acetaminophen, 1.4 mM uric acid or 20 mM glucose.

173 sociated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-de

174 ed by severe neurological manifestations and uric acid overproduction.

175 sizes, expressed as the percentage change in uric acid per deleted copy, are most pronounced among wo

176 ctivated protein kinase phosphorylation, but uric acid priming induced phosphorylation of AKT and pro

177 broad inflammatory pathways associated with uric acid priming, with NF-kappaB and mammalian target o

178 oxygen species production was diminished by uric acid priming.

179 etion/export with a concomitant reduction of uric acid production.

180 sma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio

181 renal secretion of d-lactate in exchange for uric acid reabsorption culminated in hyperuricemia and g

182 abolites whose renal excretion is coupled to uric acid reabsorption.

183 We evaluated whether soluble uric acid regulates aldose reductase expression both in

184 rescence microscopy, we investigated whether uric acid regulates aldose reductase, a key enzyme in th

185 In addition, ORMDL3 mediated uric acid release, another marker of cellular stress.

186 we investigated the mechanisms through which uric acid selectively lowers human blood monocyte produc

187 Serum uric acid showed a poor correlation with RNFL and macula

188 ared with placebo, allopurinol lowered serum uric acid significantly but did not improve endothelial

189 The linear regression equations for uric acid substrate was stated as A = 0.0039C + 0.0519 w

190 were higher with potassium citrate; however, uric acid supersaturation was lower.

191 In the placenta, fructose induced de novo uric acid synthesis by activating the activities of the

192 used for ammonia detoxification and [(13)C] uric acid synthesis through multiple metabolic pathways,

193 rmediate of the electrochemical oxidation of uric acid that has a lifetime in solution of 23 ms as we

194 Uric acid therapy was associated with reduced infarct gr

195 Uric acid therapy was more effective than placebo in lim

196 sporter and sterically hinder the transit of uric acid through the substrate channel, albeit with vas

197 peroxidase), which is involved in oxidizing uric acid to allaintoin and hydrogen peroxide.

198 We found serum uric acid to be significantly heritable [h(2) +/- SD = 0

199 High affinity inhibition of uric acid transport requires URAT1 residues Cys-32, Ser-

200 which can be treated using inhibitors of the uric acid transporter, URAT1.

201 sults demonstrate the association of SU with uric acid transporters in a minority population of Ameri

202 Uric acid triggered inflammatory responses in the gut, i

203 15, 18) per SD increase and explained 4% of uric acid variation.

204 nd study that compared the administration of uric acid versus placebo in stroke patients treated with

205 Continuous sensing of uric acid was also performed using this biosensor which

206 Higher uric acid was associated with a higher diabetes risk aft

207 Uric acid was associated with a range of prevalent disea

208 Uric acid was associated with an increased rate of excel

209 Higher uric acid was associated with impulsivity in both humans

210 ant activity, we sought to determine whether uric acid was elevated and participated in a mouse model

211 The level of plasma uric acid was found to be highly significantly increased

212 The linear range for uric acid was from 4.0 to 70 muM, and the LOD was measur

213 Uric acid was higher in participants with an SSB intake

214 The linearity of the system toward uric acid was in the concentration range of 125-1000 mic

215 We found that uric acid was increased in the airways of mice exposed t

216 Serum uric acid was measured in 3315 patients of the Ludwigsha

217 The mean serum uric acid was significantly higher in patient with HbA1C

218 ncentrations of leukocytes, haptoglobin, and uric acid were associated with a lower risk of Parkinson

219 lesterol high-density lipoprotein (HDL), and uric acid were measured.

220 s not known whether the association of serum uric acid with SLC2A9 polymorphisms manifests in childre

221 Further, uric acid with the concentration of 0.1 muM is detected

222 g lipid/lipoprotein risk factors for CVD and uric acid within 2 wk.

223 rips were developed for on-site detection of uric acid without involving any sophisticated instrument

224 ), foods (fructose), and metabolic products (uric acid) function as survival signals to help reduce w

225 homeostasis (potassium), purine degradation (uric acid), and oxidative stress as regulated by glutath

226 terferants (ascorbic acid, acetaminophen and uric acid), was revealed to be negligible.

227 ated AR metabolites (sorbitol, fructose, and uric acid), which correlated significantly with (1) incr

228 cal pathways (e.g., involving bile acids and uric acid).

229 principle, this biosensor was used to detect uric acid, a biomarker for wound severity and healing, i

230 Excess circulating uric acid, a product of hepatic glycolysis and purine me

231 eading to de novo lipogenesis, production of uric acid, and accumulation of visceral and ectopic fat.

232 ine N-oxide, beta-hydroxybutyrate, trimethyl uric acid, and alanine.

233 tose (dietary or endogenous), its metabolite uric acid, and aldose reductase (AR, the only endogenous

234 um(III) chloride, ferricyanide/ferrocyanide, uric acid, and ascorbic acid.

235 Fasting glucose, triglycerides, uric acid, and bilirubin levels were decreased in the sa

236 eart rates, respiratory rates, and sweat pH, uric acid, and glucose, as well as deliver programmed th

237 quent elevation in fructose, sorbitol and/or uric acid, are important factors contributing to alcohol

238 iated with any biochemical marker except for uric acid, arguing against pleiotropy.

