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1 mall molecules with fast blood clearance and urinary excretion.
2 elimination from nontargeted organs, through urinary excretion.
3 collected over a period of 21 h to calculate urinary excretion.
4 ed rapid absorption into the circulation and urinary excretion.
5 449, which cleared rapidly from the body by urinary excretion.
6 s of plasma total Hcy (approximately 38%) by urinary excretion.
7 ethyl-arsenical species (DMAs), facilitating urinary excretion.
8 ion resulted in rapid tumor localization and urinary excretion.
9 d mice, whereas the control mice showed only urinary excretion.
10 a correlation of >/=0.8 with true long-term urinary excretion.
11 of megalin-dependent recapture, resulting in urinary excretion.
12 Urine samples were collected to calculate urinary excretion.
13 idney was seen, with clearance primarily via urinary excretion.
14 e from the protein, and this may explain its urinary excretion.
15 umulation of [(11)C]13 and hepatobiliary and urinary excretions.
19 ntake was estimated on the basis of measured urinary excretion, an estimated sodium intake between 3
20 lting from NNMT inhibition includes elevated urinary excretion and adipocyte secretion of diacetylspe
22 om surveys on sodium intake as determined by urinary excretion and diet in persons from 66 countries
23 eter <5.5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from t
24 s account for a substantial portion of total urinary excretion and must be considered in bioavailabil
27 er g, 1 h p.i.) is indicative of rapid renal-urinary excretion and suggests very high in vivo kinetic
30 vity to circulating blood, which cleared via urinary excretion, and no specific uptake in major organ
31 that links baseline sodium, measured by 24-h urinary excretion, and subsequent cardiovascular outcome
33 like MSC, GGMSC was well absorbed p.o., with urinary excretion as the major route for eliminating exc
36 The proposed model was calibrated against urinary excretion data for 42 drugs, and the utility for
37 uptake in a human population (inferred from urinary excretion data) divided by the rate that chemica
38 e (AUC) of serial blood draws and cumulative urinary excretion during a 24-h period and from a kineti
40 was determined in human volunteers by (14)C urinary excretion following topical [(14)C]-estradiol (0
41 ed a dose-dependent change from the baseline urinary excretion for NE, DHPG, and the DHPG/NE ratio.
42 ion to being cleared from the circulation by urinary excretion, Hcy-thiolactone is detoxified by the
44 e, like humans, eliminate Hcy-thiolactone by urinary excretion; in contrast to humans, however, mice
45 fluid of patients with arthritis, nor is its urinary excretion increased in patients with diabetes or
46 n at 2-10 min (PETearly), and, subsequently, urinary excretion into the collecting system and bladder
47 ility is similar to that of daidzein and its urinary excretion is significantly higher than that of g
48 the activities of these two enzymes and the urinary excretion level of the N2-glucuronide conjugate
49 these seven analogues and to evaluate their urinary excretion levels in samples from 164 Fabry patie
52 it NPD1 systemic circulation and prevent its urinary excretion, making difficult its detection and qu
53 linical centers are calibrated using 24-hour urinary excretion measures in cohorts from the Women's H
54 -reported dietary intake of sodium with 24-h urinary excretion obtained in the USDA Automated Multipl
56 tive extents of absorption were evaluated by urinary excretion of (2)H(2)- and (13)C(5)-labeled folat
58 h' efficiency uptake kinetics and fractional urinary excretion of 0.025%, whereas albumin and alpha(1
62 lationship between the extent of increase in urinary excretion of 11beta-prostaglandinF2alpha and N-m
64 NO synthesis was quantified by measuring the urinary excretion of 15N-nitrate after the intravenous a
65 Dietary adherence was good as reflected by urinary excretion of 174+/-64 mmol Na(+) per day in the
66 ry infusions of 2',3'-cAMP in vivo increased urinary excretion of 2'-AMP, 3'-AMP and adenosine, and i
67 LPS caused also dose-dependent elevations in urinary excretion of 2,3-dinor 6-keto PGF(1alpha) (PGI-M
68 n isoflavones increased the cycle mean daily urinary excretion of 2-hydroxyestrone (averaged over the
70 pregnant women have an abnormally increased urinary excretion of 3-hydroxyisovaleric acid (3-HIA), w
74 is an early-onset syndrome characterized by urinary excretion of 3-methylglutaconic acid (MGC), opti
76 studied a group of individuals with elevated urinary excretion of 3-methylglutaconic acid, neutropeni
82 vity of the L-arginine-NO metabolic pathway, urinary excretion of [15N]nitrates and [15N]urea was det
83 After infusion of L-[15N]arginine, 24-hour urinary excretion of [15N]nitrates was decreased in pati
84 in concert with increased tissue efflux and urinary excretion of acetylcarnitine and improvement of
85 and infusions of 2'-AMP and 3'-AMP increased urinary excretion of adenosine as efficiently as 5'-AMP.
