ライフサイエンスコーパス: urothelium

1 amina propria) and targeting the epithelium (urothelium).

2 hway may exert these effects directly on the urothelium.

3 ld higher than in wild type mice with intact urothelium.

4 network resulted in an accurate detection of urothelium.

5 ormation and terminal differentiation of the urothelium.

6 in the developing and mature murine bladder urothelium.

7 d ATP release which presumably occurs in the urothelium.

8 P and type 1 pili for attachment to the host urothelium.

9 advanced transitional-cell carcinoma of the urothelium.

10 nd normally to mannosylated receptors in the urothelium.

11 thways including primary afferent nerves and urothelium.

12 wards developing specific endodermal derived urothelium.

13 erficial, 72 invasive lesions, and 52 normal urothelium.

14 eatment of patients with advanced TCC of the urothelium.

15 line expressing a cyclin D1 oncogene in the urothelium.

16 een UPEC and terminally differentiated human urothelium.

17 ponents originate from the same cells in the urothelium.

18 ill develop recurrent lesions throughout the urothelium.

19 id not cause histologic abnormalities of the urothelium.

20 el of expression compared to adjacent normal urothelium.

21 cell lineages in the prostate epithelium and urothelium.

22 1 and PTEN in intermediate and luminal mouse urothelium.

23 ceptor (B1R) is expressed in control bladder urothelium.

24 study as compared to their respective normal urothelium.

25 here through the interstitium to beneath the urothelium.

26 major differentiation products of mammalian urothelium.

27 ced transitional-cell carcinoma (TCC) of the urothelium.

28 iously shown that p63 is expressed in normal urothelium.

29 m; strong expression was also seen in normal urothelium.

30 g growth, differentiation, and repair of the urothelium.

31 e specific differentiation of a transitional urothelium.

32 hanically evoked purinergic signaling by the urothelium.

33 vivo involved a direct effect on neoplastic urothelium.

34 itional cell carcinomas compared with normal urothelium.

35 te in promoting COM crystal retention by the urothelium.

36 th the level of potential carcinogens in the urothelium.

37 in the treatment of advanced cancers of the urothelium.

38 for patients with advanced carcinoma of the urothelium.

39 duction pathway in TCC cell lines and normal urothelium.

40 major differentiation products of mammalian urothelium.

41 ngle-agent activity against carcinoma of the urothelium.

42 ssary for the proliferative action of KGF on urothelium.

43 the kidney's intercalated cells and bladder urothelium.

44 network was trained to automatically detect urothelium.

45 cells that recapitulate many aspects of the urothelium.

46 ntation of the cells within the multilayered urothelium.

47 dder compliance is governed primarily by the urothelium.

48 fections without causing lasting harm to the urothelium.

49 and one major type in the sub-urothelium and urothelium.

50 d invade the epithelial cells of the bladder urothelium.

51 24 was elevated compared with normal bladder urothelium.

52 l pilus for UPEC persistence in the inflamed urothelium.

53 matic BK virus latency is established in the urothelium.

54 in mechanically-induced ATP release from the urothelium.

55 alized pannexin 1 to all three layers of the urothelium.

56 naling, Ret expression, and apoptosis of the urothelium.

57 by the urethra and external adherence to the urothelium.

58 y and raised P2X3 receptor expression in the urothelium.

59 uld contribute to spread of cells within the urothelium.

60 ctivated beta-catenin signaling in the adult urothelium.

61 commonly predicted were biliary tract (18%), urothelium (11%), colorectal (10%), and non-small-cell l

62 rcinomatous urothelium but not in the normal urothelium; (2) uptake was detected at a very early stag

63 5-HT(3) receptors were not detected in mouse urothelium, 5-HT(3) receptors expressed on bladder senso

64 ernal surface of the bladder is lined by the urothelium, a stratified epithelium that forms an imperm

65 ibroblast growth factor receptor (FGFR) 2 in urothelium after cyclophosphamide exposure.