239 on Resonance (LRSPR) biosensor for detecting uric acid, as a model analyte, has been developed in thi

240 omavirus, dopamine, glutamic acid, IgG, IgE, uric acid, ascorbic acid, acetlycholine, cortisol, cytos

241 ng compounds in biological fluids, including uric acid, ascorbic acid, glucose and acetaminophen.

242 lobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminas

243 ated with higher levels of serum creatinine, uric acid, calcium and lower urine pH level.

244 itive relationship with the concentration of uric acid, cholesterol, and amylase.

245 e increasing lysophosphatidylcholine (18:2), uric acid, citrulline, and inosine levels, which are gen

246 predictors of disease progression including uric acid, creatinine and surprisingly, blood pressure,

247 errets, that form calcium oxalate, struvite, uric acid, cystine and other stone types.

248 Elevated brain natriuretic peptide and uric acid, decreased left ventricular ejection fraction,

249 ixture of graphene oxide, copper nitrate and uric acid, followed by thermal annealing at 900 degrees

250 Uric acid, generated from the metabolism of purines, has

251 selectivity against ascorbic acid, dopamine, uric acid, glucose and bovine serum albumin.

252 iopotential) sensors, sweat biochemical (pH, uric acid, glucose) sensors, thermal stimulators, and hu

253 g metabolic and signaling pathways involving uric acid, gut microbiome products, and so-called uremic

254 Baseline sputum uric acid, high mobility group box-1, CXCL8 mRNA, sputum

255 ion end-products, high-mobility group box 1, uric acid, IL-33, or inflammasome activation.

256 sent study, we sought to investigate whether uric acid, in the soluble form, could also activate the

257 uvant in CD4KO mice might be associated with uric acid, inflammatory cytokines, and the recruitment o

258 these damage-associated molecular patterns, uric acid, is increased in the maternal circulation in p

259 We show that XO-derived ROS, but not uric acid, is the trigger for IL1beta release and that X

260 roup differences in changes in hs-cTnI, CRP, uric acid, or urine protein-creatinine ratio were observ

261 jury associated with ATP depletion, elevated uric acid, oxidative stress and inflammation.

262 enic factors, including uremic toxins (i.e., uric acid, phosphates, endothelin-1, advanced glycation

263 tively related to blood urea nitrogen, serum uric acid, proteinuria, and supernatant IL-4; whereas po

264 status, body mass index, haemoglobin, serum uric acid, serum albumin, albuminuria, and C reactive pr

265 waist-to-height ratio, alanine transaminase, uric acid, serum triglycerides, and blood pressure.

266 male gender, higher body mass index, higher uric acid, smoking, alcohol drinking, and hiatal hernia

267 te structural elucidation of niacinamide and uric acid, two compounds potentially involved in the pat

268 nary citrate, magnesium, oxalate, phosphate, uric acid, volume, and pH, and lower urinary sodium, res

269 Thus, the Akt-PRAS40 pathway is activated by uric acid, which inhibits autophagy and recapitulates th

270 ovo pyrimidine synthesis-an effect traced to uric acid, which is 10-fold higher in the blood of human

271 Moreover, fructose metabolism yields uric acid, which is highly associated with NAFLD.

272 was performed using a genetic score with 24 uric acid-associated loci.

273 rs placental function via a xanthine oxidase/uric acid-dependent mechanism, and similar effects may o

274 This stimulatory mechanism was mediated by uric acid-induced oxidative stress and stimulation of th

275 ich inhibits autophagy and recapitulates the uric acid-induced proinflammatory cytokine phenotype.

276 Uric acid-lowering therapies may therefore not be benefi

277 ot be used as an argument against the use of uric acid-lowering therapy.

278 Obesity and diets rich in uric acid-raising components appear to account for the i

279 ) for uric acid concentration based on eight uric acid-regulating single nucleotide polymorphisms.

280 ukocytes, immunoglobulin G, haptoglobin, and uric acid.

281 endent modulation in optical response toward uric acid.

282 acid and 100% of glycine, glutamic acid and uric acid.

283 pro-oxidant and pro-inflammatory effects of uric acid.

284 accounted for 4.3% of the variance of serum uric acid.

285 thine oxidase of hypoxanthine to xanthine to uric acid.

286 I 1.11, 1.30) per 59.48 micromol/L (1 mg/dL) uric acid.

287 , apolipoprotein B, apolipoprotein CIII, and uric acid.

288 C2A9), polymorphisms with variation in serum uric acid.

289 for calcium oxalate, calcium phosphate, and uric acid.

290 or vitamin D, oxalate, cysteine, purines and uric acid.

291 shold, mostly due to renal underexcretion of uric acid.

292 nity of immobilized enzyme (uricase) towards uric acid.

293 approach to identify loci influencing serum uric acid.

294 The uric acid/xanthine H(+) symporter, UapA, is a high-affin

295 f lipid/lipoprotein risk factors for CVD and uric acid: postprandial triglyceride (0%: 0 +/- 4; 10%:

296 ells, macrophages, and neutrophils; elevated uric acid; and increased NLRP3, a major inflammasome com

297 toxic effect when combined with cyanuric and uric acids; however, it is unknown whether such effect c

298 se and ascorbate oxidase were used to remove uric and ascorbic acids and showed that the peaks obtain

299 d serotonin and 0.5 mM concentration of both uric and ascorbic acids.

300 Creatinine (Cr), uric (UA) and ascorbic acid (AA) are common constituents