87 red with control rats, D developed increased urinary excretion of albumin and transforming growth fac
88 rior longitudinal glycemic control in D-INS, urinary excretion of albumin and transforming growth fac
91 bited a reversible leukoencephalopathy and a urinary excretion of alpha-ketoglutarate (alphaKG) that
96 revious study of 10 subjects showed that the urinary excretion of biotin and 3-hydroxyisovaleric acid
97 he utility of 3 indicators of biotin status: urinary excretion of biotin and 3HIA and the increase in
101 ransferase-alpha Additionally, we quantified urinary excretion of blood plasma proteins alpha1-microg
102 glomeruli compared with normal controls, and urinary excretion of both cathepsins was significantly g
103 aluminum citrate significantly increased the urinary excretion of both crystalline calcium and crysta
104 ce, we examined kidney uptake of albumin and urinary excretion of both intact albumin and its fragmen
111 e kidney stones, including gender, diet, and urinary excretion of calcium, oxalate, and uric acid.
113 lamines (norepinephrine and epinephrine) and urinary excretion of catecholamines, metanephrines, and
114 wing infection, there was an increase in the urinary excretion of choline- and amino-acid-derived met
116 a cohort of ADPKD patients, lower levels of urinary excretion of citrate, an endogenous inhibitor of
120 dibasic amino acids that results in elevated urinary excretion of cystine, ornithine, lysine, and arg
121 lated with soy protein from 24-h recalls and urinary excretion of daidzein, genistein, and TIFLs.
122 e compared against repeated 24-h recalls and urinary excretion of daidzein, genistein, total isoflavo
123 mones, or fasting, associated with increased urinary excretion of delta-aminolevulinic acid (ALA).
124 a(1)-antitrypsin (AAT) to reduce the rate of urinary excretion of desmosine (DES), a specific marker
136 noreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early
138 on mass spectrometry.During training, 0-24-h urinary excretion of flavanone metabolites, mainly hespe
140 ed by cytoplasmic accumulation and increased urinary excretion of free N-acetylneuraminic acid (NeuAc
141 lpha-/- mice and a corresponding increase in urinary excretion of free sulfates as compared with wild
142 Genistein at 10mg/kg/day effectively reduces urinary excretion of GAGs and plasma HS concentration in
144 in both knockout strains, kidney levels and urinary excretion of genotoxic PhIP-metabolites were sig
148 osphatase and osteocalcin concentrations and urinary excretion of hydroxyproline and deoxypyridinolin
149 e mice, megalin-deficient mice showed higher urinary excretion of injected hhep25 and no hepcidin sta
150 ed the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanopar
151 ake and degradation of albumin and increased urinary excretion of intact albumin; we did not, however
153 study shows an important correlation between urinary excretion of IP-10 and Mig and acute rejection i
155 ar capacity to generate the isoprostane, nor urinary excretion of IPF2alpha-I, an index of actual gen
160 creases systemic oxidant stress, we measured urinary excretion of isoprostanes (iPs), free radical-ca
162 In contrast, both serum thromboxane B2 and urinary excretion of its 11-dehydro metabolite are depre
165 ce (measured by transit time nanoprobes) and urinary excretion of kidney injury molecule-1 and neutro
166 r plasma alpha-tocopherol concentrations and urinary excretion of labeled and unlabeled alpha-CEHC (P
167 idney is accompanied by a marked increase in urinary excretion of lactate as well as a decrease in bl
168 ized the 6-h postprandial serum kinetics and urinary excretion of lactose, galactose, galactitol, and
169 LTC4 S mRNA transcripts in whole blood and urinary excretion of leukotriene E4 were similar in EoE
173 risk factors for progression were amount of urinary excretion of M protein per 24 h, proportion of b
177 basis of these results, it is concluded that urinary excretion of MCP-1 is increased in the majority
181 avan disease (CD)] reportedly have increased urinary excretion of N-acetylaspartylglutamate (NAAG), a
182 urinary concentration ability, and augmented urinary excretion of Na(+) and urea in both mutant mice.
189 es in plasma glucose concentrations, GFR, or urinary excretion of other proximal tubular substrates (
191 he plasma concentration of glycolate and the urinary excretion of oxalate, the major metabolites of e
193 ntestinal absorption, biliary excretion, and urinary excretion of P-gp substrates can therefore be al
194 abolite ratio suggest that women with higher urinary excretion of parent estrogens are at lower risk.
197 increased arterial glutamine (P < 0.01) and urinary excretion of phenylacetylglutamine (P < 0.01) in
198 doses of nitisinone on circulating and 24 h urinary excretion of phenylalanine (PA), tyrosine (TYR),
199 -23) is a hormone that increases the rate of urinary excretion of phosphate and inhibits renal produc
200 NHERF-1 null mice demonstrate increased urinary excretion of phosphate associated with mistarget
201 e, and indomethacin treatment normalizes the urinary excretion of phosphate by a direct tubular effec
202 rmal blood electrolytes but showed increased urinary excretion of phosphate when compared with wild-t
203 RF-1(-/-)) mice demonstrate increases in the urinary excretion of phosphate, calcium, and uric acid a
207 ciated with lower serum potassium and higher urinary excretion of potassium, but only when renin was
209 Under these 2 settings of salt loading, urinary excretion of prostaglandin E(2) and nitrate/nitr
210 h the p.A396T variant demonstrated increased urinary excretion of prostaglandin E2 and metabolites.