66 , synthesis of the HB-EGF precursor by human urothelium also suggests the possibility of using the DT

67 ed to increased proliferation of the bladder urothelium although this was not associated with hyperpl

68 Urothelium, an anatomical barrier for innate immune resp

69 due to their strategic position between the urothelium and afferent fibres.

70 long-term culture system of the normal mouse urothelium and an efficient culture system of human blad

71 amined the expression of PPARgamma in normal urothelium and bladder cancer in an attempt to assess it

72 distinct layer of smooth muscle between the urothelium and bladder detrusor, termed the muscularis m

73 in nine bladder cancer cells, paired normal urothelium and bladder tumor samples (n = 25), and tissu

74 ar bacterial reservoirs, which reside in the urothelium and can seed recurrent infections.

75 Mutation of Dlg1 in urothelium and collecting ducts (via HoxB7-Cre or Pax2-C

76 family member expressed in both normal human urothelium and cultured normal human urothelial (NHU) ce

77 alized throughout the bladder, including the urothelium and detrusor smooth muscle.

78 ic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell d

79 ptor mRNA transcripts are expressed in mouse urothelium and exert functional responses to 5-HT.

80 fection, we showed that MRSA attached to the urothelium and implant in patterns that colocalized with

81 Invasion of the urothelium and induction of host inflammation are hypoth

82 PIEZO2 acts as a sensor in both the bladder urothelium and innervating sensory neurons.

83 erents, but new findings have pointed to the urothelium and interstitial cells as key participants in

84 ed kidney rudiments can induce production of urothelium and organize the mesenchyme to produce rhythm

85 hich are considered to be progenitors in the urothelium and other specialized epithelia.

86 t that it is also detected in mature bladder urothelium and primary urothelial cultures.

87 an 8-fold increase) is reminiscent of normal urothelium and remains slow-cycling.

88 se but few studies have investigated how the urothelium and sensory pathways are affected.

89 x vivo mouse bladder preparation with intact urothelium and SubU/LP but no detrusor, which allows dir

90 The preparation wall contained intact urothelium and suburothelium (SubU)/lamina propria (LP)

91 sive evidence that bacteria invade the human urothelium and suggest that diverse bacterial species an

92 he PTCH, SMOH and GLI3 transcripts in normal urothelium and TCC cell lines and rare PTCH mutations in

93 Normal urothelium and TCC cell lines express these three genes

94 m of transitional cells of the human bladder urothelium and that the soluble form of the growth facto

95 y be attributed to the interplay between the urothelium and the release of urothelially derived media

96 y signal feedback between basal cells of the urothelium and the stromal cells that underlie them.

97 erally, a prominent role has emerged for the urothelium and the underlying suburothelium in mechanose

98 ophosphamide (CYP)-induced cystitis) bladder urothelium and their contribution to lower urinary tract

99 s not expressed by normal or malignant human urothelium and therefore is unlikely to play a role in a

100 etrusor muscle and one major type in the sub-urothelium and urothelium.

101 s that block bacterial interactions with the urothelium and vaccines focused on preventing both acute

102 le of regenerating all cell types within the urothelium, and are marked by expression of the secreted

103 ed that B7-H3 is expressed within the liver, urothelium, and fetal kidney.

104 -cells, were detected within the mesenchyme, urothelium, and follicular aggregates in the majority of

105 helial cells, HCV29, established from normal urothelium, and H69, established from cholangiocytes, in

106 increases with age, is not present in normal urothelium, and occurs early in tumorigenesis, it can be

107 epithelial layers in the epidermis, cervix, urothelium, and prostate.

108 onal crystals covering the apical surface of urothelium, and provide unique opportunities for studyin

109 to the permeability barrier function of the urothelium, and UPIII deficiency can lead to global anom

110 nvasive tumors with matched normal-appearing urothelium, and urothelium from 12 age-matched UC-free p

111 VNUT was abundantly expressed in the bladder urothelium, and when the urothelium was weakly stimulate

112 m the apical and basolateral surfaces of the urothelium appears to be mediated by separate mechanisms

113 een low-grade, noninvasive tumors and normal urothelium are needed to identify genes involved in earl

114 It is proposed that ATP is released from the urothelium as a sensory mediator for the degree of diste

115 ER1 interaction, and identification of human urothelium as a site of HB-EGF precursor (proHB-EGF) syn

116 e examined the distribution of nAChRs in the urothelium, as well as their ability to influence the re

117 Deletion of Klf5 from the developing bladder urothelium blocked epithelial cell differentiation, impa

118 RPV4 is not only abundantly expressed in the urothelium but may also be localized in subepithelium, d

119 served in the hyperplastic and carcinomatous urothelium but not in the normal urothelium; (2) uptake

120 rategy: 67LR was not expressed in the normal urothelium but was present in the tumor, whereas TATI ex

121 was confined to umbrella cells in the normal urothelium, but extended to all cell layers in the tumor

122 mirabilisrapidly invades the bladder urothelium, but generally fails to establish an intracel

123 ns innervated the detrusor, vasculature, and urothelium, but only part of this innervation was sensor

124 esent in most normal human tissues including urothelium, but was reduced or absent in the majority of

125 reduce contact time between carcinogens and urothelium by diluting urinary metabolites and increasin

126 GFR3 may confer a selective advantage in the urothelium by overcoming normal contact inhibition of pr

127 ctivation of tumor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carc

128 ne, our data establish that normal mammalian urothelium can function not only as a permeability barri

129 ith our recent finding that transgenic mouse urothelium can secrete ectopically expressed human growt

130 ur data strongly support the hypothesis that urothelium can undergo at least three pathways of differ

131 ct4 is expressed in normal and in neoplastic urothelium carrying implications for a bladder cancer st

132 e developing prostate epithelium and bladder urothelium, cell lineages in these endoderm-derived epit

133 toxicity to telomerase-negative human normal urothelium cells but was highly cytotoxic to telomerase-

134 null mice develop a bladder with an abnormal urothelium, constituted by a single layer of cells that

135 cultures from the rat demonstrated that the urothelium contains both alpha3* and alpha7 receptors.

136 -dependent transcription plays a role in the urothelium controlling mitochondrial function developmen

137 inogen activators of ruminants are therefore urothelium derived rather then kidney derived as in some

138 der tumour-derived cell lines and one normal urothelium-derived cell line for genome-wide copy number

139 odel that enables studies on availability of urothelium-derived mediators at the luminal and anti-lum

140 itable for understanding local mechanisms of urothelium-DSM connectivity and for broad understanding

141 s to examine p63 isoforms in mouse and human urothelium during embryogenesis and tumor progression, r

142 the luminal and anti-luminal aspects of the urothelium during filling.

143 lows direct access to the SubU/LP surface of urothelium during filling.

144 thogenic Escherichia coli (UPEC) in the host urothelium during urinary tract infection (UTI) via the

145 t models utilized to study properties of the urothelium (e.g. cultured urothelial cells, bladder muco

146 interplay between invading bacteria and the urothelium elicits a mucosal response aimed at clearing

147 Mice with conditional deletion of Fgfr2 in urothelium enriched for KRT14(+) cells reproduced Fgfr2K

148 The bladder urothelium exhibits dynamic sensory properties that adap

149 Primary urothelium expressed high levels of FGFR3 transcripts.

150 Urothelium-expressed p53 mutant binds to and stabilizes

151 However, our findings also indicate that urothelium expresses a variety of other Oct4 splice-vari

152 Normal urothelium expresses myopodin in the cytoplasm and nucle

153 epithelial lining of the urinary bladder, or urothelium, expresses two subtypes of nicotinic acetylch

154 expressing FGFR3b-S243C in transgenic mouse urothelium expressing SV40T converted carcinoma-in-situ

155 al inactivation of both RB1 alleles in mouse urothelium failed to accelerate urothelial proliferation

156 The bladder urothelium failed to stratify and did not express termin

157 The UPIII-depleted urothelium features small plaques, becomes leaky, and ha

158 luding the bladder, is lined by a stratified urothelium forming a highly differentiated, superficial

159 ith matched normal-appearing urothelium, and urothelium from 12 age-matched UC-free patients.