211 Bone resorption was calculated by measuring urinary excretion of pyridinoline and deoxypyridinoline
214 etinide, a synthetic retinoid that increases urinary excretion of RBP4, normalizes serum RBP4 levels
217 onsumption is associated with an increase in urinary excretion of sex steroid hormones and their meta
220 blood pressure and hypertension with 24-hour urinary excretion of sodium and potassium among US adult
222 one (18 +/- 18 pg/ml) remained low but daily urinary excretion of sodium and potassium were not diffe
223 ated with an improvement in urine volume and urinary excretion of sodium during the first day of trea
226 GTP treatment also significantly reduced urinary excretion of sphinganine (Sa), sphingosine (So),
227 alcium oxalate stones) had a 40% decrease in urinary excretion of succinate, a 35% increase in serum
229 distinct inhibitory effect of etoricoxib on urinary excretion of tetranor-prostaglandin E2 (P < .001
230 ted increases in macrophage infiltration and urinary excretion of TGF-beta and prostaglandin E2 metab
231 eta and collagen IV, renal cortical MDA, and urinary excretion of TGF-beta in D-SOD mice did not diff
235 retion of soy molybdenum was also lower than urinary excretion of the extrinsic label, but excretion
236 lects local oxidative stress), and augmented urinary excretion of the isoprostane 8,12-iso-iPF(2alpha
240 -95 +/- 2% vs. -6.9 +/- 4.2%; P < 0.001) and urinary excretion of the major Tx metabolite, 11-dehydro
242 f thromboxane was highly correlated with the urinary excretion of the major urinary metabolite of pro
246 enhanced bone remodeling as well as enhanced urinary excretion of the osteoclastic activity marker de
249 nopausal women, and men daily and determined urinary excretion of the renal tubular enzymes fructose-
251 was applied to monitor plasma appearance and urinary excretion of these AGEs in type 2 diabetes melli
252 This study addresses the question of whether urinary excretion of these chemokines correlates with ac
253 PhIP and PhIP metabolites leads to increased urinary excretion of these metabolites and increased sys
257 This study measured serum concentrations and urinary excretion of TMAO in a CKD cohort (n=104), ident
258 istein resulted in a significant decrease in urinary excretion of total GAGs (p = 0.02, slope -0.68 m
259 served that women in the highest quartile of urinary excretion of total lignans had significantly low
261 ervation of renal Mrp2 expression may permit urinary excretion of toxic organic anions and xenobiotic
265 ral population, increase UMOD expression and urinary excretion of uromodulin, causing salt-sensitive
266 at the UMOD ancestral allele, driving higher urinary excretion of uromodulin, has been kept at a high
267 ive dermatosis with hepatic accumulation and urinary excretion of uroporphyrin and hepta-carboxylic p
269 ), the model yields segmental deliveries and urinary excretion of volume and key solutes that are con
271 After infusion of L-[15N]arginine, 24-hour urinary excretions of [15N]urea at rest in patients with
272 based on a molecular understanding of excess urinary excretions of calcium, oxalate, cystine, and uri
274 nges in mineralocorticoid and glucocorticoid urinary excretion on day-to-day osmolyte and water balan
275 fect on either the time course of furosemide urinary excretion or overall amount excreted: 49 +/- 15
277 In a retrospective case control study the urinary excretion parameters were analysed from 56 patie
278 beled AGE diet produced serum absorption and urinary excretion peaks kinetically distinct from those
281 The pharmacokinetics of Rasburicase, the urinary excretion rate of allantoin, and antibodies to R
282 manner by the following six parameters: (1) urinary excretion rate of total protein, (2) glomerular
283 unction, and plasma 3-nitrotyrosine and 24-h urinary excretion rates of free 8-iso PGF2 alpha, two ma
284 ether plasma concentrations of antioxidants, urinary excretion rates of polyphenols, and antioxidants
285 oss through phenylacetylglutamine excretion; urinary excretion rates of urea, ammonium, urate, creati
286 stion of each test beverage due to decreased urinary excretion rates, 2) glucose (glu)- and amino aci
287 cetylglutamine level correlated with 24-hour urinary excretion (rho=0.55; P<0.001) and clearance of p
289 on the physiological variables affecting FDG urinary excretion that are critical to minimizing urinar
298 Furthermore, HO-1 kidney expression and urinary excretion were reduced in AngII-treated mice wit
300 ations were assessed for dietary intakes and urinary excretions with BMI adjusted for potential confo