160 We isolated the urothelium from a low-grade tumor and corresponding norm

161 ethylation patterns between normal-appearing urothelium from bladders with cancer and urothelium from

162 ci were hypermethylated in apparently normal urothelium from bladders with cancer, indicating an epig

163 ing urothelium from bladders with cancer and urothelium from cancer-free bladders.

164 the various stages in the differentiation of urothelium from ES cells, including the commitment to an

165 n and, in ketamine-induced cystitis, loss of urothelium from large areas of the bladder wall is a rep

166 A separate cohort of normal urothelium from noncancer patients showed significantly

167 with the prostate findings, analysis of the urothelium from rescued p63-/- chimeras shows that umbre

168 When the bladder is distended, the urothelium functions as a sensor to initiate the voiding

169 ays after cyclophosphamide exposure, Fgfr2KO urothelium had defective regeneration, fewer cells, larg

170 Fgfr2KO urothelium had defects up to 6 months after injury versu

171 By 12 weeks, the urothelium had regenerated and micturition patterns were

172 Nonmalignant urothelium had uniform expression of LN5 genes and lacke

173 f culture models for the bladder epithelium (urothelium) hampers the development of new therapeutics.

174 The newly recognized sensory role of bladder urothelium has generated intense interest in identifying

175 ced transitional-cell carcinoma (TCC) of the urothelium has promising activity and acceptable toxicit

176 ve diseases of the human bladder epithelium (urothelium), however a cognate HER1 ligand that can act

177 atic carcinoma, but not in the nonneoplastic urothelium, implicates BKV as an etiologic agent in the

178 The luminal surface of mouse urothelium in contact with the urine is almost entirely

179 The involvement of the urothelium in patterning the urinary tract is supported

180 y and for broad understanding of the role of urothelium in regulating continence and voiding.

181 Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modul

182 The release of ATP from urothelium in response to distension and its action on P

183 he release of several neurotransmitters from urothelium in response to distension and its action on r

184 ng evidence points to critical roles for the urothelium in the developing urinary tract and in the ge

185 s decreased pannexin 1 expression in the rat urothelium in vivo and increased bladder capacity.

186 K3CA may confer a selective advantage in the urothelium in vivo by overcoming normal contact-mediated

187 evels were greatly reduced (to <5% of normal urothelium) in cultured urothelial cells, which synthesi

188 from the bladder epithelium, also termed the urothelium, in response to mechanical or chemical stimul

189 n of a constitutively active Ha-ras in mouse urothelium induces simple urothelial hyperplasia that is

190 We employed a culture model of UPEC-urothelium interactions to examine the biochemical event

191 have suggested that mediators released from urothelium into suburothelium (SubU)/lamina propria (LP)

192 erapeutic agents can be absorbed through the urothelium into the bloodstream, leading to systemic adv

193 We found that in the presence of a leaky urothelium, intravesical K(+) sensitizes bladder afferen

194 rom being a passive container for urine, the urothelium is a crucial area within the bladder wall and

195 rom being a passive container for urine, the urothelium is a crucial part of the bladder.

196 Although normal bladder urothelium is a mitotically quiescent barrier epithelium

197 The urothelium is a multilayered epithelium that serves as a

198 The urothelium is also known to secrete proteins into the ur

199 The urothelium is an epithelial barrier lining the bladder t

200 enes or inactivation of tumor suppressors in urothelium is considered critical for development of uro

201 Although urothelium is constantly bathed in high concentrations o

202 The apical surface of mammalian urothelium is covered by 16-nm protein particles packed

203 The apical surface of mammalian bladder urothelium is covered by large (500-1000 nm) two-dimensi

204 The apical surface of mouse urothelium is covered by two-dimensional crystals (plaqu

205 Carcinogenesis in human urothelium is driven by a high burden of mutations cause

206 The bladder urothelium is more than just a barrier.

207 Mutant RXRA-driven growth of urothelium is reversible by PPAR inhibition, supporting

208 tivation of all Rb family genes in the mouse urothelium is sufficient to initiate bladder cancer deve

209 Urothelium is the protective lining of the urinary tract

210 owever, the function of Pparg in the healthy urothelium is unknown.

211 first- or second-line setting in TCC of the urothelium is warranted.

212 ncer arises in the superficial lining of the urothelium, it is a likely candidate for site-directed a

213 In the urothelium, its expression can be up-regulated after act

214 PPARgamma reportedly is expressed in normal urothelium, its function is unknown.

215 on; more broadly, our findings indicate that urothelium itself directly modulates voiding.

216 g in the ureteral mesenchyme, but not in the urothelium itself, led to urothelial disorganization, hi

217 und in both the smooth muscle (detrusor) and urothelium layers of the urinary bladder.

218 e direct effects of ketamine on normal human urothelium maintained in organ culture or as finite cell

219 invasive cancers (n = 56) or benign adjacent urothelium (n = 49).

220 related genes compared with tumor-associated urothelium, noninvasive urothelial lesions, and CIS.

221 sed angiogenesis when compared to the normal urothelium (NU) from which they are derived.

222 e-driven system ablating Foxa1 expression in urothelium of adult mice resulted in sex-specific histol

223 ansion but occurred independently across the urothelium of bladders with cancer.

224 CPV was detected in the urothelium of graft ureters, associated with ureteritis

225 ser capture microdissection from the bladder urothelium of infected C3H/HeJ female mice.

226 we eliminated beta1-integrin selectively in urothelium of mice using Cre-LoxP targeted gene deletion

227 ings and urinary biomarkers derived from the urothelium of patients with CAKUTs might aid their contr

228 increase in cytokeratin 14 expression in the urothelium of the female Foxa1 knockout mouse and an inc

229 ble hyperplasia of intestinal epithelia, and urothelium of the urinary bladder and ureters.

230 akin II gene promoter, we have targeted into urothelium of transgenic mice a dominant-negative mutant

231 of an activated form of beta-catenin to the urothelium of transgenic mice using Cre-Lox technology (

232 Cancers arising from the bladder urothelium often exhibit lineage plasticity with regions

233 Bladder cancers derive from the urothelium, one of the most quiescent epithelia in the b

234 provide compelling evidence, indicating that urothelium, one of the slowest cycling epithelia, is rem

235 rase (ChAT) were performed in wholemounts of urothelium or detrusor or cryostat sections of the bladd

236 d in quiescent (G(0)) cells, indicating that urothelium overexpressing the cyclin D1 (an 8-fold incre

237 lin E immunoreactivity, compared with normal urothelium (P < 0.01).

238 ed in response to infection in the wild type urothelium, persists for months.

239 ct and HA degeneration and bladder repair by urothelium proliferation and differentiation.

240 D34(+) grafts provided the impetus for rapid urothelium regeneration.

241 my, ensuring complete removal of susceptible urothelium, remains to be determined.

242 experimental approaches previously used for urothelium research.

243 d that disrupting the uroplakin layer of the urothelium resulted in water and urea permeabilities (P)

244 onclude that loss of integrin signaling from urothelium results in incontinence and overactive bladde

245 both patients relative to a panel of normal urothelium samples obtained from individuals free of bla

246 Moreover, we demonstrate that the urothelium secretes these proteins in a polarized fashio

247 Bladder urothelium senses and communicates information about bla

248 ty of the UPII promoter in the generation of urothelium-specific adenoviral vectors and provide a pot

249 We recently showed that the urothelium-specific expression of activated H-ras and SV

250 Using a urothelium-specific promoter of the uroplakin II gene, w

251 Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and g

252 b promoter of uroplakin II gene to drive the urotheliums-specific expression of oncogenes.

253 ere we showed TRPV4 expression in guinea-pig urothelium, suburothelium, and bladder smooth muscle, wi

254 excitatory and inhibitory mediators from the urothelium such as ATP and nitric oxide.

255 (Uro) A subtype shares features with normal urothelium such as keratin 5 (KRT5), P-cadherin (P-Cad),

256 a downregulation of SERT mRNA expression in urothelium, suggesting increased 5-HT bioavailability.

257 diminish the proliferative effect of KGF on urothelium, suggesting that the contribution of urinary

258 Hierarchical clustering classified normal urothelium, superficial, and invasive tumors with 82.2%

259 n of interferon gamma (IFNgamma) to infected urothelium suppressed expression of the viral genome.

260 ltilayered water-tight epithelium called the urothelium, surrounded by smooth muscle layers that, by

261 Urothelium synthesizes a group of integral membrane prot

262 Our data indicate that normal bovine urothelium synthesizes, as its major differentiation pro

263 er level of the EGFr mRNA and protein in the urothelium than the nontransgenic controls.

264 , and intrinsic signalling mechanisms of the urothelium that may contribute to the altered sensory pr

265 lving ATP and NO release presumably from the urothelium, that in turn could act on bladder C-fiber af

266 Cs are progenitors in the adult regenerating urothelium, that P cells, a transient population, are pr

267 Within the urothelium, the IL-6 native-tissue origin, the target ce

268 s to frank carcinoma nor regresses to normal urothelium through a period of one year.

269 lls, followed by rapid reconstitution of the urothelium through differentiation of underlying basal a

270 GF-beta1) may stimulate ATP release from the urothelium through vesicular exocytosis mechanisms with

271 Immunohistochemical staining revealed normal urothelium to express PPARgamma uniformly.

272 evidence that p53 deficiency predisposes the urothelium to hyperproliferation, but is insufficient fo

273 Exposure of urothelium to ketamine resulted in apoptosis, with cytoc

274 f uropathogenic Escherichia coli to the host urothelium to trigger the infection.

275 either low- or high-grade carcinomas in the urothelium transitional epithelium supporting a key role

276 least three pathways of differentiation: (a) urothelium-type pathway; (b) epidermis-type pathway; and

277 in metaplastic recombinants reflected human urothelium undergoing KSM.

278 -dsP21-322-2'F into mouse bladder results in urothelium uptake and extends survival of mice with esta

279 udy demonstrates that in the face of a leaky urothelium, urinary K(+) is the main determinant of affe

280 imian vacuolating virus 40 T (SV40T), in the urothelium (Uro-SV40T-AR(-/y)) had a similar incidence o

281 5-HT-producing enzymes was determined in the urothelium using RT-PCR.

282 ering to mannosylated receptors on the human urothelium via the carbohydrate-binding domain of the Fi

283 tability by stimulating ATP release from the urothelium via vesicular exocytosis mechanisms with mini

284 facet cell layer of the bladder epithelium (urothelium) via its FimH adhesin.

285 The slides were digitized, and the urothelium was annotated by expert observers.

286 e fibers in the urinary bladder detrusor and urothelium was decreased or eliminated after SCI.

287 rganization, terminal differentiation of the urothelium was not significantly affected.

288 ing of the urethral diameter and with normal urothelium was noted in all dogs surviving at least 28 d

289 ssed in the bladder urothelium, and when the urothelium was weakly stimulated (i.e. in the early fill

290 ts with measurable stage IV carcinoma of the urothelium were enrolled onto this trial.

291 arker of exposure, and are found also in the urothelium, where they give rise to a unique mutational

292 All four PARs are co-expressed in the urothelium, whereas PAR-1 and PAR-2 are predominant in t

293 dinary high level (0.1% of total protein) in urothelium, whereas Rab27b levels were greatly reduced (

294 an increase in NGF expression in the bladder urothelium, which depended on activation of the pelvic n

295 n limit sustained drug concentrations in the urothelium, which reduces efficacy, and small-molecule c

296 in PNCA in Uro-AR(-/y) than that found in WT urothelium, which suggests that Uro-AR may modulate blad

297 Patients with cancers of the urothelium who had no prior chemotherapy (prior adjuvant

298 mutational processes and selection in normal urothelium with large heterogeneity across clones and in

299 mans for the key functional role of TRPV4 in urothelium with specific mechanisms and identify TRPV4 u

300 ing water develop hyperplasia of the bladder urothelium within 4 weeks of exposure.